Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	K	L	L	K	T	V	P	A	I	V	M	L	A	G	G	M	F	A	S	L	N	A	A	A	D	D	S	V	F	T	V	M	D	D	P	A	S	A	K	K	P	F	E	G	N	L	N	A	G	Y	L	A	Q	S	G	N	T	K	S
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?											?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?																	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		S	S	L	T	A	D	T	T	M	T	W	Y	G	H	T	T	A	W	S	L	W	G	N	A	S	N	T	S	S	N	D	E	R	S	S	E	K	Y	A	A	G	G	R	S	R	F	N	L	T	D	Y	D	Y	L	F	G	Q	A	S	W
Secondary structure
SS confidence
Disorder																												?		?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		L	T	D	R	Y	N	G	Y	R	E	R	D	V	L	T	A	G	Y	G	R	Q	F	L	N	G	P	V	H	S	F	R	F	E	F	G	P	G	V	R	Y	D	K	Y	T	D	N	A	S	E	T	Q	P	L	G	Y	A	S	G	A	Y
Secondary structure
SS confidence
Disorder																																												?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		A	W	Q	L	T	D	N	A	K	F	T	Q	G	V	S	V	F	G	A	E	D	T	T	L	N	S	E	S	A	L	N	V	A	I	N	E	H	F	G	L	K	V	A	Y	N	V	T	W	N	S	E	P	P	E	S	A	P	E	H	T
Secondary structure
SS confidence
Disorder																						?																																		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.
Sequence		D	R	R	T	T	L	S	L	G	Y	S	M
Secondary structure
SS confidence
Disorder													?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2iwv chain D Region: 74 - 252 Aligned: 177 Modelled: 179 Confidence: 97.9% Identity: 16% PDB header:ion channel Chain: D: PDB Molecule:outer membrane protein g; PDBTitle: structure of the monomeric outer membrane porin ompg in the2 open and closed conformation Phyre2 PDB 3qra chain A Region: 81 - 225 Aligned: 132 Modelled: 134 Confidence: 96.9% Identity: 11% PDB header:cell invasion Chain: A: PDB Molecule:attachment invasion locus protein; PDBTitle: the crystal structure of ail, the attachment invasion locus protein of2 yersinia pestis Phyre2 PDB 3nb3 chain C Region: 95 - 250 Aligned: 116 Modelled: 130 Confidence: 96.8% Identity: 16% PDB header:virus Chain: C: PDB Molecule:outer membrane protein a; PDBTitle: the host outer membrane proteins ompa and ompc are packed at specific2 sites in the shigella phage sf6 virion as structural components Phyre2 PDB 1p4t chain A Region: 38 - 250 Aligned: 152 Modelled: 153 Confidence: 96.8% Identity: 10% Fold: Transmembrane beta-barrels Superfamily: OMPA-like Family: Outer membrane protein Phyre2 PDB 2f1t chain B Region: 72 - 251 Aligned: 162 Modelled: 162 Confidence: 96.7% Identity: 10% PDB header:membrane protein Chain: B: PDB Molecule:outer membrane protein w; PDBTitle: outer membrane protein ompw Phyre2 PDB 2wjq chain A Region: 64 - 252 Aligned: 182 Modelled: 189 Confidence: 96.6% Identity: 8% PDB header:transport protein Chain: A: PDB Molecule:probable n-acetylneuraminic acid outer membrane channel PDBTitle: nanc porin structure in hexagonal crystal form. Phyre2 PDB 1qjp chain A Region: 73 - 251 Aligned: 134 Modelled: 152 Confidence: 96.6% Identity: 16% Fold: Transmembrane beta-barrels Superfamily: OMPA-like Family: Outer membrane protein Phyre2 PDB 2k0l chain A Region: 25 - 250 Aligned: 183 Modelled: 183 Confidence: 96.5% Identity: 12% PDB header:membrane protein Chain: A: PDB Molecule:outer membrane protein a; PDBTitle: nmr structure of the transmembrane domain of the outer2 membrane protein a from klebsiella pneumoniae in dhpc3 micelles. Phyre2 PDB 1g90 chain A Region: 86 - 250 Aligned: 139 Modelled: 139 Confidence: 95.9% Identity: 12% Fold: Transmembrane beta-barrels Superfamily: OMPA-like Family: Outer membrane protein Phyre2 PDB 3aeh chain B Region: 43 - 251 Aligned: 203 Modelled: 209 Confidence: 95.5% Identity: 11% PDB header:hydrolase Chain: B: PDB Molecule:hemoglobin-binding protease hbp autotransporter; PDBTitle: integral membrane domain of autotransporter hbp Phyre2 PDB 3slj chain A Region: 45 - 251 Aligned: 199 Modelled: 207 Confidence: 95.3% Identity: 13% PDB header:protein transport Chain: A: PDB Molecule:serine protease espp; PDBTitle: pre-cleavage structure of the autotransporter espp - n1023a mutant Phyre2 PDB 2vdf chain A domain 1 Region: 92 - 226 Aligned: 134 Modelled: 135 Confidence: 94.7% Identity: 19% Fold: Transmembrane beta-barrels Superfamily: OMPT-like Family: Outer membrane adhesin/invasin OpcA Phyre2 PDB 2jmm chain A Region: 38 - 182 Aligned: 135 Modelled: 145 Confidence: 94.5% Identity: 10% PDB header:membrane protein Chain: A: PDB Molecule:outer membrane protein a; PDBTitle: nmr solution structure of a minimal transmembrane beta-2 barrel platform protein Phyre2 PDB 3kvn chain A Region: 8 - 251 Aligned: 236 Modelled: 244 Confidence: 93.1% Identity: 12% PDB header:hydrolase Chain: A: PDB Molecule:esterase esta; PDBTitle: crystal structure of the full-length autotransporter esta from2 pseudomonas aeruginosa Phyre2 PDB 2odj chain A Region: 16 - 252 Aligned: 222 Modelled: 228 Confidence: 92.7% Identity: 14% PDB header:membrane protein Chain: A: PDB Molecule:porin d; PDBTitle: crystal structure of the outer membrane protein oprd from pseudomonas2 aeruginosa Phyre2 PDB 3dwo chain X Region: 42 - 185 Aligned: 140 Modelled: 144 Confidence: 92.4% Identity: 14% PDB header:membrane protein Chain: X: PDB Molecule:probable outer membrane protein; PDBTitle: crystal structure of a pseudomonas aeruginosa fadl homologue Phyre2 PDB 2qom chain B Region: 45 - 251 Aligned: 201 Modelled: 207 Confidence: 90.1% Identity: 12% PDB header:hydrolase Chain: B: PDB Molecule:serine protease espp; PDBTitle: the crystal structure of the e.coli espp autotransporter beta-domain. Phyre2 PDB 3qq2 chain C Region: 43 - 251 Aligned: 203 Modelled: 209 Confidence: 90.1% Identity: 12% PDB header:membrane protein/protein transport Chain: C: PDB Molecule:brka autotransporter; PDBTitle: crystal structure of the beta domain of the bordetella autotransporter2 brka Phyre2 PDB 2x27 chain X Region: 34 - 229 Aligned: 176 Modelled: 177 Confidence: 85.9% Identity: 11% PDB header:membrane protein Chain: X: PDB Molecule:outer membrane protein oprg; PDBTitle: crystal structure of the outer membrane protein oprg from2 pseudomonas aeruginosa Phyre2 PDB 1qj8 chain A Region: 47 - 182 Aligned: 129 Modelled: 136 Confidence: 85.0% Identity: 12% Fold: Transmembrane beta-barrels Superfamily: OMPA-like Family: Outer membrane protein Phyre2 1 c2iwvD_ 2 c3qraA_ 3 c3nb3C_ 4 d1p4ta_ 5 c2f1tB_ 6 c2wjqA_ 7 d1qjpa_ 8 c2k0lA_ 9 d1g90a_ 10 c3aehB_ 11 c3sljA_ 12 d2vdfa1 13 c2jmmA_ 14 c3kvnA_ 15 c2odjA_ 16 c3dwoX_ 17 c2qomB_ 18 c3qq2C_ 19 c2x27X_ 20 d1qj8a_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c2iwvD_ 97.9 16 PDB header:ion channel Chain: D: PDB Molecule:outer membrane protein g; PDBTitle: structure of the monomeric outer membrane porin ompg in the2 open and closed conformation 2 c3qraA_ 96.9 11 PDB header:cell invasion Chain: A: PDB Molecule:attachment invasion locus protein; PDBTitle: the crystal structure of ail, the attachment invasion locus protein of2 yersinia pestis 3 c3nb3C_ 96.8 16 PDB header:virus Chain: C: PDB Molecule:outer membrane protein a; PDBTitle: the host outer membrane proteins ompa and ompc are packed at specific2 sites in the shigella phage sf6 virion as structural components 4 d1p4ta_ 96.8 10 Fold:Transmembrane beta-barrels Superfamily:OMPA-like Family:Outer membrane protein 5 c2f1tB_ 96.7 10 PDB header:membrane protein Chain: B: PDB Molecule:outer membrane protein w; PDBTitle: outer membrane protein ompw 6 c2wjqA_ 96.6 8 PDB header:transport protein Chain: A: PDB Molecule:probable n-acetylneuraminic acid outer membrane channel PDBTitle: nanc porin structure in hexagonal crystal form. 7 d1qjpa_ 96.6 16 Fold:Transmembrane beta-barrels Superfamily:OMPA-like Family:Outer membrane protein 8 c2k0lA_ 96.5 12 PDB header:membrane protein Chain: A: PDB Molecule:outer membrane protein a; PDBTitle: nmr structure of the transmembrane domain of the outer2 membrane protein a from klebsiella pneumoniae in dhpc3 micelles. 9 d1g90a_ 95.9 12 Fold:Transmembrane beta-barrels Superfamily:OMPA-like Family:Outer membrane protein 10 c3aehB_ 95.5 11 PDB header:hydrolase Chain: B: PDB Molecule:hemoglobin-binding protease hbp autotransporter; PDBTitle: integral membrane domain of autotransporter hbp 11 c3sljA_ 95.3 13 PDB header:protein transport Chain: A: PDB Molecule:serine protease espp; PDBTitle: pre-cleavage structure of the autotransporter espp - n1023a mutant 12 d2vdfa1 94.7 19 Fold:Transmembrane beta-barrels Superfamily:OMPT-like Family:Outer membrane adhesin/invasin OpcA 13 c2jmmA_ 94.5 10 PDB header:membrane protein Chain: A: PDB Molecule:outer membrane protein a; PDBTitle: nmr solution structure of a minimal transmembrane beta-2 barrel platform protein 14 c3kvnA_ 93.1 12 PDB header:hydrolase Chain: A: PDB Molecule:esterase esta; PDBTitle: crystal structure of the full-length autotransporter esta from2 pseudomonas aeruginosa 15 c2odjA_ 92.7 14 PDB header:membrane protein Chain: A: PDB Molecule:porin d; PDBTitle: crystal structure of the outer membrane protein oprd from pseudomonas2 aeruginosa 16 c3dwoX_ 92.4 14 PDB header:membrane protein Chain: X: PDB Molecule:probable outer membrane protein; PDBTitle: crystal structure of a pseudomonas aeruginosa fadl homologue 17 c2qomB_ 90.1 12 PDB header:hydrolase Chain: B: PDB Molecule:serine protease espp; PDBTitle: the crystal structure of the e.coli espp autotransporter beta-domain. 18 c3qq2C_ 90.1 12 PDB header:membrane protein/protein transport Chain: C: PDB Molecule:brka autotransporter; PDBTitle: crystal structure of the beta domain of the bordetella autotransporter2 brka 19 c2x27X_ 85.9 11 PDB header:membrane protein Chain: X: PDB Molecule:outer membrane protein oprg; PDBTitle: crystal structure of the outer membrane protein oprg from2 pseudomonas aeruginosa 20 d1qj8a_ 85.0 12 Fold:Transmembrane beta-barrels Superfamily:OMPA-like Family:Outer membrane protein 21 c2x4mD_ not modelled 78.6 9 PDB header:hydrolase Chain: D: PDB Molecule:coagulase/fibrinolysin; PDBTitle: yersinia pestis plasminogen activator pla 22 c3a2rX_ not modelled 70.2 10 PDB header:membrane protein Chain: X: PDB Molecule:outer membrane protein ii; PDBTitle: crystal structure of outer membrane protein porb from neisseria2 meningitidis 23 c2hdiA_ not modelled 69.8 12 PDB header:protein transport,antimicrobial protein Chain: A: PDB Molecule:colicin i receptor; PDBTitle: crystal structure of the colicin i receptor cir from e.coli in complex2 with receptor binding domain of colicin ia. 24 d1uynx_ not modelled 64.3 15 Fold:Transmembrane beta-barrels Superfamily:Autotransporter Family:Autotransporter 25 d1i78a_ not modelled 62.4 10 Fold:Transmembrane beta-barrels Superfamily:OMPT-like Family:Outer membrane protease OMPT 26 c2lhfA_ not modelled 61.2 11 PDB header:membrane protein Chain: A: PDB Molecule:outer membrane protein h1; PDBTitle: solution structure of outer membrane protein h (oprh) from p.2 aeruginosa in dhpc micelles 27 d1by5a_ not modelled 53.4 11 Fold:Transmembrane beta-barrels Superfamily:Porins Family:Ligand-gated protein channel 28 c3brzA_ not modelled 51.7 12 PDB header:transport protein Chain: A: PDB Molecule:todx; PDBTitle: crystal structure of the pseudomonas putida toluene2 transporter todx 29 c2grxB_ not modelled 40.9 9 PDB header:metal transport Chain: B: PDB Molecule:ferrichrome-iron receptor; PDBTitle: crystal structure of tonb in complex with fhua, e. coli2 outer membrane receptor for ferrichrome 30 c2y0kA_ not modelled 37.2 7 PDB header:transport protein Chain: A: PDB Molecule:pyroglutatmate porin opdo; PDBTitle: crystal structure of pseudomonas aeruginosa opdo 31 c3qlbA_ not modelled 36.8 10 PDB header:metal transport Chain: A: PDB Molecule:enantio-pyochelin receptor; PDBTitle: enantiopyochelin outer membrane tonb-dependent transporter from2 pseudomonas fluorescens bound to the ferri-enantiopyochelin 32 d2fgqx1 not modelled 33.9 8 Fold:Transmembrane beta-barrels Superfamily:Porins Family:Porin 33 d2pora_ not modelled 32.8 8 Fold:Transmembrane beta-barrels Superfamily:Porins Family:Porin 34 c2y0hA_ not modelled 32.5 7 PDB header:transport protein Chain: A: PDB Molecule:probable porin; PDBTitle: crystal structure of pseudomonas aeruginosa opdl 35 c2qdzA_ not modelled 30.4 10 PDB header:protein transport Chain: A: PDB Molecule:tpsb transporter fhac; PDBTitle: structure of the membrane protein fhac: a member of the2 omp85/tpsb transporter family 36 d1t16a_ not modelled 29.4 15 Fold:Transmembrane beta-barrels Superfamily:Porins Family:Outer membrane protein transport protein 37 d1v54g_ not modelled 28.1 13 Fold:Single transmembrane helix Superfamily:Mitochondrial cytochrome c oxidase subunit VIa Family:Mitochondrial cytochrome c oxidase subunit VIa 38 d2zfga1 not modelled 17.3 7 Fold:Transmembrane beta-barrels Superfamily:Porins Family:Porin 39 d1af6a_ not modelled 16.6 18 Fold:Transmembrane beta-barrels Superfamily:Porins Family:Maltoporin-like 40 c2iahA_ not modelled 11.7 11 PDB header:membrane protein Chain: A: PDB Molecule:ferripyoverdine receptor; PDBTitle: crystal structure of the ferripyoverdine receptor of the outer2 membrane of pseudomonas aeruginosa bound to ferripyoverdine. 41 c3bryB_ not modelled 7.6 14 PDB header:transport protein Chain: B: PDB Molecule:tbux; PDBTitle: crystal structure of the ralstonia pickettii toluene2 transporter tbux 42 d2f0ca1 not modelled 7.5 26 Fold:Virus attachment protein globular domain Superfamily:Virus attachment protein globular domain Family:Lactophage receptor-binding protein head domain 43 c1xkwA_ not modelled 7.2 12 PDB header:membrane protein Chain: A: PDB Molecule:fe(iii)-pyochelin receptor; PDBTitle: pyochelin outer membrane receptor fpta from pseudomonas2 aeruginosa 44 c1xkhC_ not modelled 6.6 9 PDB header:membrane protein Chain: C: PDB Molecule:ferripyoverdine receptor; PDBTitle: pyoverdine outer membrane receptor fpva from pseudomonas aeruginosa2 pao1 bound to pyoverdine 45 d1a0tp_ not modelled 6.1 8 Fold:Transmembrane beta-barrels Superfamily:Porins Family:Maltoporin-like

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0