Phyre 2 Results for D6VTK4

Email	l.a.kelley@imperial.ac.uk
Description	D6VTK4
Date	Mon Jul 2 19:10:02 BST 2012
Unique Job ID	1e960aed19b3fa90

Summary

Top model

Image coloured by rainbow N → C terminus

Model (left) based on template c2k9pA_

Top template information

PDB header:membrane protein
Chain: A: PDB Molecule:pheromone alpha factor receptor;
PDBTitle: structure of tm1_tm2 in lppg micelles

Confidence and coverage

Confidence:

99.9%

Coverage:

19%

80 residues ( 19% of your sequence) have been modelled with 99.9% confidence by the single highest scoring template.

You may wish to submit your sequence to Phyrealarm. This will automatically scan your sequence every week for new potential templates as they appear in the Phyre2 library.

3D viewing

Interactive 3D view in Jmol

Sequence analysis

Secondary structure and disorder prediction

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60

Sequence M S D A A P S L S N L F Y D P T Y N P G Q S T I N Y T S I Y G N G S T I T F D E L Q G L V N S T V T Q A I M F G V R C G

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ?
? ? ? ?
?

Disorder confidence

. . . . . . . . . 70 . . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120

Sequence A A A L T L I V M W M T S R S R K T P I F I I N Q V S L F L I I L H S A L Y F K Y L L S N Y S S V T Y A L T G F P Q F I

Secondary structure

SS confidence

Disorder
?
?
?

Disorder confidence

. . . . . . . . . 130 . . . . . . . . . 140 . . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180

Sequence S R G D V H V Y G A T N I I Q V L L V A S I E T S L V F Q I K V I F T G D N F K R I G L M L T S I S F T L G I A T V T M

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210 . . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240

Sequence Y F V S A V K G M I V T Y N D V S A T Q D K Y F N A S T I L L A S S I N F M S F V L V V K L I L A I R S R R F L G L K Q

Secondary structure

SS confidence

Disorder
? ?
? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 250 . . . . . . . . . 260 . . . . . . . . . 270 . . . . . . . . . 280 . . . . . . . . . 290 . . . . . . . . . 300

Sequence F D S F H I L L I M S C Q S L L V P S I I F I L A Y S L K P N Q G T D V L T T V A T L L A V L S L P L S S M W A T A A N

Secondary structure

SS confidence

Disorder
?
?
? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 310 . . . . . . . . . 320 . . . . . . . . . 330 . . . . . . . . . 340 . . . . . . . . . 350 . . . . . . . . . 360

Sequence N A S K T N T I T S D F T T S T D R F Y P G T L S S F Q T D S I N N D A K S S L R S R L Y D L Y P R R K E T T S D K H S

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 370 . . . . . . . . . 380 . . . . . . . . . 390 . . . . . . . . . 400 . . . . . . . . . 410 . . . . . . . . . 420

Sequence E R T F V S E T A D D I E K N Q F Y Q L P T P T S S K N T R I G P F A D A S Y K E G E V E P V D M Y T P D T A A D E E A

Secondary structure

SS confidence

Disorder ?
?
? ?
?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
? ? ? ? ?

Disorder confidence

. . . . . . . . . 430 .

Sequence R K F W T E D N N N L

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ?

Disorder confidence

Confidence Key
High(9) Low (0)

? Disordered

Alpha helix

Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank	Aligned region

PDB 2k9p chain A

Region: 31 - 110
Aligned: 80
Modelled: 80
Confidence: 99.9%
Identity: 95%
PDB header:membrane protein
Chain: A: PDB Molecule:pheromone alpha factor receptor;
PDBTitle: structure of tm1_tm2 in lppg micelles

Phyre2

PDB 4dbl chain B

Region: 51 - 180
Aligned: 127
Modelled: 130
Confidence: 77.4%
Identity: 12%
PDB header:transport protein
Chain: B: PDB Molecule:vitamin b12 import system permease protein btuc;
PDBTitle: crystal structure of e159q mutant of btucdf

Phyre2

PDB 1l7v chain A

Region: 51 - 180
Aligned: 129
Modelled: 130
Confidence: 63.6%
Identity: 10%
Fold: ABC transporter involved in vitamin B12 uptake, BtuC
Superfamily: ABC transporter involved in vitamin B12 uptake, BtuC
Family: ABC transporter involved in vitamin B12 uptake, BtuC

Phyre2

PDB 2knc chain A

Region: 53 - 79
Aligned: 27
Modelled: 27
Confidence: 24.2%
Identity: 19%
PDB header:cell adhesion
Chain: A: PDB Molecule:integrin alpha-iib;
PDBTitle: platelet integrin alfaiib-beta3 transmembrane-cytoplasmic2 heterocomplex

Phyre2

PDB 3gvz chain B

Region: 402 - 431
Aligned: 23
Modelled: 30
Confidence: 19.9%
Identity: 30%
PDB header:structural genomics, unknown function
Chain: B: PDB Molecule:uncharacterized protein cv2077;
PDBTitle: crystal structure of the protein cv2077 from2 chromobacterium violaceum. northeast structural genomics3 consortium target cvr62

Phyre2

PDB 2hku chain A domain 2

Region: 417 - 424
Aligned: 8
Modelled: 8
Confidence: 19.0%
Identity: 50%
Fold: Tetracyclin repressor-like, C-terminal domain
Superfamily: Tetracyclin repressor-like, C-terminal domain
Family: Tetracyclin repressor-like, C-terminal domain

Phyre2

PDB 2cbl chain A

Region: 417 - 426
Aligned: 10
Modelled: 10
Confidence: 14.1%
Identity: 30%
PDB header:complex (proto-oncogene/peptide)
Chain: A: PDB Molecule:proto-oncogene cbl;
PDBTitle: n-terminal domain of cbl in complex with its binding site2 on zap-70

Phyre2

PDB 3bun chain B

Region: 417 - 426
Aligned: 10
Modelled: 10
Confidence: 14.0%
Identity: 30%
PDB header:ligase/signaling protein
Chain: B: PDB Molecule:e3 ubiquitin-protein ligase cbl;
PDBTitle: crystal structure of c-cbl-tkb domain complexed with its2 binding motif in sprouty4

Phyre2

PDB 2k1a chain A

Region: 53 - 79
Aligned: 27
Modelled: 27
Confidence: 13.5%
Identity: 19%
PDB header:cell adhesion
Chain: A: PDB Molecule:integrin alpha-iib;
PDBTitle: bicelle-embedded integrin alpha(iib) transmembrane segment

Phyre2

PDB 2nq2 chain A

Region: 51 - 180
Aligned: 128
Modelled: 130
Confidence: 13.1%
Identity: 14%
PDB header:metal transport
Chain: A: PDB Molecule:hypothetical abc transporter permease protein
PDBTitle: an inward-facing conformation of a putative metal-chelate2 type abc transporter.

Phyre2

PDB 3pf6 chain C

Region: 393 - 423
Aligned: 29
Modelled: 31
Confidence: 12.3%
Identity: 28%
PDB header:structural genomics, unknown function
Chain: C: PDB Molecule:hypothetical protein pp-luz7_gp033;
PDBTitle: the structure of uncharacterized protein pp-luz7_gp033 from2 pseudomonas phage luz7.

Phyre2

PDB 1u2p chain A

Region: 243 - 252
Aligned: 10
Modelled: 10
Confidence: 10.2%
Identity: 10%
PDB header:hydrolase
Chain: A: PDB Molecule:low molecular weight protein-tyrosine-
PDBTitle: crystal structure of mycobacterium tuberculosis low2 molecular protein tyrosine phosphatase (mptpa) at 1.9a3 resolution

Phyre2

PDB 3g4d chain B

Region: 390 - 426
Aligned: 37
Modelled: 37
Confidence: 8.9%
Identity: 16%
PDB header:lyase
Chain: B: PDB Molecule:(+)-delta-cadinene synthase isozyme xc1;
PDBTitle: crystal structure of (+)-delta-cadinene synthase from gossypium2 arboreum and evolutionary divergence of metal binding motifs for3 catalysis

Phyre2

PDB 2jz2 chain A

Region: 107 - 127
Aligned: 21
Modelled: 21
Confidence: 8.6%
Identity: 29%
PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:ssl0352 protein;
PDBTitle: solution nmr structure of ssl0352 protein from synechocystis sp. pcc2 6803. northeast structural genomics consortium target sgr42

Phyre2

PDB 2k57 chain A domain 1

Region: 15 - 37
Aligned: 23
Modelled: 23
Confidence: 8.2%
Identity: 17%
Fold: Sm-like fold
Superfamily: Sm-like ribonucleoproteins
Family: YgdI/YgdR-like

Phyre2

PDB 1wlf chain A domain 1

Region: 142 - 162
Aligned: 21
Modelled: 21
Confidence: 6.9%
Identity: 24%
Fold: Cdc48 domain 2-like
Superfamily: Cdc48 domain 2-like
Family: Cdc48 domain 2-like

Phyre2

PDB 3n0f chain A

Region: 390 - 423
Aligned: 34
Modelled: 34
Confidence: 6.8%
Identity: 21%
PDB header:lyase
Chain: A: PDB Molecule:isoprene synthase;
PDBTitle: crystal structure of isoprene synthase from grey poplar leaves2 (populus x canescens)

Phyre2

PDB 1hx9 chain A

Region: 390 - 423
Aligned: 34
Modelled: 34
Confidence: 6.8%
Identity: 24%
PDB header:lyase
Chain: A: PDB Molecule:5-epi-aristolochene synthase;
PDBTitle: crystal structure of teas w273s form 1

Phyre2

PDB 1mke chain A domain 1

Region: 415 - 426
Aligned: 12
Modelled: 12
Confidence: 6.4%
Identity: 50%
Fold: PH domain-like barrel
Superfamily: PH domain-like
Family: Enabled/VASP homology 1 domain (EVH1 domain)

Phyre2

PDB 2ong chain A

Region: 390 - 423
Aligned: 34
Modelled: 34
Confidence: 6.2%
Identity: 21%
PDB header:lyase
Chain: A: PDB Molecule:4s-limonene synthase;
PDBTitle: crystal structure of of limonene synthase with 2-2 fluorogeranyl diphosphate (fgpp).

Phyre2

	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence	M	S	D	A	A	P	S	L	S	N	L	F	Y	D	P	T	Y	N	P	G	Q	S	T	I	N	Y	T	S	I	Y	G	N	G	S	T	I	T	F	D	E	L	Q	G	L	V	N	S	T	V	T	Q	A	I	M	F	G	V	R	C	G
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?	?																						?	?	?	?		?
Disorder confidence

	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence	A	A	A	L	T	L	I	V	M	W	M	T	S	R	S	R	K	T	P	I	F	I	I	N	Q	V	S	L	F	L	I	I	L	H	S	A	L	Y	F	K	Y	L	L	S	N	Y	S	S	V	T	Y	A	L	T	G	F	P	Q	F	I
Secondary structure
SS confidence
Disorder																																																							?		?			?
Disorder confidence

	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence	S	R	G	D	V	H	V	Y	G	A	T	N	I	I	Q	V	L	L	V	A	S	I	E	T	S	L	V	F	Q	I	K	V	I	F	T	G	D	N	F	K	R	I	G	L	M	L	T	S	I	S	F	T	L	G	I	A	T	V	T	M
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence	Y	F	V	S	A	V	K	G	M	I	V	T	Y	N	D	V	S	A	T	Q	D	K	Y	F	N	A	S	T	I	L	L	A	S	S	I	N	F	M	S	F	V	L	V	V	K	L	I	L	A	I	R	S	R	R	F	L	G	L	K	Q
Secondary structure
SS confidence
Disorder													?	?			?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence	F	D	S	F	H	I	L	L	I	M	S	C	Q	S	L	L	V	P	S	I	I	F	I	L	A	Y	S	L	K	P	N	Q	G	T	D	V	L	T	T	V	A	T	L	L	A	V	L	S	L	P	L	S	S	M	W	A	T	A	A	N
Secondary structure
SS confidence
Disorder																																	?			?													?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence	N	A	S	K	T	N	T	I	T	S	D	F	T	T	S	T	D	R	F	Y	P	G	T	L	S	S	F	Q	T	D	S	I	N	N	D	A	K	S	S	L	R	S	R	L	Y	D	L	Y	P	R	R	K	E	T	T	S	D	K	H	S
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence	E	R	T	F	V	S	E	T	A	D	D	I	E	K	N	Q	F	Y	Q	L	P	T	P	T	S	S	K	N	T	R	I	G	P	F	A	D	A	S	Y	K	E	G	E	V	E	P	V	D	M	Y	T	P	D	T	A	A	D	E	E	A
Secondary structure
SS confidence
Disorder	?			?		?	?								?			?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?				?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	430	.
Sequence	R	K	F	W	T	E	D	N	N	N	L
Secondary structure
SS confidence
Disorder					?	?	?	?	?	?	?
Disorder confidence