Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	N	A	S	S	W	S	L	R	N	L	P	W	F	R	A	T	L	A	Q	W	R	Y	A	L	R	N	T	I	A	M	C	L	A	L	T	V	A	Y	Y	L	N	L	D	E	P	Y	W	A	M	T	S	A	A	V	V	S	F	P	T
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?		?				?			?																																											?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		V	G	G	V	I	S	K	S	L	G	R	I	A	G	S	L	L	G	A	I	A	A	L	L	L	A	G	H	T	L	N	E	P	W	F	F	L	L	S	M	S	A	W	L	G	F	C	T	W	A	C	A	H	F	T	N	N	V	A	Y
Secondary structure
SS confidence
Disorder																																																							?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		A	F	Q	L	A	G	Y	T	A	A	I	I	A	F	P	M	V	N	I	T	E	A	S	Q	L	W	D	I	A	Q	A	R	V	C	E	V	I	V	G	I	L	C	G	G	M	M	M	M	I	L	P	S	S	S	D	A	T	A	L	L
Secondary structure
SS confidence
Disorder																		?	?	?	?																																			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		T	A	L	K	N	M	H	A	R	L	L	E	H	A	S	L	L	W	Q	P	E	T	T	D	A	I	R	A	A	H	E	G	V	I	G	Q	I	L	T	M	N	L	L	R	I	Q	A	F	W	S	H	Y	R	F	R	Q	Q	N	A	R
Secondary structure
SS confidence
Disorder																						?	?	?	?	?	?																					?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		L	N	A	L	L	H	Q	Q	L	R	M	T	S	V	I	S	S	L	R	R	M	L	L	N	W	P	S	P	P	G	A	T	R	E	I	L	E	Q	L	L	T	A	L	A	S	S	Q	T	D	V	Y	T	V	A	R	I	I	A	P	L
Secondary structure
SS confidence
Disorder																								?	?	?	?	?	?	?	?		?																												?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		R	P	T	N	V	A	D	Y	R	H	V	A	F	W	Q	R	L	R	Y	F	C	R	L	Y	L	Q	S	S	Q	E	L	H	R	L	Q	S	G	V	D	D	H	T	R	L	P	R	T	S	G	L	A	R	H	T	D	N	A	E	A	M
Secondary structure
SS confidence
Disorder			?			?	?		?																										?		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		W	S	G	L	R	T	F	C	T	L	M	M	I	G	A	W	S	I	A	S	Q	W	D	A	G	A	N	A	L	T	L	A	A	I	S	C	V	L	Y	S	A	V	A	A	P	F	K	S	L	S	L	L	M	R	T	L	V	L	L	S
Secondary structure
SS confidence
Disorder																																									?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		L	F	S	F	V	V	K	F	G	L	M	V	Q	I	S	D	L	W	Q	F	L	L	F	L	F	P	L	L	A	T	M	Q	L	L	K	L	Q	M	P	K	F	A	A	L	W	G	Q	L	I	V	F	M	G	S	F	I	A	V	T	N
Secondary structure
SS confidence
Disorder																																					?	?	?	?																	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence		P	P	V	Y	D	F	A	D	F	L	N	D	N	L	A	K	I	V	G	V	A	L	A	W	L	A	F	A	I	L	R	P	G	S	D	A	R	K	S	R	R	H	I	R	A	L	R	R	D	F	V	D	Q	L	S	R	H	P	T	L
Secondary structure
SS confidence
Disorder		?	?																																																					?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600
Sequence		S	E	S	E	F	E	S	L	T	Y	H	H	V	S	Q	L	S	N	S	Q	D	A	L	A	R	R	W	L	L	R	W	G	V	V	L	L	N	C	S	H	V	V	W	Q	L	R	D	W	E	S	R	S	D	P	L	S	R	V	R	D
Secondary structure
SS confidence
Disorder		?	?	?														?	?	?	?	?	?	?	?																										?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630	.	.	.	.	.	.	.	.	.	640	.	.	.	.	.	.	.	.	.	650	.	.	.	.	.	.	.	.	.	660
Sequence		N	C	I	S	L	L	R	G	V	M	S	E	R	G	V	Q	Q	K	S	L	A	A	T	L	E	E	L	Q	R	I	C	D	S	L	A	R	H	H	Q	P	A	A	R	E	L	A	A	I	V	W	R	L	Y	C	S	L	S	Q	L	E
Secondary structure
SS confidence
Disorder												?	?	?	?	?	?	?	?	?	?	?	?													?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	670
Sequence		Q	A	P	P	Q	G	T	L	A	S
Secondary structure
SS confidence
Disorder				?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 3k3g chain A Region: 19 - 134 Aligned: 93 Modelled: 99 Confidence: 85.9% Identity: 12% PDB header:transport protein Chain: A: PDB Molecule:urea transporter; PDBTitle: crystal structure of the urea transporter from desulfovibrio vulgaris2 bound to 1,3-dimethylurea Phyre2 PDB 2ksf chain A Region: 416 - 509 Aligned: 93 Modelled: 94 Confidence: 54.6% Identity: 16% PDB header:transferase Chain: A: PDB Molecule:sensor protein kdpd; PDBTitle: backbone structure of the membrane domain of e. coli2 histidine kinase receptor kdpd, center for structures of3 membrane proteins (csmp) target 4312c Phyre2 PDB 2r6g chain F domain 1 Region: 413 - 478 Aligned: 66 Modelled: 66 Confidence: 36.2% Identity: 11% Fold: MalF N-terminal region-like Superfamily: MalF N-terminal region-like Family: MalF N-terminal region-like Phyre2 PDB 1ymg chain A domain 1 Region: 363 - 522 Aligned: 157 Modelled: 160 Confidence: 34.6% Identity: 13% Fold: Aquaporin-like Superfamily: Aquaporin-like Family: Aquaporin-like Phyre2 PDB 1ymg chain A Region: 363 - 522 Aligned: 157 Modelled: 160 Confidence: 34.6% Identity: 13% PDB header:membrane protein Chain: A: PDB Molecule:lens fiber major intrinsic protein; PDBTitle: the channel architecture of aquaporin o at 2.2 angstrom resolution Phyre2 PDB 3llq chain B Region: 361 - 510 Aligned: 147 Modelled: 150 Confidence: 26.9% Identity: 20% PDB header:membrane protein Chain: B: PDB Molecule:aquaporin z 2; PDBTitle: aquaporin structure from plant pathogen agrobacterium tumerfaciens Phyre2 PDB 2b5f chain D Region: 363 - 510 Aligned: 145 Modelled: 148 Confidence: 26.7% Identity: 17% PDB header:transport protein,membrane protein Chain: D: PDB Molecule:aquaporin; PDBTitle: crystal structure of the spinach aquaporin sopip2;1 in an2 open conformation to 3.9 resolution Phyre2 PDB 1rc2 chain A Region: 361 - 514 Aligned: 151 Modelled: 154 Confidence: 22.3% Identity: 17% Fold: Aquaporin-like Superfamily: Aquaporin-like Family: Aquaporin-like Phyre2 PDB 3k07 chain A Region: 21 - 172 Aligned: 134 Modelled: 136 Confidence: 20.7% Identity: 18% PDB header:transport protein Chain: A: PDB Molecule:cation efflux system protein cusa; PDBTitle: crystal structure of cusa Phyre2 PDB 1fx8 chain A Region: 366 - 511 Aligned: 140 Modelled: 146 Confidence: 13.6% Identity: 14% Fold: Aquaporin-like Superfamily: Aquaporin-like Family: Aquaporin-like Phyre2 PDB 1lda chain A Region: 366 - 511 Aligned: 140 Modelled: 146 Confidence: 13.6% Identity: 14% PDB header:transport protein Chain: A: PDB Molecule:glycerol uptake facilitator protein; PDBTitle: crystal structure of the e. coli glycerol facilitator (glpf) without2 substrate glycerol Phyre2 PDB 1iwg chain A domain 7 Region: 380 - 432 Aligned: 53 Modelled: 53 Confidence: 13.2% Identity: 17% Fold: Multidrug efflux transporter AcrB transmembrane domain Superfamily: Multidrug efflux transporter AcrB transmembrane domain Family: Multidrug efflux transporter AcrB transmembrane domain Phyre2 PDB 2yvx chain D Region: 403 - 511 Aligned: 104 Modelled: 109 Confidence: 12.4% Identity: 14% PDB header:transport protein Chain: D: PDB Molecule:mg2+ transporter mgte; PDBTitle: crystal structure of magnesium transporter mgte Phyre2 PDB 1kpl chain A Region: 72 - 189 Aligned: 97 Modelled: 118 Confidence: 11.4% Identity: 18% Fold: Clc chloride channel Superfamily: Clc chloride channel Family: Clc chloride channel Phyre2 PDB 3d9s chain B Region: 363 - 523 Aligned: 158 Modelled: 161 Confidence: 10.8% Identity: 11% PDB header:membrane protein Chain: B: PDB Molecule:aquaporin-5; PDBTitle: human aquaporin 5 (aqp5) - high resolution x-ray structure Phyre2 PDB 2kr6 chain A Region: 465 - 511 Aligned: 47 Modelled: 47 Confidence: 10.2% Identity: 17% PDB header:hydrolase Chain: A: PDB Molecule:presenilin-1; PDBTitle: solution structure of presenilin-1 ctf subunit Phyre2 PDB 2nr9 chain A domain 1 Region: 383 - 509 Aligned: 127 Modelled: 127 Confidence: 9.2% Identity: 7% Fold: Rhomboid-like Superfamily: Rhomboid-like Family: Rhomboid-like Phyre2 PDB 2w2e chain A Region: 363 - 511 Aligned: 146 Modelled: 149 Confidence: 8.9% Identity: 16% PDB header:membrane protein Chain: A: PDB Molecule:aquaporin; PDBTitle: 1.15 angstrom crystal structure of p.pastoris aquaporin,2 aqy1, in a closed conformation at ph 3.5 Phyre2 PDB 2d57 chain A Region: 363 - 513 Aligned: 148 Modelled: 148 Confidence: 8.8% Identity: 7% PDB header:transport protein Chain: A: PDB Molecule:aquaporin-4; PDBTitle: double layered 2d crystal structure of aquaporin-4 (aqp4m23) at 3.2 a2 resolution by electron crystallography Phyre2 PDB 2ht2 chain B Region: 50 - 183 Aligned: 108 Modelled: 134 Confidence: 8.1% Identity: 19% PDB header:membrane protein Chain: B: PDB Molecule:h(+)/cl(-) exchange transporter clca; PDBTitle: structure of the escherichia coli clc chloride channel2 y445h mutant and fab complex Phyre2 1 c3k3gA_ 2 c2ksfA_ 3 d2r6gf1 4 d1ymga1 5 c1ymgA_ 6 c3llqB_ 7 c2b5fD_ 8 d1rc2a_ 9 c3k07A_ 10 d1fx8a_ 11 c1ldaA_ 12 d1iwga7 13 c2yvxD_ 14 d1kpla_ 15 c3d9sB_ 16 c2kr6A_ 17 d2nr9a1 18 c2w2eA_ 19 c2d57A_ 20 c2ht2B_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37