Secondary structure and disorder prediction

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Sequence		M	K	K	R	G	A	F	L	G	L	L	L	V	S	A	C	A	S	V	F	A	A	N	N	E	T	S	K	S	V	T	F	P	K	C	E	D	L	D	A	A	G	I	A	A	S	V	K	R	D	Y	Q	Q	N	R	V	A	R	W	A
Secondary structure
SS confidence
Disorder		?	?	?	?																?	?	?	?	?	?	?	?	?						?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.
Sequence		D	D	Q	K	I	V	G	Q	A	D	P	V	A	W	V	S	L	Q	D	I	Q	G	K	D	D	K	W	S	V	P	L	T	V	R	G	K	S	A	D	I	H	Y	Q	V	S	V	D	C	K	A	G	M	A	E	Y	Q	R	R
Secondary structure
SS confidence
Disorder					?	?	?	?	?		?								?	?	?		?	?	?	?																											?			?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2xgl chain B Region: 31 - 115 Aligned: 84 Modelled: 85 Confidence: 100.0% Identity: 26% PDB header:antibiotic Chain: B: PDB Molecule:colicin-m immunity protein; PDBTitle: the x-ray structure of the escherichia coli colicin m immunity2 protein demonstrates the presence of a disulphide bridge, which is3 functionally essential Phyre2 PDB 3dd7 chain A Region: 2 - 49 Aligned: 48 Modelled: 48 Confidence: 47.1% Identity: 13% PDB header:ribosome inhibitor Chain: A: PDB Molecule:death on curing protein; PDBTitle: structure of doch66y in complex with the c-terminal domain of phd Phyre2 PDB 2nxy chain B domain 2 Region: 64 - 116 Aligned: 52 Modelled: 53 Confidence: 38.8% Identity: 12% Fold: Immunoglobulin-like beta-sandwich Superfamily: Immunoglobulin Family: C2 set domains Phyre2 PDB 3fsn chain A Region: 47 - 110 Aligned: 61 Modelled: 64 Confidence: 25.1% Identity: 20% PDB header:isomerase Chain: A: PDB Molecule:retinal pigment epithelium-specific 65 kda protein; PDBTitle: crystal structure of rpe65 at 2.14 angstrom resolution Phyre2 PDB 2k87 chain A Region: 64 - 82 Aligned: 17 Modelled: 19 Confidence: 21.2% Identity: 24% PDB header:viral protein, rna binding protein Chain: A: PDB Molecule:non-structural protein 3 of replicase polyprotein 1a; PDBTitle: nmr structure of a putative rna binding protein (sars1) from sars2 coronavirus Phyre2 PDB 2qh7 chain A Region: 28 - 37 Aligned: 10 Modelled: 10 Confidence: 19.3% Identity: 40% PDB header:metal binding protein Chain: A: PDB Molecule:zinc finger cdgsh-type domain 1; PDBTitle: mitoneet is a uniquely folded 2fe-2s outer mitochondrial membrane2 protein stabilized by pioglitazone Phyre2 PDB 3fnv chain B Region: 28 - 37 Aligned: 10 Modelled: 10 Confidence: 18.8% Identity: 50% PDB header:metal binding protein Chain: B: PDB Molecule:cdgsh iron sulfur domain-containing protein 2; PDBTitle: crystal structure of miner1: the redox-active 2fe-2s protein causative2 in wolfram syndrome 2 Phyre2 PDB 1wh6 chain A Region: 35 - 69 Aligned: 35 Modelled: 35 Confidence: 16.2% Identity: 17% Fold: lambda repressor-like DNA-binding domains Superfamily: lambda repressor-like DNA-binding domains Family: CUT domain Phyre2 PDB 2l25 chain A Region: 57 - 112 Aligned: 56 Modelled: 56 Confidence: 15.5% Identity: 23% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: np_888769.1 Phyre2 PDB 3iyn chain R Region: 51 - 60 Aligned: 10 Modelled: 10 Confidence: 14.4% Identity: 40% PDB header:virus Chain: R: PDB Molecule:hexon-associated protein; PDBTitle: 3.6-angstrom cryoem structure of human adenovirus type 5 Phyre2 PDB 3arc chain L Region: 1 - 21 Aligned: 21 Modelled: 21 Confidence: 14.3% Identity: 33% PDB header:electron transport, photosynthesis Chain: L: PDB Molecule:photosystem ii reaction center protein l; PDBTitle: crystal structure of oxygen-evolving photosystem ii at 1.9 angstrom2 resolution Phyre2 PDB 1s7e chain A domain 2 Region: 37 - 69 Aligned: 33 Modelled: 33 Confidence: 13.6% Identity: 6% Fold: lambda repressor-like DNA-binding domains Superfamily: lambda repressor-like DNA-binding domains Family: CUT domain Phyre2 PDB 3kfo chain A Region: 105 - 116 Aligned: 12 Modelled: 12 Confidence: 13.1% Identity: 17% PDB header:protein transport Chain: A: PDB Molecule:nucleoporin nup133; PDBTitle: crystal structure of the c-terminal domain from the nuclear pore2 complex component nup133 from saccharomyces cerevisiae Phyre2 PDB 2csf chain A domain 1 Region: 30 - 69 Aligned: 40 Modelled: 40 Confidence: 13.0% Identity: 8% Fold: lambda repressor-like DNA-binding domains Superfamily: lambda repressor-like DNA-binding domains Family: CUT domain Phyre2 PDB 1o6e chain A Region: 43 - 71 Aligned: 29 Modelled: 29 Confidence: 12.8% Identity: 21% Fold: Herpes virus serine proteinase, assemblin Superfamily: Herpes virus serine proteinase, assemblin Family: Herpes virus serine proteinase, assemblin Phyre2 PDB 1r17 chain A domain 1 Region: 73 - 106 Aligned: 34 Modelled: 34 Confidence: 12.1% Identity: 12% Fold: Common fold of diphtheria toxin/transcription factors/cytochrome f Superfamily: Bacterial adhesins Family: Fibrinogen-binding domain Phyre2 PDB 1fyh chain B domain 2 Region: 66 - 116 Aligned: 49 Modelled: 51 Confidence: 11.3% Identity: 18% Fold: Immunoglobulin-like beta-sandwich Superfamily: Fibronectin type III Family: Fibronectin type III Phyre2 PDB 2l9w chain A Region: 23 - 48 Aligned: 26 Modelled: 26 Confidence: 10.4% Identity: 12% PDB header:splicing, rna binding protein Chain: A: PDB Molecule:u4/u6 snrna-associated-splicing factor prp24; PDBTitle: solution structure of the c-terminal domain of prp24 Phyre2 PDB 1ieg chain A Region: 43 - 77 Aligned: 35 Modelled: 35 Confidence: 10.4% Identity: 23% Fold: Herpes virus serine proteinase, assemblin Superfamily: Herpes virus serine proteinase, assemblin Family: Herpes virus serine proteinase, assemblin Phyre2 PDB 3nqy chain A Region: 37 - 116 Aligned: 74 Modelled: 80 Confidence: 9.8% Identity: 18% PDB header:hydrolase Chain: A: PDB Molecule:secreted metalloprotease mcp02; PDBTitle: crystal structure of the autoprocessed complex of vibriolysin mcp-022 with a single point mutation e346a Phyre2 1 c2xglB_ 2 c3dd7A_ 3 d2nxyb2 4 c3fsnA_ 5 c2k87A_ 6 c2qh7A_ 7 c3fnvB_ 8 d1wh6a_ 9 c2l25A_ 10 c3iynR_ 11 c3arcl_ 12 d1s7ea2 13 c3kfoA_ 14 d2csfa1 15 d1o6ea_ 16 d1r17a1 17 d1fyhb2 18 c2l9wA_ 19 d1iega_ 20 c3nqyA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c2xglB_ 100.0 26 PDB header:antibiotic Chain: B: PDB Molecule:colicin-m immunity protein; PDBTitle: the x-ray structure of the escherichia coli colicin m immunity2 protein demonstrates the presence of a disulphide bridge, which is3 functionally essential 2 c3dd7A_ 47.1 13 PDB header:ribosome inhibitor Chain: A: PDB Molecule:death on curing protein; PDBTitle: structure of doch66y in complex with the c-terminal domain of phd 3 d2nxyb2 38.8 12 Fold:Immunoglobulin-like beta-sandwich Superfamily:Immunoglobulin Family:C2 set domains 4 c3fsnA_ 25.1 20 PDB header:isomerase Chain: A: PDB Molecule:retinal pigment epithelium-specific 65 kda protein; PDBTitle: crystal structure of rpe65 at 2.14 angstrom resolution 5 c2k87A_ 21.2 24 PDB header:viral protein, rna binding protein Chain: A: PDB Molecule:non-structural protein 3 of replicase polyprotein 1a; PDBTitle: nmr structure of a putative rna binding protein (sars1) from sars2 coronavirus 6 c2qh7A_ 19.3 40 PDB header:metal binding protein Chain: A: PDB Molecule:zinc finger cdgsh-type domain 1; PDBTitle: mitoneet is a uniquely folded 2fe-2s outer mitochondrial membrane2 protein stabilized by pioglitazone 7 c3fnvB_ 18.8 50 PDB header:metal binding protein Chain: B: PDB Molecule:cdgsh iron sulfur domain-containing protein 2; PDBTitle: crystal structure of miner1: the redox-active 2fe-2s protein causative2 in wolfram syndrome 2 8 d1wh6a_ 16.2 17 Fold:lambda repressor-like DNA-binding domains Superfamily:lambda repressor-like DNA-binding domains Family:CUT domain 9 c2l25A_ 15.5 23 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: np_888769.1 10 c3iynR_ 14.4 40 PDB header:virus Chain: R: PDB Molecule:hexon-associated protein; PDBTitle: 3.6-angstrom cryoem structure of human adenovirus type 5 11 c3arcl_ 14.3 33 PDB header:electron transport, photosynthesis Chain: L: PDB Molecule:photosystem ii reaction center protein l; PDBTitle: crystal structure of oxygen-evolving photosystem ii at 1.9 angstrom2 resolution 12 d1s7ea2 13.6 6 Fold:lambda repressor-like DNA-binding domains Superfamily:lambda repressor-like DNA-binding domains Family:CUT domain 13 c3kfoA_ 13.1 17 PDB header:protein transport Chain: A: PDB Molecule:nucleoporin nup133; PDBTitle: crystal structure of the c-terminal domain from the nuclear pore2 complex component nup133 from saccharomyces cerevisiae 14 d2csfa1 13.0 8 Fold:lambda repressor-like DNA-binding domains Superfamily:lambda repressor-like DNA-binding domains Family:CUT domain 15 d1o6ea_ 12.8 21 Fold:Herpes virus serine proteinase, assemblin Superfamily:Herpes virus serine proteinase, assemblin Family:Herpes virus serine proteinase, assemblin 16 d1r17a1 12.1 12 Fold:Common fold of diphtheria toxin/transcription factors/cytochrome f Superfamily:Bacterial adhesins Family:Fibrinogen-binding domain 17 d1fyhb2 11.3 18 Fold:Immunoglobulin-like beta-sandwich Superfamily:Fibronectin type III Family:Fibronectin type III 18 c2l9wA_ 10.4 12 PDB header:splicing, rna binding protein Chain: A: PDB Molecule:u4/u6 snrna-associated-splicing factor prp24; PDBTitle: solution structure of the c-terminal domain of prp24 19 d1iega_ 10.4 23 Fold:Herpes virus serine proteinase, assemblin Superfamily:Herpes virus serine proteinase, assemblin Family:Herpes virus serine proteinase, assemblin 20 c3nqyA_ 9.8 18 PDB header:hydrolase Chain: A: PDB Molecule:secreted metalloprotease mcp02; PDBTitle: crystal structure of the autoprocessed complex of vibriolysin mcp-022 with a single point mutation e346a 21 d2pbka1 not modelled 9.7 13 Fold:Herpes virus serine proteinase, assemblin Superfamily:Herpes virus serine proteinase, assemblin Family:Herpes virus serine proteinase, assemblin 22 c2j0kB_ not modelled 9.3 20 PDB header:transferase Chain: B: PDB Molecule:focal adhesion kinase 1; PDBTitle: crystal structure of a fragment of focal adhesion kinase2 containing the ferm and kinase domains. 23 d1at3a_ not modelled 9.2 16 Fold:Herpes virus serine proteinase, assemblin Superfamily:Herpes virus serine proteinase, assemblin Family:Herpes virus serine proteinase, assemblin 24 c2eo1A_ not modelled 9.0 22 PDB header:contractile protein Chain: A: PDB Molecule:cdna flj14124 fis, clone mamma1002498; PDBTitle: solution structure of the ig domain of human obscn protein 25 d1wh8a_ not modelled 8.5 24 Fold:lambda repressor-like DNA-binding domains Superfamily:lambda repressor-like DNA-binding domains Family:CUT domain 26 d1x2la1 not modelled 8.1 26 Fold:lambda repressor-like DNA-binding domains Superfamily:lambda repressor-like DNA-binding domains Family:CUT domain 27 c2druA_ not modelled 7.9 8 PDB header:immune system Chain: A: PDB Molecule:chimera of cd48 antigen and t-cell surface antigen cd2; PDBTitle: crystal structure and binding properties of the cd2 and cd244 (2b4)2 binding protein, cd48 28 c3p02A_ not modelled 7.8 21 PDB header:unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of a protein of unknown function (bacova_00267) from2 bacteroides ovatus at 1.55 a resolution 29 d1vcaa2 not modelled 7.6 23 Fold:Immunoglobulin-like beta-sandwich Superfamily:Immunoglobulin Family:I set domains 30 d1biha3 not modelled 7.5 5 Fold:Immunoglobulin-like beta-sandwich Superfamily:Immunoglobulin Family:I set domains 31 c2yqeA_ not modelled 6.8 22 PDB header:dna binding protein Chain: A: PDB Molecule:jumonji/arid domain-containing protein 1d; PDBTitle: solution structure of the arid domain of jarid1d protein 32 c2axtl_ not modelled 6.5 33 PDB header:electron transport Chain: L: PDB Molecule:photosystem ii reaction center l protein; PDBTitle: crystal structure of photosystem ii from thermosynechococcus elongatus 33 c3a0bL_ not modelled 6.5 33 PDB header:electron transport Chain: L: PDB Molecule:photosystem ii reaction center protein l; PDBTitle: crystal structure of br-substituted photosystem ii complex 34 c3arcL_ not modelled 6.5 33 PDB header:electron transport, photosynthesis Chain: L: PDB Molecule:photosystem ii reaction center protein l; PDBTitle: crystal structure of oxygen-evolving photosystem ii at 1.9 angstrom2 resolution 35 c3a0bl_ not modelled 6.5 33 PDB header:electron transport Chain: L: PDB Molecule:photosystem ii reaction center protein l; PDBTitle: crystal structure of br-substituted photosystem ii complex 36 c3bz1L_ not modelled 6.5 33 PDB header:electron transport Chain: L: PDB Molecule:photosystem ii reaction center protein l; PDBTitle: crystal structure of cyanobacterial photosystem ii (part 12 of 2). this file contains first monomer of psii dimer 37 c2axtL_ not modelled 6.5 33 PDB header:electron transport Chain: L: PDB Molecule:photosystem ii reaction center l protein; PDBTitle: crystal structure of photosystem ii from thermosynechococcus elongatus 38 c3prrL_ not modelled 6.5 33 PDB header:photosynthesis Chain: L: PDB Molecule:photosystem ii reaction center protein l; PDBTitle: crystal structure of cyanobacterial photosystem ii in complex with2 terbutryn (part 2 of 2). this file contains second monomer of psii3 dimer 39 c3bz2L_ not modelled 6.5 33 PDB header:electron transport Chain: L: PDB Molecule:photosystem ii reaction center protein l; PDBTitle: crystal structure of cyanobacterial photosystem ii (part 22 of 2). this file contains second monomer of psii dimer 40 c1s5lL_ not modelled 6.5 33 PDB header:photosynthesis Chain: L: PDB Molecule:photosystem ii reaction center l protein; PDBTitle: architecture of the photosynthetic oxygen evolving center 41 c3prqL_ not modelled 6.5 33 PDB header:photosynthesis Chain: L: PDB Molecule:photosystem ii reaction center protein l; PDBTitle: crystal structure of cyanobacterial photosystem ii in complex with2 terbutryn (part 1 of 2). this file contains first monomer of psii3 dimer 42 c3kziL_ not modelled 6.5 33 PDB header:electron transport Chain: L: PDB Molecule:photosystem ii reaction center protein l; PDBTitle: crystal structure of monomeric form of cyanobacterial photosystem ii 43 c3a0hl_ not modelled 6.5 33 PDB header:electron transport Chain: L: PDB Molecule:photosystem ii reaction center protein l; PDBTitle: crystal structure of i-substituted photosystem ii complex 44 d2axtl1 not modelled 6.5 33 Fold:Single transmembrane helix Superfamily:Photosystem II reaction center protein L, PsbL Family:PsbL-like 45 c1s5ll_ not modelled 6.5 33 PDB header:photosynthesis Chain: L: PDB Molecule:photosystem ii reaction center l protein; PDBTitle: architecture of the photosynthetic oxygen evolving center 46 c3a0hL_ not modelled 6.5 33 PDB header:electron transport Chain: L: PDB Molecule:photosystem ii reaction center protein l; PDBTitle: crystal structure of i-substituted photosystem ii complex 47 c3h6sE_ not modelled 6.5 18 PDB header:hydrolase/hydrolase inhibitor Chain: E: PDB Molecule:clitocypin analog; PDBTitle: strucure of clitocypin - cathepsin v complex 48 c2dkuA_ not modelled 6.3 15 PDB header:contractile protein Chain: A: PDB Molecule:kiaa1556 protein; PDBTitle: solution structure of the third ig-like domain of human2 kiaa1556 protein 49 c3nqkA_ not modelled 6.3 15 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of a structural genomics, unknown function2 (bacova_03322) from bacteroides ovatus at 2.61 a resolution 50 c3ts7B_ not modelled 6.0 17 PDB header:transferase Chain: B: PDB Molecule:geranyltranstransferase; PDBTitle: crystal structure of farnesyl diphosphate synthase (target efi-501951)2 from methylococcus capsulatus 51 c3epzA_ not modelled 5.8 15 PDB header:transferase Chain: A: PDB Molecule:dna (cytosine-5)-methyltransferase 1; PDBTitle: structure of the replication foci-targeting sequence of human dna2 cytosine methyltransferase dnmt1 52 d1tdpa_ not modelled 5.7 14 Fold:Bromodomain-like Superfamily:Bacteriocin immunity protein-like Family:Carnobacteriocin B2 immunity protein 53 d2cs7a1 not modelled 5.6 38 Fold:IL8-like Superfamily:PhtA domain-like Family:PhtA domain-like 54 c2q97T_ not modelled 5.4 24 PDB header:structural protein/cell invasion Chain: T: PDB Molecule:toxofilin; PDBTitle: complex of mammalian actin with toxofilin from toxoplasma gondii 55 c3rjoA_ not modelled 5.4 24 PDB header:hydrolase Chain: A: PDB Molecule:endoplasmic reticulum aminopeptidase 1; PDBTitle: crystal structure of erap1 peptide binding domain 56 d1gpja3 not modelled 5.2 25 Fold:Ferredoxin-like Superfamily:Glutamyl tRNA-reductase catalytic, N-terminal domain Family:Glutamyl tRNA-reductase catalytic, N-terminal domain 57 d1ni5a3 not modelled 5.2 17 Fold:PheT/TilS domain Superfamily:PheT/TilS domain Family:tRNA-Ile-lysidine synthetase, TilS, C-terminal domain 58 c2cpcA_ not modelled 5.2 11 PDB header:immune system Chain: A: PDB Molecule:kiaa0657 protein; PDBTitle: solution structure of rsgi ruh-030, an ig like domain from2 human cdna

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0