Secondary structure and disorder prediction

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Sequence		M	I	D	K	I	K	S	N	A	R	D	L	R	R	N	L	T	L	Q	E	R	K	L	W	R	Y	L	R	S	R	R	F	S	D	F	K	F	R	R	Q	H	P	V	G	S	Y	I	L	D	F	A	C	C	S	A	R	V	V	V	E
Secondary structure
SS confidence
Disorder		?	?												?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.
Sequence		L	D	G	G	Q	H	D	L	A	V	A	Y	D	S	R	R	T	S	W	L	E	S	Q	G	W	T	V	L	R	F	W	N	N	E	I	D	C	N	E	E	T	V	L	E	N	I	L	Q	E	L	N	R	R	S	P	S	P
Secondary structure
SS confidence
Disorder										?																																											?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 3hrl chain A Region: 15 - 113 Aligned: 92 Modelled: 99 Confidence: 100.0% Identity: 49% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:endonuclease-like protein; PDBTitle: crystal structure of a putative endonuclease-like protein (ngo0050)2 from neisseria gonorrhoeae Phyre2 PDB 1cw0 chain A Region: 3 - 116 Aligned: 111 Modelled: 111 Confidence: 99.9% Identity: 25% Fold: Restriction endonuclease-like Superfamily: Restriction endonuclease-like Family: Very short patch repair (VSR) endonuclease Phyre2 PDB 1vsr chain A Region: 19 - 116 Aligned: 95 Modelled: 95 Confidence: 99.7% Identity: 25% Fold: Restriction endonuclease-like Superfamily: Restriction endonuclease-like Family: Very short patch repair (VSR) endonuclease Phyre2 PDB 1m0d chain A Region: 17 - 82 Aligned: 60 Modelled: 66 Confidence: 87.7% Identity: 22% Fold: Restriction endonuclease-like Superfamily: Restriction endonuclease-like Family: Endonuclease I (Holliday junction resolvase) Phyre2 PDB 2fqz chain C Region: 5 - 54 Aligned: 47 Modelled: 47 Confidence: 26.9% Identity: 11% PDB header:hydrolase/dna Chain: C: PDB Molecule:r.ecl18ki; PDBTitle: metal-depleted ecl18ki in complex with uncleaved dna Phyre2 PDB 1tex chain A Region: 77 - 111 Aligned: 35 Modelled: 35 Confidence: 25.3% Identity: 14% Fold: P-loop containing nucleoside triphosphate hydrolases Superfamily: P-loop containing nucleoside triphosphate hydrolases Family: PAPS sulfotransferase Phyre2 PDB 2ovf chain A Region: 86 - 111 Aligned: 26 Modelled: 26 Confidence: 24.7% Identity: 19% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:stal; PDBTitle: crystal structure of stal-pap complex Phyre2 PDB 2kyr chain A Region: 84 - 113 Aligned: 30 Modelled: 30 Confidence: 22.0% Identity: 10% PDB header:transferase Chain: A: PDB Molecule:fructose-like phosphotransferase enzyme iib component 1; PDBTitle: solution structure of enzyme iib subunit of pts system from2 escherichia coli k12. northeast structural genomics consortium target3 er315/ontario center for structural proteomics target ec0544 Phyre2 PDB 3mg9 chain A Region: 84 - 111 Aligned: 28 Modelled: 28 Confidence: 20.0% Identity: 14% PDB header:transferase/antibiotic Chain: A: PDB Molecule:teg12; PDBTitle: teg 12 binary structure complexed with the teicoplanin aglycone Phyre2 PDB 3mgb chain A Region: 86 - 111 Aligned: 26 Modelled: 26 Confidence: 16.2% Identity: 15% PDB header:transferase/antibiotic Chain: A: PDB Molecule:teg12; PDBTitle: teg 12 ternary structure complexed with pap and the teicoplanin2 aglycone Phyre2 PDB 3rnl chain A Region: 87 - 111 Aligned: 25 Modelled: 25 Confidence: 15.5% Identity: 16% PDB header:transferase Chain: A: PDB Molecule:sulfotransferase; PDBTitle: crystal structure of sulfotransferase from alicyclobacillus2 acidocaldarius Phyre2 PDB 1xv1 chain A Region: 87 - 111 Aligned: 25 Modelled: 25 Confidence: 12.4% Identity: 16% Fold: P-loop containing nucleoside triphosphate hydrolases Superfamily: P-loop containing nucleoside triphosphate hydrolases Family: PAPS sulfotransferase Phyre2 PDB 1aqu chain A Region: 87 - 111 Aligned: 25 Modelled: 25 Confidence: 12.0% Identity: 12% Fold: P-loop containing nucleoside triphosphate hydrolases Superfamily: P-loop containing nucleoside triphosphate hydrolases Family: PAPS sulfotransferase Phyre2 PDB 1nst chain A Region: 87 - 111 Aligned: 25 Modelled: 25 Confidence: 12.0% Identity: 12% Fold: P-loop containing nucleoside triphosphate hydrolases Superfamily: P-loop containing nucleoside triphosphate hydrolases Family: PAPS sulfotransferase Phyre2 PDB 1nst chain A Region: 87 - 111 Aligned: 25 Modelled: 25 Confidence: 12.0% Identity: 12% PDB header:sulfotransferase Chain: A: PDB Molecule:heparan sulfate n-deacetylase/n-sulfotransferase; PDBTitle: the sulfotransferase domain of human haparin sulfate n-2 deacetylase/n-sulfotransferase Phyre2 PDB 1zd1 chain B Region: 87 - 111 Aligned: 25 Modelled: 25 Confidence: 11.9% Identity: 20% PDB header:transferase Chain: B: PDB Molecule:sulfotransferase 4a1; PDBTitle: human sulfortransferase sult4a1 Phyre2 PDB 3bfx chain A domain 1 Region: 86 - 111 Aligned: 26 Modelled: 26 Confidence: 11.2% Identity: 12% Fold: P-loop containing nucleoside triphosphate hydrolases Superfamily: P-loop containing nucleoside triphosphate hydrolases Family: PAPS sulfotransferase Phyre2 PDB 1xe1 chain A Region: 33 - 63 Aligned: 31 Modelled: 31 Confidence: 11.2% Identity: 26% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical protein pf0907; PDBTitle: hypothetical protein from pyrococcus furiosus pfu-880080-001 Phyre2 PDB 1xe1 chain A Region: 33 - 63 Aligned: 31 Modelled: 31 Confidence: 11.2% Identity: 26% Fold: Reductase/isomerase/elongation factor common domain Superfamily: Translation proteins Family: Elongation factors Phyre2 PDB 2gwh chain A Region: 87 - 111 Aligned: 25 Modelled: 25 Confidence: 10.1% Identity: 8% PDB header:transferase Chain: A: PDB Molecule:sulfotransferase 1c2; PDBTitle: human sulfotranferase sult1c2 in complex with pap and2 pentachlorophenol Phyre2 1 c3hrlA_ 2 d1cw0a_ 3 d1vsra_ 4 d1m0da_ 5 c2fqzC_ 6 d1texa_ 7 c2ovfA_ 8 c2kyrA_ 9 c3mg9A_ 10 c3mgbA_ 11 c3rnlA_ 12 d1xv1a_ 13 d1aqua_ 14 d1nsta_ 15 c1nstA_ 16 c1zd1B_ 17 d3bfxa1 18 c1xe1A_ 19 d1xe1a_ 20 c2gwhA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c3hrlA_ 100.0 49 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:endonuclease-like protein; PDBTitle: crystal structure of a putative endonuclease-like protein (ngo0050)2 from neisseria gonorrhoeae 2 d1cw0a_ 99.9 25 Fold:Restriction endonuclease-like Superfamily:Restriction endonuclease-like Family:Very short patch repair (VSR) endonuclease 3 d1vsra_ 99.7 25 Fold:Restriction endonuclease-like Superfamily:Restriction endonuclease-like Family:Very short patch repair (VSR) endonuclease 4 d1m0da_ 87.7 22 Fold:Restriction endonuclease-like Superfamily:Restriction endonuclease-like Family:Endonuclease I (Holliday junction resolvase) 5 c2fqzC_ 26.9 11 PDB header:hydrolase/dna Chain: C: PDB Molecule:r.ecl18ki; PDBTitle: metal-depleted ecl18ki in complex with uncleaved dna 6 d1texa_ 25.3 14 Fold:P-loop containing nucleoside triphosphate hydrolases Superfamily:P-loop containing nucleoside triphosphate hydrolases Family:PAPS sulfotransferase 7 c2ovfA_ 24.7 19 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:stal; PDBTitle: crystal structure of stal-pap complex 8 c2kyrA_ 22.0 10 PDB header:transferase Chain: A: PDB Molecule:fructose-like phosphotransferase enzyme iib component 1; PDBTitle: solution structure of enzyme iib subunit of pts system from2 escherichia coli k12. northeast structural genomics consortium target3 er315/ontario center for structural proteomics target ec0544 9 c3mg9A_ 20.0 14 PDB header:transferase/antibiotic Chain: A: PDB Molecule:teg12; PDBTitle: teg 12 binary structure complexed with the teicoplanin aglycone 10 c3mgbA_ 16.2 15 PDB header:transferase/antibiotic Chain: A: PDB Molecule:teg12; PDBTitle: teg 12 ternary structure complexed with pap and the teicoplanin2 aglycone 11 c3rnlA_ 15.5 16 PDB header:transferase Chain: A: PDB Molecule:sulfotransferase; PDBTitle: crystal structure of sulfotransferase from alicyclobacillus2 acidocaldarius 12 d1xv1a_ 12.4 16 Fold:P-loop containing nucleoside triphosphate hydrolases Superfamily:P-loop containing nucleoside triphosphate hydrolases Family:PAPS sulfotransferase 13 d1aqua_ 12.0 12 Fold:P-loop containing nucleoside triphosphate hydrolases Superfamily:P-loop containing nucleoside triphosphate hydrolases Family:PAPS sulfotransferase 14 d1nsta_ 12.0 12 Fold:P-loop containing nucleoside triphosphate hydrolases Superfamily:P-loop containing nucleoside triphosphate hydrolases Family:PAPS sulfotransferase 15 c1nstA_ 12.0 12 PDB header:sulfotransferase Chain: A: PDB Molecule:heparan sulfate n-deacetylase/n-sulfotransferase; PDBTitle: the sulfotransferase domain of human haparin sulfate n-2 deacetylase/n-sulfotransferase 16 c1zd1B_ 11.9 20 PDB header:transferase Chain: B: PDB Molecule:sulfotransferase 4a1; PDBTitle: human sulfortransferase sult4a1 17 d3bfxa1 11.2 12 Fold:P-loop containing nucleoside triphosphate hydrolases Superfamily:P-loop containing nucleoside triphosphate hydrolases Family:PAPS sulfotransferase 18 c1xe1A_ 11.2 26 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical protein pf0907; PDBTitle: hypothetical protein from pyrococcus furiosus pfu-880080-001 19 d1xe1a_ 11.2 26 Fold:Reductase/isomerase/elongation factor common domain Superfamily:Translation proteins Family:Elongation factors 20 c2gwhA_ 10.1 8 PDB header:transferase Chain: A: PDB Molecule:sulfotransferase 1c2; PDBTitle: human sulfotranferase sult1c2 in complex with pap and2 pentachlorophenol 21 d1j99a_ not modelled 10.0 24 Fold:P-loop containing nucleoside triphosphate hydrolases Superfamily:P-loop containing nucleoside triphosphate hydrolases Family:PAPS sulfotransferase 22 d1vkja_ not modelled 9.7 4 Fold:P-loop containing nucleoside triphosphate hydrolases Superfamily:P-loop containing nucleoside triphosphate hydrolases Family:PAPS sulfotransferase 23 c1vkjA_ not modelled 9.7 4 PDB header:transferase Chain: A: PDB Molecule:heparan sulfate (glucosamine) 3-o- PDBTitle: crystal structure of heparan sulfate 3-o-sulfotransferase2 isoform 1 in the presence of pap 24 c2h8kA_ not modelled 9.6 24 PDB header:transferase Chain: A: PDB Molecule:sult1c3 splice variant d; PDBTitle: human sulfotranferase sult1c3 in complex with pap 25 c3fovA_ not modelled 9.6 15 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:upf0102 protein rpa0323; PDBTitle: crystal structure of protein rpa0323 of unknown function from2 rhodopseudomonas palustris 26 c3u3oA_ not modelled 9.6 20 PDB header:transferase Chain: A: PDB Molecule:sulfotransferase 1a1; PDBTitle: crystal structure of human sult1a1 bound to pap and two 3-cyano-7-2 hydroxycoumarin 27 d1ls6a_ not modelled 9.6 20 Fold:P-loop containing nucleoside triphosphate hydrolases Superfamily:P-loop containing nucleoside triphosphate hydrolases Family:PAPS sulfotransferase 28 c3ap3A_ not modelled 9.5 20 PDB header:transferase Chain: A: PDB Molecule:protein-tyrosine sulfotransferase 2; PDBTitle: crystal structure of human tyrosylprotein sulfotransferase-2 complexed2 with pap 29 d2a3ra1 not modelled 9.4 20 Fold:P-loop containing nucleoside triphosphate hydrolases Superfamily:P-loop containing nucleoside triphosphate hydrolases Family:PAPS sulfotransferase 30 d1g3ma_ not modelled 9.4 12 Fold:P-loop containing nucleoside triphosphate hydrolases Superfamily:P-loop containing nucleoside triphosphate hydrolases Family:PAPS sulfotransferase 31 d1fmja_ not modelled 9.3 12 Fold:P-loop containing nucleoside triphosphate hydrolases Superfamily:P-loop containing nucleoside triphosphate hydrolases Family:PAPS sulfotransferase 32 c2zvpX_ not modelled 9.0 20 PDB header:transferase Chain: X: PDB Molecule:tyrosine-ester sulfotransferase; PDBTitle: crystal structure of mouse cytosolic sulfotransferase msult1d1 complex2 with pap and p-nitrophenol 33 d1jg5a_ not modelled 8.7 36 Fold:GTP cyclohydrolase I feedback regulatory protein, GFRP Superfamily:GTP cyclohydrolase I feedback regulatory protein, GFRP Family:GTP cyclohydrolase I feedback regulatory protein, GFRP 34 c2zq5A_ not modelled 7.9 4 PDB header:transferase Chain: A: PDB Molecule:putative uncharacterized protein; PDBTitle: crystal structure of sulfotransferase stf1 from2 mycobacterium tuberculosis h37rv (type1 form) 35 d1x9ga_ not modelled 7.9 18 Fold:Isochorismatase-like hydrolases Superfamily:Isochorismatase-like hydrolases Family:Isochorismatase-like hydrolases 36 c2z6vA_ not modelled 7.8 12 PDB header:unknown function Chain: A: PDB Molecule:putative uncharacterized protein; PDBTitle: crystal structure of sulfotransferase stf9 from2 mycobacterium avium 37 c2vldA_ not modelled 7.2 19 PDB header:hydrolase Chain: A: PDB Molecule:upf0286 protein pyrab01260; PDBTitle: crystal structure of a repair endonuclease from pyrococcus2 abyssi 38 c3bm3A_ not modelled 7.2 13 PDB header:hydrolase/dna Chain: A: PDB Molecule:pspgi restriction endonuclease; PDBTitle: restriction endonuclease pspgi-substrate dna complex 39 d1q44a_ not modelled 6.9 24 Fold:P-loop containing nucleoside triphosphate hydrolases Superfamily:P-loop containing nucleoside triphosphate hydrolases Family:PAPS sulfotransferase 40 c2qjwA_ not modelled 6.5 16 PDB header:hydrolase Chain: A: PDB Molecule:uncharacterized protein xcc1541; PDBTitle: crystal structure of a putative hydrolase of the alpha/beta2 superfamily (xcc1541) from xanthomonas campestris pv. campestris at3 1.35 a resolution 41 c1q1qA_ not modelled 6.5 20 PDB header:transferase Chain: A: PDB Molecule:sulfotransferase family, cytosolic, 2b, member 1 PDBTitle: crystal structure of human pregnenolone sulfotransferase2 (sult2b1a) in the presence of pap 42 c2i9iA_ not modelled 6.2 40 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical protein; PDBTitle: crystal structure of helicobacter pylori protein hp0492 43 d2i9ia1 not modelled 6.2 40 Fold:Anticodon-binding domain-like Superfamily:XCC0632-like Family:NLBH-like 44 d1t8ta_ not modelled 6.1 12 Fold:P-loop containing nucleoside triphosphate hydrolases Superfamily:P-loop containing nucleoside triphosphate hydrolases Family:PAPS sulfotransferase 45 d1q20a_ not modelled 5.5 20 Fold:P-loop containing nucleoside triphosphate hydrolases Superfamily:P-loop containing nucleoside triphosphate hydrolases Family:PAPS sulfotransferase 46 c3fcgB_ not modelled 5.3 24 PDB header:membrane protein, protein transport Chain: B: PDB Molecule:f1 capsule-anchoring protein; PDBTitle: crystal structure analysis of the middle domain of the2 caf1a usher 47 c3bd9A_ not modelled 5.3 12 PDB header:transferase Chain: A: PDB Molecule:heparan sulfate glucosamine 3-o-sulfotransferase PDBTitle: human 3-o-sulfotransferase isoform 5 with bound pap 48 c3gzbC_ not modelled 5.1 32 PDB header:lyase Chain: C: PDB Molecule:putative snoal-like polyketide cyclase; PDBTitle: crystal structure of putative snoal-like polyketide cyclase2 (yp_001182657.1) from shewanella putrefaciens cn-32 at 1.44 a3 resolution 49 c1f3mB_ not modelled 5.1 22 PDB header:transferase Chain: B: PDB Molecule:serine/threonine-protein kinase pak-alpha; PDBTitle: crystal structure of human serine/threonine kinase pak1 50 d1whza_ not modelled 5.1 13 Fold:dsRBD-like Superfamily:YcfA/nrd intein domain Family:YcfA-like

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0