Phyre 2 Results for A0PJK1

Email	l.a.kelley@imperial.ac.uk
Description	A0PJK1
Date	Tue Apr 3 14:59:03 BST 2012
Unique Job ID	4119271ea0e6f686

Summary

Top model

Image coloured by rainbow N → C terminus

Model (left) based on template c2xq2A_

Top template information

PDB header:transport protein
Chain: A: PDB Molecule:sodium/glucose cotransporter;
PDBTitle: structure of the k294a mutant of vsglt

Confidence and coverage

Confidence:

100.0%

Coverage:

85%

508 residues ( 85% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.

3D viewing

Interactive 3D view in Jmol

Sequence analysis

Secondary structure and disorder prediction

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60

Sequence M A A N S T S D L H T P G T Q L S V A D I I V I T V Y F A L N V A V G I W S S C R A S R N T V N G Y F L A G R D M T W W

Secondary structure

SS confidence

Disorder ? ? ? ? ? ?
? ? ? ? ? ? ?
? ? ? ? ? ?
?

Disorder confidence

. . . . . . . . . 70 . . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120

Sequence P I G A S L F A S S E G S G L F I G L A G S G A A G G L A V A G F E W N A T Y V L L A L A W V F V P I Y I S S E I V T L

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 130 . . . . . . . . . 140 . . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180

Sequence P E Y I Q K R Y G G Q R I R M Y L S V L S L L L S V F T K I S L D L Y A G A L F V H I C L G W N F Y L S T I L T L G I T

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210 . . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240

Sequence A L Y T I A G G L A A V I Y T D A L Q T L I M V V G A V I L T I K A F D Q I G G Y G Q L E A A Y A Q A I P S R T I A N T

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 250 . . . . . . . . . 260 . . . . . . . . . 270 . . . . . . . . . 280 . . . . . . . . . 290 . . . . . . . . . 300

Sequence T C H L P R T D A M H M F R D P H T G D L P W T G M T F G L T I M A T W Y W C T D Q V I V Q R S L S A R D L N H A K A G

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ?
? ? ? ? ?
?

Disorder confidence

. . . . . . . . . 310 . . . . . . . . . 320 . . . . . . . . . 330 . . . . . . . . . 340 . . . . . . . . . 350 . . . . . . . . . 360

Sequence S I L A S Y L K M L P M G L I I M P G M I S R A L F P D D V G C V V P S E C L R A C G A E V G C S N I A Y P K L V M E L

Secondary structure

SS confidence

Disorder
? ? ?
? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 370 . . . . . . . . . 380 . . . . . . . . . 390 . . . . . . . . . 400 . . . . . . . . . 410 . . . . . . . . . 420

Sequence M P I G L R G L M I A V M L A A L M S S L T S I F N S S S T L F T M D I W R R L R P R S G E R E L L L V G R L V I V A L

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 430 . . . . . . . . . 440 . . . . . . . . . 450 . . . . . . . . . 460 . . . . . . . . . 470 . . . . . . . . . 480

Sequence I G V S V A W I P V L Q D S N S G Q L F I Y M Q S V T S S L A P P V T A V F V L G V F W R R A N E Q G A F W G L I A G L

Secondary structure

SS confidence

Disorder
?
?
?

Disorder confidence

. . . . . . . . . 490 . . . . . . . . . 500 . . . . . . . . . 510 . . . . . . . . . 520 . . . . . . . . . 530 . . . . . . . . . 540

Sequence V V G A T R L V L E F L N P A P P C G E P D T R P A V L G S I H Y L H F A V A L F A L S G A V V V A G S L L T P P P Q S

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ?
?

Disorder confidence

. . . . . . . . . 550 . . . . . . . . . 560 . . . . . . . . . 570 . . . . . . . . . 580 . . . . . . . . . 590 . . . . . .

Sequence V Q I E N L T W W T L A Q D V P L G T K A G D G Q T P Q K H A F W A R V C G F N A I L L M C V N I F F Y A Y F A

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
? ? ?

Disorder confidence

Confidence Key
High(9) Low (0)

? Disordered

Alpha helix

Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank	Aligned region

PDB 2xq2 chain A

Region: 17 - 593
Aligned: 508
Modelled: 508
Confidence: 100.0%
Identity: 27%
PDB header:transport protein
Chain: A: PDB Molecule:sodium/glucose cotransporter;
PDBTitle: structure of the k294a mutant of vsglt

Phyre2

PDB 3dh4 chain A

Region: 47 - 595
Aligned: 499
Modelled: 493
Confidence: 100.0%
Identity: 26%
PDB header:transport protein
Chain: A: PDB Molecule:sodium/glucose cotransporter;
PDBTitle: crystal structure of sodium/sugar symporter with bound galactose from2 vibrio parahaemolyticus

Phyre2

PDB 2jln chain A

Region: 53 - 552
Aligned: 425
Modelled: 425
Confidence: 99.0%
Identity: 12%
PDB header:membrane protein
Chain: A: PDB Molecule:mhp1;
PDBTitle: structure of mhp1, a nucleobase-cation-symport-1 family2 transporter

Phyre2

PDB 3gia chain A

Region: 55 - 544
Aligned: 426
Modelled: 426
Confidence: 98.9%
Identity: 11%
PDB header:transport protein
Chain: A: PDB Molecule:uncharacterized protein mj0609;
PDBTitle: crystal structure of apct transporter

Phyre2

PDB 3lrc chain C

Region: 55 - 558
Aligned: 399
Modelled: 399
Confidence: 98.5%
Identity: 10%
PDB header:transport protein
Chain: C: PDB Molecule:arginine/agmatine antiporter;
PDBTitle: structure of e. coli adic (p1)

Phyre2

PDB 4dji chain A

Region: 55 - 565
Aligned: 457
Modelled: 470
Confidence: 98.4%
Identity: 11%
PDB header:transport protein
Chain: A: PDB Molecule:probable glutamate/gamma-aminobutyrate antiporter;
PDBTitle: structure of glutamate-gaba antiporter gadc

Phyre2

PDB 2w8a chain C

Region: 15 - 463
Aligned: 406
Modelled: 447
Confidence: 96.1%
Identity: 11%
PDB header:membrane protein
Chain: C: PDB Molecule:glycine betaine transporter betp;
PDBTitle: crystal structure of the sodium-coupled glycine betaine2 symporter betp from corynebacterium glutamicum with bound3 substrate

Phyre2

PDB 3hfx chain A

Region: 81 - 463
Aligned: 345
Modelled: 383
Confidence: 95.2%
Identity: 11%
PDB header:transport protein
Chain: A: PDB Molecule:l-carnitine/gamma-butyrobetaine antiporter;
PDBTitle: crystal structure of carnitine transporter

Phyre2

PDB 2a65 chain A domain 1

Region: 64 - 466
Aligned: 359
Modelled: 359
Confidence: 93.8%
Identity: 14%
Fold: SNF-like
Superfamily: SNF-like
Family: SNF-like

Phyre2

PDB 3rlb chain A

Region: 410 - 540
Aligned: 126
Modelled: 131
Confidence: 68.9%
Identity: 8%
PDB header:thiamine-binding protein
Chain: A: PDB Molecule:thit;
PDBTitle: crystal structure at 2.0 a of the s-component for thiamin from an ecf-2 type abc transporter

Phyre2

PDB 3hd6 chain A

Region: 517 - 555
Aligned: 39
Modelled: 39
Confidence: 30.1%
Identity: 10%
PDB header:membrane protein, transport protein
Chain: A: PDB Molecule:ammonium transporter rh type c;
PDBTitle: crystal structure of the human rhesus glycoprotein rhcg

Phyre2

PDB 3ria chain C

Region: 449 - 595
Aligned: 118
Modelled: 126
Confidence: 28.0%
Identity: 11%
PDB header:transport protein/immune system
Chain: C: PDB Molecule:avermectin-sensitive glutamate-gated chloride channel glucl
PDBTitle: c. elegans glutamate-gated chloride channel (glucl) in complex with2 fab, ivermectin and iodide.

Phyre2

PDB 3hd7 chain A

Region: 540 - 595
Aligned: 56
Modelled: 56
Confidence: 24.6%
Identity: 9%
PDB header:exocytosis
Chain: A: PDB Molecule:vesicle-associated membrane protein 2;
PDBTitle: helical extension of the neuronal snare complex into the membrane,2 spacegroup c 1 2 1

Phyre2

PDB 2k9y chain B

Region: 15 - 43
Aligned: 29
Modelled: 29
Confidence: 6.7%
Identity: 24%
PDB header:transferase
Chain: B: PDB Molecule:ephrin type-a receptor 2;
PDBTitle: epha2 dimeric structure in the lipidic bicelle at ph 5.0

Phyre2

PDB 2k9y chain A

Region: 15 - 43
Aligned: 29
Modelled: 29
Confidence: 6.7%
Identity: 24%
PDB header:transferase
Chain: A: PDB Molecule:ephrin type-a receptor 2;
PDBTitle: epha2 dimeric structure in the lipidic bicelle at ph 5.0

Phyre2

PDB 3mk7 chain F

Region: 19 - 81
Aligned: 63
Modelled: 63
Confidence: 5.8%
Identity: 10%
PDB header:oxidoreductase
Chain: F: PDB Molecule:cytochrome c oxidase, cbb3-type, subunit p;
PDBTitle: the structure of cbb3 cytochrome oxidase

Phyre2

PDB 1zza chain A

Region: 10 - 49
Aligned: 40
Modelled: 40
Confidence: 5.6%
Identity: 23%
PDB header:membrane protein
Chain: A: PDB Molecule:stannin;
PDBTitle: solution nmr structure of the membrane protein stannin

Phyre2

	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence	M	A	A	N	S	T	S	D	L	H	T	P	G	T	Q	L	S	V	A	D	I	I	V	I	T	V	Y	F	A	L	N	V	A	V	G	I	W	S	S	C	R	A	S	R	N	T	V	N	G	Y	F	L	A	G	R	D	M	T	W	W
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?		?	?	?	?	?	?	?																											?	?	?	?	?	?					?
Disorder confidence

	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence	P	I	G	A	S	L	F	A	S	S	E	G	S	G	L	F	I	G	L	A	G	S	G	A	A	G	G	L	A	V	A	G	F	E	W	N	A	T	Y	V	L	L	A	L	A	W	V	F	V	P	I	Y	I	S	S	E	I	V	T	L
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence	P	E	Y	I	Q	K	R	Y	G	G	Q	R	I	R	M	Y	L	S	V	L	S	L	L	L	S	V	F	T	K	I	S	L	D	L	Y	A	G	A	L	F	V	H	I	C	L	G	W	N	F	Y	L	S	T	I	L	T	L	G	I	T
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence	A	L	Y	T	I	A	G	G	L	A	A	V	I	Y	T	D	A	L	Q	T	L	I	M	V	V	G	A	V	I	L	T	I	K	A	F	D	Q	I	G	G	Y	G	Q	L	E	A	A	Y	A	Q	A	I	P	S	R	T	I	A	N	T
Secondary structure
SS confidence
Disorder																																																		?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence	T	C	H	L	P	R	T	D	A	M	H	M	F	R	D	P	H	T	G	D	L	P	W	T	G	M	T	F	G	L	T	I	M	A	T	W	Y	W	C	T	D	Q	V	I	V	Q	R	S	L	S	A	R	D	L	N	H	A	K	A	G
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?	?	?	?	?	?	?			?	?	?	?	?																																		?
Disorder confidence

	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence	S	I	L	A	S	Y	L	K	M	L	P	M	G	L	I	I	M	P	G	M	I	S	R	A	L	F	P	D	D	V	G	C	V	V	P	S	E	C	L	R	A	C	G	A	E	V	G	C	S	N	I	A	Y	P	K	L	V	M	E	L
Secondary structure
SS confidence
Disorder																															?	?	?				?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence	M	P	I	G	L	R	G	L	M	I	A	V	M	L	A	A	L	M	S	S	L	T	S	I	F	N	S	S	S	T	L	F	T	M	D	I	W	R	R	L	R	P	R	S	G	E	R	E	L	L	L	V	G	R	L	V	I	V	A	L
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence	I	G	V	S	V	A	W	I	P	V	L	Q	D	S	N	S	G	Q	L	F	I	Y	M	Q	S	V	T	S	S	L	A	P	P	V	T	A	V	F	V	L	G	V	F	W	R	R	A	N	E	Q	G	A	F	W	G	L	I	A	G	L
Secondary structure
SS confidence
Disorder												?		?		?
Disorder confidence

	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence	V	V	G	A	T	R	L	V	L	E	F	L	N	P	A	P	P	C	G	E	P	D	T	R	P	A	V	L	G	S	I	H	Y	L	H	F	A	V	A	L	F	A	L	S	G	A	V	V	V	A	G	S	L	L	T	P	P	P	Q	S
Secondary structure
SS confidence
Disorder													?	?	?	?	?	?	?				?
Disorder confidence

	.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.
Sequence	V	Q	I	E	N	L	T	W	W	T	L	A	Q	D	V	P	L	G	T	K	A	G	D	G	Q	T	P	Q	K	H	A	F	W	A	R	V	C	G	F	N	A	I	L	L	M	C	V	N	I	F	F	Y	A	Y	F	A
Secondary structure
SS confidence
Disorder													?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?																									?	?	?
Disorder confidence