Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	K	T	R	I	H	V	V	Q	G	D	I	T	K	L	A	V	D	V	I	V	N	A	A	N	P	S	L	M	G	G	G	G	V	D	G	A	I	H	R	A	A	G	P	A	L	L	D	A	C	L	K	V	R	Q	Q	Q	G	D	C
Secondary structure
SS confidence
Disorder		?	?	?																							?				?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		P	T	G	H	A	V	I	T	L	A	G	D	L	P	A	K	A	V	V	H	T	V	G	P	V	W	R	G	G	E	Q	N	E	D	Q	L	L	Q	D	A	Y	L	N	S	L	R	L	V	A	A	N	S	Y	T	S	V	A	F	P	A
Secondary structure
SS confidence
Disorder																													?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.
Sequence		I	S	T	G	V	Y	G	Y	P	R	A	A	A	A	E	I	A	V	K	T	V	S	E	F	I	T	R	H	A	L	P	E	Q	V	Y	F	V	C	Y	D	E	E	N	A	H	L	Y	E	R	L	L	T	Q	Q	G	D	E
Secondary structure
SS confidence
Disorder				?																																																				?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1spv chain A Region: 3 - 174 Aligned: 172 Modelled: 172 Confidence: 100.0% Identity: 99% Fold: Macro domain-like Superfamily: Macro domain-like Family: Macro domain Phyre2 PDB 2x47 chain A Region: 1 - 176 Aligned: 172 Modelled: 176 Confidence: 100.0% Identity: 47% PDB header:signaling protein Chain: A: PDB Molecule:macro domain-containing protein 1; PDBTitle: crystal structure of human macrod1 Phyre2 PDB 1zr5 chain B Region: 1 - 174 Aligned: 172 Modelled: 172 Confidence: 100.0% Identity: 27% PDB header:gene regulation Chain: B: PDB Molecule:h2afy protein; PDBTitle: crystal structure of the macro-domain of human core histone variant2 macroh2a1.2 Phyre2 PDB 1zr5 chain A domain 1 Region: 1 - 174 Aligned: 172 Modelled: 172 Confidence: 100.0% Identity: 27% Fold: Macro domain-like Superfamily: Macro domain-like Family: Macro domain Phyre2 PDB 2xd7 chain B Region: 1 - 174 Aligned: 172 Modelled: 174 Confidence: 100.0% Identity: 24% PDB header:dna-binding protein Chain: B: PDB Molecule:core histone macro-h2a.2; PDBTitle: crystal structure of the macro domain of human core histone2 h2a Phyre2 PDB 1yd9 chain A domain 1 Region: 1 - 176 Aligned: 174 Modelled: 176 Confidence: 100.0% Identity: 29% Fold: Macro domain-like Superfamily: Macro domain-like Family: Macro domain Phyre2 PDB 3q6z chain A Region: 2 - 175 Aligned: 174 Modelled: 174 Confidence: 100.0% Identity: 35% PDB header:transferase Chain: A: PDB Molecule:poly [adp-ribose] polymerase 14; PDBTitle: human parp14 (artd8)-macro domain 1 in complex with adenosine-5-2 diphosphoribose Phyre2 PDB 3q71 chain A Region: 2 - 176 Aligned: 174 Modelled: 175 Confidence: 100.0% Identity: 26% PDB header:transferase Chain: A: PDB Molecule:poly [adp-ribose] polymerase 14; PDBTitle: human parp14 (artd8) - macro domain 2 in complex with adenosine-5-2 diphosphoribose Phyre2 PDB 1vhu chain A Region: 2 - 175 Aligned: 172 Modelled: 174 Confidence: 100.0% Identity: 32% Fold: Macro domain-like Superfamily: Macro domain-like Family: Macro domain Phyre2 PDB 3kh6 chain A Region: 2 - 174 Aligned: 159 Modelled: 173 Confidence: 100.0% Identity: 28% PDB header:transferase Chain: A: PDB Molecule:poly [adp-ribose] polymerase 15; PDBTitle: human poly(adp-ribose) polymerase 15, macro domain 2 in2 complex with adenosine-5-diphosphoribose Phyre2 PDB 2acf chain A domain 1 Region: 1 - 166 Aligned: 148 Modelled: 166 Confidence: 100.0% Identity: 34% Fold: Macro domain-like Superfamily: Macro domain-like Family: Macro domain Phyre2 PDB 2dx6 chain B Region: 3 - 171 Aligned: 158 Modelled: 169 Confidence: 100.0% Identity: 37% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:hypothetical protein ttha0132; PDBTitle: crystal structure of conserved hypothetical protein, ttha0132 from2 thermus thermophilus hb8 Phyre2 PDB 2vri chain A Region: 2 - 171 Aligned: 154 Modelled: 170 Confidence: 100.0% Identity: 26% PDB header:viral protein Chain: A: PDB Molecule:non-structural protein 3; PDBTitle: structure of the nsp3 x-domain of human coronavirus nl63 Phyre2 PDB 3ew5 chain B Region: 2 - 167 Aligned: 153 Modelled: 166 Confidence: 100.0% Identity: 27% PDB header:rna binding protein Chain: B: PDB Molecule:macro domain of non-structural protein 3; PDBTitle: structure of the tetragonal crystal form of x (adrp) domain2 from fcov Phyre2 PDB 3ejf chain A Region: 4 - 169 Aligned: 151 Modelled: 166 Confidence: 100.0% Identity: 21% PDB header:hydrolase Chain: A: PDB Molecule:non-structural protein 3; PDBTitle: crystal structure of ibv x-domain at ph 8.5 Phyre2 PDB 3ejg chain A Region: 2 - 172 Aligned: 152 Modelled: 171 Confidence: 100.0% Identity: 23% PDB header:hydrolase Chain: A: PDB Molecule:non-structural protein 3; PDBTitle: crystal structure of hcov-229e x-domain Phyre2 PDB 3gqe chain A Region: 3 - 174 Aligned: 157 Modelled: 172 Confidence: 100.0% Identity: 28% PDB header:viral protein Chain: A: PDB Molecule:non-structural protein 3; PDBTitle: crystal structure of macro domain of venezuelan equine encephalitis2 virus Phyre2 PDB 3ewq chain A Region: 2 - 172 Aligned: 152 Modelled: 171 Confidence: 100.0% Identity: 24% PDB header:hydrolase Chain: A: PDB Molecule:non-structural protein 3; PDBTitle: hcov-229e nsp3 adrp domain Phyre2 PDB 3gpq chain A Region: 5 - 175 Aligned: 156 Modelled: 171 Confidence: 100.0% Identity: 27% PDB header:viral protein/rna Chain: A: PDB Molecule:non-structural protein 3; PDBTitle: crystal structure of macro domain of chikungunya virus in complex with2 rna Phyre2 PDB 2eee chain A Region: 2 - 141 Aligned: 129 Modelled: 140 Confidence: 100.0% Identity: 14% PDB header:gene regulation Chain: A: PDB Molecule:uncharacterized protein c6orf130; PDBTitle: solution structure of the a1pp domain from human protein2 c6orf130 Phyre2 1 d1spva_ 2 c2x47A_ 3 c1zr5B_ 4 d1zr5a1 5 c2xd7B_ 6 d1yd9a1 7 c3q6zA_ 8 c3q71A_ 9 d1vhua_ 10 c3kh6A_ 11 d2acfa1 12 c2dx6B_ 13 c2vriA_ 14 c3ew5B_ 15 c3ejfA_ 16 c3ejgA_ 17 c3gqeA_ 18 c3ewqA_ 19 c3gpqA_ 20 c2eeeA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d1spva_ 100.0 99 Fold:Macro domain-like Superfamily:Macro domain-like Family:Macro domain 2 c2x47A_ 100.0 47 PDB header:signaling protein Chain: A: PDB Molecule:macro domain-containing protein 1; PDBTitle: crystal structure of human macrod1 3 c1zr5B_ 100.0 27 PDB header:gene regulation Chain: B: PDB Molecule:h2afy protein; PDBTitle: crystal structure of the macro-domain of human core histone variant2 macroh2a1.2 4 d1zr5a1 100.0 27 Fold:Macro domain-like Superfamily:Macro domain-like Family:Macro domain 5 c2xd7B_ 100.0 24 PDB header:dna-binding protein Chain: B: PDB Molecule:core histone macro-h2a.2; PDBTitle: crystal structure of the macro domain of human core histone2 h2a 6 d1yd9a1 100.0 29 Fold:Macro domain-like Superfamily:Macro domain-like Family:Macro domain 7 c3q6zA_ 100.0 35 PDB header:transferase Chain: A: PDB Molecule:poly [adp-ribose] polymerase 14; PDBTitle: human parp14 (artd8)-macro domain 1 in complex with adenosine-5-2 diphosphoribose 8 c3q71A_ 100.0 26 PDB header:transferase Chain: A: PDB Molecule:poly [adp-ribose] polymerase 14; PDBTitle: human parp14 (artd8) - macro domain 2 in complex with adenosine-5-2 diphosphoribose 9 d1vhua_ 100.0 32 Fold:Macro domain-like Superfamily:Macro domain-like Family:Macro domain 10 c3kh6A_ 100.0 28 PDB header:transferase Chain: A: PDB Molecule:poly [adp-ribose] polymerase 15; PDBTitle: human poly(adp-ribose) polymerase 15, macro domain 2 in2 complex with adenosine-5-diphosphoribose 11 d2acfa1 100.0 34 Fold:Macro domain-like Superfamily:Macro domain-like Family:Macro domain 12 c2dx6B_ 100.0 37 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:hypothetical protein ttha0132; PDBTitle: crystal structure of conserved hypothetical protein, ttha0132 from2 thermus thermophilus hb8 13 c2vriA_ 100.0 26 PDB header:viral protein Chain: A: PDB Molecule:non-structural protein 3; PDBTitle: structure of the nsp3 x-domain of human coronavirus nl63 14 c3ew5B_ 100.0 27 PDB header:rna binding protein Chain: B: PDB Molecule:macro domain of non-structural protein 3; PDBTitle: structure of the tetragonal crystal form of x (adrp) domain2 from fcov 15 c3ejfA_ 100.0 21 PDB header:hydrolase Chain: A: PDB Molecule:non-structural protein 3; PDBTitle: crystal structure of ibv x-domain at ph 8.5 16 c3ejgA_ 100.0 23 PDB header:hydrolase Chain: A: PDB Molecule:non-structural protein 3; PDBTitle: crystal structure of hcov-229e x-domain 17 c3gqeA_ 100.0 28 PDB header:viral protein Chain: A: PDB Molecule:non-structural protein 3; PDBTitle: crystal structure of macro domain of venezuelan equine encephalitis2 virus 18 c3ewqA_ 100.0 24 PDB header:hydrolase Chain: A: PDB Molecule:non-structural protein 3; PDBTitle: hcov-229e nsp3 adrp domain 19 c3gpqA_ 100.0 27 PDB header:viral protein/rna Chain: A: PDB Molecule:non-structural protein 3; PDBTitle: crystal structure of macro domain of chikungunya virus in complex with2 rna 20 c2eeeA_ 100.0 14 PDB header:gene regulation Chain: A: PDB Molecule:uncharacterized protein c6orf130; PDBTitle: solution structure of the a1pp domain from human protein2 c6orf130 21 d1njra_ not modelled 99.9 17 Fold:Macro domain-like Superfamily:Macro domain-like Family:Macro domain 22 d2fg1a1 not modelled 99.9 18 Fold:Macro domain-like Superfamily:Macro domain-like Family:Macro domain 23 c3siiA_ not modelled 98.5 17 PDB header:hydrolase/hydrolase inhibitor Chain: A: PDB Molecule:poly(adp-ribose) glycohydrolase; PDBTitle: the x-ray crystal structure of poly(adp-ribose) glycohydrolase bound2 to the inhibitor adp-hpd from thermomonospora curvata 24 d1gyta1 not modelled 97.3 10 Fold:Macro domain-like Superfamily:Macro domain-like Family:Leucine aminopeptidase (Aminopeptidase A), N-terminal domain 25 c1gytG_ not modelled 76.4 10 PDB header:hydrolase Chain: G: PDB Molecule:cytosol aminopeptidase; PDBTitle: e. coli aminopeptidase a (pepa) 26 c3jruB_ not modelled 35.4 16 PDB header:hydrolase Chain: B: PDB Molecule:probable cytosol aminopeptidase; PDBTitle: crystal structure of leucyl aminopeptidase (pepa) from xoo0834,2 xanthomonas oryzae pv. oryzae kacc10331 27 c3h8gC_ not modelled 30.5 12 PDB header:hydrolase Chain: C: PDB Molecule:cytosol aminopeptidase; PDBTitle: bestatin complex structure of leucine aminopeptidase from pseudomonas2 putida 28 d2amxa1 not modelled 29.4 12 Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:Adenosine/AMP deaminase 29 c2vg2C_ not modelled 29.0 8 PDB header:transferase Chain: C: PDB Molecule:undecaprenyl pyrophosphate synthetase; PDBTitle: rv2361 with ipp 30 c2zf8A_ not modelled 18.5 15 PDB header:structural protein Chain: A: PDB Molecule:component of sodium-driven polar flagellar motor; PDBTitle: crystal structure of moty 31 c3g5rA_ not modelled 14.2 20 PDB header:transferase Chain: A: PDB Molecule:methylenetetrahydrofolate--trna-(uracil-5-)- PDBTitle: crystal structure of thermus thermophilus trmfo in complex with2 tetrahydrofolate 32 c2yztA_ not modelled 13.5 5 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:putative uncharacterized protein ttha1756; PDBTitle: crystal structure of uncharacterized conserved protein from thermus2 thermophilus hb8 33 d1mlda1 not modelled 12.0 13 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:LDH N-terminal domain-like 34 c2vfwB_ not modelled 9.5 10 PDB header:transferase Chain: B: PDB Molecule:short-chain z-isoprenyl diphosphate synthetase; PDBTitle: rv1086 native 35 c3ugsB_ not modelled 9.4 10 PDB header:transferase Chain: B: PDB Molecule:undecaprenyl pyrophosphate synthase; PDBTitle: crystal structure of a probable undecaprenyl diphosphate synthase2 (upps) from campylobacter jejuni 36 d2o5aa1 not modelled 8.3 16 Fold:Nucleotidyltransferase Superfamily:Nucleotidyltransferase Family:Iojap/YbeB-like 37 c3krbB_ not modelled 5.9 15 PDB header:oxidoreductase Chain: B: PDB Molecule:aldose reductase; PDBTitle: structure of aldose reductase from giardia lamblia at 1.75a resolution 38 c3k6qB_ not modelled 5.7 8 PDB header:ligand binding protein Chain: B: PDB Molecule:putative ligand binding protein; PDBTitle: crystal structure of an antitoxin part of a putative toxin/antitoxin2 system (swol_0700) from syntrophomonas wolfei subsp. wolfei at 1.80 a3 resolution 39 d1ueha_ not modelled 5.6 10 Fold:Undecaprenyl diphosphate synthase Superfamily:Undecaprenyl diphosphate synthase Family:Undecaprenyl diphosphate synthase

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0