Phyre Home Retrieve Phyre Job Id
Emaill.a.kelley@imperial.ac.uk
DescriptionP59048
DateWed Jul 10 14:04:54 BST 2013
Unique Job IDeba552cc3c21b6c7
SequenceMLSPEAERVL ... Download FASTA

Summary 

Top model
Image coloured by rainbow N → C terminus
Model dimensions (Å):X:24.026 Y:28.647 Z:84.229
Model (left) based on template c2zdiC_
Top template information
PDB header:chaperone
Chain: C: PDB Molecule:prefoldin subunit alpha;
PDBTitle: crystal structure of prefoldin from pyrococcus horikoshii2 ot3
Confidence and coverage
Confidence: 96.6% Coverage: 79%
105 residues ( 79% of your sequence) have been modelled with 96.6% confidence by the single highest scoring template.
3D viewing
Interactive 3D view in Jmol

Sequence analysis 

Secondary structure and disorder prediction 

   1........10.........20.........30.........40.........50.........60
Sequence  MLSPEAERVLRYLVEVEELAEAVLSDKRQIVDLDTKRNQNREGLRALQKDLSVSEDVMVC
Secondary structure 
SS confidence 
Disorder  ?????
???
?
?
Disorder confidence 
 
   .........70.........80.........90.........100.........110.........120
Sequence  FGNMFIKMPHPKTKEMIQKDQEHLDKEIERLRSQLKVKVNRLFEAQGKPELKGFNLNPLS
Secondary structure 
SS confidence 
Disorder 
??
?
??
???
Disorder confidence 
 
   .........130...
Sequence  PDEVKALKVILKG
Secondary structure 
SS confidence 
Disorder 
???
Disorder confidence 
 

Confidence Key
High(9)                    Low (0)
?Disordered ( 16%)
Alpha helix ( 79%)
Beta strand ( 0%)

Domain analysis 

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

RankAligned region

PDB 2zdi chain C

3D model

Region: 2 - 106
Aligned: 105
Modelled: 105
Confidence: 96.6%
Identity: 15%
PDB header:chaperone
Chain: C: PDB Molecule:prefoldin subunit alpha;
PDBTitle: crystal structure of prefoldin from pyrococcus horikoshii2 ot3

Phyre2

PDB 1fxk chain C

3D model

Region: 4 - 106
Aligned: 103
Modelled: 103
Confidence: 96.3%
Identity: 15%
Fold: Long alpha-hairpin
Superfamily: Prefoldin
Family: Prefoldin

Phyre2

PDB 2zdi chain A

3D model

Region: 13 - 106
Aligned: 93
Modelled: 94
Confidence: 96.0%
Identity: 14%
PDB header:chaperone
Chain: A: PDB Molecule:prefoldin subunit beta;
PDBTitle: crystal structure of prefoldin from pyrococcus horikoshii2 ot3

Phyre2

PDB 1fxk chain A

3D model

Region: 5 - 106
Aligned: 98
Modelled: 100
Confidence: 85.3%
Identity: 19%
Fold: Long alpha-hairpin
Superfamily: Prefoldin
Family: Prefoldin

Phyre2

PDB 3aei chain A

3D model

Region: 50 - 105
Aligned: 56
Modelled: 56
Confidence: 69.8%
Identity: 18%
PDB header:chaperone
Chain: A: PDB Molecule:prefoldin beta subunit 2;
PDBTitle: crystal structure of the prefoldin beta2 subunit from thermococcus2 strain ks-1

Phyre2

PDB 1go4 chain F

3D model

Region: 21 - 96
Aligned: 72
Modelled: 72
Confidence: 51.8%
Identity: 26%
PDB header:cell cycle
Chain: F: PDB Molecule:mad1 (mitotic arrest deficient)-like 1;
PDBTitle: crystal structure of mad1-mad2 reveals a conserved mad22 binding motif in mad1 and cdc20.

Phyre2

PDB 2ke4 chain A

3D model

Region: 7 - 110
Aligned: 79
Modelled: 99
Confidence: 41.5%
Identity: 22%
PDB header:membrane protein
Chain: A: PDB Molecule:cdc42-interacting protein 4;
PDBTitle: the nmr structure of the tc10 and cdc42 interacting domain2 of cip4

Phyre2

PDB 2gbo chain B

3D model

Region: 68 - 95
Aligned: 28
Modelled: 28
Confidence: 27.5%
Identity: 14%
PDB header:structural genomics, unknown function
Chain: B: PDB Molecule:upf0358 protein ef2458;
PDBTitle: protein of unknown function ef2458 from enterococcus faecalis

Phyre2

PDB 2gbo chain A domain 1

3D model

Region: 68 - 95
Aligned: 28
Modelled: 28
Confidence: 27.5%
Identity: 14%
Fold: Open three-helical up-and-down bundle
Superfamily: EF2458-like
Family: EF2458-like

Phyre2

PDB 4dnc chain D

3D model

Region: 16 - 39
Aligned: 24
Modelled: 24
Confidence: 20.0%
Identity: 33%
PDB header:transcription
Chain: D: PDB Molecule:male-specific lethal 1 homolog;
PDBTitle: crystal structure of human mof in complex with msl1

Phyre2

PDB 3lyv chain F

3D model

Region: 110 - 124
Aligned: 15
Modelled: 15
Confidence: 18.6%
Identity: 27%
PDB header:chaperone
Chain: F: PDB Molecule:ribosome-associated factor y;
PDBTitle: crystal structure of a domain of ribosome-associated factor y from2 streptococcus pyogenes serotype m6. northeast structural genomics3 consortium target id dr64a

Phyre2

PDB 3ka5 chain A

3D model

Region: 112 - 124
Aligned: 13
Modelled: 11
Confidence: 16.4%
Identity: 38%
PDB header:chaperone
Chain: A: PDB Molecule:ribosome-associated protein y (psrp-1);
PDBTitle: crystal structure of ribosome-associated protein y (psrp-1)2 from clostridium acetobutylicum. northeast structural3 genomics consortium target id car123a

Phyre2

PDB 1wpg chain A domain 2

3D model

Region: 33 - 63
Aligned: 28
Modelled: 31
Confidence: 16.3%
Identity: 18%
Fold: HAD-like
Superfamily: HAD-like
Family: Meta-cation ATPase, catalytic domain P

Phyre2

PDB 3hde chain A

3D model

Region: 50 - 90
Aligned: 41
Modelled: 41
Confidence: 15.5%
Identity: 22%
PDB header:hydrolase
Chain: A: PDB Molecule:lysozyme;
PDBTitle: crystal structure of full-length endolysin r21 from phage 21

Phyre2

PDB 3he4 chain A

3D model

Region: 77 - 95
Aligned: 19
Modelled: 19
Confidence: 14.5%
Identity: 32%
PDB header:de novo protein
Chain: A: PDB Molecule:synzip6;
PDBTitle: heterospecific coiled-coil pair synzip5:synzip6

Phyre2

PDB 1lpy chain A

3D model

Region: 49 - 90
Aligned: 42
Modelled: 42
Confidence: 13.9%
Identity: 14%
Fold: Lysozyme-like
Superfamily: Lysozyme-like
Family: Phage lysozyme

Phyre2

PDB 2kz6 chain A

3D model

Region: 39 - 58
Aligned: 20
Modelled: 20
Confidence: 13.8%
Identity: 30%
PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:uncharacterized protein;
PDBTitle: solution structure of protein cv0426 from chromobacterium violaceum,2 northeast structural genomics consortium (nesg) target cvt2

Phyre2

PDB 3kyz chain A

3D model

Region: 25 - 61
Aligned: 37
Modelled: 37
Confidence: 13.1%
Identity: 27%
PDB header:transferase
Chain: A: PDB Molecule:sensor protein pfes;
PDBTitle: the crystal structure of the sensor domain of two-component2 sensor pfes from pseudomonas aeruginosa pa01

Phyre2

PDB 176l chain A

3D model

Region: 49 - 90
Aligned: 42
Modelled: 42
Confidence: 12.5%
Identity: 19%
Fold: Lysozyme-like
Superfamily: Lysozyme-like
Family: Phage lysozyme

Phyre2

PDB 1t3j chain A

3D model

Region: 62 - 96
Aligned: 35
Modelled: 35
Confidence: 12.2%
Identity: 20%
PDB header:membrane protein
Chain: A: PDB Molecule:mitofusin 1;
PDBTitle: mitofusin domain hr2 v686m/i708m mutant

Phyre2
1
c2zdiC_
2
d1fxkc_
3
c2zdiA_
4
d1fxka_
5
c3aeiA_
6
c1go4F_
7
c2ke4A_
8
c2gboB_
9
d2gboa1
10
c4dncD_
11
c3lyvF_
12
c3ka5A_
13
d1wpga2
14
c3hdeA_
15
c3he4A_
16
d1lpya_
17
c2kz6A_
18
c3kyzA_
19
d176la_
20
c1t3jA_
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73



Detailed template information 

#
Template Alignment Coverage3D Model Confidence
% i.d. Template Information
1c2zdiC_
96.6 15 PDB header:chaperone
Chain: C: PDB Molecule:prefoldin subunit alpha;
PDBTitle: crystal structure of prefoldin from pyrococcus horikoshii2 ot3
2d1fxkc_
96.3 15 Fold:Long alpha-hairpin
Superfamily:Prefoldin
Family:Prefoldin
3c2zdiA_
96.0 14 PDB header:chaperone
Chain: A: PDB Molecule:prefoldin subunit beta;
PDBTitle: crystal structure of prefoldin from pyrococcus horikoshii2 ot3
4d1fxka_
85.3 19 Fold:Long alpha-hairpin
Superfamily:Prefoldin
Family:Prefoldin
5c3aeiA_
69.8 18 PDB header:chaperone
Chain: A: PDB Molecule:prefoldin beta subunit 2;
PDBTitle: crystal structure of the prefoldin beta2 subunit from thermococcus2 strain ks-1
6c1go4F_
51.8 26 PDB header:cell cycle
Chain: F: PDB Molecule:mad1 (mitotic arrest deficient)-like 1;
PDBTitle: crystal structure of mad1-mad2 reveals a conserved mad22 binding motif in mad1 and cdc20.
7c2ke4A_
41.5 22 PDB header:membrane protein
Chain: A: PDB Molecule:cdc42-interacting protein 4;
PDBTitle: the nmr structure of the tc10 and cdc42 interacting domain2 of cip4
8c2gboB_
27.5 14 PDB header:structural genomics, unknown function
Chain: B: PDB Molecule:upf0358 protein ef2458;
PDBTitle: protein of unknown function ef2458 from enterococcus faecalis
9d2gboa1
27.5 14 Fold:Open three-helical up-and-down bundle
Superfamily:EF2458-like
Family:EF2458-like
10c4dncD_
20.0 33 PDB header:transcription
Chain: D: PDB Molecule:male-specific lethal 1 homolog;
PDBTitle: crystal structure of human mof in complex with msl1
11c3lyvF_
18.6 27 PDB header:chaperone
Chain: F: PDB Molecule:ribosome-associated factor y;
PDBTitle: crystal structure of a domain of ribosome-associated factor y from2 streptococcus pyogenes serotype m6. northeast structural genomics3 consortium target id dr64a
12c3ka5A_
16.4 38 PDB header:chaperone
Chain: A: PDB Molecule:ribosome-associated protein y (psrp-1);
PDBTitle: crystal structure of ribosome-associated protein y (psrp-1)2 from clostridium acetobutylicum. northeast structural3 genomics consortium target id car123a
13d1wpga2
16.3 18 Fold:HAD-like
Superfamily:HAD-like
Family:Meta-cation ATPase, catalytic domain P
14c3hdeA_
15.5 22 PDB header:hydrolase
Chain: A: PDB Molecule:lysozyme;
PDBTitle: crystal structure of full-length endolysin r21 from phage 21
15c3he4A_
14.5 32 PDB header:de novo protein
Chain: A: PDB Molecule:synzip6;
PDBTitle: heterospecific coiled-coil pair synzip5:synzip6
16d1lpya_
13.9 14 Fold:Lysozyme-like
Superfamily:Lysozyme-like
Family:Phage lysozyme
17c2kz6A_
13.8 30 PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:uncharacterized protein;
PDBTitle: solution structure of protein cv0426 from chromobacterium violaceum,2 northeast structural genomics consortium (nesg) target cvt2
18c3kyzA_
13.1 27 PDB header:transferase
Chain: A: PDB Molecule:sensor protein pfes;
PDBTitle: the crystal structure of the sensor domain of two-component2 sensor pfes from pseudomonas aeruginosa pa01
19d176la_
12.5 19 Fold:Lysozyme-like
Superfamily:Lysozyme-like
Family:Phage lysozyme
20c1t3jA_
12.2 20 PDB header:membrane protein
Chain: A: PDB Molecule:mitofusin 1;
PDBTitle: mitofusin domain hr2 v686m/i708m mutant
21d1p37a_
not modelled 12.2 21 Fold:Lysozyme-like
Superfamily:Lysozyme-like
Family:Phage lysozyme
22c3b8cB_
not modelled 11.6 26 PDB header:hydrolase
Chain: B: PDB Molecule:atpase 2, plasma membrane-type;
PDBTitle: crystal structure of a plasma membrane proton pump
23c1mhsA_
not modelled 11.5 15 PDB header:membrane protein, proton transport
Chain: A: PDB Molecule:plasma membrane atpase;
PDBTitle: model of neurospora crassa proton atpase
24c2y0mB_
not modelled 11.0 35 PDB header:transcription
Chain: B: PDB Molecule:male-specific lethal 1 homolog;
PDBTitle: crystal structure of the complex between dosage2 compensation factors msl1 and mof
25c3rkgA_
not modelled 10.8 11 PDB header:metal transport
Chain: A: PDB Molecule:magnesium transporter mrs2, mitochondrial;
PDBTitle: structural and functional characterization of the yeast mg2+ channel2 mrs2
26c2ka6B_
not modelled 10.4 41 PDB header:transcription regulator
Chain: B: PDB Molecule:signal transducer and activator of transcription
PDBTitle: nmr structure of the cbp-taz2/stat1-tad complex
27d1hqz1_
not modelled 9.8 10 Fold:Gelsolin-like
Superfamily:Actin depolymerizing proteins
Family:Cofilin-like
28d1hh8a_
not modelled 9.7 12 Fold:alpha-alpha superhelix
Superfamily:TPR-like
Family:Tetratricopeptide repeat (TPR)
29d1oqya1
not modelled 9.7 26 Fold:RuvA C-terminal domain-like
Superfamily:UBA-like
Family:UBA domain
30c2ykqC_
not modelled 9.5 13 PDB header:rna-binding protein
Chain: C: PDB Molecule:line-1 orf1p;
PDBTitle: structure of the human line-1 orf1p trimer
31c3hdfA_
not modelled 9.1 22 PDB header:hydrolase
Chain: A: PDB Molecule:lysozyme;
PDBTitle: crystal structure of truncated endolysin r21 from phage 21
32c2anxB_
not modelled 8.7 19 PDB header:hydrolase
Chain: B: PDB Molecule:lysozyme;
PDBTitle: crystal structure of bacteriophage p22 lysozyme mutant l87m
33c1y4mC_
not modelled 8.7 33 PDB header:membrane protein
Chain: C: PDB Molecule:herv-frd_6p24.1 provirus ancestral env polyprotein;
PDBTitle: crystal structure of human endogenous retrovirus herv-frd envelope2 protein (syncitin-2)
34c2ko2A_
not modelled 8.4 15 PDB header:membrane protein
Chain: A: PDB Molecule:reticulon-4;
PDBTitle: nogo66
35d1xjta_
not modelled 8.3 12 Fold:Lysozyme-like
Superfamily:Lysozyme-like
Family:Phage lysozyme
36c1mofA_
not modelled 8.3 24 PDB header:viral protein
Chain: A: PDB Molecule:moloney murine leukemia virus p15;
PDBTitle: coat protein
37c2l5gB_
not modelled 8.0 18 PDB header:transcription regulator
Chain: B: PDB Molecule:putative uncharacterized protein ncor2;
PDBTitle: co-ordinates and 1h, 13c and 15n chemical shift assignments for the2 complex of gps2 53-90 and smrt 167-207
38c1lb1C_
not modelled 7.9 13 PDB header:signaling protein
Chain: C: PDB Molecule:guanine nucleotide exchange factor dbs;
PDBTitle: crystal structure of the dbl and pleckstrin homology2 domains of dbs in complex with rhoa
39d2a8ea1
not modelled 7.4 20 Fold:YktB/PF0168-like
Superfamily:YktB/PF0168-like
Family:YktB-like
40c2odmA_
not modelled 7.4 15 PDB header:unknown function
Chain: A: PDB Molecule:upf0358 protein mw0995;
PDBTitle: crystal structure of s. aureus ylan, an essential leucine rich protein2 involved in the control of cell shape
41d1zl8a1
not modelled 7.3 16 Fold:L27 domain
Superfamily:L27 domain
Family:L27 domain
42d2b8ea1
not modelled 7.3 22 Fold:HAD-like
Superfamily:HAD-like
Family:Meta-cation ATPase, catalytic domain P
43d1ubea2
not modelled 7.2 3 Fold:Anti-LPS factor/recA domain
Superfamily:RecA protein, C-terminal domain
Family:RecA protein, C-terminal domain
44c2l3aA_
not modelled 7.2 33 PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:uncharacterized protein;
PDBTitle: solution nmr structure of homodimer protein sp_0782 (7-79) from2 streptococcus pneumoniae northeast structural genomics consortium3 target spr104 .
45d1mo6a2
not modelled 7.2 5 Fold:Anti-LPS factor/recA domain
Superfamily:RecA protein, C-terminal domain
Family:RecA protein, C-terminal domain
46c1a3wB_
not modelled 7.1 24 PDB header:transferase
Chain: B: PDB Molecule:pyruvate kinase;
PDBTitle: pyruvate kinase from saccharomyces cerevisiae complexed with fbp, pg,2 mn2+ and k+
47d1xp8a2
not modelled 6.9 18 Fold:Anti-LPS factor/recA domain
Superfamily:RecA protein, C-terminal domain
Family:RecA protein, C-terminal domain
48d189la_
not modelled 6.8 21 Fold:Lysozyme-like
Superfamily:Lysozyme-like
Family:Phage lysozyme
49c3virA_
not modelled 6.8 14 PDB header:recombination activator
Chain: A: PDB Molecule:mating-type switching protein swi5;
PDBTitle: crystal strcture of swi5 from fission yeast
50c2q7cC_
not modelled 6.8 25 PDB header:viral protein
Chain: C: PDB Molecule:fusion protein between yeast variant gcn4 and
PDBTitle: crystal structure of iqn17
51c3t07D_
not modelled 6.8 26 PDB header:transferase/transferase inhibitor
Chain: D: PDB Molecule:pyruvate kinase;
PDBTitle: crystal structure of s. aureus pyruvate kinase in complex with a2 naturally occurring bis-indole alkaloid
52c4exmB_
not modelled 6.8 17 PDB header:toxin, hydrolase
Chain: B: PDB Molecule:pesticin, lysozyme chimera;
PDBTitle: the crystal structure of an engineered phage lysin containing the2 binding domain of pesticin and the killing domain of t4-lysozyme
53c1d6uB_
not modelled 6.6 47 PDB header:oxidoreductase
Chain: B: PDB Molecule:copper amine oxidase;
PDBTitle: crystal structure of e. coli amine oxidase anaerobically reduced with2 beta-phenylethylamine
54d1y74a1
not modelled 6.6 13 Fold:L27 domain
Superfamily:L27 domain
Family:L27 domain
55c3uuxD_
not modelled 6.4 15 PDB header:apoptosis
Chain: D: PDB Molecule:mitochondrial division protein 1;
PDBTitle: crystal structure of yeast fis1 in complex with mdv1 fragment2 containing n-terminal extension and coiled coil domains
56d1u94a2
not modelled 6.3 10 Fold:Anti-LPS factor/recA domain
Superfamily:RecA protein, C-terminal domain
Family:RecA protein, C-terminal domain
57d1udma_
not modelled 6.3 21 Fold:Gelsolin-like
Superfamily:Actin depolymerizing proteins
Family:Cofilin-like
58d1is1a_
not modelled 6.2 13 Fold:RRF/tRNA synthetase additional domain-like
Superfamily:Ribosome recycling factor, RRF
Family:Ribosome recycling factor, RRF
59d2j0111
not modelled 6.1 44 Fold:L28p-like
Superfamily:L28p-like
Family:Ribosomal protein L28
60d1vdra_
not modelled 6.0 16 Fold:Dihydrofolate reductase-like
Superfamily:Dihydrofolate reductase-like
Family:Dihydrofolate reductases
61d191la_
not modelled 5.9 21 Fold:Lysozyme-like
Superfamily:Lysozyme-like
Family:Phage lysozyme
62c2w9yA_
not modelled 5.8 18 PDB header:lipid transport
Chain: A: PDB Molecule:fatty acid/retinol binding protein protein 7,
PDBTitle: the structure of the lipid binding protein ce-far-7 from2 caenorhabditis elegans
63c3tnuB_
not modelled 5.7 12 PDB header:cytosolic protein
Chain: B: PDB Molecule:keratin, type ii cytoskeletal 5;
PDBTitle: heterocomplex of coil 2b domains of human intermediate filament2 proteins, keratin 5 (krt5) and keratin 14 (krt14)
64c3b9bA_
not modelled 5.6 15 PDB header:hydrolase
Chain: A: PDB Molecule:sarcoplasmic/endoplasmic reticulum calcium
PDBTitle: structure of the e2 beryllium fluoride complex of the serca2 ca2+-atpase
65c2la3A_
not modelled 5.5 14 PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:uncharacterized protein;
PDBTitle: the nmr structure of the protein np_344798.1 reveals a cca-adding2 enzyme head domain
66d1vega_
not modelled 5.5 17 Fold:RuvA C-terminal domain-like
Superfamily:UBA-like
Family:UBA domain
67c1b89A_
not modelled 5.5 20 PDB header:clathrin
Chain: A: PDB Molecule:protein (clathrin heavy chain);
PDBTitle: clathrin heavy chain proximal leg segment (bovine)
68d1b89a_
not modelled 5.5 20 Fold:alpha-alpha superhelix
Superfamily:ARM repeat
Family:Clathrin heavy chain proximal leg segment
69c3mqzA_
not modelled 5.5 7 PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:uncharacterized conserved protein duf1054;
PDBTitle: crystal structure of conserved protein duf1054 from pink subaerial2 biofilm microbial leptospirillum sp. group ii uba.
70c3ma8A_
not modelled 5.3 24 PDB header:transferase
Chain: A: PDB Molecule:pyruvate kinase;
PDBTitle: crystal structure of cgd1_2040, a pyruvate kinase from cryptosporidium2 parvum
71d1ifya_
not modelled 5.3 26 Fold:RuvA C-terminal domain-like
Superfamily:UBA-like
Family:UBA domain
72c4aj5M_
not modelled 5.3 9 PDB header:cell cycle
Chain: M: PDB Molecule:spindle and kinetochore-associated protein 2;
PDBTitle: crystal structure of the ska core complex
73c2ivfB_
not modelled 5.2 20 PDB header:oxidoreductase
Chain: B: PDB Molecule:ethylbenzene dehydrogenase beta-subunit;
PDBTitle: ethylbenzene dehydrogenase from aromatoleum aromaticum

Binding site prediction 

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

Transmembrane helix prediction 

Transmembrane helices have been predicted in your sequence to adopt the topology shown below