Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	R	T	T	I	A	V	V	L	G	A	I	S	L	T	S	A	F	V	F	A	D	K	P	D	V	A	R	S	A	N	D	E	V	S	T	L	F	F	G	H	D	D	R	V	P	V	N	D	T	T	Q	S	P	W	D	A	V	G	Q
Secondary structure
SS confidence
Disorder		?	?															?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		L	E	T	A	S	G	N	L	C	T	A	T	L	I	A	P	N	L	A	L	T	A	G	H	C	L	L	T	P	P	K	G	K	A	D	K	A	V	A	L	R	F	V	S	N	K	G	L	W	R	Y	E	I	H	D	I	E	G	R	V
Secondary structure
SS confidence
Disorder				?	?	?	?																									?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		D	P	T	L	G	K	R	L	K	A	D	G	D	G	W	I	V	P	P	A	A	A	P	W	D	F	G	L	I	V	L	R	N	P	P	S	G	I	T	P	L	P	L	F	E	G	D	K	A	A	L	T	A	A	L	K	A	A	G	R
Secondary structure
SS confidence
Disorder																																																	?	?		?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		K	V	T	Q	A	G	Y	P	E	D	H	L	D	T	L	Y	S	H	Q	N	C	E	V	T	G	W	A	Q	T	S	V	M	S	H	Q	C	D	T	L	P	G	D	S	G	S	P	L	M	L	H	T	D	D	G	W	Q	L	I	G	V
Secondary structure
SS confidence
Disorder												?	?		?			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.
Sequence		Q	S	S	A	P	A	A	K	D	R	W	R	A	D	N	R	A	I	S	V	T	G	F	R	D	K	L	D	Q	L	S	Q	K
Secondary structure
SS confidence
Disorder																																	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 3nxp chain A Region: 28 - 269 Aligned: 230 Modelled: 242 Confidence: 100.0% Identity: 20% PDB header:hydrolase Chain: A: PDB Molecule:prethrombin-1; PDBTitle: crystal structure of human prethrombin-1 Phyre2 PDB 2b9l chain A Region: 24 - 269 Aligned: 231 Modelled: 246 Confidence: 100.0% Identity: 17% PDB header:immune system/protein binding Chain: A: PDB Molecule:prophenoloxidase activating factor; PDBTitle: crystal structure of prophenoloxidase activating factor-ii from the2 beetle holotrichia diomphalia Phyre2 PDB 2f83 chain A Region: 33 - 248 Aligned: 197 Modelled: 216 Confidence: 100.0% Identity: 18% PDB header:hydrolase Chain: A: PDB Molecule:coagulation factor xi; PDBTitle: crystal structure at 2.9 angstroms resolution of human plasma2 coagulation factor xi zymogen Phyre2 PDB 1z8g chain A Region: 26 - 269 Aligned: 230 Modelled: 244 Confidence: 100.0% Identity: 19% PDB header:hydrolase/hydrolase inhibitor Chain: A: PDB Molecule:serine protease hepsin; PDBTitle: crystal structure of the extracellular region of the transmembrane2 serine protease hepsin with covalently bound preferred substrate. Phyre2 PDB 1zjk chain A Region: 23 - 269 Aligned: 225 Modelled: 247 Confidence: 100.0% Identity: 22% PDB header:hydrolase Chain: A: PDB Molecule:mannan-binding lectin serine protease 2; PDBTitle: crystal structure of the zymogen catalytic region of human masp-2 Phyre2 PDB 2i6s chain A Region: 39 - 244 Aligned: 191 Modelled: 206 Confidence: 100.0% Identity: 17% PDB header:hydrolase Chain: A: PDB Molecule:complement c2a fragment; PDBTitle: complement component c2a Phyre2 PDB 1rs0 chain A Region: 48 - 269 Aligned: 209 Modelled: 222 Confidence: 100.0% Identity: 20% PDB header:hydrolase Chain: A: PDB Molecule:complement factor b; PDBTitle: crystal structure analysis of the bb segment of factor b2 complexed with di-isopropyl-phosphate (dip) Phyre2 PDB 2ok5 chain A Region: 48 - 269 Aligned: 210 Modelled: 222 Confidence: 100.0% Identity: 22% PDB header:hydrolase Chain: A: PDB Molecule:complement factor b; PDBTitle: human complement factor b Phyre2 PDB 3f1s chain B Region: 48 - 270 Aligned: 201 Modelled: 223 Confidence: 100.0% Identity: 18% PDB header:hydrolase inhibitor/hydrolase Chain: B: PDB Molecule:vitamin k-dependent protein z; PDBTitle: crystal structure of protein z complexed with protein z-dependent2 inhibitor Phyre2 PDB 1p3c chain A Region: 37 - 273 Aligned: 214 Modelled: 230 Confidence: 100.0% Identity: 19% Fold: Trypsin-like serine proteases Superfamily: Trypsin-like serine proteases Family: Prokaryotic proteases Phyre2 PDB 3h5c chain B Region: 48 - 270 Aligned: 199 Modelled: 219 Confidence: 100.0% Identity: 18% PDB header:hydrolase inhibitor/blood clotting Chain: B: PDB Molecule:vitamin k-dependent protein z; PDBTitle: x-ray structure of protein z-protein z inhibitor complex Phyre2 PDB 2xrc chain D Region: 35 - 269 Aligned: 190 Modelled: 208 Confidence: 100.0% Identity: 19% PDB header:immune system Chain: D: PDB Molecule:human complement factor i; PDBTitle: human complement factor i Phyre2 PDB 1gpz chain B Region: 28 - 269 Aligned: 220 Modelled: 241 Confidence: 100.0% Identity: 16% PDB header:hydrolase Chain: B: PDB Molecule:complement c1r component; PDBTitle: the crystal structure of the zymogen catalytic domain of2 complement protease c1r Phyre2 PDB 2xxl chain B Region: 33 - 269 Aligned: 218 Modelled: 234 Confidence: 100.0% Identity: 18% PDB header:hydrolase Chain: B: PDB Molecule:gram-positive specific serine protease, isoform b; PDBTitle: crystal structure of drosophila grass clip serine protease2 of toll pathway Phyre2 PDB 1a5i chain A Region: 25 - 269 Aligned: 228 Modelled: 245 Confidence: 100.0% Identity: 18% Fold: Trypsin-like serine proteases Superfamily: Trypsin-like serine proteases Family: Eukaryotic proteases Phyre2 PDB 1z71 chain A Region: 35 - 269 Aligned: 223 Modelled: 224 Confidence: 100.0% Identity: 20% PDB header:hydrolase/hydrolase inhibitor Chain: A: PDB Molecule:thrombin; PDBTitle: thrombin and p2 pyridine n-oxide inhibitor complex structure Phyre2 PDB 1mza chain A Region: 37 - 269 Aligned: 210 Modelled: 233 Confidence: 100.0% Identity: 16% Fold: Trypsin-like serine proteases Superfamily: Trypsin-like serine proteases Family: Eukaryotic proteases Phyre2 PDB 1md7 chain A Region: 29 - 269 Aligned: 222 Modelled: 236 Confidence: 100.0% Identity: 14% PDB header:hydrolase Chain: A: PDB Molecule:c1r complement serine protease; PDBTitle: monomeric structure of the zymogen of complement protease2 c1r Phyre2 PDB 1rjx chain B Region: 28 - 265 Aligned: 214 Modelled: 225 Confidence: 100.0% Identity: 21% Fold: Trypsin-like serine proteases Superfamily: Trypsin-like serine proteases Family: Eukaryotic proteases Phyre2 PDB 1q3x chain A Region: 21 - 269 Aligned: 229 Modelled: 244 Confidence: 100.0% Identity: 20% PDB header:hydrolase Chain: A: PDB Molecule:mannan-binding lectin serine protease 2; PDBTitle: crystal structure of the catalytic region of human masp-2 Phyre2 1 c3nxpA_ 2 c2b9lA_ 3 c2f83A_ 4 c1z8gA_ 5 c1zjkA_ 6 c2i6sA_ 7 c1rs0A_ 8 c2ok5A_ 9 c3f1sB_ 10 d1p3ca_ 11 c3h5cB_ 12 c2xrcD_ 13 c1gpzB_ 14 c2xxlB_ 15 d1a5ia_ 16 c1z71A_ 17 d1mzaa_ 18 c1md7A_ 19 d1rjxb_ 20 c1q3xA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c3nxpA_ 100.0 20 PDB header:hydrolase Chain: A: PDB Molecule:prethrombin-1; PDBTitle: crystal structure of human prethrombin-1 2 c2b9lA_ 100.0 17 PDB header:immune system/protein binding Chain: A: PDB Molecule:prophenoloxidase activating factor; PDBTitle: crystal structure of prophenoloxidase activating factor-ii from the2 beetle holotrichia diomphalia 3 c2f83A_ 100.0 18 PDB header:hydrolase Chain: A: PDB Molecule:coagulation factor xi; PDBTitle: crystal structure at 2.9 angstroms resolution of human plasma2 coagulation factor xi zymogen 4 c1z8gA_ 100.0 19 PDB header:hydrolase/hydrolase inhibitor Chain: A: PDB Molecule:serine protease hepsin; PDBTitle: crystal structure of the extracellular region of the transmembrane2 serine protease hepsin with covalently bound preferred substrate. 5 c1zjkA_ 100.0 22 PDB header:hydrolase Chain: A: PDB Molecule:mannan-binding lectin serine protease 2; PDBTitle: crystal structure of the zymogen catalytic region of human masp-2 6 c2i6sA_ 100.0 17 PDB header:hydrolase Chain: A: PDB Molecule:complement c2a fragment; PDBTitle: complement component c2a 7 c1rs0A_ 100.0 20 PDB header:hydrolase Chain: A: PDB Molecule:complement factor b; PDBTitle: crystal structure analysis of the bb segment of factor b2 complexed with di-isopropyl-phosphate (dip) 8 c2ok5A_ 100.0 22 PDB header:hydrolase Chain: A: PDB Molecule:complement factor b; PDBTitle: human complement factor b 9 c3f1sB_ 100.0 18 PDB header:hydrolase inhibitor/hydrolase Chain: B: PDB Molecule:vitamin k-dependent protein z; PDBTitle: crystal structure of protein z complexed with protein z-dependent2 inhibitor 10 d1p3ca_ 100.0 19 Fold:Trypsin-like serine proteases Superfamily:Trypsin-like serine proteases Family:Prokaryotic proteases 11 c3h5cB_ 100.0 18 PDB header:hydrolase inhibitor/blood clotting Chain: B: PDB Molecule:vitamin k-dependent protein z; PDBTitle: x-ray structure of protein z-protein z inhibitor complex 12 c2xrcD_ 100.0 19 PDB header:immune system Chain: D: PDB Molecule:human complement factor i; PDBTitle: human complement factor i 13 c1gpzB_ 100.0 16 PDB header:hydrolase Chain: B: PDB Molecule:complement c1r component; PDBTitle: the crystal structure of the zymogen catalytic domain of2 complement protease c1r 14 c2xxlB_ 100.0 18 PDB header:hydrolase Chain: B: PDB Molecule:gram-positive specific serine protease, isoform b; PDBTitle: crystal structure of drosophila grass clip serine protease2 of toll pathway 15 d1a5ia_ 100.0 18 Fold:Trypsin-like serine proteases Superfamily:Trypsin-like serine proteases Family:Eukaryotic proteases 16 c1z71A_ 100.0 20 PDB header:hydrolase/hydrolase inhibitor Chain: A: PDB Molecule:thrombin; PDBTitle: thrombin and p2 pyridine n-oxide inhibitor complex structure 17 d1mzaa_ 100.0 16 Fold:Trypsin-like serine proteases Superfamily:Trypsin-like serine proteases Family:Eukaryotic proteases 18 c1md7A_ 100.0 14 PDB header:hydrolase Chain: A: PDB Molecule:c1r complement serine protease; PDBTitle: monomeric structure of the zymogen of complement protease2 c1r 19 d1rjxb_ 100.0 21 Fold:Trypsin-like serine proteases Superfamily:Trypsin-like serine proteases Family:Eukaryotic proteases 20 c1q3xA_ 100.0 20 PDB header:hydrolase Chain: A: PDB Molecule:mannan-binding lectin serine protease 2; PDBTitle: crystal structure of the catalytic region of human masp-2 21 d1pytd_ not modelled 100.0 20 Fold:Trypsin-like serine proteases Superfamily:Trypsin-like serine proteases Family:Eukaryotic proteases 22 c1wczA_ not modelled 100.0 18 PDB header:hydrolase Chain: A: PDB Molecule:glutamyl endopeptidase; PDBTitle: crystal structure of an alkaline form of v8 protease from2 staphylococcus aureus 23 c1elvA_ not modelled 100.0 16 PDB header:hydrolase Chain: A: PDB Molecule:complement c1s component; PDBTitle: crystal structure of the catalytic domain of human complement c1s2 protease 24 c2w7uC_ not modelled 100.0 16 PDB header:hydrolase Chain: C: PDB Molecule:serine protease spla; PDBTitle: spla serine protease of staphylococcus aureus (2.4a) 25 c2vntE_ not modelled 100.0 20 PDB header:hydrolase Chain: E: PDB Molecule:urokinase-type plasminogen activator; PDBTitle: urokinase-type plasminogen activator inhibitor complex with2 a 1-(7-sulphoamidoisoquinolinyl)guanidine 26 d1z8ga1 not modelled 100.0 19 Fold:Trypsin-like serine proteases Superfamily:Trypsin-like serine proteases Family:Eukaryotic proteases 27 c2asuB_ not modelled 100.0 14 PDB header:hydrolase Chain: B: PDB Molecule:hepatocyte growth factor-like protein; PDBTitle: crystal structure of the beta-chain of hgfl/msp 28 d1agja_ not modelled 100.0 23 Fold:Trypsin-like serine proteases Superfamily:Trypsin-like serine proteases Family:Prokaryotic proteases 29 d1rrka1 not modelled 100.0 20 Fold:Trypsin-like serine proteases Superfamily:Trypsin-like serine proteases Family:Eukaryotic proteases 30 c1ybwA_ not modelled 100.0 17 PDB header:hydrolase Chain: A: PDB Molecule:hepatocyte growth factor activator precursor; PDBTitle: protease domain of hgfa with no inhibitor 31 c2olgA_ not modelled 100.0 17 PDB header:hydrolase Chain: A: PDB Molecule:pro-phenoloxidase activating enzyme-i; PDBTitle: crystal structure of the serine protease domain of prophenoloxidase2 activating factor-i in a zymogen form 32 d2o8la1 not modelled 100.0 16 Fold:Trypsin-like serine proteases Superfamily:Trypsin-like serine proteases Family:Prokaryotic proteases 33 c2o8lA_ not modelled 100.0 16 PDB header:hydrolase Chain: A: PDB Molecule:v8 protease; PDBTitle: structure of v8 protease from staphylococcus aureus 34 c1fizA_ not modelled 100.0 17 PDB header:hydrolase Chain: A: PDB Molecule:beta-acrosin heavy chain; PDBTitle: three dimensional structure of beta-acrosin from boar2 spermatozoa 35 c1w0zU_ not modelled 100.0 19 PDB header:hydrolase Chain: U: PDB Molecule:urokinase-type plasminogen activator; PDBTitle: urokinase type plasminogen activator 36 c1ghwH_ not modelled 100.0 20 PDB header:hydrolase/hydrolase inhibitor Chain: H: PDB Molecule:thrombin; PDBTitle: a novel serine protease inhibition motif involving a multi-centered2 short hydrogen bonding network at the active site 37 c2vidA_ not modelled 100.0 19 PDB header:hydrolase Chain: A: PDB Molecule:serine protease splb; PDBTitle: serine protease splb from staphylococcus aureus at 1.8a2 resolution 38 c1qy6A_ not modelled 100.0 15 PDB header:protease Chain: A: PDB Molecule:serine protease; PDBTitle: structue of v8 protease from staphylococcus aureus 39 d1gvza_ not modelled 100.0 15 Fold:Trypsin-like serine proteases Superfamily:Trypsin-like serine proteases Family:Eukaryotic proteases 40 c3cp7B_ not modelled 100.0 19 PDB header:hydrolase Chain: B: PDB Molecule:alkaline serine protease al20; PDBTitle: crystal structure of a thermostable serine protease al202 from extremophilic microoganism 41 c2r0lA_ not modelled 100.0 16 PDB header:hydrolase, immune system Chain: A: PDB Molecule:hepatocyte growth factor activator; PDBTitle: short form hgfa with inhibitory fab75 42 c3e16B_ not modelled 100.0 19 PDB header:hydrolase Chain: B: PDB Molecule:prostasin; PDBTitle: x-ray structure of human prostasin in complex with benzoxazole warhead2 peptidomimic, lysine in p3 43 d1xx9a_ not modelled 100.0 16 Fold:Trypsin-like serine proteases Superfamily:Trypsin-like serine proteases Family:Eukaryotic proteases 44 c3govB_ not modelled 100.0 19 PDB header:hydrolase Chain: B: PDB Molecule:masp-1; PDBTitle: crystal structure of the catalytic region of human masp-1 45 d1npma_ not modelled 100.0 18 Fold:Trypsin-like serine proteases Superfamily:Trypsin-like serine proteases Family:Eukaryotic proteases 46 d3rp2a_ not modelled 100.0 16 Fold:Trypsin-like serine proteases Superfamily:Trypsin-like serine proteases Family:Eukaryotic proteases 47 c3h7tB_ not modelled 100.0 13 PDB header:hydrolase Chain: B: PDB Molecule:group 3 allergen smipp-s yvt004a06; PDBTitle: crystal structure of scabies mite inactivated protease paralogue s-d12 (smipp-s-d1) 48 d1gvkb_ not modelled 100.0 16 Fold:Trypsin-like serine proteases Superfamily:Trypsin-like serine proteases Family:Eukaryotic proteases 49 c3s9cA_ not modelled 100.0 20 PDB header:hydrolase Chain: A: PDB Molecule:vipera russelli proteinase rvv-v gamma; PDBTitle: russell's viper venom serine proteinase, rvv-v in complex with the2 fragment (residues 1533-1546) of human factor v 50 d2f91a1 not modelled 100.0 19 Fold:Trypsin-like serine proteases Superfamily:Trypsin-like serine proteases Family:Eukaryotic proteases 51 d1rfna_ not modelled 100.0 16 Fold:Trypsin-like serine proteases Superfamily:Trypsin-like serine proteases Family:Eukaryotic proteases 52 d1si5h_ not modelled 100.0 14 Fold:Trypsin-like serine proteases Superfamily:Trypsin-like serine proteases Family:Eukaryotic proteases 53 c1gl1C_ not modelled 100.0 16 PDB header:hydrolase/inhibitor Chain: C: PDB Molecule:alpha-chymotrypsin; PDBTitle: structure of the complex between bovine alpha-chymotrypsin2 and pmp-c, an inhibitor from the insect locusta migratoria 54 d1elta_ not modelled 100.0 20 Fold:Trypsin-like serine proteases Superfamily:Trypsin-like serine proteases Family:Eukaryotic proteases 55 d1eaxa_ not modelled 100.0 19 Fold:Trypsin-like serine proteases Superfamily:Trypsin-like serine proteases Family:Eukaryotic proteases 56 d1ekbb_ not modelled 100.0 16 Fold:Trypsin-like serine proteases Superfamily:Trypsin-like serine proteases Family:Eukaryotic proteases 57 c3h7oB_ not modelled 100.0 13 PDB header:hydrolase Chain: B: PDB Molecule:group 3 allergen smipp-s yv6023a04; PDBTitle: crystal structure of scabies mite inactivated protease paralogue s-i12 (smipp-s-i1) 58 d1bioa_ not modelled 99.9 21 Fold:Trypsin-like serine proteases Superfamily:Trypsin-like serine proteases Family:Eukaryotic proteases 59 d1t32a1 not modelled 99.9 16 Fold:Trypsin-like serine proteases Superfamily:Trypsin-like serine proteases Family:Eukaryotic proteases 60 d1ao5a_ not modelled 99.9 18 Fold:Trypsin-like serine proteases Superfamily:Trypsin-like serine proteases Family:Eukaryotic proteases 61 c2zghA_ not modelled 99.9 19 PDB header:hydrolase Chain: A: PDB Molecule:granzyme m; PDBTitle: crystal structure of active granzyme m bound to its product 62 c1ym0A_ not modelled 99.9 15 PDB header:hydrolase Chain: A: PDB Molecule:fibrinotic enzyme component b; PDBTitle: crystal structure of earthworm fibrinolytic enzyme component b: a2 novel, glycosylated two-chained trypsin 63 d2bz6h1 not modelled 99.9 20 Fold:Trypsin-like serine proteases Superfamily:Trypsin-like serine proteases Family:Eukaryotic proteases 64 d1ltoa_ not modelled 99.9 19 Fold:Trypsin-like serine proteases Superfamily:Trypsin-like serine proteases Family:Eukaryotic proteases 65 d1fi8a_ not modelled 99.9 16 Fold:Trypsin-like serine proteases Superfamily:Trypsin-like serine proteases Family:Eukaryotic proteases 66 c3fzzB_ not modelled 99.9 15 PDB header:hydrolase Chain: B: PDB Molecule:granzyme c; PDBTitle: structure of grc 67 c2aiqA_ not modelled 99.9 19 PDB header:hydrolase Chain: A: PDB Molecule:protein c activator; PDBTitle: crystal structure of benzamidine-inhibited protein c activator from2 the venom of copperhead snake agkistrodon contortrix contortrix 68 d1elva1 not modelled 99.9 15 Fold:Trypsin-like serine proteases Superfamily:Trypsin-like serine proteases Family:Eukaryotic proteases 69 d1eufa_ not modelled 99.9 17 Fold:Trypsin-like serine proteases Superfamily:Trypsin-like serine proteases Family:Eukaryotic proteases 70 c2zchP_ not modelled 99.9 16 PDB header:immune system Chain: P: PDB Molecule:prostate-specific antigen; PDBTitle: crystal structure of human prostate specific antigen2 complexed with an activating antibody 71 d1iaua_ not modelled 99.9 14 Fold:Trypsin-like serine proteases Superfamily:Trypsin-like serine proteases Family:Eukaryotic proteases 72 d1gdna_ not modelled 99.9 20 Fold:Trypsin-like serine proteases Superfamily:Trypsin-like serine proteases Family:Eukaryotic proteases 73 d1kigh_ not modelled 99.9 16 Fold:Trypsin-like serine proteases Superfamily:Trypsin-like serine proteases Family:Eukaryotic proteases 74 c1fiwA_ not modelled 99.9 20 PDB header:hydrolase Chain: A: PDB Molecule:beta-acrosin heavy chain; PDBTitle: three-dimensional structure of beta-acrosin from ram spermatozoa 75 d1brup_ not modelled 99.9 14 Fold:Trypsin-like serine proteases Superfamily:Trypsin-like serine proteases Family:Eukaryotic proteases 76 d1lo6a_ not modelled 99.9 24 Fold:Trypsin-like serine proteases Superfamily:Trypsin-like serine proteases Family:Eukaryotic proteases 77 d2p3ub1 not modelled 99.9 16 Fold:Trypsin-like serine proteases Superfamily:Trypsin-like serine proteases Family:Eukaryotic proteases 78 c2oq5A_ not modelled 99.9 19 PDB header:hydrolase Chain: A: PDB Molecule:transmembrane protease, serine 11e; PDBTitle: crystal structure of desc1, a new member of the type ii2 transmembrane serine proteinases family 79 d1fxya_ not modelled 99.9 18 Fold:Trypsin-like serine proteases Superfamily:Trypsin-like serine proteases Family:Eukaryotic proteases 80 d2fpza1 not modelled 99.9 20 Fold:Trypsin-like serine proteases Superfamily:Trypsin-like serine proteases Family:Eukaryotic proteases 81 c2qxhA_ not modelled 99.9 16 PDB header:hydrolase Chain: A: PDB Molecule:kallikrein-7; PDBTitle: crystal structure of human kallikrein 7 in complex with suc-2 ala-ala-pro-phe-chloromethylketone 82 d1autc_ not modelled 99.9 21 Fold:Trypsin-like serine proteases Superfamily:Trypsin-like serine proteases Family:Eukaryotic proteases 83 d1m9ua_ not modelled 99.9 19 Fold:Trypsin-like serine proteases Superfamily:Trypsin-like serine proteases Family:Eukaryotic proteases 84 d1os8a_ not modelled 99.9 19 Fold:Trypsin-like serine proteases Superfamily:Trypsin-like serine proteases Family:Prokaryotic proteases 85 d1op0a_ not modelled 99.9 19 Fold:Trypsin-like serine proteases Superfamily:Trypsin-like serine proteases Family:Eukaryotic proteases 86 d1sgfg_ not modelled 99.9 18 Fold:Trypsin-like serine proteases Superfamily:Trypsin-like serine proteases Family:Eukaryotic proteases 87 d1qtfa_ not modelled 99.9 19 Fold:Trypsin-like serine proteases Superfamily:Trypsin-like serine proteases Family:Prokaryotic proteases 88 c2anyA_ not modelled 99.9 16 PDB header:blood clotting, hydrolase Chain: A: PDB Molecule:plasma kallikrein, light chain; PDBTitle: expression, crystallization and the three-dimensional2 structure of the catalytic domain of human plasma3 kallikrein: implications for structure-based design of4 protease inhibitors 89 c2bdiO_ not modelled 99.9 16 PDB header:hydrolase Chain: O: PDB Molecule:kallikrein-4; PDBTitle: human kallikrein 4 complex with cobalt and p-2 aminobenzamidine 90 d1arba_ not modelled 99.9 22 Fold:Trypsin-like serine proteases Superfamily:Trypsin-like serine proteases Family:Prokaryotic proteases 91 d1sgfa_ not modelled 99.9 18 Fold:Trypsin-like serine proteases Superfamily:Trypsin-like serine proteases Family:Eukaryotic proteases 92 d1v2lt_ not modelled 99.9 15 Fold:Trypsin-like serine proteases Superfamily:Trypsin-like serine proteases Family:Eukaryotic proteases 93 d1trna_ not modelled 99.9 18 Fold:Trypsin-like serine proteases Superfamily:Trypsin-like serine proteases Family:Eukaryotic proteases 94 c1spjA_ not modelled 99.9 18 PDB header:hydrolase Chain: A: PDB Molecule:kallikrein 1; PDBTitle: structure of mature human tissue kallikrein (human kallikrein 1 or2 klk1) at 1.70 angstrom resolution with vacant active site 95 d1eq9a_ not modelled 99.9 20 Fold:Trypsin-like serine proteases Superfamily:Trypsin-like serine proteases Family:Eukaryotic proteases 96 d1pfxc_ not modelled 99.9 15 Fold:Trypsin-like serine proteases Superfamily:Trypsin-like serine proteases Family:Eukaryotic proteases 97 d1a7sa_ not modelled 99.9 21 Fold:Trypsin-like serine proteases Superfamily:Trypsin-like serine proteases Family:Eukaryotic proteases 98 d1fuja_ not modelled 99.9 19 Fold:Trypsin-like serine proteases Superfamily:Trypsin-like serine proteases Family:Eukaryotic proteases 99 d1nn6a_ not modelled 99.9 18 Fold:Trypsin-like serine proteases Superfamily:Trypsin-like serine proteases Family:Eukaryotic proteases 100 d1tona_ not modelled 99.9 17 Fold:Trypsin-like serine proteases Superfamily:Trypsin-like serine proteases Family:Eukaryotic proteases 101 d2hlca_ not modelled 99.9 19 Fold:Trypsin-like serine proteases Superfamily:Trypsin-like serine proteases Family:Eukaryotic proteases 102 d1dpoa_ not modelled 99.9 16 Fold:Trypsin-like serine proteases Superfamily:Trypsin-like serine proteases Family:Eukaryotic proteases 103 d1hj9a_ not modelled 99.9 16 Fold:Trypsin-like serine proteases Superfamily:Trypsin-like serine proteases Family:Eukaryotic proteases 104 d1q3xa1 not modelled 99.9 19 Fold:Trypsin-like serine proteases Superfamily:Trypsin-like serine proteases Family:Eukaryotic proteases 105 d1hj8a_ not modelled 99.9 12 Fold:Trypsin-like serine proteases Superfamily:Trypsin-like serine proteases Family:Eukaryotic proteases 106 d1a0ja_ not modelled 99.9 17 Fold:Trypsin-like serine proteases Superfamily:Trypsin-like serine proteases Family:Eukaryotic proteases 107 d2qy0b1 not modelled 99.9 16 Fold:Trypsin-like serine proteases Superfamily:Trypsin-like serine proteases Family:Eukaryotic proteases 108 d1h4wa_ not modelled 99.9 18 Fold:Trypsin-like serine proteases Superfamily:Trypsin-like serine proteases Family:Eukaryotic proteases 109 d1orfa_ not modelled 99.9 18 Fold:Trypsin-like serine proteases Superfamily:Trypsin-like serine proteases Family:Eukaryotic proteases 110 c2as9B_ not modelled 99.9 15 PDB header:hydrolase Chain: B: PDB Molecule:serine protease; PDBTitle: functional and structural characterization of spl proteases2 from staphylococcus aureus 111 d2a31a1 not modelled 99.9 18 Fold:Trypsin-like serine proteases Superfamily:Trypsin-like serine proteases Family:Eukaryotic proteases 112 c2psxA_ not modelled 99.9 18 PDB header:hydrolase/hydrolase inhibitor Chain: A: PDB Molecule:kallikrein-5; PDBTitle: crystal structure of human kallikrein 5 in complex with leupeptin 113 d1pytc_ not modelled 99.9 17 Fold:Trypsin-like serine proteases Superfamily:Trypsin-like serine proteases Family:Eukaryotic proteases 114 c1bhxB_ not modelled 99.9 22 PDB header:serine protease Chain: B: PDB Molecule:alpha thrombin; PDBTitle: x-ray structure of the complex of human alpha thrombin with the2 inhibitor sdz 229-357 115 d1bqya_ not modelled 99.9 22 Fold:Trypsin-like serine proteases Superfamily:Trypsin-like serine proteases Family:Eukaryotic proteases 116 d1azza_ not modelled 99.9 17 Fold:Trypsin-like serine proteases Superfamily:Trypsin-like serine proteases Family:Eukaryotic proteases 117 d2z7fe1 not modelled 99.9 19 Fold:Trypsin-like serine proteases Superfamily:Trypsin-like serine proteases Family:Eukaryotic proteases 118 c1uhbA_ not modelled 99.9 16 PDB header:hydrolase Chain: A: PDB Molecule:trypsin; PDBTitle: crystal structure of porcine alpha trypsin bound with auto2 catalyticaly produced native peptide at 2.15 a resolution 119 d1fona_ not modelled 99.9 18 Fold:Trypsin-like serine proteases Superfamily:Trypsin-like serine proteases Family:Eukaryotic proteases 120 c2ea3A_ not modelled 99.8 16 PDB header:hydrolase Chain: A: PDB Molecule:chymotrypsin; PDBTitle: crystal structure of cellulomonas bogoriensis chymotrypsin

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0