Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	K	S	S	T	T	I	I	T	A	Y	F	D	I	G	R	G	D	W	T	A	N	K	G	F	R	E	K	L	A	R	S	V	D	V	Y	F	S	Y	F	E	R	L	A	A	L	E	N	E	M	I	I	F	T	S	P	D	L	K	P
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?															?		?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		R	V	E	A	I	R	N	G	K	P	T	T	V	I	V	I	D	I	K	K	K	F	R	Y	I	R	S	R	I	E	K	I	Q	K	D	E	S	F	T	N	R	L	E	P	R	Q	L	K	N	P	E	Y	W	S	P	E	Y	V	L	V
Secondary structure
SS confidence
Disorder																					?		?	?	?																				?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		C	N	L	K	A	Y	F	V	N	K	A	I	N	M	G	L	V	K	T	P	L	V	A	W	I	D	F	G	Y	C	H	K	P	N	V	T	R	G	L	K	I	W	D	F	P	F	D	E	S	K	M	H	L	F	T	I	K	K	G	L
Secondary structure
SS confidence
Disorder																																				?			?																				?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		T	V	T	S	Q	Q	Q	V	F	D	F	M	I	G	N	H	V	Y	I	I	G	G	A	I	V	G	S	Q	H	K	W	K	E	F	Y	K	L	V	L	E	S	Q	K	I	T	L	N	N	N	I	V	D	D	D	Q	G	I	F	V	M
Secondary structure
SS confidence
Disorder																?										?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.
Sequence		C	Y	Y	K	R	P	D	L	F	N	L	N	Y	L	G	R	G	K	W	F	D	L	F	R	C	F	R	S	N	T	L	G	A	K	M	Q	A	L	R	I	F	L	S	R	K
Secondary structure
SS confidence
Disorder																													?	?	?	?								?	?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2xsb chain A Region: 7 - 57 Aligned: 36 Modelled: 51 Confidence: 65.2% Identity: 28% PDB header:hydrolase Chain: A: PDB Molecule:hyaluronoglucosaminidase; PDBTitle: ogoga pugnac complex Phyre2 PDB 2i4r chain A domain 1 Region: 42 - 95 Aligned: 54 Modelled: 53 Confidence: 44.1% Identity: 11% Fold: AtpF-like Superfamily: AtpF-like Family: AtpF-like Phyre2 PDB 2cbi chain A domain 2 Region: 15 - 57 Aligned: 30 Modelled: 30 Confidence: 35.8% Identity: 13% Fold: TIM beta/alpha-barrel Superfamily: (Trans)glycosidases Family: alpha-D-glucuronidase/Hyaluronidase catalytic domain Phyre2 PDB 2cbj chain A Region: 7 - 80 Aligned: 57 Modelled: 74 Confidence: 20.9% Identity: 18% PDB header:hydrolase Chain: A: PDB Molecule:hyaluronidase; PDBTitle: structure of the clostridium perfringens nagj family 842 glycoside hydrolase, a homologue of human o-glcnacase in3 complex with pugnac Phyre2 PDB 2k0m chain A Region: 194 - 247 Aligned: 52 Modelled: 54 Confidence: 19.8% Identity: 17% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: solution nmr structure of the uncharacterized protein from2 rhodospirillum rubrum gene locus rru_a0810. northeast3 structural genomics target rrr43 Phyre2 PDB 3tp9 chain B Region: 13 - 53 Aligned: 41 Modelled: 41 Confidence: 19.5% Identity: 20% PDB header:hydrolase Chain: B: PDB Molecule:beta-lactamase and rhodanese domain protein; PDBTitle: crystal structure of alicyclobacillus acidocaldarius protein with2 beta-lactamase and rhodanese domains Phyre2 PDB 1lzi chain A Region: 196 - 231 Aligned: 36 Modelled: 36 Confidence: 19.2% Identity: 19% Fold: Nucleotide-diphospho-sugar transferases Superfamily: Nucleotide-diphospho-sugar transferases Family: alpha-1,3-galactosyltransferase-like Phyre2 PDB 1wv9 chain B Region: 166 - 205 Aligned: 39 Modelled: 40 Confidence: 18.9% Identity: 13% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:rhodanese homolog tt1651; PDBTitle: crystal structure of rhodanese homolog tt1651 from an2 extremely thermophilic bacterium thermus thermophilus hb8 Phyre2 PDB 3fq6 chain A Region: 29 - 77 Aligned: 48 Modelled: 49 Confidence: 16.3% Identity: 13% PDB header:transferase Chain: A: PDB Molecule:methyltransferase; PDBTitle: the crystal structure of a methyltransferase domain from bacteroides2 thetaiotaomicron vpi Phyre2 PDB 2cho chain A Region: 15 - 57 Aligned: 30 Modelled: 29 Confidence: 13.6% Identity: 20% PDB header:hydrolase Chain: A: PDB Molecule:glucosaminidase; PDBTitle: bacteroides thetaiotaomicron hexosaminidase with o-2 glcnacase activity Phyre2 PDB 2xe4 chain A Region: 218 - 257 Aligned: 40 Modelled: 40 Confidence: 12.4% Identity: 28% PDB header:hydrolase/inhibitor Chain: A: PDB Molecule:oligopeptidase b; PDBTitle: structure of oligopeptidase b from leishmania major Phyre2 PDB 1jak chain A domain 1 Region: 11 - 78 Aligned: 56 Modelled: 56 Confidence: 10.6% Identity: 29% Fold: TIM beta/alpha-barrel Superfamily: (Trans)glycosidases Family: beta-N-acetylhexosaminidase catalytic domain Phyre2 PDB 1i0e chain A domain 1 Region: 187 - 218 Aligned: 32 Modelled: 32 Confidence: 10.5% Identity: 22% Fold: Guanido kinase N-terminal domain Superfamily: Guanido kinase N-terminal domain Family: Guanido kinase N-terminal domain Phyre2 PDB 1ph4 chain A Region: 11 - 56 Aligned: 35 Modelled: 46 Confidence: 10.4% Identity: 14% PDB header:dna binding protein/dna Chain: A: PDB Molecule:telomere-binding protein alpha subunit; PDBTitle: crystal structure of the oxytricha nova telomere end-binding protein2 complexed with noncognate ssdna ggggttttggcg Phyre2 PDB 1jb7 chain A Region: 11 - 56 Aligned: 35 Modelled: 46 Confidence: 10.4% Identity: 14% PDB header:dna-binding protein/dna Chain: A: PDB Molecule:telomere-binding protein alpha subunit; PDBTitle: dna g-quartets in a 1.86 a resolution structure of an oxytricha nova2 telomeric protein-dna complex Phyre2 PDB 1qfm chain A Region: 218 - 257 Aligned: 40 Modelled: 40 Confidence: 9.3% Identity: 20% PDB header:hydrolase Chain: A: PDB Molecule:protein (prolyl oligopeptidase); PDBTitle: prolyl oligopeptidase from porcine muscle Phyre2 PDB 1r8s chain E Region: 209 - 284 Aligned: 73 Modelled: 76 Confidence: 8.5% Identity: 21% Fold: alpha-alpha superhelix Superfamily: Sec7 domain Family: Sec7 domain Phyre2 PDB 1bc9 chain A Region: 209 - 284 Aligned: 73 Modelled: 76 Confidence: 8.1% Identity: 22% Fold: alpha-alpha superhelix Superfamily: Sec7 domain Family: Sec7 domain Phyre2 PDB 1yr2 chain A Region: 218 - 257 Aligned: 40 Modelled: 40 Confidence: 7.1% Identity: 18% PDB header:hydrolase Chain: A: PDB Molecule:prolyl oligopeptidase; PDBTitle: structural and mechanistic analysis of two prolyl endopeptidases: role2 of inter-domain dynamics in catalysis and specificity Phyre2 PDB 1g0w chain A domain 1 Region: 187 - 225 Aligned: 39 Modelled: 39 Confidence: 6.9% Identity: 15% Fold: Guanido kinase N-terminal domain Superfamily: Guanido kinase N-terminal domain Family: Guanido kinase N-terminal domain Phyre2 1 c2xsbA_ 2 d2i4ra1 3 d2cbia2 4 c2cbjA_ 5 c2k0mA_ 6 c3tp9B_ 7 d1lzia_ 8 c1wv9B_ 9 c3fq6A_ 10 c2choA_ 11 c2xe4A_ 12 d1jaka1 13 d1i0ea1 14 c1ph4A_ 15 c1jb7A_ 16 c1qfmA_ 17 d1r8se_ 18 d1bc9a_ 19 c1yr2A_ 20 d1g0wa1 21 22 23 24 25 26 27 28 29 30 31 32 33

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c2xsbA_ 65.2 28 PDB header:hydrolase Chain: A: PDB Molecule:hyaluronoglucosaminidase; PDBTitle: ogoga pugnac complex 2 d2i4ra1 44.1 11 Fold:AtpF-like Superfamily:AtpF-like Family:AtpF-like 3 d2cbia2 35.8 13 Fold:TIM beta/alpha-barrel Superfamily:(Trans)glycosidases Family:alpha-D-glucuronidase/Hyaluronidase catalytic domain 4 c2cbjA_ 20.9 18 PDB header:hydrolase Chain: A: PDB Molecule:hyaluronidase; PDBTitle: structure of the clostridium perfringens nagj family 842 glycoside hydrolase, a homologue of human o-glcnacase in3 complex with pugnac 5 c2k0mA_ 19.8 17 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: solution nmr structure of the uncharacterized protein from2 rhodospirillum rubrum gene locus rru_a0810. northeast3 structural genomics target rrr43 6 c3tp9B_ 19.5 20 PDB header:hydrolase Chain: B: PDB Molecule:beta-lactamase and rhodanese domain protein; PDBTitle: crystal structure of alicyclobacillus acidocaldarius protein with2 beta-lactamase and rhodanese domains 7 d1lzia_ 19.2 19 Fold:Nucleotide-diphospho-sugar transferases Superfamily:Nucleotide-diphospho-sugar transferases Family:alpha-1,3-galactosyltransferase-like 8 c1wv9B_ 18.9 13 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:rhodanese homolog tt1651; PDBTitle: crystal structure of rhodanese homolog tt1651 from an2 extremely thermophilic bacterium thermus thermophilus hb8 9 c3fq6A_ 16.3 13 PDB header:transferase Chain: A: PDB Molecule:methyltransferase; PDBTitle: the crystal structure of a methyltransferase domain from bacteroides2 thetaiotaomicron vpi 10 c2choA_ 13.6 20 PDB header:hydrolase Chain: A: PDB Molecule:glucosaminidase; PDBTitle: bacteroides thetaiotaomicron hexosaminidase with o-2 glcnacase activity 11 c2xe4A_ 12.4 28 PDB header:hydrolase/inhibitor Chain: A: PDB Molecule:oligopeptidase b; PDBTitle: structure of oligopeptidase b from leishmania major 12 d1jaka1 10.6 29 Fold:TIM beta/alpha-barrel Superfamily:(Trans)glycosidases Family:beta-N-acetylhexosaminidase catalytic domain 13 d1i0ea1 10.5 22 Fold:Guanido kinase N-terminal domain Superfamily:Guanido kinase N-terminal domain Family:Guanido kinase N-terminal domain 14 c1ph4A_ 10.4 14 PDB header:dna binding protein/dna Chain: A: PDB Molecule:telomere-binding protein alpha subunit; PDBTitle: crystal structure of the oxytricha nova telomere end-binding protein2 complexed with noncognate ssdna ggggttttggcg 15 c1jb7A_ 10.4 14 PDB header:dna-binding protein/dna Chain: A: PDB Molecule:telomere-binding protein alpha subunit; PDBTitle: dna g-quartets in a 1.86 a resolution structure of an oxytricha nova2 telomeric protein-dna complex 16 c1qfmA_ 9.3 20 PDB header:hydrolase Chain: A: PDB Molecule:protein (prolyl oligopeptidase); PDBTitle: prolyl oligopeptidase from porcine muscle 17 d1r8se_ 8.5 21 Fold:alpha-alpha superhelix Superfamily:Sec7 domain Family:Sec7 domain 18 d1bc9a_ 8.1 22 Fold:alpha-alpha superhelix Superfamily:Sec7 domain Family:Sec7 domain 19 c1yr2A_ 7.1 18 PDB header:hydrolase Chain: A: PDB Molecule:prolyl oligopeptidase; PDBTitle: structural and mechanistic analysis of two prolyl endopeptidases: role2 of inter-domain dynamics in catalysis and specificity 20 d1g0wa1 6.9 15 Fold:Guanido kinase N-terminal domain Superfamily:Guanido kinase N-terminal domain Family:Guanido kinase N-terminal domain 21 c2dcqA_ not modelled 6.8 14 PDB header:unknown function Chain: A: PDB Molecule:putative protein at4g01050; PDBTitle: fully automated nmr structure determination of the2 rhodanese homology domain at4g01050(175-295) from3 arabidopsis thaliana 22 d1u6ra1 not modelled 6.7 13 Fold:Guanido kinase N-terminal domain Superfamily:Guanido kinase N-terminal domain Family:Guanido kinase N-terminal domain 23 d1okta2 not modelled 6.6 33 Fold:Thioredoxin fold Superfamily:Thioredoxin-like Family:Glutathione S-transferase (GST), N-terminal domain 24 d2choa2 not modelled 6.4 19 Fold:TIM beta/alpha-barrel Superfamily:(Trans)glycosidases Family:alpha-D-glucuronidase/Hyaluronidase catalytic domain 25 d1qh4a1 not modelled 6.2 13 Fold:Guanido kinase N-terminal domain Superfamily:Guanido kinase N-terminal domain Family:Guanido kinase N-terminal domain 26 d1syxb1 not modelled 6.2 21 Fold:GYF/BRK domain-like Superfamily:GYF domain Family:GYF domain 27 c1syxF_ not modelled 6.2 21 PDB header:translation/immune system Chain: F: PDB Molecule:cd2 antigen cytoplasmic tail-binding protein 2; PDBTitle: the crystal structure of a binary u5 snrnp complex 28 d2r09a1 not modelled 6.2 22 Fold:alpha-alpha superhelix Superfamily:Sec7 domain Family:Sec7 domain 29 d2i09a2 not modelled 5.9 50 Fold:DeoB insert domain-like Superfamily:DeoB insert domain-like Family:DeoB insert domain-like 30 d1e7ua4 not modelled 5.5 25 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Phoshoinositide 3-kinase (PI3K), catalytic domain 31 c3ktsA_ not modelled 5.4 14 PDB header:transcriptional regulator Chain: A: PDB Molecule:glycerol uptake operon antiterminator regulatory protein; PDBTitle: crystal structure of glycerol uptake operon antiterminator regulatory2 protein from listeria monocytogenes str. 4b f2365 32 d1or7a2 not modelled 5.3 14 Fold:Sigma2 domain of RNA polymerase sigma factors Superfamily:Sigma2 domain of RNA polymerase sigma factors Family:Sigma2 domain of RNA polymerase sigma factors 33 d2gjxa1 not modelled 5.2 20 Fold:TIM beta/alpha-barrel Superfamily:(Trans)glycosidases Family:beta-N-acetylhexosaminidase catalytic domain

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0