Phyre 2 Results for P08321

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Email | l.a.kelley@imperial.ac.uk
Description | P08321
Date | Thu Jan 5 11:01:04 GMT 2012
Unique Job ID | 278667a2e219db3b

Summary |

Top model
Image coloured by rainbow N → C terminus
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Model (left) based on template c3gebC_
Top template information
PDB header:hydrolase Chain: C: PDB Molecule:eyes absent homolog 2; PDBTitle: crystal structure of edeya2
Confidence and coverage
Confidence: | 52.2% | Coverage: | 33%
30 residues ( 33% of your sequence) have been modelled with 52.2% confidence by the single highest scoring template.
You may wish to submit your sequence to Phyrealarm. This will automatically scan your sequence every week for new potential templates as they appear in the Phyre2 library.
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3D viewing
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Sequence analysis |

Secondary structure and disorder prediction |

|  | 1 | . | . | . | . | . | . | . | . | 10 | . | . | . | . | . | . | . | . | . | 20 | . | . | . | . | . | . | . | . | . | 30 | . | . | . | . | . | . | . | . | . | 40 | . | . | . | . | . | . | . | . | . | 50 | . | . | . | . | . | . | . | . | . | 60
Sequence |  | M | S | G | D | E | N | K | L | K | K | Y | R | F | P | E | T | L | T | N | Q | S | R | W | F | G | L | P | L | D | E | L | I | P | A | A | I | C | I | G | W | G | I | T | T | S | K | Y | L | F | G | I | G | A | A | V | L | V | Y | F | G
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  | ? | ? | ? | ? | ? | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 70 | . | . | . | . | . | . | . | . | . | 80 | . | . | . | . | . | . | . | . | . | 90 | .
Sequence |  | I | K | K | L | K | K | G | R | G | S | S | W | L | R | D | L | I | Y | W | Y | M | P | T | A | L | L | R | G | I | F | S
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ?
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |

Confidence Key
High(9) |  |  |  |  |  |  |  |  |  |  | Low (0)

? | Disordered
| Alpha helix
| Beta strand

Domain analysis |

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank | Aligned region
--- | ---
1 |
| c3gebC_ |

### PDB 3geb chain C

Region: 18 - 47
Aligned: 30
Modelled: 30
Confidence: 52.2%
Identity: 30%
PDB header:hydrolase
Chain: C: PDB Molecule:eyes absent homolog 2;
PDBTitle: crystal structure of edeya2

Phyre2
2 |
| d1ttza_ |

### PDB 1ttz chain A

Region: 10 - 31
Aligned: 22
Modelled: 22
Confidence: 30.0%
Identity: 23%
Fold: Thioredoxin fold
Superfamily: Thioredoxin-like
Family: Thioltransferase

Phyre2
3 |
| c3d35A_ |

### PDB 3d35 chain A

Region: 1 - 24
Aligned: 24
Modelled: 24
Confidence: 14.9%
Identity: 25%
PDB header:transferase
Chain: A: PDB Molecule:regulator of ty1 transposition protein 109;
PDBTitle: crystal structure of rtt109-ac-coa complex

Phyre2
4 |
| c3a0bX_ |

### PDB 3a0b chain X

Region: 33 - 60
Aligned: 28
Modelled: 28
Confidence: 14.9%
Identity: 21%
PDB header:electron transport
Chain: X: PDB Molecule:photosystem ii reaction center protein x;
PDBTitle: crystal structure of br-substituted photosystem ii complex

Phyre2
5 |
| c3a0hX_ |

### PDB 3a0h chain X

Region: 33 - 60
Aligned: 28
Modelled: 28
Confidence: 14.9%
Identity: 21%
PDB header:electron transport
Chain: X: PDB Molecule:photosystem ii reaction center protein x;
PDBTitle: crystal structure of i-substituted photosystem ii complex

Phyre2
6 |
| c3a0bx_ |

### PDB 3a0b chain X

Region: 33 - 60
Aligned: 28
Modelled: 28
Confidence: 14.9%
Identity: 21%
PDB header:electron transport
Chain: X: PDB Molecule:photosystem ii reaction center protein x;
PDBTitle: crystal structure of br-substituted photosystem ii complex

Phyre2
7 |
| c3a0hx_ |

### PDB 3a0h chain X

Region: 33 - 60
Aligned: 28
Modelled: 28
Confidence: 14.9%
Identity: 21%
PDB header:electron transport
Chain: X: PDB Molecule:photosystem ii reaction center protein x;
PDBTitle: crystal structure of i-substituted photosystem ii complex

Phyre2
8 |
| c2zfnA_ |

### PDB 2zfn chain A

Region: 1 - 24
Aligned: 24
Modelled: 24
Confidence: 13.4%
Identity: 25%
PDB header:transferase
Chain: A: PDB Molecule:regulator of ty1 transposition protein 109;
PDBTitle: self-acetylation mediated histone h3 lysine 56 acetylation by rtt109

Phyre2
9 |
| c1s5lx_ |

### PDB 1s5l chain X

Region: 33 - 60
Aligned: 28
Modelled: 28
Confidence: 13.1%
Identity: 21%
PDB header:photosynthesis
Chain: X: PDB Molecule:photosystem ii psbx protein;
PDBTitle: architecture of the photosynthetic oxygen evolving center

Phyre2
10 |
| c2y3aA_ |

### PDB 2y3a chain A

Region: 54 - 85
Aligned: 29
Modelled: 32
Confidence: 11.9%
Identity: 14%
PDB header:transferase
Chain: A: PDB Molecule:phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic
PDBTitle: crystal structure of p110beta in complex with icsh2 of p85beta and2 the drug gdc-0941

Phyre2
11 |
| c3cz7A_ |

### PDB 3cz7 chain A

Region: 1 - 24
Aligned: 24
Modelled: 24
Confidence: 11.6%
Identity: 25%
PDB header:replication
Chain: A: PDB Molecule:regulator of ty1 transposition protein 109;
PDBTitle: molecular basis for the autoregulation of the protein acetyl2 transferase rtt109

Phyre2
12 |
| c2wxoA_ |

### PDB 2wxo chain A

Region: 56 - 85
Aligned: 27
Modelled: 30
Confidence: 10.1%
Identity: 15%
PDB header:transferase
Chain: A: PDB Molecule:phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic
PDBTitle: the crystal structure of the murine class ia pi 3-kinase2 p110delta in complex with as5.

Phyre2
13 |
| c2rlfA_ |

### PDB 2rlf chain A

Region: 73 - 90
Aligned: 18
Modelled: 18
Confidence: 8.8%
Identity: 22%
PDB header:proton transport
Chain: A: PDB Molecule:matrix protein 2;
PDBTitle: proton channel m2 from influenza a in complex with2 inhibitor rimantadine

Phyre2
14 |
| d2ysca1 |

### PDB 2ysc chain A domain 1

Region: 78 - 83
Aligned: 6
Modelled: 6
Confidence: 8.5%
Identity: 50%
Fold: WW domain-like
Superfamily: WW domain
Family: WW domain

Phyre2
15 |
| c2rd0A_ |

### PDB 2rd0 chain A

Region: 56 - 85
Aligned: 27
Modelled: 30
Confidence: 8.2%
Identity: 22%
PDB header:transferase/oncoprotein
Chain: A: PDB Molecule:phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic
PDBTitle: structure of a human p110alpha/p85alpha complex

Phyre2
16 |
| c2qvwA_ |

### PDB 2qvw chain A

Region: 3 - 23
Aligned: 21
Modelled: 21
Confidence: 7.6%
Identity: 24%
PDB header:hydrolase
Chain: A: PDB Molecule:glp_546_48378_50642;
PDBTitle: structure of giardia dicer refined against twinned data

Phyre2
17 |
| c1e8zA_ |

### PDB 1e8z chain A

Region: 56 - 87
Aligned: 29
Modelled: 32
Confidence: 6.5%
Identity: 14%
PDB header:transferase
Chain: A: PDB Molecule:phosphatidylinositol 3-kinase catalytic subunit;
PDBTitle: structure determinants of phosphoinositide 3-kinase2 inhibition by wortmannin, ly294002, quercetin, myricetin3 and staurosporine

Phyre2
18 |
| d2ho2a1 |

### PDB 2ho2 chain A domain 1

Region: 78 - 83
Aligned: 6
Modelled: 6
Confidence: 6.1%
Identity: 67%
Fold: WW domain-like
Superfamily: WW domain
Family: WW domain

Phyre2
19 |
| c1fw5A_ |

### PDB 1fw5 chain A

Region: 79 - 83
Aligned: 5
Modelled: 5
Confidence: 6.0%
Identity: 40%
PDB header:viral protein
Chain: A: PDB Molecule:nonstructural protein nsp1;
PDBTitle: solution structure of membrane binding peptide of semliki2 forest virus mrna capping enzyme nsp1

Phyre2
20 |
| d1e7ua1 |

### PDB 1e7u chain A domain 1

Region: 54 - 87
Aligned: 31
Modelled: 34
Confidence: 5.1%
Identity: 13%
Fold: alpha-alpha superhelix
Superfamily: ARM repeat
Family: Phoshoinositide 3-kinase (PI3K) helical domain

Phyre2
21 |

Detailed template information |

# | Template | Alignment Coverage | 3D Model | Confidence | % i.d. | Template Information
--- | --- | --- | --- | --- | --- | ---
1 | c3gebC_ |
|  | 52.2 | 30 | PDB header:hydrolase Chain: C: PDB Molecule:eyes absent homolog 2; PDBTitle: crystal structure of edeya2
2 | d1ttza_ |
|  | 30.0 | 23 | Fold:Thioredoxin fold Superfamily:Thioredoxin-like Family:Thioltransferase
3 | c3d35A_ |
|  | 14.9 | 25 | PDB header:transferase Chain: A: PDB Molecule:regulator of ty1 transposition protein 109; PDBTitle: crystal structure of rtt109-ac-coa complex
4 | c3a0bX_ |
|  | 14.9 | 21 | PDB header:electron transport Chain: X: PDB Molecule:photosystem ii reaction center protein x; PDBTitle: crystal structure of br-substituted photosystem ii complex
5 | c3a0hX_ |
|  | 14.9 | 21 | PDB header:electron transport Chain: X: PDB Molecule:photosystem ii reaction center protein x; PDBTitle: crystal structure of i-substituted photosystem ii complex
6 | c3a0bx_ |
|  | 14.9 | 21 | PDB header:electron transport Chain: X: PDB Molecule:photosystem ii reaction center protein x; PDBTitle: crystal structure of br-substituted photosystem ii complex
7 | c3a0hx_ |
|  | 14.9 | 21 | PDB header:electron transport Chain: X: PDB Molecule:photosystem ii reaction center protein x; PDBTitle: crystal structure of i-substituted photosystem ii complex
8 | c2zfnA_ |
|  | 13.4 | 25 | PDB header:transferase Chain: A: PDB Molecule:regulator of ty1 transposition protein 109; PDBTitle: self-acetylation mediated histone h3 lysine 56 acetylation by rtt109
9 | c1s5lx_ |
|  | 13.1 | 21 | PDB header:photosynthesis Chain: X: PDB Molecule:photosystem ii psbx protein; PDBTitle: architecture of the photosynthetic oxygen evolving center
10 | c2y3aA_ |
|  | 11.9 | 14 | PDB header:transferase Chain: A: PDB Molecule:phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic PDBTitle: crystal structure of p110beta in complex with icsh2 of p85beta and2 the drug gdc-0941
11 | c3cz7A_ |
|  | 11.6 | 25 | PDB header:replication Chain: A: PDB Molecule:regulator of ty1 transposition protein 109; PDBTitle: molecular basis for the autoregulation of the protein acetyl2 transferase rtt109
12 | c2wxoA_ |
|  | 10.1 | 15 | PDB header:transferase Chain: A: PDB Molecule:phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic PDBTitle: the crystal structure of the murine class ia pi 3-kinase2 p110delta in complex with as5.
13 | c2rlfA_ |
|  | 8.8 | 22 | PDB header:proton transport Chain: A: PDB Molecule:matrix protein 2; PDBTitle: proton channel m2 from influenza a in complex with2 inhibitor rimantadine
14 | d2ysca1 |
|  | 8.5 | 50 | Fold:WW domain-like Superfamily:WW domain Family:WW domain
15 | c2rd0A_ |
|  | 8.2 | 22 | PDB header:transferase/oncoprotein Chain: A: PDB Molecule:phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic PDBTitle: structure of a human p110alpha/p85alpha complex
16 | c2qvwA_ |
|  | 7.6 | 24 | PDB header:hydrolase Chain: A: PDB Molecule:glp_546_48378_50642; PDBTitle: structure of giardia dicer refined against twinned data
17 | c1e8zA_ |
|  | 6.5 | 14 | PDB header:transferase Chain: A: PDB Molecule:phosphatidylinositol 3-kinase catalytic subunit; PDBTitle: structure determinants of phosphoinositide 3-kinase2 inhibition by wortmannin, ly294002, quercetin, myricetin3 and staurosporine
18 | d2ho2a1 |
|  | 6.1 | 67 | Fold:WW domain-like Superfamily:WW domain Family:WW domain
19 | c1fw5A_ |
|  | 6.0 | 40 | PDB header:viral protein Chain: A: PDB Molecule:nonstructural protein nsp1; PDBTitle: solution structure of membrane binding peptide of semliki2 forest virus mrna capping enzyme nsp1
20 | d1e7ua1 |
|  | 5.1 | 13 | Fold:alpha-alpha superhelix Superfamily:ARM repeat Family:Phoshoinositide 3-kinase (PI3K) helical domain
21 | d1tlqa_ |
| not modelled | 5.0 | 32 | Fold:YutG-like Superfamily:YutG-like Family:YutG-like

Binding site prediction |

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group
Imperial College London
Lawrence Kelley, Benjamin Jefferys
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Component software
Template detection: HHpred 1.51
Secondary structure prediction: Psi-pred 2.5
Disorder prediction: Disopred 2.4
Transmembrane prediction: Memsat_SVM
Multi-template modelling and ab initio: Poing 1.0