Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	W	R	L	V	Y	A	S	T	V	G	T	S	H	I	S	A	D	L	P	C	Q	D	A	C	Q	M	Q	I	A	W	L	N	D	Q	Q	P	L	L	S	V	F	V	A	D	G	A	G	S	V	S	Q	G	G	E	G	A	M	L
Secondary structure
SS confidence
Disorder		?	?	?															?		?																																?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	V	N	E	A	M	A	Y	M	S	Q	K	V	Q	G	G	E	L	G	L	N	D	V	L	A	T	N	M	V	L	T	I	R	Q	R	L	F	A	E	A	E	A	K	E	L	A	V	R	D	F	A	C	T	F	L	G	L	I	S	S
Secondary structure
SS confidence
Disorder																	?																										?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		P	D	G	T	L	I	M	Q	I	G	D	G	G	V	V	V	D	L	G	H	G	L	Q	L	P	L	T	P	M	A	G	E	Y	A	N	M	T	H	F	I	T	D	E	D	A	V	S	R	L	E	T	F	T	S	T	G	R	A	H	K
Secondary structure
SS confidence
Disorder																																													?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		V	A	A	F	T	D	G	I	Q	R	L	A	L	N	M	L	D	N	S	P	H	V	P	F	F	T	P	F	F	N	G	L	A	A	A	T	Q	E	Q	L	D	L	L	P	E	L	L	K	Q	F	L	S	S	P	A	V	N	E	R	T
Secondary structure
SS confidence
Disorder																			?																			?	?	?																			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.
Sequence		D	D	D	K	T	L	A	L	A	L	W	A	E
Secondary structure
SS confidence
Disorder													?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1a6q chain A Region: 4 - 251 Aligned: 229 Modelled: 237 Confidence: 100.0% Identity: 16% PDB header:hydrolase Chain: A: PDB Molecule:phosphatase 2c; PDBTitle: crystal structure of the protein serine/threonine phosphatase 2c at 22 a resolution Phyre2 PDB 1txo chain A Region: 1 - 251 Aligned: 214 Modelled: 251 Confidence: 100.0% Identity: 16% Fold: PP2C-like Superfamily: PP2C-like Family: PP2C-like Phyre2 PDB 2pk0 chain C Region: 4 - 251 Aligned: 220 Modelled: 237 Confidence: 100.0% Identity: 15% PDB header:signaling protein Chain: C: PDB Molecule:serine/threonine protein phosphatase stp1; PDBTitle: structure of the s. agalactiae serine/threonine phosphatase at 2.652 resolution Phyre2 PDB 1a6q chain A domain 2 Region: 3 - 251 Aligned: 230 Modelled: 238 Confidence: 100.0% Identity: 16% Fold: PP2C-like Superfamily: PP2C-like Family: PP2C-like Phyre2 PDB 3kdj chain B Region: 5 - 251 Aligned: 233 Modelled: 247 Confidence: 100.0% Identity: 15% PDB header:hydrolase/hormone receptor Chain: B: PDB Molecule:protein phosphatase 2c 56; PDBTitle: complex structure of (+)-aba-bound pyl1 and abi1 Phyre2 PDB 2i44 chain A Region: 2 - 251 Aligned: 232 Modelled: 238 Confidence: 100.0% Identity: 13% PDB header:hydrolase Chain: A: PDB Molecule:serine-threonine phosphatase 2c; PDBTitle: crystal structure of serine-threonine phosphatase 2c from2 toxoplasma gondii Phyre2 PDB 2cm1 chain A Region: 1 - 253 Aligned: 216 Modelled: 253 Confidence: 100.0% Identity: 15% PDB header:hydrolase Chain: A: PDB Molecule:serine threonine protein phosphatase pstp; PDBTitle: crystal structure of the catalytic domain of serine2 threonine protein phosphatase pstp in complex with3 2 manganese ions. Phyre2 PDB 3kb3 chain B Region: 4 - 251 Aligned: 227 Modelled: 237 Confidence: 100.0% Identity: 15% PDB header:signaling protein Chain: B: PDB Molecule:protein phosphatase 2c 16; PDBTitle: crystal structure of abscisic acid-bound pyl2 in complex with hab1 Phyre2 PDB 2jfs chain A Region: 4 - 249 Aligned: 206 Modelled: 235 Confidence: 100.0% Identity: 17% PDB header:hydrolase Chain: A: PDB Molecule:ser-thr phosphatase mspp; PDBTitle: crystal structure of the ppm ser-thr phosphatase mspp from2 mycobacterium smegmatis in complex with cacodylate Phyre2 PDB 2i0o chain A Region: 3 - 251 Aligned: 223 Modelled: 238 Confidence: 100.0% Identity: 15% PDB header:hydrolase Chain: A: PDB Molecule:ser/thr phosphatase; PDBTitle: crystal structure of anopheles gambiae ser/thr phosphatase complexed2 with zn2+ Phyre2 PDB 2iq1 chain A Region: 5 - 252 Aligned: 215 Modelled: 232 Confidence: 100.0% Identity: 15% PDB header:hydrolase Chain: A: PDB Molecule:protein phosphatase 2c kappa, ppm1k; PDBTitle: crystal structure of human ppm1k Phyre2 PDB 2irm chain A Region: 5 - 251 Aligned: 241 Modelled: 247 Confidence: 100.0% Identity: 11% PDB header:transferase Chain: A: PDB Molecule:mitogen-activated protein kinase kinase kinase 7 PDBTitle: crystal structure of mitogen-activated protein kinase kinase kinase 72 interacting protein 1 from anopheles gambiae Phyre2 PDB 2isn chain B Region: 4 - 253 Aligned: 230 Modelled: 224 Confidence: 100.0% Identity: 14% PDB header:hydrolase Chain: B: PDB Molecule:nysgxrc-8828z, phosphatase; PDBTitle: crystal structure of a phosphatase from a pathogenic strain toxoplasma2 gondii Phyre2 PDB 2pnq chain A Region: 18 - 251 Aligned: 217 Modelled: 234 Confidence: 100.0% Identity: 15% PDB header:hydrolase Chain: A: PDB Molecule:[pyruvate dehydrogenase [lipoamide]]-phosphatase PDBTitle: crystal structure of pyruvate dehydrogenase phosphatase 12 (pdp1) Phyre2 PDB 2j82 chain A Region: 4 - 249 Aligned: 215 Modelled: 235 Confidence: 100.0% Identity: 17% PDB header:hydrolase Chain: A: PDB Molecule:protein serine-threonine phosphatase; PDBTitle: structural analysis of the pp2c family phosphatase tppha2 from thermosynechococcus elongatus Phyre2 PDB 2pom chain A Region: 5 - 251 Aligned: 241 Modelled: 245 Confidence: 99.9% Identity: 12% PDB header:signaling protein/metal binding protein Chain: A: PDB Molecule:mitogen-activated protein kinase kinase kinase 7- PDBTitle: tab1 with manganese ion Phyre2 PDB 2j4o chain A Region: 5 - 251 Aligned: 241 Modelled: 247 Confidence: 99.9% Identity: 12% PDB header:protein binding Chain: A: PDB Molecule:mitogen-activated protein kinase kinase kinase PDBTitle: structure of tab1 Phyre2 PDB 3rnr chain B Region: 23 - 249 Aligned: 192 Modelled: 205 Confidence: 99.9% Identity: 16% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:stage ii sporulation e family protein; PDBTitle: crystal structure of stage ii sporulation e family protein from2 thermanaerovibrio acidaminovorans Phyre2 PDB 3d8k chain D Region: 7 - 253 Aligned: 213 Modelled: 229 Confidence: 99.9% Identity: 14% PDB header:hydrolase Chain: D: PDB Molecule:protein phosphatase 2c; PDBTitle: crsytal structure of a phosphatase from a toxoplasma gondii Phyre2 PDB 3pu9 chain A Region: 1 - 253 Aligned: 217 Modelled: 239 Confidence: 99.8% Identity: 14% PDB header:transferase Chain: A: PDB Molecule:protein serine/threonine phosphatase; PDBTitle: crystal structure of serine/threonine phosphatase sphaerobacter2 thermophilus dsm 20745 Phyre2 1 c1a6qA_ 2 d1txoa_ 3 c2pk0C_ 4 d1a6qa2 5 c3kdjB_ 6 c2i44A_ 7 c2cm1A_ 8 c3kb3B_ 9 c2jfsA_ 10 c2i0oA_ 11 c2iq1A_ 12 c2irmA_ 13 c2isnB_ 14 c2pnqA_ 15 c2j82A_ 16 c2pomA_ 17 c2j4oA_ 18 c3rnrB_ 19 c3d8kD_ 20 c3pu9A_ 21 22 23 24 25 26 27 28 29 30 31 32 33

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c1a6qA_ 100.0 16 PDB header:hydrolase Chain: A: PDB Molecule:phosphatase 2c; PDBTitle: crystal structure of the protein serine/threonine phosphatase 2c at 22 a resolution 2 d1txoa_ 100.0 16 Fold:PP2C-like Superfamily:PP2C-like Family:PP2C-like 3 c2pk0C_ 100.0 15 PDB header:signaling protein Chain: C: PDB Molecule:serine/threonine protein phosphatase stp1; PDBTitle: structure of the s. agalactiae serine/threonine phosphatase at 2.652 resolution 4 d1a6qa2 100.0 16 Fold:PP2C-like Superfamily:PP2C-like Family:PP2C-like 5 c3kdjB_ 100.0 15 PDB header:hydrolase/hormone receptor Chain: B: PDB Molecule:protein phosphatase 2c 56; PDBTitle: complex structure of (+)-aba-bound pyl1 and abi1 6 c2i44A_ 100.0 13 PDB header:hydrolase Chain: A: PDB Molecule:serine-threonine phosphatase 2c; PDBTitle: crystal structure of serine-threonine phosphatase 2c from2 toxoplasma gondii 7 c2cm1A_ 100.0 15 PDB header:hydrolase Chain: A: PDB Molecule:serine threonine protein phosphatase pstp; PDBTitle: crystal structure of the catalytic domain of serine2 threonine protein phosphatase pstp in complex with3 2 manganese ions. 8 c3kb3B_ 100.0 15 PDB header:signaling protein Chain: B: PDB Molecule:protein phosphatase 2c 16; PDBTitle: crystal structure of abscisic acid-bound pyl2 in complex with hab1 9 c2jfsA_ 100.0 17 PDB header:hydrolase Chain: A: PDB Molecule:ser-thr phosphatase mspp; PDBTitle: crystal structure of the ppm ser-thr phosphatase mspp from2 mycobacterium smegmatis in complex with cacodylate 10 c2i0oA_ 100.0 15 PDB header:hydrolase Chain: A: PDB Molecule:ser/thr phosphatase; PDBTitle: crystal structure of anopheles gambiae ser/thr phosphatase complexed2 with zn2+ 11 c2iq1A_ 100.0 15 PDB header:hydrolase Chain: A: PDB Molecule:protein phosphatase 2c kappa, ppm1k; PDBTitle: crystal structure of human ppm1k 12 c2irmA_ 100.0 11 PDB header:transferase Chain: A: PDB Molecule:mitogen-activated protein kinase kinase kinase 7 PDBTitle: crystal structure of mitogen-activated protein kinase kinase kinase 72 interacting protein 1 from anopheles gambiae 13 c2isnB_ 100.0 14 PDB header:hydrolase Chain: B: PDB Molecule:nysgxrc-8828z, phosphatase; PDBTitle: crystal structure of a phosphatase from a pathogenic strain toxoplasma2 gondii 14 c2pnqA_ 100.0 15 PDB header:hydrolase Chain: A: PDB Molecule:[pyruvate dehydrogenase [lipoamide]]-phosphatase PDBTitle: crystal structure of pyruvate dehydrogenase phosphatase 12 (pdp1) 15 c2j82A_ 100.0 17 PDB header:hydrolase Chain: A: PDB Molecule:protein serine-threonine phosphatase; PDBTitle: structural analysis of the pp2c family phosphatase tppha2 from thermosynechococcus elongatus 16 c2pomA_ 99.9 12 PDB header:signaling protein/metal binding protein Chain: A: PDB Molecule:mitogen-activated protein kinase kinase kinase 7- PDBTitle: tab1 with manganese ion 17 c2j4oA_ 99.9 12 PDB header:protein binding Chain: A: PDB Molecule:mitogen-activated protein kinase kinase kinase PDBTitle: structure of tab1 18 c3rnrB_ 99.9 16 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:stage ii sporulation e family protein; PDBTitle: crystal structure of stage ii sporulation e family protein from2 thermanaerovibrio acidaminovorans 19 c3d8kD_ 99.9 14 PDB header:hydrolase Chain: D: PDB Molecule:protein phosphatase 2c; PDBTitle: crsytal structure of a phosphatase from a toxoplasma gondii 20 c3pu9A_ 99.8 14 PDB header:transferase Chain: A: PDB Molecule:protein serine/threonine phosphatase; PDBTitle: crystal structure of serine/threonine phosphatase sphaerobacter2 thermophilus dsm 20745 21 c3t9qB_ not modelled 99.6 11 PDB header:hydrolase Chain: B: PDB Molecule:stage ii sporulation protein e; PDBTitle: structure of the phosphatase domain of the cell fate determinant2 spoiie from bacillus subtilis (mn presoaked) 22 c3ke6A_ not modelled 98.8 12 PDB header:unknown function Chain: A: PDB Molecule:protein rv1364c/mt1410; PDBTitle: the crystal structure of the rsbu and rsbw domains of rv1364c from2 mycobacterium tuberculosis 23 c3es2A_ not modelled 98.7 12 PDB header:signaling protein Chain: A: PDB Molecule:probable two-component response regulator; PDBTitle: structure of the c-terminal phosphatase domain of p.2 aeruginonsa rssb 24 c3eq2A_ not modelled 28.8 11 PDB header:signaling protein Chain: A: PDB Molecule:probable two-component response regulator; PDBTitle: structure of hexagonal crystal form of pseudomonas2 aeruginosa rssb 25 c1rfoC_ not modelled 10.1 25 PDB header:viral protein Chain: C: PDB Molecule:whisker antigen control protein; PDBTitle: trimeric foldon of the t4 phagehead fibritin 26 c3iddA_ not modelled 6.7 20 PDB header:isomerase Chain: A: PDB Molecule:2,3-bisphosphoglycerate-independent PDBTitle: cofactor-independent phosphoglycerate mutase from2 thermoplasma acidophilum dsm 1728 27 c3m8yC_ not modelled 5.7 25 PDB header:isomerase Chain: C: PDB Molecule:phosphopentomutase; PDBTitle: phosphopentomutase from bacillus cereus after glucose-1,6-bisphosphate2 activation 28 c3q4fG_ not modelled 5.6 14 PDB header:dna binding protein/protein binding Chain: G: PDB Molecule:dna repair protein xrcc4; PDBTitle: crystal structure of xrcc4/xlf-cernunnos complex 29 c3mudA_ not modelled 5.4 14 PDB header:contractile protein Chain: A: PDB Molecule:dna repair protein xrcc4, tropomyosin alpha-1 chain; PDBTitle: structure of the tropomyosin overlap complex from chicken smooth2 muscle 30 c2zktB_ not modelled 5.4 17 PDB header:isomerase Chain: B: PDB Molecule:2,3-bisphosphoglycerate-independent phosphoglycerate PDBTitle: structure of ph0037 protein from pyrococcus horikoshii 31 c3sr2A_ not modelled 5.4 14 PDB header:dna binding protein/protein binding Chain: A: PDB Molecule:dna repair protein xrcc4; PDBTitle: crystal structure of human xlf-xrcc4 complex 32 d1ik9a1 not modelled 5.3 14 Fold:XRCC4, N-terminal domain Superfamily:XRCC4, N-terminal domain Family:XRCC4, N-terminal domain 33 c1avyA_ not modelled 5.3 25 PDB header:coiled coil Chain: A: PDB Molecule:fibritin; PDBTitle: fibritin deletion mutant m (bacteriophage t4)

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0