Secondary structure and disorder prediction

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Sequence		M	I	A	E	F	E	S	R	I	L	A	L	I	D	G	M	V	D	H	A	S	D	D	E	L	F	A	S	G	Y	L	R	G	H	L	T	L	A	I	A	E	L	E	S	G	D	D	H	S	A	Q	A	V	H	T	T	V	S	Q	S
Secondary structure
SS confidence
Disorder		?																																											?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.
Sequence		L	E	K	A	I	G	A	G	E	L	S	P	R	D	Q	A	L	V	T	D	M	W	E	N	L	F	Q	Q	A	S	Q	Q
Secondary structure
SS confidence
Disorder								?	?	?	?																				?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1sgm chain A domain 2 Region: 6 - 89 Aligned: 83 Modelled: 84 Confidence: 60.0% Identity: 10% Fold: Tetracyclin repressor-like, C-terminal domain Superfamily: Tetracyclin repressor-like, C-terminal domain Family: Tetracyclin repressor-like, C-terminal domain Phyre2 PDB 2hyj chain A domain 2 Region: 7 - 90 Aligned: 83 Modelled: 84 Confidence: 47.5% Identity: 14% Fold: Tetracyclin repressor-like, C-terminal domain Superfamily: Tetracyclin repressor-like, C-terminal domain Family: Tetracyclin repressor-like, C-terminal domain Phyre2 PDB 3dfg chain A Region: 6 - 35 Aligned: 30 Modelled: 30 Confidence: 36.8% Identity: 20% PDB header:recombination Chain: A: PDB Molecule:regulatory protein recx; PDBTitle: crystal structure of recx: a potent inhibitor protein of2 reca from xanthomonas campestris Phyre2 PDB 3c1d chain A Region: 5 - 36 Aligned: 32 Modelled: 32 Confidence: 35.6% Identity: 16% PDB header:recombination, dna binding protein Chain: A: PDB Molecule:regulatory protein recx; PDBTitle: x-ray crystal structure of recx Phyre2 PDB 2g7s chain A domain 2 Region: 6 - 87 Aligned: 80 Modelled: 77 Confidence: 26.3% Identity: 15% Fold: Tetracyclin repressor-like, C-terminal domain Superfamily: Tetracyclin repressor-like, C-terminal domain Family: Tetracyclin repressor-like, C-terminal domain Phyre2 PDB 1uw0 chain A Region: 69 - 92 Aligned: 24 Modelled: 24 Confidence: 25.4% Identity: 21% Fold: Glucocorticoid receptor-like (DNA-binding domain) Superfamily: Glucocorticoid receptor-like (DNA-binding domain) Family: PARP-type zinc finger Phyre2 PDB 1ug8 chain A Region: 4 - 25 Aligned: 22 Modelled: 22 Confidence: 25.2% Identity: 14% Fold: IF3-like Superfamily: R3H domain Family: R3H domain Phyre2 PDB 3fgr chain A Region: 18 - 36 Aligned: 19 Modelled: 19 Confidence: 23.4% Identity: 16% PDB header:hydrolase Chain: A: PDB Molecule:putative phospholipase b-like 2 28 kda form; PDBTitle: two chain form of the 66.3 kda protein at 1.8 angstroem Phyre2 PDB 2k0m chain A Region: 48 - 83 Aligned: 36 Modelled: 36 Confidence: 20.8% Identity: 11% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: solution nmr structure of the uncharacterized protein from2 rhodospirillum rubrum gene locus rru_a0810. northeast3 structural genomics target rrr43 Phyre2 PDB 1pzr chain A Region: 20 - 26 Aligned: 7 Modelled: 7 Confidence: 18.8% Identity: 100% Fold: HLH-like Superfamily: Docking domain B of the erythromycin polyketide synthase (DEBS) Family: Docking domain B of the erythromycin polyketide synthase (DEBS) Phyre2 PDB 2i76 chain A domain 1 Region: 26 - 68 Aligned: 43 Modelled: 43 Confidence: 17.4% Identity: 12% Fold: 6-phosphogluconate dehydrogenase C-terminal domain-like Superfamily: 6-phosphogluconate dehydrogenase C-terminal domain-like Family: ProC C-terminal domain-like Phyre2 PDB 1hlb chain A Region: 68 - 88 Aligned: 21 Modelled: 21 Confidence: 15.9% Identity: 24% Fold: Globin-like Superfamily: Globin-like Family: Globins Phyre2 PDB 1xho chain A Region: 46 - 74 Aligned: 29 Modelled: 29 Confidence: 14.0% Identity: 17% Fold: Bacillus chorismate mutase-like Superfamily: YjgF-like Family: Chorismate mutase Phyre2 PDB 1xho chain B Region: 46 - 74 Aligned: 29 Modelled: 29 Confidence: 14.0% Identity: 17% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:chorismate mutase; PDBTitle: chorismate mutase from clostridium thermocellum cth-682 Phyre2 PDB 2vxd chain A Region: 49 - 83 Aligned: 35 Modelled: 35 Confidence: 13.5% Identity: 26% PDB header:nuclear protein Chain: A: PDB Molecule:nucleophosmin; PDBTitle: the structure of the c-terminal domain of nucleophosmin Phyre2 PDB 1fnj chain A Region: 46 - 74 Aligned: 29 Modelled: 29 Confidence: 13.1% Identity: 24% Fold: Bacillus chorismate mutase-like Superfamily: YjgF-like Family: Chorismate mutase Phyre2 PDB 2v4j chain C domain 1 Region: 36 - 81 Aligned: 46 Modelled: 46 Confidence: 12.8% Identity: 13% Fold: DsrC, the gamma subunit of dissimilatory sulfite reductase Superfamily: DsrC, the gamma subunit of dissimilatory sulfite reductase Family: DsrC, the gamma subunit of dissimilatory sulfite reductase Phyre2 PDB 2dmj chain A Region: 69 - 84 Aligned: 16 Modelled: 16 Confidence: 12.7% Identity: 38% PDB header:transferase Chain: A: PDB Molecule:poly (adp-ribose) polymerase family, member 1; PDBTitle: solution structure of the first zf-parp domain of human2 poly(adp-ribose)polymerase-1 Phyre2 PDB 2lhb chain A Region: 68 - 91 Aligned: 24 Modelled: 24 Confidence: 12.6% Identity: 13% Fold: Globin-like Superfamily: Globin-like Family: Globins Phyre2 PDB 3hug chain J Region: 63 - 80 Aligned: 18 Modelled: 18 Confidence: 12.3% Identity: 28% PDB header:transcription/membrane protein Chain: J: PDB Molecule:probable conserved membrane protein; PDBTitle: crystal structure of mycobacterium tuberculosis anti-sigma factor rsla2 in complex with -35 promoter binding domain of sigl Phyre2 1 d1sgma2 2 d2hyja2 3 c3dfgA_ 4 c3c1dA_ 5 d2g7sa2 6 d1uw0a_ 7 d1ug8a_ 8 c3fgrA_ 9 c2k0mA_ 10 d1pzra_ 11 d2i76a1 12 d1hlba_ 13 d1xhoa_ 14 c1xhoB_ 15 c2vxdA_ 16 d1fnja_ 17 d2v4jc1 18 c2dmjA_ 19 d2lhba_ 20 c3hugJ_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d1sgma2 60.0 10 Fold:Tetracyclin repressor-like, C-terminal domain Superfamily:Tetracyclin repressor-like, C-terminal domain Family:Tetracyclin repressor-like, C-terminal domain 2 d2hyja2 47.5 14 Fold:Tetracyclin repressor-like, C-terminal domain Superfamily:Tetracyclin repressor-like, C-terminal domain Family:Tetracyclin repressor-like, C-terminal domain 3 c3dfgA_ 36.8 20 PDB header:recombination Chain: A: PDB Molecule:regulatory protein recx; PDBTitle: crystal structure of recx: a potent inhibitor protein of2 reca from xanthomonas campestris 4 c3c1dA_ 35.6 16 PDB header:recombination, dna binding protein Chain: A: PDB Molecule:regulatory protein recx; PDBTitle: x-ray crystal structure of recx 5 d2g7sa2 26.3 15 Fold:Tetracyclin repressor-like, C-terminal domain Superfamily:Tetracyclin repressor-like, C-terminal domain Family:Tetracyclin repressor-like, C-terminal domain 6 d1uw0a_ 25.4 21 Fold:Glucocorticoid receptor-like (DNA-binding domain) Superfamily:Glucocorticoid receptor-like (DNA-binding domain) Family:PARP-type zinc finger 7 d1ug8a_ 25.2 14 Fold:IF3-like Superfamily:R3H domain Family:R3H domain 8 c3fgrA_ 23.4 16 PDB header:hydrolase Chain: A: PDB Molecule:putative phospholipase b-like 2 28 kda form; PDBTitle: two chain form of the 66.3 kda protein at 1.8 angstroem 9 c2k0mA_ 20.8 11 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: solution nmr structure of the uncharacterized protein from2 rhodospirillum rubrum gene locus rru_a0810. northeast3 structural genomics target rrr43 10 d1pzra_ 18.8 100 Fold:HLH-like Superfamily:Docking domain B of the erythromycin polyketide synthase (DEBS) Family:Docking domain B of the erythromycin polyketide synthase (DEBS) 11 d2i76a1 17.4 12 Fold:6-phosphogluconate dehydrogenase C-terminal domain-like Superfamily:6-phosphogluconate dehydrogenase C-terminal domain-like Family:ProC C-terminal domain-like 12 d1hlba_ 15.9 24 Fold:Globin-like Superfamily:Globin-like Family:Globins 13 d1xhoa_ 14.0 17 Fold:Bacillus chorismate mutase-like Superfamily:YjgF-like Family:Chorismate mutase 14 c1xhoB_ 14.0 17 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:chorismate mutase; PDBTitle: chorismate mutase from clostridium thermocellum cth-682 15 c2vxdA_ 13.5 26 PDB header:nuclear protein Chain: A: PDB Molecule:nucleophosmin; PDBTitle: the structure of the c-terminal domain of nucleophosmin 16 d1fnja_ 13.1 24 Fold:Bacillus chorismate mutase-like Superfamily:YjgF-like Family:Chorismate mutase 17 d2v4jc1 12.8 13 Fold:DsrC, the gamma subunit of dissimilatory sulfite reductase Superfamily:DsrC, the gamma subunit of dissimilatory sulfite reductase Family:DsrC, the gamma subunit of dissimilatory sulfite reductase 18 c2dmjA_ 12.7 38 PDB header:transferase Chain: A: PDB Molecule:poly (adp-ribose) polymerase family, member 1; PDBTitle: solution structure of the first zf-parp domain of human2 poly(adp-ribose)polymerase-1 19 d2lhba_ 12.6 13 Fold:Globin-like Superfamily:Globin-like Family:Globins 20 c3hugJ_ 12.3 28 PDB header:transcription/membrane protein Chain: J: PDB Molecule:probable conserved membrane protein; PDBTitle: crystal structure of mycobacterium tuberculosis anti-sigma factor rsla2 in complex with -35 promoter binding domain of sigl 21 c3s1sA_ not modelled 11.8 24 PDB header:hydrolase, transferase Chain: A: PDB Molecule:restriction endonuclease bpusi; PDBTitle: characterization and crystal structure of the type iig restriction2 endonuclease bpusi 22 d2ea9a1 not modelled 11.7 19 Fold:Profilin-like Superfamily:YeeU-like Family:YagB/YeeU/YfjZ-like 23 d1it2a_ not modelled 11.4 18 Fold:Globin-like Superfamily:Globin-like Family:Globins 24 c3e3vA_ not modelled 10.1 27 PDB header:recombination Chain: A: PDB Molecule:regulatory protein recx; PDBTitle: crystal structure of recx from lactobacillus salivarius 25 c3k66A_ not modelled 10.1 9 PDB header:cell adhesion Chain: A: PDB Molecule:beta-amyloid-like protein; PDBTitle: x-ray crystal structure of the e2 domain of c. elegans apl-1 26 d1dbfa_ not modelled 9.9 24 Fold:Bacillus chorismate mutase-like Superfamily:YjgF-like Family:Chorismate mutase 27 d2h28a1 not modelled 9.3 24 Fold:Profilin-like Superfamily:YeeU-like Family:YagB/YeeU/YfjZ-like 28 d2ox6a1 not modelled 9.1 33 Fold:lambda repressor-like DNA-binding domains Superfamily:lambda repressor-like DNA-binding domains Family:YdiL-like 29 c2xvcA_ not modelled 9.0 33 PDB header:cell cycle Chain: A: PDB Molecule:escrt-iii; PDBTitle: molecular and structural basis of escrt-iii recruitment to2 membranes during archaeal cell division 30 d2inwa1 not modelled 8.9 24 Fold:Profilin-like Superfamily:YeeU-like Family:YagB/YeeU/YfjZ-like 31 d1uc3a_ not modelled 8.5 13 Fold:Globin-like Superfamily:Globin-like Family:Globins 32 d3sdha_ not modelled 8.3 25 Fold:Globin-like Superfamily:Globin-like Family:Globins 33 c1o06A_ not modelled 7.1 23 PDB header:transport protein Chain: A: PDB Molecule:vacuolar protein sorting-associated protein vps27; PDBTitle: crystal structure of the vps27p ubiquitin interacting motif (uim) 34 c1q15A_ not modelled 7.1 56 PDB header:biosynthetic protein Chain: A: PDB Molecule:cara; PDBTitle: carbapenam synthetase 35 c1g2cN_ not modelled 7.1 37 PDB header:viral protein Chain: N: PDB Molecule:fusion protein (f); PDBTitle: human respiratory syncytial virus fusion protein core 36 c3mjhD_ not modelled 6.5 63 PDB header:protein transport Chain: D: PDB Molecule:early endosome antigen 1; PDBTitle: crystal structure of human rab5a in complex with the c2h2 zinc finger2 of eea1 37 c3b5nE_ not modelled 6.3 15 PDB header:membrane protein Chain: E: PDB Molecule:synaptobrevin homolog 1; PDBTitle: structure of the yeast plasma membrane snare complex 38 c3iz5t_ not modelled 6.2 33 PDB header:ribosome Chain: T: PDB Molecule:60s ribosomal protein l19 (l19e); PDBTitle: localization of the large subunit ribosomal proteins into a 5.5 a2 cryo-em map of triticum aestivum translating 80s ribosome 39 d1hlma_ not modelled 6.1 33 Fold:Globin-like Superfamily:Globin-like Family:Globins 40 d2fq4a2 not modelled 6.0 36 Fold:Tetracyclin repressor-like, C-terminal domain Superfamily:Tetracyclin repressor-like, C-terminal domain Family:Tetracyclin repressor-like, C-terminal domain 41 c2vsgB_ not modelled 6.0 20 PDB header:membrane protein Chain: B: PDB Molecule:variant surface glycoprotein iltat 1.24; PDBTitle: a structural motif in the variant surface glycoproteins of2 trypanosoma brucei 42 c1o1nA_ not modelled 5.9 19 PDB header:oxygen storage/transport Chain: A: PDB Molecule:hemoglobin alpha chain; PDBTitle: deoxy hemoglobin (a-glyglygly-c:v1m,l29w; b,d:v1m) 43 c1yx3A_ not modelled 5.9 12 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical protein dsrc; PDBTitle: nmr structure of allochromatium vinosum dsrc: northeast2 structural genomics consortium target op4 44 d1gdta1 not modelled 5.9 36 Fold:DNA/RNA-binding 3-helical bundle Superfamily:Homeodomain-like Family:Recombinase DNA-binding domain 45 c2lbfA_ not modelled 5.8 42 PDB header:ribosomal protein Chain: A: PDB Molecule:60s acidic ribosomal protein p1; PDBTitle: solution structure of the dimerization domain of human ribosomal2 protein p1/p2 heterodimer 46 c3izct_ not modelled 5.5 25 PDB header:ribosome Chain: T: PDB Molecule:60s ribosomal protein rpl19 (l19e); PDBTitle: localization of the large subunit ribosomal proteins into a 6.1 a2 cryo-em map of saccharomyces cerevisiae translating 80s ribosome 47 c2v3sB_ not modelled 5.3 21 PDB header:transferase Chain: B: PDB Molecule:serine/threonine-protein kinase osr1; PDBTitle: structural insights into the recognition of substrates and2 activators by the osr1 kinase 48 c3hq2A_ not modelled 5.2 30 PDB header:hydrolase Chain: A: PDB Molecule:bacillus subtilis m32 carboxypeptidase; PDBTitle: bsucp crystal structure

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0