Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	H	A	D	T	A	T	R	Q	H	W	M	S	V	L	A	H	S	Q	P	A	E	L	A	A	R	L	N	A	L	N	I	T	A	D	Y	E	V	I	R	A	A	E	T	G	L	V	Q	I	Q	A	R	M	G	G	T	G	E	R	F
Secondary structure
SS confidence
Disorder		?	?	?	?	?																																							?									?	?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		F	A	G	D	A	T	L	T	R	A	A	V	R	L	T	D	G	T	L	G	Y	S	W	V	Q	G	R	D	K	Q	H	A	E	R	C	A	L	I	D	A	L	M	Q	Q	S	R	H	F	Q	N	L	S	E	T	L	I	A	P	L	D
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150
Sequence		A	D	R	M	A	R	I	A	A	R	Q	A	E	V	N	A	S	R	V	D	F	F	T	M	V	R	G	D	N	A
Secondary structure
SS confidence
Disorder																	?	?								?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2pc9 chain B Region: 28 - 106 Aligned: 78 Modelled: 79 Confidence: 20.4% Identity: 18% PDB header:lyase Chain: B: PDB Molecule:phosphoenolpyruvate carboxykinase [atp]; PDBTitle: crystal structure of atp-dependent phosphoenolpyruvate carboxykinase2 from thermus thermophilus hb8 Phyre2 PDB 2h12 chain C Region: 79 - 145 Aligned: 66 Modelled: 66 Confidence: 19.8% Identity: 12% PDB header:transferase Chain: C: PDB Molecule:citrate synthase; PDBTitle: structure of acetobacter aceti citrate synthase complexed2 with oxaloacetate and carboxymethyldethia coenzyme a (cmx) Phyre2 PDB 1bqg chain A domain 2 Region: 68 - 115 Aligned: 48 Modelled: 48 Confidence: 17.2% Identity: 23% Fold: Enolase N-terminal domain-like Superfamily: Enolase N-terminal domain-like Family: Enolase N-terminal domain-like Phyre2 PDB 2a9d chain A domain 1 Region: 37 - 77 Aligned: 41 Modelled: 41 Confidence: 16.2% Identity: 17% Fold: Immunoglobulin-like beta-sandwich Superfamily: E set domains Family: Molybdenum-containing oxidoreductases-like dimerisation domain Phyre2 PDB 3f4y chain F Region: 88 - 119 Aligned: 32 Modelled: 32 Confidence: 11.9% Identity: 31% PDB header:viral protein Chain: F: PDB Molecule:mutant peptide derived from hiv gp41 chr domain; PDBTitle: hiv gp41 six-helix bundle containing a mutant chr alpha-2 peptide sequence Phyre2 PDB 1ogp chain A domain 1 Region: 37 - 77 Aligned: 41 Modelled: 41 Confidence: 10.9% Identity: 17% Fold: Immunoglobulin-like beta-sandwich Superfamily: E set domains Family: Molybdenum-containing oxidoreductases-like dimerisation domain Phyre2 PDB 2eqj chain A Region: 47 - 79 Aligned: 29 Modelled: 33 Confidence: 10.1% Identity: 24% PDB header:transcription Chain: A: PDB Molecule:metal-response element-binding transcription PDBTitle: solution structure of the tudor domain of metal-response2 element-binding transcription factor 2 Phyre2 PDB 2e5p chain A Region: 47 - 79 Aligned: 29 Modelled: 33 Confidence: 9.5% Identity: 24% PDB header:transcription Chain: A: PDB Molecule:phd finger protein 1; PDBTitle: solution structure of the tudor domain of phd finger2 protein 1 (phf1 protein) Phyre2 PDB 1z1b chain A domain 1 Region: 76 - 97 Aligned: 22 Modelled: 22 Confidence: 9.4% Identity: 32% Fold: DNA-binding domain Superfamily: DNA-binding domain Family: lambda integrase N-terminal domain Phyre2 PDB 1kjk chain A Region: 76 - 97 Aligned: 22 Modelled: 22 Confidence: 9.4% Identity: 32% PDB header:viral protein Chain: A: PDB Molecule:integrase; PDBTitle: solution structure of the lambda integrase amino-terminal2 domain Phyre2 PDB 3c4t chain A Region: 69 - 101 Aligned: 31 Modelled: 33 Confidence: 9.1% Identity: 29% PDB header:hydrolase Chain: A: PDB Molecule:endoribonuclease dicer; PDBTitle: structure of rnaseiiib and dsrna binding domains of mouse dicer Phyre2 PDB 1o0w chain B Region: 66 - 101 Aligned: 34 Modelled: 36 Confidence: 8.7% Identity: 29% PDB header:hydrolase Chain: B: PDB Molecule:ribonuclease iii; PDBTitle: crystal structure of ribonuclease iii (tm1102) from2 thermotoga maritima at 2.0 a resolution Phyre2 PDB 1x47 chain A domain 1 Region: 69 - 101 Aligned: 31 Modelled: 33 Confidence: 8.2% Identity: 26% Fold: dsRBD-like Superfamily: dsRNA-binding domain-like Family: Double-stranded RNA-binding domain (dsRBD) Phyre2 PDB 2enp chain A Region: 51 - 68 Aligned: 18 Modelled: 18 Confidence: 8.0% Identity: 17% PDB header:transport protein Chain: A: PDB Molecule:b/k protein; PDBTitle: solution structure of the first c2 domain from human b/k2 protein Phyre2 PDB 2e5q chain A Region: 47 - 79 Aligned: 29 Modelled: 33 Confidence: 8.0% Identity: 24% PDB header:transcription Chain: A: PDB Molecule:phd finger protein 19; PDBTitle: solution structure of the tudor domain of phd finger2 protein 19, isoform b [homo sapiens] Phyre2 PDB 2fd6 chain U domain 2 Region: 40 - 71 Aligned: 32 Modelled: 32 Confidence: 7.4% Identity: 6% Fold: Snake toxin-like Superfamily: Snake toxin-like Family: Extracellular domain of cell surface receptors Phyre2 PDB 1stu chain A Region: 19 - 101 Aligned: 62 Modelled: 64 Confidence: 7.3% Identity: 19% Fold: dsRBD-like Superfamily: dsRNA-binding domain-like Family: Double-stranded RNA-binding domain (dsRBD) Phyre2 PDB 2bv3 chain A domain 4 Region: 29 - 51 Aligned: 23 Modelled: 23 Confidence: 6.9% Identity: 26% Fold: Ferredoxin-like Superfamily: EF-G C-terminal domain-like Family: EF-G/eEF-2 domains III and V Phyre2 PDB 3ts3 chain D Region: 39 - 85 Aligned: 38 Modelled: 47 Confidence: 6.9% Identity: 26% PDB header:viral protein Chain: D: PDB Molecule:capsid polyprotein; PDBTitle: crystal structure of the projection domain of the turkey astrovirus2 capsid protein at 1.5 angstrom resolution Phyre2 PDB 1ef1 chain C Region: 107 - 142 Aligned: 35 Modelled: 36 Confidence: 6.2% Identity: 14% Fold: Non-globular all-alpha subunits of globular proteins Superfamily: Moesin tail domain Family: Moesin tail domain Phyre2 1 c2pc9B_ 2 c2h12C_ 3 d1bqga2 4 d2a9da1 5 c3f4yF_ 6 d1ogpa1 7 c2eqjA_ 8 c2e5pA_ 9 d1z1ba1 10 c1kjkA_ 11 c3c4tA_ 12 c1o0wB_ 13 d1x47a1 14 c2enpA_ 15 c2e5qA_ 16 d2fd6u2 17 d1stua_ 18 d2bv3a4 19 c3ts3D_ 20 d1ef1c_ 21 22 23 24 25 26 27 28 29 30

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c2pc9B_ 20.4 18 PDB header:lyase Chain: B: PDB Molecule:phosphoenolpyruvate carboxykinase [atp]; PDBTitle: crystal structure of atp-dependent phosphoenolpyruvate carboxykinase2 from thermus thermophilus hb8 2 c2h12C_ 19.8 12 PDB header:transferase Chain: C: PDB Molecule:citrate synthase; PDBTitle: structure of acetobacter aceti citrate synthase complexed2 with oxaloacetate and carboxymethyldethia coenzyme a (cmx) 3 d1bqga2 17.2 23 Fold:Enolase N-terminal domain-like Superfamily:Enolase N-terminal domain-like Family:Enolase N-terminal domain-like 4 d2a9da1 16.2 17 Fold:Immunoglobulin-like beta-sandwich Superfamily:E set domains Family:Molybdenum-containing oxidoreductases-like dimerisation domain 5 c3f4yF_ 11.9 31 PDB header:viral protein Chain: F: PDB Molecule:mutant peptide derived from hiv gp41 chr domain; PDBTitle: hiv gp41 six-helix bundle containing a mutant chr alpha-2 peptide sequence 6 d1ogpa1 10.9 17 Fold:Immunoglobulin-like beta-sandwich Superfamily:E set domains Family:Molybdenum-containing oxidoreductases-like dimerisation domain 7 c2eqjA_ 10.1 24 PDB header:transcription Chain: A: PDB Molecule:metal-response element-binding transcription PDBTitle: solution structure of the tudor domain of metal-response2 element-binding transcription factor 2 8 c2e5pA_ 9.5 24 PDB header:transcription Chain: A: PDB Molecule:phd finger protein 1; PDBTitle: solution structure of the tudor domain of phd finger2 protein 1 (phf1 protein) 9 d1z1ba1 9.4 32 Fold:DNA-binding domain Superfamily:DNA-binding domain Family:lambda integrase N-terminal domain 10 c1kjkA_ 9.4 32 PDB header:viral protein Chain: A: PDB Molecule:integrase; PDBTitle: solution structure of the lambda integrase amino-terminal2 domain 11 c3c4tA_ 9.1 29 PDB header:hydrolase Chain: A: PDB Molecule:endoribonuclease dicer; PDBTitle: structure of rnaseiiib and dsrna binding domains of mouse dicer 12 c1o0wB_ 8.7 29 PDB header:hydrolase Chain: B: PDB Molecule:ribonuclease iii; PDBTitle: crystal structure of ribonuclease iii (tm1102) from2 thermotoga maritima at 2.0 a resolution 13 d1x47a1 8.2 26 Fold:dsRBD-like Superfamily:dsRNA-binding domain-like Family:Double-stranded RNA-binding domain (dsRBD) 14 c2enpA_ 8.0 17 PDB header:transport protein Chain: A: PDB Molecule:b/k protein; PDBTitle: solution structure of the first c2 domain from human b/k2 protein 15 c2e5qA_ 8.0 24 PDB header:transcription Chain: A: PDB Molecule:phd finger protein 19; PDBTitle: solution structure of the tudor domain of phd finger2 protein 19, isoform b [homo sapiens] 16 d2fd6u2 7.4 6 Fold:Snake toxin-like Superfamily:Snake toxin-like Family:Extracellular domain of cell surface receptors 17 d1stua_ 7.3 19 Fold:dsRBD-like Superfamily:dsRNA-binding domain-like Family:Double-stranded RNA-binding domain (dsRBD) 18 d2bv3a4 6.9 26 Fold:Ferredoxin-like Superfamily:EF-G C-terminal domain-like Family:EF-G/eEF-2 domains III and V 19 c3ts3D_ 6.9 26 PDB header:viral protein Chain: D: PDB Molecule:capsid polyprotein; PDBTitle: crystal structure of the projection domain of the turkey astrovirus2 capsid protein at 1.5 angstrom resolution 20 d1ef1c_ 6.2 14 Fold:Non-globular all-alpha subunits of globular proteins Superfamily:Moesin tail domain Family:Moesin tail domain 21 d2gl5a2 not modelled 6.1 15 Fold:Enolase N-terminal domain-like Superfamily:Enolase N-terminal domain-like Family:Enolase N-terminal domain-like 22 d2bo3a1 not modelled 5.9 16 Fold:HP0242-like Superfamily:HP0242-like Family:HP0242-like 23 d1m06f_ not modelled 5.8 75 Fold:Nucleoplasmin-like/VP (viral coat and capsid proteins) Superfamily:ssDNA viruses Family:Microviridae-like VP 24 d1x48a1 not modelled 5.7 23 Fold:dsRBD-like Superfamily:dsRNA-binding domain-like Family:Double-stranded RNA-binding domain (dsRBD) 25 d1hi9a_ not modelled 5.5 10 Fold:Dipeptide transport protein Superfamily:Dipeptide transport protein Family:Dipeptide transport protein 26 d1t0aa_ not modelled 5.5 16 Fold:Bacillus chorismate mutase-like Superfamily:IpsF-like Family:IpsF-like 27 c1h2iG_ not modelled 5.4 35 PDB header:dna-binding protein Chain: G: PDB Molecule:dna repair protein rad52 homolog; PDBTitle: human rad52 protein, n-terminal domain 28 d1w55a2 not modelled 5.2 16 Fold:Bacillus chorismate mutase-like Superfamily:IpsF-like Family:IpsF-like 29 d1pvma3 not modelled 5.2 22 Fold:Rubredoxin-like Superfamily:Hypothetical protein Ta0289 C-terminal domain Family:Hypothetical protein Ta0289 C-terminal domain 30 c3kysB_ not modelled 5.1 29 PDB header:transcription/protein binding Chain: B: PDB Molecule:65 kda yes-associated protein; PDBTitle: crystal structure of human yap and tead complex

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0