Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	G	D	E	N	K	L	K	K	Y	R	F	P	E	T	L	T	N	Q	S	R	W	F	G	L	P	L	D	E	L	I	P	A	A	I	C	I	G	W	G	I	T	T	S	K	Y	L	F	G	I	G	A	A	V	L	V	Y	F	G
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.
Sequence		I	K	K	L	K	K	G	R	G	S	S	W	L	R	D	L	I	Y	W	Y	M	P	T	A	L	L	R	G	I	F	S
Secondary structure
SS confidence
Disorder																														?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 3geb chain C Region: 18 - 47 Aligned: 30 Modelled: 30 Confidence: 52.2% Identity: 30% PDB header:hydrolase Chain: C: PDB Molecule:eyes absent homolog 2; PDBTitle: crystal structure of edeya2 Phyre2 PDB 1ttz chain A Region: 10 - 31 Aligned: 22 Modelled: 22 Confidence: 30.0% Identity: 23% Fold: Thioredoxin fold Superfamily: Thioredoxin-like Family: Thioltransferase Phyre2 PDB 3d35 chain A Region: 1 - 24 Aligned: 24 Modelled: 24 Confidence: 14.9% Identity: 25% PDB header:transferase Chain: A: PDB Molecule:regulator of ty1 transposition protein 109; PDBTitle: crystal structure of rtt109-ac-coa complex Phyre2 PDB 3a0b chain X Region: 33 - 60 Aligned: 28 Modelled: 28 Confidence: 14.9% Identity: 21% PDB header:electron transport Chain: X: PDB Molecule:photosystem ii reaction center protein x; PDBTitle: crystal structure of br-substituted photosystem ii complex Phyre2 PDB 3a0h chain X Region: 33 - 60 Aligned: 28 Modelled: 28 Confidence: 14.9% Identity: 21% PDB header:electron transport Chain: X: PDB Molecule:photosystem ii reaction center protein x; PDBTitle: crystal structure of i-substituted photosystem ii complex Phyre2 PDB 3a0b chain X Region: 33 - 60 Aligned: 28 Modelled: 28 Confidence: 14.9% Identity: 21% PDB header:electron transport Chain: X: PDB Molecule:photosystem ii reaction center protein x; PDBTitle: crystal structure of br-substituted photosystem ii complex Phyre2 PDB 3a0h chain X Region: 33 - 60 Aligned: 28 Modelled: 28 Confidence: 14.9% Identity: 21% PDB header:electron transport Chain: X: PDB Molecule:photosystem ii reaction center protein x; PDBTitle: crystal structure of i-substituted photosystem ii complex Phyre2 PDB 2zfn chain A Region: 1 - 24 Aligned: 24 Modelled: 24 Confidence: 13.4% Identity: 25% PDB header:transferase Chain: A: PDB Molecule:regulator of ty1 transposition protein 109; PDBTitle: self-acetylation mediated histone h3 lysine 56 acetylation by rtt109 Phyre2 PDB 1s5l chain X Region: 33 - 60 Aligned: 28 Modelled: 28 Confidence: 13.1% Identity: 21% PDB header:photosynthesis Chain: X: PDB Molecule:photosystem ii psbx protein; PDBTitle: architecture of the photosynthetic oxygen evolving center Phyre2 PDB 2y3a chain A Region: 54 - 85 Aligned: 29 Modelled: 32 Confidence: 11.9% Identity: 14% PDB header:transferase Chain: A: PDB Molecule:phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic PDBTitle: crystal structure of p110beta in complex with icsh2 of p85beta and2 the drug gdc-0941 Phyre2 PDB 3cz7 chain A Region: 1 - 24 Aligned: 24 Modelled: 24 Confidence: 11.6% Identity: 25% PDB header:replication Chain: A: PDB Molecule:regulator of ty1 transposition protein 109; PDBTitle: molecular basis for the autoregulation of the protein acetyl2 transferase rtt109 Phyre2 PDB 2wxo chain A Region: 56 - 85 Aligned: 27 Modelled: 30 Confidence: 10.1% Identity: 15% PDB header:transferase Chain: A: PDB Molecule:phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic PDBTitle: the crystal structure of the murine class ia pi 3-kinase2 p110delta in complex with as5. Phyre2 PDB 2rlf chain A Region: 73 - 90 Aligned: 18 Modelled: 18 Confidence: 8.8% Identity: 22% PDB header:proton transport Chain: A: PDB Molecule:matrix protein 2; PDBTitle: proton channel m2 from influenza a in complex with2 inhibitor rimantadine Phyre2 PDB 2ysc chain A domain 1 Region: 78 - 83 Aligned: 6 Modelled: 6 Confidence: 8.5% Identity: 50% Fold: WW domain-like Superfamily: WW domain Family: WW domain Phyre2 PDB 2rd0 chain A Region: 56 - 85 Aligned: 27 Modelled: 30 Confidence: 8.2% Identity: 22% PDB header:transferase/oncoprotein Chain: A: PDB Molecule:phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic PDBTitle: structure of a human p110alpha/p85alpha complex Phyre2 PDB 2qvw chain A Region: 3 - 23 Aligned: 21 Modelled: 21 Confidence: 7.6% Identity: 24% PDB header:hydrolase Chain: A: PDB Molecule:glp_546_48378_50642; PDBTitle: structure of giardia dicer refined against twinned data Phyre2 PDB 1e8z chain A Region: 56 - 87 Aligned: 29 Modelled: 32 Confidence: 6.5% Identity: 14% PDB header:transferase Chain: A: PDB Molecule:phosphatidylinositol 3-kinase catalytic subunit; PDBTitle: structure determinants of phosphoinositide 3-kinase2 inhibition by wortmannin, ly294002, quercetin, myricetin3 and staurosporine Phyre2 PDB 2ho2 chain A domain 1 Region: 78 - 83 Aligned: 6 Modelled: 6 Confidence: 6.1% Identity: 67% Fold: WW domain-like Superfamily: WW domain Family: WW domain Phyre2 PDB 1fw5 chain A Region: 79 - 83 Aligned: 5 Modelled: 5 Confidence: 6.0% Identity: 40% PDB header:viral protein Chain: A: PDB Molecule:nonstructural protein nsp1; PDBTitle: solution structure of membrane binding peptide of semliki2 forest virus mrna capping enzyme nsp1 Phyre2 PDB 1e7u chain A domain 1 Region: 54 - 87 Aligned: 31 Modelled: 34 Confidence: 5.1% Identity: 13% Fold: alpha-alpha superhelix Superfamily: ARM repeat Family: Phoshoinositide 3-kinase (PI3K) helical domain Phyre2 1 c3gebC_ 2 d1ttza_ 3 c3d35A_ 4 c3a0bX_ 5 c3a0hX_ 6 c3a0bx_ 7 c3a0hx_ 8 c2zfnA_ 9 c1s5lx_ 10 c2y3aA_ 11 c3cz7A_ 12 c2wxoA_ 13 c2rlfA_ 14 d2ysca1 15 c2rd0A_ 16 c2qvwA_ 17 c1e8zA_ 18 d2ho2a1 19 c1fw5A_ 20 d1e7ua1 21

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c3gebC_ 52.2 30 PDB header:hydrolase Chain: C: PDB Molecule:eyes absent homolog 2; PDBTitle: crystal structure of edeya2 2 d1ttza_ 30.0 23 Fold:Thioredoxin fold Superfamily:Thioredoxin-like Family:Thioltransferase 3 c3d35A_ 14.9 25 PDB header:transferase Chain: A: PDB Molecule:regulator of ty1 transposition protein 109; PDBTitle: crystal structure of rtt109-ac-coa complex 4 c3a0bX_ 14.9 21 PDB header:electron transport Chain: X: PDB Molecule:photosystem ii reaction center protein x; PDBTitle: crystal structure of br-substituted photosystem ii complex 5 c3a0hX_ 14.9 21 PDB header:electron transport Chain: X: PDB Molecule:photosystem ii reaction center protein x; PDBTitle: crystal structure of i-substituted photosystem ii complex 6 c3a0bx_ 14.9 21 PDB header:electron transport Chain: X: PDB Molecule:photosystem ii reaction center protein x; PDBTitle: crystal structure of br-substituted photosystem ii complex 7 c3a0hx_ 14.9 21 PDB header:electron transport Chain: X: PDB Molecule:photosystem ii reaction center protein x; PDBTitle: crystal structure of i-substituted photosystem ii complex 8 c2zfnA_ 13.4 25 PDB header:transferase Chain: A: PDB Molecule:regulator of ty1 transposition protein 109; PDBTitle: self-acetylation mediated histone h3 lysine 56 acetylation by rtt109 9 c1s5lx_ 13.1 21 PDB header:photosynthesis Chain: X: PDB Molecule:photosystem ii psbx protein; PDBTitle: architecture of the photosynthetic oxygen evolving center 10 c2y3aA_ 11.9 14 PDB header:transferase Chain: A: PDB Molecule:phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic PDBTitle: crystal structure of p110beta in complex with icsh2 of p85beta and2 the drug gdc-0941 11 c3cz7A_ 11.6 25 PDB header:replication Chain: A: PDB Molecule:regulator of ty1 transposition protein 109; PDBTitle: molecular basis for the autoregulation of the protein acetyl2 transferase rtt109 12 c2wxoA_ 10.1 15 PDB header:transferase Chain: A: PDB Molecule:phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic PDBTitle: the crystal structure of the murine class ia pi 3-kinase2 p110delta in complex with as5. 13 c2rlfA_ 8.8 22 PDB header:proton transport Chain: A: PDB Molecule:matrix protein 2; PDBTitle: proton channel m2 from influenza a in complex with2 inhibitor rimantadine 14 d2ysca1 8.5 50 Fold:WW domain-like Superfamily:WW domain Family:WW domain 15 c2rd0A_ 8.2 22 PDB header:transferase/oncoprotein Chain: A: PDB Molecule:phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic PDBTitle: structure of a human p110alpha/p85alpha complex 16 c2qvwA_ 7.6 24 PDB header:hydrolase Chain: A: PDB Molecule:glp_546_48378_50642; PDBTitle: structure of giardia dicer refined against twinned data 17 c1e8zA_ 6.5 14 PDB header:transferase Chain: A: PDB Molecule:phosphatidylinositol 3-kinase catalytic subunit; PDBTitle: structure determinants of phosphoinositide 3-kinase2 inhibition by wortmannin, ly294002, quercetin, myricetin3 and staurosporine 18 d2ho2a1 6.1 67 Fold:WW domain-like Superfamily:WW domain Family:WW domain 19 c1fw5A_ 6.0 40 PDB header:viral protein Chain: A: PDB Molecule:nonstructural protein nsp1; PDBTitle: solution structure of membrane binding peptide of semliki2 forest virus mrna capping enzyme nsp1 20 d1e7ua1 5.1 13 Fold:alpha-alpha superhelix Superfamily:ARM repeat Family:Phoshoinositide 3-kinase (PI3K) helical domain 21 d1tlqa_ not modelled 5.0 32 Fold:YutG-like Superfamily:YutG-like Family:YutG-like

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0