Phyre Home Retrieve Phyre Job Id
Emaill.a.kelley@imperial.ac.uk
DescriptionP77726
DateThu Jan 5 12:32:08 GMT 2012
Unique Job IDc3328e9df60909bc

Summary 

Top model
Image coloured by rainbow N → C terminus
Model (left) based on template d1pv7a_
Top template information
Fold:MFS general substrate transporter
Superfamily:MFS general substrate transporter
Family:LacY-like proton/sugar symporter
Confidence and coverage
Confidence:100.0% Coverage: 88%
400 residues ( 88% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.
Additional confident templates have been detected (see Domain analysis) which cover other regions of your sequence.
454 residues (100%) could be modelled at >90% confidence using multiple-templates.
You may wish to try resubmitting your sequence in "intensive" mode to model more of your sequence.
3D viewing
Interactive 3D view in Jmol

Sequence analysis 

Secondary structure and disorder prediction 

   1........10.........20.........30.........40.........50.........60
Sequence  MNDYKMTPGERRATWGLGTVFSLRMLGMFMVLPVLTTYGMALQGASEALIGIAIGIYGLT
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Disorder  ?????????































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   .........70.........80.........90.........100.........110.........120
Sequence  QAVFQIPFGLLSDRIGRKPLIVGGLAVFAAGSVIAALSDSIWGIILGRALQGSGAIAAAV
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   .........130.........140.........150.........160.........170.........180
Sequence  MALLSDLTREQNRTKAMAFIGVSFGITFAIAMVLGPIITHKLGLHALFWMIAILATTGIA
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   .........190.........200.........210.........220.........230.........240
Sequence  LTIWVVPNSSTHVLNRESGMVKGSFSKVLAEPRLLKLNFGIMCLHILLMSTFVALPGQLA
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   .........250.........260.........270.........280.........290.........300
Sequence  DAGFPAAEHWKVYLATMLIAFGSVVPFIIYAEVKRKMKQVFVFCVGLIVVAEIVLWNAQT
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   .........310.........320.........330.........340.........350.........360
Sequence  QFWQLVVGVQLFFVAFNLMEALLPSLISKESPAGYKGTAMGVYSTSQFLGVAIGGSLGGW
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   .........370.........380.........390.........400.........410.........420
Sequence  INGMFDGQGVFLAGAMLAAVWLTVASTMKEPPYVSSLRIEIPANIAANEALKVRLLETEG
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?????????????????????




????

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   .........430.........440.........450....
Sequence  IKEVLIAEEEHSAYVKIDSKVTNRFEIEQAIRQA
Secondary structure 










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?
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???
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Confidence Key
High(9)                    Low (0)
?Disordered
Alpha helix
Beta strand

Domain analysis 

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

RankAligned region

PDB 1pv7 chain A

3D model

Region: 6 - 405
Aligned: 400
Modelled: 400
Confidence: 100.0%
Identity: 16%
Fold: MFS general substrate transporter
Superfamily: MFS general substrate transporter
Family: LacY-like proton/sugar symporter

Phyre2

PDB 1pw4 chain A

3D model

Region: 1 - 402
Aligned: 401
Modelled: 402
Confidence: 100.0%
Identity: 10%
Fold: MFS general substrate transporter
Superfamily: MFS general substrate transporter
Family: Glycerol-3-phosphate transporter

Phyre2

PDB 2gfp chain A

3D model

Region: 14 - 382
Aligned: 367
Modelled: 369
Confidence: 100.0%
Identity: 19%
PDB header:membrane protein
Chain: A: PDB Molecule:multidrug resistance protein d;
PDBTitle: structure of the multidrug transporter emrd from2 escherichia coli

Phyre2

PDB 3o7p chain A

3D model

Region: 12 - 390
Aligned: 376
Modelled: 379
Confidence: 99.9%
Identity: 12%
PDB header:transport protein
Chain: A: PDB Molecule:l-fucose-proton symporter;
PDBTitle: crystal structure of the e.coli fucose:proton symporter, fucp (n162a)

Phyre2

PDB 2xut chain C

3D model

Region: 17 - 388
Aligned: 372
Modelled: 372
Confidence: 99.9%
Identity: 13%
PDB header:transport protein
Chain: C: PDB Molecule:proton/peptide symporter family protein;
PDBTitle: crystal structure of a proton dependent oligopeptide (pot)2 family transporter.

Phyre2

PDB 2ofh chain X

3D model

Region: 391 - 454
Aligned: 64
Modelled: 64
Confidence: 95.0%
Identity: 14%
PDB header:hydrolase, membrane protein
Chain: X: PDB Molecule:zinc-transporting atpase;
PDBTitle: solution structure of the n-terminal domain of the zinc(ii) atpase2 ziaa in its apo form

Phyre2

PDB 2ldi chain A

3D model

Region: 391 - 454
Aligned: 64
Modelled: 64
Confidence: 94.7%
Identity: 16%
PDB header:hydrolase
Chain: A: PDB Molecule:zinc-transporting atpase;
PDBTitle: nmr solution structure of ziaan sub mutant

Phyre2

PDB 2l3m chain A

3D model

Region: 390 - 454
Aligned: 65
Modelled: 65
Confidence: 93.2%
Identity: 22%
PDB header:metal binding protein
Chain: A: PDB Molecule:copper-ion-binding protein;
PDBTitle: solution structure of the putative copper-ion-binding protein from2 bacillus anthracis str. ames

Phyre2

PDB 1osd chain A

3D model

Region: 392 - 454
Aligned: 63
Modelled: 63
Confidence: 92.7%
Identity: 21%
Fold: Ferredoxin-like
Superfamily: HMA, heavy metal-associated domain
Family: HMA, heavy metal-associated domain

Phyre2

PDB 1afi chain A

3D model

Region: 392 - 453
Aligned: 62
Modelled: 62
Confidence: 92.5%
Identity: 19%
Fold: Ferredoxin-like
Superfamily: HMA, heavy metal-associated domain
Family: HMA, heavy metal-associated domain

Phyre2

PDB 2qif chain A domain 1

3D model

Region: 396 - 454
Aligned: 59
Modelled: 59
Confidence: 92.3%
Identity: 20%
Fold: Ferredoxin-like
Superfamily: HMA, heavy metal-associated domain
Family: HMA, heavy metal-associated domain

Phyre2

PDB 1cpz chain A

3D model

Region: 395 - 454
Aligned: 60
Modelled: 60
Confidence: 92.3%
Identity: 20%
Fold: Ferredoxin-like
Superfamily: HMA, heavy metal-associated domain
Family: HMA, heavy metal-associated domain

Phyre2

PDB 1yjr chain A

3D model

Region: 396 - 453
Aligned: 58
Modelled: 58
Confidence: 92.1%
Identity: 17%
PDB header:hydrolase
Chain: A: PDB Molecule:copper-transporting atpase 1;
PDBTitle: solution structure of the apo form of the sixth soluble2 domain a69p mutant of menkes protein

Phyre2

PDB 1q8l chain A

3D model

Region: 396 - 454
Aligned: 59
Modelled: 59
Confidence: 92.0%
Identity: 8%
Fold: Ferredoxin-like
Superfamily: HMA, heavy metal-associated domain
Family: HMA, heavy metal-associated domain

Phyre2

PDB 2kkh chain A

3D model

Region: 388 - 453
Aligned: 66
Modelled: 66
Confidence: 91.7%
Identity: 17%
PDB header:metal transport
Chain: A: PDB Molecule:putative heavy metal transporter;
PDBTitle: structure of the zinc binding domain of the atpase hma4

Phyre2

PDB 2kt2 chain A

3D model

Region: 394 - 454
Aligned: 60
Modelled: 61
Confidence: 91.6%
Identity: 17%
PDB header:oxidoreductase
Chain: A: PDB Molecule:mercuric reductase;
PDBTitle: structure of nmera, the n-terminal hma domain of tn501 mercuric2 reductase

Phyre2

PDB 1kvj chain A

3D model

Region: 388 - 453
Aligned: 66
Modelled: 66
Confidence: 91.2%
Identity: 18%
Fold: Ferredoxin-like
Superfamily: HMA, heavy metal-associated domain
Family: HMA, heavy metal-associated domain

Phyre2

PDB 2ga7 chain A

3D model

Region: 391 - 454
Aligned: 64
Modelled: 64
Confidence: 91.2%
Identity: 13%
PDB header:hydrolase
Chain: A: PDB Molecule:copper-transporting atpase 1;
PDBTitle: solution structure of the copper(i) form of the third metal-2 binding domain of atp7a protein (menkes disease protein)

Phyre2

PDB 3dxs chain X

3D model

Region: 396 - 454
Aligned: 59
Modelled: 59
Confidence: 91.2%
Identity: 17%
PDB header:hydrolase
Chain: X: PDB Molecule:copper-transporting atpase ran1;
PDBTitle: crystal structure of a copper binding domain from hma7, a p-2 type atpase

Phyre2

PDB 1s6u chain A

3D model

Region: 396 - 453
Aligned: 58
Modelled: 58
Confidence: 90.2%
Identity: 9%
Fold: Ferredoxin-like
Superfamily: HMA, heavy metal-associated domain
Family: HMA, heavy metal-associated domain

Phyre2
1

d1pv7a_
2

d1pw4a_
3

c2gfpA_
4

c3o7pA_
5

c2xutC_
6

c2ofhX_
7

c2ldiA_
8

c2l3mA_
9

d1osda_
10

d1afia_
11

d2qifa1
12

d1cpza_
13

c1yjrA_
14

d1q8la_
15

c2kkhA_
16

c2kt2A_
17

d1kvja_
18

c2ga7A_
19

c3dxsX_
20

d1s6ua_
21



22



23



24



25



26



27



28



29



30



31



32



33



34



35



36



37



38



39



40



41



42



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48



49



50



51



52



53



54



55



56



57



58






Detailed template information 

#
Template Alignment Coverage3D Model Confidence
% i.d. Template Information
1d1pv7a_



100.0 16 Fold:MFS general substrate transporter
Superfamily:MFS general substrate transporter
Family:LacY-like proton/sugar symporter
2d1pw4a_



100.0 10 Fold:MFS general substrate transporter
Superfamily:MFS general substrate transporter
Family:Glycerol-3-phosphate transporter
3c2gfpA_



100.0 19 PDB header:membrane protein
Chain: A: PDB Molecule:multidrug resistance protein d;
PDBTitle: structure of the multidrug transporter emrd from2 escherichia coli
4c3o7pA_



99.9 12 PDB header:transport protein
Chain: A: PDB Molecule:l-fucose-proton symporter;
PDBTitle: crystal structure of the e.coli fucose:proton symporter, fucp (n162a)
5c2xutC_



99.9 13 PDB header:transport protein
Chain: C: PDB Molecule:proton/peptide symporter family protein;
PDBTitle: crystal structure of a proton dependent oligopeptide (pot)2 family transporter.
6c2ofhX_



95.0 14 PDB header:hydrolase, membrane protein
Chain: X: PDB Molecule:zinc-transporting atpase;
PDBTitle: solution structure of the n-terminal domain of the zinc(ii) atpase2 ziaa in its apo form
7c2ldiA_



94.7 16 PDB header:hydrolase
Chain: A: PDB Molecule:zinc-transporting atpase;
PDBTitle: nmr solution structure of ziaan sub mutant
8c2l3mA_



93.2 22 PDB header:metal binding protein
Chain: A: PDB Molecule:copper-ion-binding protein;
PDBTitle: solution structure of the putative copper-ion-binding protein from2 bacillus anthracis str. ames
9d1osda_



92.7 21 Fold:Ferredoxin-like
Superfamily:HMA, heavy metal-associated domain
Family:HMA, heavy metal-associated domain
10d1afia_



92.5 19 Fold:Ferredoxin-like
Superfamily:HMA, heavy metal-associated domain
Family:HMA, heavy metal-associated domain
11d2qifa1



92.3 20 Fold:Ferredoxin-like
Superfamily:HMA, heavy metal-associated domain
Family:HMA, heavy metal-associated domain
12d1cpza_



92.3 20 Fold:Ferredoxin-like
Superfamily:HMA, heavy metal-associated domain
Family:HMA, heavy metal-associated domain
13c1yjrA_



92.1 17 PDB header:hydrolase
Chain: A: PDB Molecule:copper-transporting atpase 1;
PDBTitle: solution structure of the apo form of the sixth soluble2 domain a69p mutant of menkes protein
14d1q8la_



92.0 8 Fold:Ferredoxin-like
Superfamily:HMA, heavy metal-associated domain
Family:HMA, heavy metal-associated domain
15c2kkhA_



91.7 17 PDB header:metal transport
Chain: A: PDB Molecule:putative heavy metal transporter;
PDBTitle: structure of the zinc binding domain of the atpase hma4
16c2kt2A_



91.6 17 PDB header:oxidoreductase
Chain: A: PDB Molecule:mercuric reductase;
PDBTitle: structure of nmera, the n-terminal hma domain of tn501 mercuric2 reductase
17d1kvja_



91.2 18 Fold:Ferredoxin-like
Superfamily:HMA, heavy metal-associated domain
Family:HMA, heavy metal-associated domain
18c2ga7A_



91.2 13 PDB header:hydrolase
Chain: A: PDB Molecule:copper-transporting atpase 1;
PDBTitle: solution structure of the copper(i) form of the third metal-2 binding domain of atp7a protein (menkes disease protein)
19c3dxsX_



91.2 17 PDB header:hydrolase
Chain: X: PDB Molecule:copper-transporting atpase ran1;
PDBTitle: crystal structure of a copper binding domain from hma7, a p-2 type atpase
20d1s6ua_



90.2 9 Fold:Ferredoxin-like
Superfamily:HMA, heavy metal-associated domain
Family:HMA, heavy metal-associated domain
21d2aw0a_



not modelled 90.0 13 Fold:Ferredoxin-like
Superfamily:HMA, heavy metal-associated domain
Family:HMA, heavy metal-associated domain
22c2ropA_



not modelled 89.5 15 PDB header:hydrolase
Chain: A: PDB Molecule:copper-transporting atpase 2;
PDBTitle: solution structure of domains 3 and 4 of human atp7b
23c2ew9A_



not modelled 89.4 20 PDB header:hydrolase
Chain: A: PDB Molecule:copper-transporting atpase 2;
PDBTitle: solution structure of apowln5-6
24d1p6ta1



not modelled 88.9 14 Fold:Ferredoxin-like
Superfamily:HMA, heavy metal-associated domain
Family:HMA, heavy metal-associated domain
25c1y3kA_



not modelled 87.3 19 PDB header:hydrolase
Chain: A: PDB Molecule:copper-transporting atpase 1;
PDBTitle: solution structure of the apo form of the fifth domain of2 menkes protein
26d1p6ta2



not modelled 87.1 16 Fold:Ferredoxin-like
Superfamily:HMA, heavy metal-associated domain
Family:HMA, heavy metal-associated domain
27c3j09A_



not modelled 85.9 18 PDB header:hydrolase, metal transport
Chain: A: PDB Molecule:copper-exporting p-type atpase a;
PDBTitle: high resolution helical reconstruction of the bacterial p-type atpase2 copper transporter copa
28d2ggpb1



not modelled 84.5 15 Fold:Ferredoxin-like
Superfamily:HMA, heavy metal-associated domain
Family:HMA, heavy metal-associated domain
29c1yg0A_



not modelled 84.4 17 PDB header:metal transport
Chain: A: PDB Molecule:cop associated protein;
PDBTitle: solution structure of apo-copp from helicobacter pylori
30c2rmlA_



not modelled 82.0 16 PDB header:hydrolase
Chain: A: PDB Molecule:copper-transporting p-type atpase copa;
PDBTitle: solution structure of the n-terminal soluble domains of2 bacillus subtilis copa
31c2rogA_



not modelled 78.3 20 PDB header:metal binding protein
Chain: A: PDB Molecule:heavy metal binding protein;
PDBTitle: solution structure of thermus thermophilus hb8 ttha17182 protein in living e. coli cells
32c2k2pA_



not modelled 72.8 18 PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:uncharacterized protein atu1203;
PDBTitle: solution nmr structure of protein atu1203 from agrobacterium2 tumefaciens. northeast structural genomics consortium (nesg) target3 att10, ontario center for structural proteomics target atc1183
33c2gcfA_



not modelled 72.7 15 PDB header:hydrolase
Chain: A: PDB Molecule:cation-transporting atpase pacs;
PDBTitle: solution structure of the n-terminal domain of the coppper(i) atpase2 pacs in its apo form
34d1sb6a_



not modelled 72.4 16 Fold:Ferredoxin-like
Superfamily:HMA, heavy metal-associated domain
Family:HMA, heavy metal-associated domain
35d1cc8a_



not modelled 52.0 16 Fold:Ferredoxin-like
Superfamily:HMA, heavy metal-associated domain
Family:HMA, heavy metal-associated domain
36c2crlA_



not modelled 49.7 16 PDB header:chaperone
Chain: A: PDB Molecule:copper chaperone for superoxide dismutase;
PDBTitle: the apo form of hma domain of copper chaperone for2 superoxide dismutase
37c1qupA_



not modelled 47.2 20 PDB header:chaperone
Chain: A: PDB Molecule:superoxide dismutase 1 copper chaperone;
PDBTitle: crystal structure of the copper chaperone for superoxide2 dismutase
38c2kyzA_



not modelled 42.8 17 PDB header:metal binding protein
Chain: A: PDB Molecule:heavy metal binding protein;
PDBTitle: nmr structure of heavy metal binding protein tm0320 from thermotoga2 maritima
39d1qupa2



not modelled 42.2 20 Fold:Ferredoxin-like
Superfamily:HMA, heavy metal-associated domain
Family:HMA, heavy metal-associated domain
40c1jk9D_



not modelled 41.4 20 PDB header:oxidoreductase
Chain: D: PDB Molecule:copper chaperone for superoxide dismutase;
PDBTitle: heterodimer between h48f-ysod1 and yccs
41c2aj1A_



not modelled 39.9 13 PDB header:hydrolase
Chain: A: PDB Molecule:probable cadmium-transporting atpase;
PDBTitle: solution structure of apocada
42d1mwza_



not modelled 28.6 16 Fold:Ferredoxin-like
Superfamily:HMA, heavy metal-associated domain
Family:HMA, heavy metal-associated domain
43c2g9pA_



not modelled 17.6 43 PDB header:antimicrobial protein
Chain: A: PDB Molecule:antimicrobial peptide latarcin 2a;
PDBTitle: nmr structure of a novel antimicrobial peptide, latarcin 2a,2 from spider (lachesana tarabaevi) venom
44d1fe0a_



not modelled 17.4 12 Fold:Ferredoxin-like
Superfamily:HMA, heavy metal-associated domain
Family:HMA, heavy metal-associated domain
45c3hd6A_



not modelled 15.3 9 PDB header:membrane protein, transport protein
Chain: A: PDB Molecule:ammonium transporter rh type c;
PDBTitle: crystal structure of the human rhesus glycoprotein rhcg
46c3ff5B_



not modelled 11.1 31 PDB header:protein transport
Chain: B: PDB Molecule:peroxisomal biogenesis factor 14;
PDBTitle: crystal structure of the conserved n-terminal domain of the2 peroxisomal matrix-protein-import receptor, pex14p
47d2czra1



not modelled 7.5 19 Fold:Restriction endonuclease-like
Superfamily:TBP-interacting protein-like
Family:TBP-interacting protein-like
48c2w85A_



not modelled 6.9 31 PDB header:protein transport
Chain: A: PDB Molecule:peroxisomal membrane anchor protein pex14;
PDBTitle: structure of pex14 in compex with pex19
49d1wi6a1



not modelled 6.9 15 Fold:Ferredoxin-like
Superfamily:RNA-binding domain, RBD
Family:Canonical RBD
50d2p02a3



not modelled 6.3 9 Fold:S-adenosylmethionine synthetase
Superfamily:S-adenosylmethionine synthetase
Family:S-adenosylmethionine synthetase
51d1weya_



not modelled 6.3 6 Fold:Ferredoxin-like
Superfamily:RNA-binding domain, RBD
Family:Canonical RBD
52c3fryB_



not modelled 6.2 15 PDB header:hydrolase
Chain: B: PDB Molecule:probable copper-exporting p-type atpase a;
PDBTitle: crystal structure of the copa c-terminal metal binding domain
53c2pc6C_



not modelled 5.4 16 PDB header:lyase
Chain: C: PDB Molecule:probable acetolactate synthase isozyme iii (small subunit);
PDBTitle: crystal structure of putative acetolactate synthase- small subunit2 from nitrosomonas europaea
54d1mxaa3



not modelled 5.4 11 Fold:S-adenosylmethionine synthetase
Superfamily:S-adenosylmethionine synthetase
Family:S-adenosylmethionine synthetase
55c2e1aD_



not modelled 5.3 20 PDB header:transcription
Chain: D: PDB Molecule:75aa long hypothetical regulatory protein asnc;
PDBTitle: crystal structure of ffrp-dm1
56c2zbcH_



not modelled 5.3 14 PDB header:transcription
Chain: H: PDB Molecule:83aa long hypothetical transcriptional regulator asnc;
PDBTitle: crystal structure of sts042, a stand-alone ram module protein, from2 hyperthermophilic archaeon sulfolobus tokodaii strain7.
57c2f1fA_



not modelled 5.3 17 PDB header:transferase
Chain: A: PDB Molecule:acetolactate synthase isozyme iii small subunit;
PDBTitle: crystal structure of the regulatory subunit of2 acetohydroxyacid synthase isozyme iii from e. coli
58c3fw2A_



not modelled 5.1 11 PDB header:oxidoreductase
Chain: A: PDB Molecule:thiol-disulfide oxidoreductase;
PDBTitle: c-terminal domain of putative thiol-disulfide oxidoreductase from2 bacteroides thetaiotaomicron.

Binding site prediction 

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite



Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
 
© Structural Bioinformatics Group
Imperial College London
Lawrence Kelley, Benjamin Jefferys
Disclaimer
Terms and Conditions
Component software
Template detection: HHpred 1.51
Secondary structure prediction: Psi-pred 2.5
Disorder prediction: Disopred 2.4
Transmembrane prediction: Memsat_SVM
Multi-template modelling and ab initio: Poing 1.0