Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	I	K	W	P	W	K	V	Q	E	S	A	H	Q	T	A	L	P	W	Q	E	A	L	S	I	P	L	L	T	C	L	T	E	Q	E	Q	S	K	L	V	T	L	A	E	R	F	L	Q	Q	K	R	L	V	P	L	Q	G	F	E	L
Secondary structure
SS confidence
Disorder		?	?	?	?					?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		D	S	L	R	S	C	R	I	A	L	L	F	C	L	P	V	L	E	L	G	L	E	W	L	D	G	F	H	E	V	L	I	Y	P	A	P	F	V	V	D	D	E	W	E	D	D	I	G	L	V	H	N	Q	R	I	V	Q	S	G	Q
Secondary structure
SS confidence
Disorder																																													?	?	?	?			?		?			?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		S	W	Q	Q	G	P	I	V	L	N	W	L	D	I	Q	D	S	F	D	A	S	G	F	N	L	I	I	H	E	V	A	H	K	L	D	T	R	N	G	D	R	A	S	G	V	P	F	I	P	L	R	E	V	A	G	W	E	H	D	L
Secondary structure
SS confidence
Disorder																		?		?		?	?																	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		H	A	A	M	N	N	I	Q	E	E	I	E	L	V	G	E	N	A	A	S	I	D	A	Y	A	A	S	D	P	A	E	C	F	A	V	L	S	E	Y	F	F	S	A	P	E	L	F	A	P	R	F	P	S	L	W	Q	R	F	C	Q
Secondary structure
SS confidence
Disorder														?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.
Sequence		F	Y	Q	Q	D	P	L	Q	R	L	H	H	A	N	D	T	D	S	F	S	A	T	N	V	H
Secondary structure
SS confidence
Disorder										?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 3dl1 chain A Region: 18 - 251 Aligned: 207 Modelled: 209 Confidence: 100.0% Identity: 80% PDB header:hydrolase Chain: A: PDB Molecule:putative metal-dependent hydrolase; PDBTitle: crystal structure of a putative metal-dependent hydrolase2 (yp_001336084.1) from klebsiella pneumoniae subsp. pneumoniae mgh3 78578 at 2.20 a resolution Phyre2 PDB 2l0r chain A Region: 136 - 244 Aligned: 95 Modelled: 95 Confidence: 99.8% Identity: 18% PDB header:hydrolase,toxin Chain: A: PDB Molecule:lethal factor; PDBTitle: conformational dynamics of the anthrax lethal factor catalytic center Phyre2 PDB 1j7n chain A domain 2 Region: 91 - 243 Aligned: 135 Modelled: 139 Confidence: 99.8% Identity: 16% Fold: Zincin-like Superfamily: Metalloproteases ("zincins"), catalytic domain Family: Anthrax toxin lethal factor, N- and C-terminal domains Phyre2 PDB 1yqy chain A Region: 147 - 240 Aligned: 75 Modelled: 81 Confidence: 97.2% Identity: 21% PDB header:hydrolase Chain: A: PDB Molecule:lethal factor; PDBTitle: structure of b. anthrax lethal factor in complex with a2 hydroxamate inhibitor Phyre2 PDB 1pwq chain A Region: 147 - 240 Aligned: 80 Modelled: 94 Confidence: 97.2% Identity: 20% PDB header:hydrolase Chain: A: PDB Molecule:lethal factor; PDBTitle: crystal structure of anthrax lethal factor complexed with2 thioacetyl-tyr-pro-met-amide, a metal-chelating peptidyl3 small molecule inhibitor Phyre2 PDB 2ejq chain A domain 1 Region: 79 - 160 Aligned: 82 Modelled: 82 Confidence: 84.6% Identity: 13% Fold: Zincin-like Superfamily: Metalloproteases ("zincins"), catalytic domain Family: TTHA0227-like Phyre2 PDB 2xpy chain A Region: 79 - 153 Aligned: 53 Modelled: 56 Confidence: 64.6% Identity: 17% PDB header:hydrolase Chain: A: PDB Molecule:leukotriene a-4 hydrolase; PDBTitle: structure of native leukotriene a4 hydrolase from saccharomyces2 cerevisiae Phyre2 PDB 3lq0 chain A Region: 97 - 158 Aligned: 58 Modelled: 62 Confidence: 59.9% Identity: 14% PDB header:hydrolase Chain: A: PDB Molecule:proastacin; PDBTitle: zymogen structure of crayfish astacin metallopeptidase Phyre2 PDB 1hv5 chain A Region: 141 - 154 Aligned: 14 Modelled: 14 Confidence: 57.3% Identity: 29% Fold: Zincin-like Superfamily: Metalloproteases ("zincins"), catalytic domain Family: Matrix metalloproteases, catalytic domain Phyre2 PDB 1qib chain A Region: 141 - 154 Aligned: 14 Modelled: 14 Confidence: 55.8% Identity: 36% Fold: Zincin-like Superfamily: Metalloproteases ("zincins"), catalytic domain Family: Matrix metalloproteases, catalytic domain Phyre2 PDB 1i76 chain A Region: 143 - 154 Aligned: 12 Modelled: 12 Confidence: 53.6% Identity: 42% Fold: Zincin-like Superfamily: Metalloproteases ("zincins"), catalytic domain Family: Matrix metalloproteases, catalytic domain Phyre2 PDB 1k7i chain A domain 2 Region: 125 - 154 Aligned: 30 Modelled: 30 Confidence: 53.2% Identity: 23% Fold: Zincin-like Superfamily: Metalloproteases ("zincins"), catalytic domain Family: Serralysin-like metalloprotease, catalytic (N-terminal) domain Phyre2 PDB 1hfc chain A Region: 143 - 154 Aligned: 12 Modelled: 12 Confidence: 53.1% Identity: 33% Fold: Zincin-like Superfamily: Metalloproteases ("zincins"), catalytic domain Family: Matrix metalloproteases, catalytic domain Phyre2 PDB 1kap chain P domain 2 Region: 139 - 154 Aligned: 16 Modelled: 16 Confidence: 52.4% Identity: 31% Fold: Zincin-like Superfamily: Metalloproteases ("zincins"), catalytic domain Family: Serralysin-like metalloprotease, catalytic (N-terminal) domain Phyre2 PDB 1q3a chain A Region: 143 - 154 Aligned: 12 Modelled: 12 Confidence: 52.2% Identity: 42% Fold: Zincin-like Superfamily: Metalloproteases ("zincins"), catalytic domain Family: Matrix metalloproteases, catalytic domain Phyre2 PDB 1ast chain A Region: 145 - 154 Aligned: 10 Modelled: 10 Confidence: 51.5% Identity: 50% Fold: Zincin-like Superfamily: Metalloproteases ("zincins"), catalytic domain Family: Astacin Phyre2 PDB 1mmq chain A Region: 141 - 154 Aligned: 14 Modelled: 14 Confidence: 51.2% Identity: 29% Fold: Zincin-like Superfamily: Metalloproteases ("zincins"), catalytic domain Family: Matrix metalloproteases, catalytic domain Phyre2 PDB 1cxv chain A Region: 144 - 154 Aligned: 11 Modelled: 11 Confidence: 50.4% Identity: 36% Fold: Zincin-like Superfamily: Metalloproteases ("zincins"), catalytic domain Family: Matrix metalloproteases, catalytic domain Phyre2 PDB 3edh chain A Region: 145 - 154 Aligned: 10 Modelled: 10 Confidence: 50.3% Identity: 30% PDB header:hydrolase Chain: A: PDB Molecule:bone morphogenetic protein 1; PDBTitle: crystal structure of bone morphogenetic protein 1 protease2 domain in complex with partially bound dmso Phyre2 PDB 3cia chain A Region: 79 - 153 Aligned: 53 Modelled: 75 Confidence: 48.9% Identity: 30% PDB header:hydrolase Chain: A: PDB Molecule:cold-active aminopeptidase; PDBTitle: crystal structure of cold-aminopeptidase from colwellia2 psychrerythraea Phyre2 1 c3dl1A_ 2 c2l0rA_ 3 d1j7na2 4 c1yqyA_ 5 c1pwqA_ 6 d2ejqa1 7 c2xpyA_ 8 c3lq0A_ 9 d1hv5a_ 10 d1qiba_ 11 d1i76a_ 12 d1k7ia2 13 d1hfca_ 14 d1kapp2 15 d1q3aa_ 16 d1asta_ 17 d1mmqa_ 18 d1cxva_ 19 c3edhA_ 20 c3ciaA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c3dl1A_ 100.0 80 PDB header:hydrolase Chain: A: PDB Molecule:putative metal-dependent hydrolase; PDBTitle: crystal structure of a putative metal-dependent hydrolase2 (yp_001336084.1) from klebsiella pneumoniae subsp. pneumoniae mgh3 78578 at 2.20 a resolution 2 c2l0rA_ 99.8 18 PDB header:hydrolase,toxin Chain: A: PDB Molecule:lethal factor; PDBTitle: conformational dynamics of the anthrax lethal factor catalytic center 3 d1j7na2 99.8 16 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Anthrax toxin lethal factor, N- and C-terminal domains 4 c1yqyA_ 97.2 21 PDB header:hydrolase Chain: A: PDB Molecule:lethal factor; PDBTitle: structure of b. anthrax lethal factor in complex with a2 hydroxamate inhibitor 5 c1pwqA_ 97.2 20 PDB header:hydrolase Chain: A: PDB Molecule:lethal factor; PDBTitle: crystal structure of anthrax lethal factor complexed with2 thioacetyl-tyr-pro-met-amide, a metal-chelating peptidyl3 small molecule inhibitor 6 d2ejqa1 84.6 13 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:TTHA0227-like 7 c2xpyA_ 64.6 17 PDB header:hydrolase Chain: A: PDB Molecule:leukotriene a-4 hydrolase; PDBTitle: structure of native leukotriene a4 hydrolase from saccharomyces2 cerevisiae 8 c3lq0A_ 59.9 14 PDB header:hydrolase Chain: A: PDB Molecule:proastacin; PDBTitle: zymogen structure of crayfish astacin metallopeptidase 9 d1hv5a_ 57.3 29 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 10 d1qiba_ 55.8 36 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 11 d1i76a_ 53.6 42 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 12 d1k7ia2 53.2 23 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Serralysin-like metalloprotease, catalytic (N-terminal) domain 13 d1hfca_ 53.1 33 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 14 d1kapp2 52.4 31 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Serralysin-like metalloprotease, catalytic (N-terminal) domain 15 d1q3aa_ 52.2 42 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 16 d1asta_ 51.5 50 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Astacin 17 d1mmqa_ 51.2 29 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 18 d1cxva_ 50.4 36 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 19 c3edhA_ 50.3 30 PDB header:hydrolase Chain: A: PDB Molecule:bone morphogenetic protein 1; PDBTitle: crystal structure of bone morphogenetic protein 1 protease2 domain in complex with partially bound dmso 20 c3ciaA_ 48.9 30 PDB header:hydrolase Chain: A: PDB Molecule:cold-active aminopeptidase; PDBTitle: crystal structure of cold-aminopeptidase from colwellia2 psychrerythraea 21 d1cgla_ not modelled 48.5 36 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 22 d1y93a1 not modelled 48.0 36 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 23 d2ixoa1 not modelled 48.0 15 Fold:PTPA-like Superfamily:PTPA-like Family:PTPA-like 24 d1g9ka2 not modelled 47.8 22 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Serralysin-like metalloprotease, catalytic (N-terminal) domain 25 c3lqbA_ not modelled 47.4 40 PDB header:hydrolase Chain: A: PDB Molecule:loc792177 protein; PDBTitle: crystal structure of the hatching enzyme zhe1 from the zebrafish danio2 rerio 26 d1hy7a_ not modelled 47.3 36 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 27 d1bqqm_ not modelled 46.4 36 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 28 d1fbla2 not modelled 45.6 28 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 29 c2xs4A_ not modelled 45.6 33 PDB header:hydrolase Chain: A: PDB Molecule:karilysin protease; PDBTitle: structure of karilysin catalytic mmp domain in complex with2 magnesium 30 d1eaka2 not modelled 45.5 15 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 31 c2jsdA_ not modelled 44.9 42 PDB header:hydrolase Chain: A: PDB Molecule:matrix metalloproteinase-20; PDBTitle: solution structure of mmp20 complexed with nngh 32 d1xuca1 not modelled 44.8 42 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 33 d1hova_ not modelled 44.6 19 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 34 d1rm8a_ not modelled 44.6 36 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 35 d2ovxa1 not modelled 44.4 36 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 36 c1su3A_ not modelled 41.5 33 PDB header:hydrolase Chain: A: PDB Molecule:interstitial collagenase; PDBTitle: x-ray structure of human prommp-1: new insights into2 collagenase action 37 d1sata2 not modelled 41.3 17 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Serralysin-like metalloprotease, catalytic (N-terminal) domain 38 c3ba0A_ not modelled 40.3 36 PDB header:hydrolase Chain: A: PDB Molecule:macrophage metalloelastase; PDBTitle: crystal structure of full-length human mmp-12 39 c3b4rB_ not modelled 40.2 30 PDB header:hydrolase Chain: B: PDB Molecule:putative zinc metalloprotease mj0392; PDBTitle: site-2 protease from methanocaldococcus jannaschii 40 c1slmA_ not modelled 39.7 42 PDB header:hydrolase Chain: A: PDB Molecule:stromelysin-1; PDBTitle: crystal structure of fibroblast stromelysin-1: the c-truncated human2 proenzyme 41 d2ixna1 not modelled 36.7 16 Fold:PTPA-like Superfamily:PTPA-like Family:PTPA-like 42 c1jiwP_ not modelled 36.3 22 PDB header:hydrolase/hyrolase inhibitor Chain: P: PDB Molecule:alkaline metalloproteinase; PDBTitle: crystal structure of the apr-aprin complex 43 c3d7iB_ not modelled 35.2 17 PDB header:lyase Chain: B: PDB Molecule:carboxymuconolactone decarboxylase family protein; PDBTitle: crystal structure of carboxymuconolactone decarboxylase family protein2 possibly involved in oxygen detoxification (1591455) from3 methanococcus jannaschii at 1.75 a resolution 44 d1kjpa_ not modelled 34.6 27 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Thermolysin-like 45 d1lmla_ not modelled 33.9 42 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Leishmanolysin 46 c2cltB_ not modelled 33.8 21 PDB header:hydrolase Chain: B: PDB Molecule:interstitial collagenase; PDBTitle: crystal structure of the active form (full-length) of human2 fibroblast collagenase. 47 d1bqba_ not modelled 33.3 18 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Thermolysin-like 48 c1y791_ not modelled 32.8 27 PDB header:hydrolase Chain: 1: PDB Molecule:peptidyl-dipeptidase dcp; PDBTitle: crystal structure of the e.coli dipeptidyl carboxypeptidase2 dcp in complex with a peptidic inhibitor 49 c1eakA_ not modelled 32.6 10 PDB header:hydrolase/hydrolase inhibitor Chain: A: PDB Molecule:72 kda type iv collagenase; PDBTitle: catalytic domain of prommp-2 e404q mutant 50 d3e11a1 not modelled 29.3 33 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:TTHA0227-like 51 c3b7uX_ not modelled 29.0 32 PDB header:hydrolase Chain: X: PDB Molecule:leukotriene a-4 hydrolase; PDBTitle: leukotriene a4 hydrolase complexed with kelatorphan 52 c1l6jA_ not modelled 23.8 16 PDB header:hydrolase Chain: A: PDB Molecule:matrix metalloproteinase-9; PDBTitle: crystal structure of human matrix metalloproteinase mmp92 (gelatinase b). 53 c1om8A_ not modelled 23.6 38 PDB header:hydrolase Chain: A: PDB Molecule:serralysin; PDBTitle: crystal structure of a cold adapted alkaline protease from pseudomonas2 tac ii 18, co-crystallyzed with 10 mm edta 54 d1neka3 not modelled 23.1 24 Fold:Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain Superfamily:Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain Family:Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain 55 c2j83B_ not modelled 22.5 18 PDB header:hydrolase Chain: B: PDB Molecule:ulilysin; PDBTitle: ulilysin metalloprotease in complex with batimastat. 56 c3c0hB_ not modelled 21.4 10 PDB header:transferase Chain: B: PDB Molecule:peripheral plasma membrane protein cask; PDBTitle: cask cam-kinase domain- amppnp complex, p1 form 57 c1satA_ not modelled 20.8 17 PDB header:hydrolase (serine protease) Chain: A: PDB Molecule:serratia protease; PDBTitle: crystal structure of the 50 kda metallo protease from s.2 marcescens 58 d3b7sa3 not modelled 20.0 40 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Leukotriene A4 hydrolase catalytic domain 59 c2oqjL_ not modelled 19.0 50 PDB header:immune system Chain: L: PDB Molecule:peptide 2g12.1 (acppshvldmrsgtclaaegk); PDBTitle: crystal structure analysis of fab 2g12 in complex with peptide 2g12.1 60 c2oqjC_ not modelled 18.9 50 PDB header:immune system Chain: C: PDB Molecule:peptide 2g12.1 (acppshvldmrsgtclaaegk); PDBTitle: crystal structure analysis of fab 2g12 in complex with peptide 2g12.1 61 d1kufa_ not modelled 18.8 23 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Reprolysin-like 62 c2oqjI_ not modelled 18.7 50 PDB header:immune system Chain: I: PDB Molecule:peptide 2g12.1 (acppshvldmrsgtclaaegk); PDBTitle: crystal structure analysis of fab 2g12 in complex with peptide 2g12.1 63 c3k7lA_ not modelled 17.9 29 PDB header:hydrolase Chain: A: PDB Molecule:atragin; PDBTitle: structures of two elapid snake venom metalloproteases with2 distinct activities highlight the disulfide patterns in the3 d domain of adamalysin family proteins 64 d2ixma1 not modelled 17.8 18 Fold:PTPA-like Superfamily:PTPA-like Family:PTPA-like 65 c2gtqA_ not modelled 17.7 30 PDB header:hydrolase Chain: A: PDB Molecule:aminopeptidase n; PDBTitle: crystal structure of aminopeptidase n from human pathogen neisseria2 meningitidis 66 d1npca_ not modelled 16.7 20 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Thermolysin-like 67 c2g62A_ not modelled 16.4 22 PDB header:hydrolase activator Chain: A: PDB Molecule:protein phosphatase 2a, regulatory subunit b' (pr 53); PDBTitle: crystal structure of human ptpa 68 c2oqjF_ not modelled 15.7 50 PDB header:immune system Chain: F: PDB Molecule:peptide 2g12.1 (acppshvldmrsgtclaaegk); PDBTitle: crystal structure analysis of fab 2g12 in complex with peptide 2g12.1 69 c2erpA_ not modelled 15.4 29 PDB header:toxin Chain: A: PDB Molecule:vascular apoptosis-inducing protein 1; PDBTitle: crystal structure of vascular apoptosis-inducing protein-1(inhibitor-2 bound form) 70 c3k7nA_ not modelled 15.3 36 PDB header:hydrolase Chain: A: PDB Molecule:k-like; PDBTitle: structures of two elapid snake venom metalloproteases with2 distinct activities highlight the disulfide patterns in the3 d domain of adamalysin family proteins 71 c3ebhA_ not modelled 14.9 30 PDB header:hydrolase inhibitor Chain: A: PDB Molecule:m1 family aminopeptidase; PDBTitle: structure of the m1 alanylaminopeptidase from malaria complexed with2 bestatin 72 d1wlfa2 not modelled 14.8 27 Fold:Double psi beta-barrel Superfamily:ADC-like Family:Cdc48 N-terminal domain-like 73 c2c1iA_ not modelled 14.7 14 PDB header:hydrolase Chain: A: PDB Molecule:peptidoglycan glcnac deacetylase; PDBTitle: structure of streptococcus pnemoniae peptidoglycan2 deacetylase (sppgda) d 275 n mutant. 74 c2i47A_ not modelled 14.7 21 PDB header:hydrolase Chain: A: PDB Molecule:adam 17; PDBTitle: crystal structure of catalytic domain of tace with inhibitor 75 c1wgzC_ not modelled 14.5 17 PDB header:hydrolase Chain: C: PDB Molecule:carboxypeptidase 1; PDBTitle: crystal structure of carboxypeptidase 1 from thermus thermophilus 76 c2c30A_ not modelled 14.2 17 PDB header:transferase Chain: A: PDB Molecule:serine/threonine-protein kinase pak 6; PDBTitle: crystal structure of the human p21-activated kinase 6 77 c3b37A_ not modelled 13.9 40 PDB header:hydrolase Chain: A: PDB Molecule:aminopeptidase n; PDBTitle: crystal structure of e. coli aminopeptidase n in complex with tyrosine 78 d2i47a1 not modelled 13.6 21 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:TNF-alpha converting enzyme, TACE, catalytic domain 79 c3ppuB_ not modelled 13.2 13 PDB header:transferase Chain: B: PDB Molecule:glutathione-s-transferase; PDBTitle: crystal structure of the glutathione-s-transferase xi from2 phanerochaete chrysosporium 80 c1yp1A_ not modelled 13.1 27 PDB header:hydrolase Chain: A: PDB Molecule:fii; PDBTitle: crystal structure of a non-hemorrhagic fibrin(ogen)olytic2 metalloproteinase from venom of agkistrodon acutus 81 d2ajfa1 not modelled 12.9 11 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Neurolysin-like 82 d1nd1a_ not modelled 12.9 29 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Reprolysin-like 83 c3famA_ not modelled 12.8 16 PDB header:transferase Chain: A: PDB Molecule:carbon catabolite-derepressing protein kinase; PDBTitle: crystal structure of the protein kinase domain of yeast amp-2 activated protein kinase snf1 84 c1yyeA_ not modelled 12.8 14 PDB header:transcription Chain: A: PDB Molecule:estrogen receptor beta; PDBTitle: crystal structure of estrogen receptor beta complexed with2 way-202196 85 d1eb6a_ not modelled 12.5 16 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Fungal zinc peptidase 86 c1z5hB_ not modelled 12.4 60 PDB header:hydrolase Chain: B: PDB Molecule:tricorn protease interacting factor f3; PDBTitle: crystal structures of the tricorn interacting factor f32 from thermoplasma acidophilum 87 c2v4bB_ not modelled 12.3 21 PDB header:hydrolase Chain: B: PDB Molecule:adamts-1; PDBTitle: crystal structure of human adamts-1 catalytic domain and2 cysteine-rich domain (apo-form) 88 c3cqbB_ not modelled 12.2 15 PDB header:hydrolase Chain: B: PDB Molecule:probable protease htpx homolog; PDBTitle: crystal structure of heat shock protein htpx domain from vibrio2 parahaemolyticus rimd 2210633 89 d1phka_ not modelled 12.2 9 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit 90 c2e3xA_ not modelled 12.2 29 PDB header:hydrolase, blood clotting, toxin Chain: A: PDB Molecule:coagulation factor x-activating enzyme heavy chain; PDBTitle: crystal structure of russell's viper venom metalloproteinase 91 c3g5cA_ not modelled 12.1 14 PDB header:membrane protein Chain: A: PDB Molecule:adam 22; PDBTitle: structural and biochemical studies on the ectodomain of human adam22 92 c3nqzB_ not modelled 11.9 20 PDB header:hydrolase Chain: B: PDB Molecule:secreted metalloprotease mcp02; PDBTitle: crystal structure of the autoprocessed vibriolysin mcp-02 with e369a2 mutation 93 d1atla_ not modelled 11.9 29 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Reprolysin-like 94 c3b8zB_ not modelled 11.8 29 PDB header:hydrolase Chain: B: PDB Molecule:protein adamts-5; PDBTitle: high resolution crystal structure of the catalytic domain2 of adamts-5 (aggrecanase-2) 95 d1chua3 not modelled 11.8 14 Fold:Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain Superfamily:Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain Family:Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain 96 c3ce2A_ not modelled 11.7 36 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:putative peptidase; PDBTitle: crystal structure of putative peptidase from chlamydophila abortus 97 c2rjpC_ not modelled 11.5 14 PDB header:hydrolase Chain: C: PDB Molecule:adamts-4; PDBTitle: crystal structure of adamts4 with inhibitor bound 98 c2rjqA_ not modelled 11.3 29 PDB header:hydrolase Chain: A: PDB Molecule:adamts-5; PDBTitle: crystal structure of adamts5 with inhibitor bound 99 c2dw1B_ not modelled 11.3 29 PDB header:apoptosis, toxin Chain: B: PDB Molecule:catrocollastatin; PDBTitle: crystal structure of vap2 from crotalus atrox venom (form 2-2 crystal)

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0