Phyre Home Retrieve Phyre Job Id
Emaill.a.kelley@imperial.ac.uk
DescriptionP76498
DateThu Jan 5 12:23:34 GMT 2012
Unique Job IDaec17e4e8f8d947f

Summary 

Top model
Image coloured by rainbow N → C terminus
Model (left) based on template d1aqta2
Top template information
Fold:Epsilon subunit of F1F0-ATP synthase N-terminal domain
Superfamily:Epsilon subunit of F1F0-ATP synthase N-terminal domain
Family:Epsilon subunit of F1F0-ATP synthase N-terminal domain
Confidence and coverage
Confidence: 37.3% Coverage: 16%
43 residues ( 16% of your sequence) have been modelled with 37.3% confidence by the single highest scoring template.
You may wish to submit your sequence to Phyrealarm. This will automatically scan your sequence every week for new potential templates as they appear in the Phyre2 library.
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3D viewing
Interactive 3D view in Jmol

Sequence analysis 

Secondary structure and disorder prediction 

   1........10.........20.........30.........40.........50.........60
Sequence  MKILRWLFALVMLIATTEAMAAGHSVDVYYGYNGDSRNIATFNLKIMMPSAVYVGEYKSS
Secondary structure 












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Disorder  ????










????????


































?
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   .........70.........80.........90.........100.........110.........120
Sequence  QWLMTGEILQNVSWSGPPPAPSVKLIGYHQNINKASCPGLPSGWNCGYYTFEVIVSAEIE
Secondary structure 





























SS confidence 



























































Disorder  ?
??



??



?










??????
???





















??
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   .........130.........140.........150.........160.........170.........180
Sequence  SYFSCPWLVIMNDSEASPGGVTYQGPDSHDTICPSVSVQPYDVSWNENYVSKSKLLTLQS
Secondary structure 
































SS confidence 



























































Disorder 













????????
??
?????
?



?










?????



??
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   .........190.........200.........210.........220.........230.........240
Sequence  TGGVVEKTLSTYLMKDGKLCDSTQMNETGGYCRWVAQMITFTASGCDKAEVSVTPNRHPI
Secondary structure 























SS confidence 



























































Disorder  ??
















?????????



















?



?

??

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   .........250.........260.........270...
Sequence  TDKQLHDMVVRVDTSSMQPIDSTCRFQYILNEL
Secondary structure 








SS confidence 
































Disorder 













???????






?????
Disorder confidence 
































 

Confidence Key
High(9)                    Low (0)
?Disordered
Alpha helix
Beta strand

Domain analysis 

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

RankAligned region

PDB 1aqt chain A domain 2

3D model

Region: 40 - 87
Aligned: 43
Modelled: 48
Confidence: 37.3%
Identity: 21%
Fold: Epsilon subunit of F1F0-ATP synthase N-terminal domain
Superfamily: Epsilon subunit of F1F0-ATP synthase N-terminal domain
Family: Epsilon subunit of F1F0-ATP synthase N-terminal domain

Phyre2

PDB 1s3r chain A

3D model

Region: 161 - 211
Aligned: 45
Modelled: 51
Confidence: 35.3%
Identity: 27%
PDB header:toxin
Chain: A: PDB Molecule:intermedilysin;
PDBTitle: crystal structure of the human-specific toxin intermedilysin

Phyre2

PDB 1pfo chain A

3D model

Region: 161 - 211
Aligned: 45
Modelled: 51
Confidence: 33.1%
Identity: 20%
PDB header:toxin
Chain: A: PDB Molecule:perfringolysin o;
PDBTitle: perfringolysin o

Phyre2

PDB 1pfo chain A

3D model

Region: 161 - 211
Aligned: 45
Modelled: 51
Confidence: 33.1%
Identity: 20%
Fold: Perfringolysin
Superfamily: Perfringolysin
Family: Perfringolysin

Phyre2

PDB 1fs0 chain E

3D model

Region: 40 - 54
Aligned: 15
Modelled: 15
Confidence: 30.3%
Identity: 13%
PDB header:hydrolase
Chain: E: PDB Molecule:atp synthase epsilon subunit;
PDBTitle: complex of gamma/epsilon atp synthase from e.coli

Phyre2

PDB 2rq7 chain A

3D model

Region: 40 - 54
Aligned: 15
Modelled: 15
Confidence: 29.8%
Identity: 7%
PDB header:hydrolase
Chain: A: PDB Molecule:atp synthase epsilon chain;
PDBTitle: solution structure of the epsilon subunit chimera combining2 the n-terminal beta-sandwich domain from t. elongatus bp-13 f1 and the c-terminal alpha-helical domain from spinach4 chloroplast f1

Phyre2

PDB 2p02 chain A domain 3

3D model

Region: 201 - 234
Aligned: 33
Modelled: 34
Confidence: 29.2%
Identity: 30%
Fold: S-adenosylmethionine synthetase
Superfamily: S-adenosylmethionine synthetase
Family: S-adenosylmethionine synthetase

Phyre2

PDB 1g94 chain A domain 1

3D model

Region: 176 - 233
Aligned: 45
Modelled: 58
Confidence: 28.2%
Identity: 20%
Fold: Glycosyl hydrolase domain
Superfamily: Glycosyl hydrolase domain
Family: alpha-Amylases, C-terminal beta-sheet domain

Phyre2

PDB 1qm4 chain A domain 3

3D model

Region: 201 - 234
Aligned: 33
Modelled: 34
Confidence: 27.6%
Identity: 30%
Fold: S-adenosylmethionine synthetase
Superfamily: S-adenosylmethionine synthetase
Family: S-adenosylmethionine synthetase

Phyre2

PDB 3dhp chain A domain 1

3D model

Region: 176 - 237
Aligned: 49
Modelled: 62
Confidence: 27.2%
Identity: 24%
Fold: Glycosyl hydrolase domain
Superfamily: Glycosyl hydrolase domain
Family: alpha-Amylases, C-terminal beta-sheet domain

Phyre2

PDB 3b5w chain E

3D model

Region: 192 - 217
Aligned: 26
Modelled: 26
Confidence: 25.2%
Identity: 19%
PDB header:membrane protein
Chain: E: PDB Molecule:lipid a export atp-binding/permease protein msba;
PDBTitle: crystal structure of eschericia coli msba

Phyre2

PDB 2xu8 chain B

3D model

Region: 73 - 127
Aligned: 51
Modelled: 55
Confidence: 22.5%
Identity: 27%
PDB header:structural genomics
Chain: B: PDB Molecule:pa1645;
PDBTitle: structure of pa1645

Phyre2

PDB 2e74 chain D domain 1

3D model

Region: 200 - 239
Aligned: 40
Modelled: 40
Confidence: 22.5%
Identity: 23%
Fold: ISP domain
Superfamily: ISP domain
Family: Rieske iron-sulfur protein (ISP)

Phyre2

PDB 3so4 chain C

3D model

Region: 201 - 234
Aligned: 33
Modelled: 34
Confidence: 21.0%
Identity: 27%
PDB header:transferase
Chain: C: PDB Molecule:methionine-adenosyltransferase;
PDBTitle: methionine-adenosyltransferase from entamoeba histolytica

Phyre2

PDB 3hvn chain A

3D model

Region: 161 - 211
Aligned: 45
Modelled: 51
Confidence: 20.2%
Identity: 20%
PDB header:toxin
Chain: A: PDB Molecule:hemolysin;
PDBTitle: crystal structure of cytotoxin protein suilysin from2 streptococcus suis

Phyre2

PDB 2e5y chain A

3D model

Region: 40 - 88
Aligned: 44
Modelled: 49
Confidence: 19.9%
Identity: 18%
PDB header:hydrolase
Chain: A: PDB Molecule:atp synthase epsilon chain;
PDBTitle: epsilon subunit and atp complex of f1f0-atp synthase from2 the thermophilic bacillus ps3

Phyre2

PDB 1v58 chain A domain 2

3D model

Region: 192 - 209
Aligned: 18
Modelled: 18
Confidence: 19.8%
Identity: 44%
Fold: Cystatin-like
Superfamily: DsbC/DsbG N-terminal domain-like
Family: DsbC/DsbG N-terminal domain-like

Phyre2

PDB 2obv chain A

3D model

Region: 201 - 234
Aligned: 33
Modelled: 34
Confidence: 19.7%
Identity: 30%
PDB header:transferase
Chain: A: PDB Molecule:s-adenosylmethionine synthetase isoform type-1;
PDBTitle: crystal structure of the human s-adenosylmethionine synthetase 1 in2 complex with the product

Phyre2

PDB 1rg9 chain D

3D model

Region: 201 - 234
Aligned: 32
Modelled: 34
Confidence: 19.2%
Identity: 34%
PDB header:transferase
Chain: D: PDB Molecule:s-adenosylmethionine synthetase;
PDBTitle: s-adenosylmethionine synthetase complexed with sam and ppnp

Phyre2

PDB 3iml chain B

3D model

Region: 201 - 234
Aligned: 33
Modelled: 34
Confidence: 18.9%
Identity: 24%
PDB header:transferase
Chain: B: PDB Molecule:s-adenosylmethionine synthetase;
PDBTitle: crystal structure of s-adenosylmethionine synthetase from burkholderia2 pseudomallei

Phyre2
1

d1aqta2
2

c1s3rA_
3

c1pfoA_
4

d1pfoa_
5

c1fs0E_
6

c2rq7A_
7

d2p02a3
8

d1g94a1
9

d1qm4a3
10

d3dhpa1
11

c3b5wE_
12

c2xu8B_
13

d2e74d1
14

c3so4C_
15

c3hvnA_
16

c2e5yA_
17

d1v58a2
18

c2obvA_
19

c1rg9D_
20

c3imlB_
21



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26



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46



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49



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59



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62



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65






Detailed template information 

#
Template Alignment Coverage3D Model Confidence
% i.d. Template Information
1d1aqta2



37.3 21 Fold:Epsilon subunit of F1F0-ATP synthase N-terminal domain
Superfamily:Epsilon subunit of F1F0-ATP synthase N-terminal domain
Family:Epsilon subunit of F1F0-ATP synthase N-terminal domain
2c1s3rA_



35.3 27 PDB header:toxin
Chain: A: PDB Molecule:intermedilysin;
PDBTitle: crystal structure of the human-specific toxin intermedilysin
3c1pfoA_



33.1 20 PDB header:toxin
Chain: A: PDB Molecule:perfringolysin o;
PDBTitle: perfringolysin o
4d1pfoa_



33.1 20 Fold:Perfringolysin
Superfamily:Perfringolysin
Family:Perfringolysin
5c1fs0E_



30.3 13 PDB header:hydrolase
Chain: E: PDB Molecule:atp synthase epsilon subunit;
PDBTitle: complex of gamma/epsilon atp synthase from e.coli
6c2rq7A_



29.8 7 PDB header:hydrolase
Chain: A: PDB Molecule:atp synthase epsilon chain;
PDBTitle: solution structure of the epsilon subunit chimera combining2 the n-terminal beta-sandwich domain from t. elongatus bp-13 f1 and the c-terminal alpha-helical domain from spinach4 chloroplast f1
7d2p02a3



29.2 30 Fold:S-adenosylmethionine synthetase
Superfamily:S-adenosylmethionine synthetase
Family:S-adenosylmethionine synthetase
8d1g94a1



28.2 20 Fold:Glycosyl hydrolase domain
Superfamily:Glycosyl hydrolase domain
Family:alpha-Amylases, C-terminal beta-sheet domain
9d1qm4a3



27.6 30 Fold:S-adenosylmethionine synthetase
Superfamily:S-adenosylmethionine synthetase
Family:S-adenosylmethionine synthetase
10d3dhpa1



27.2 24 Fold:Glycosyl hydrolase domain
Superfamily:Glycosyl hydrolase domain
Family:alpha-Amylases, C-terminal beta-sheet domain
11c3b5wE_



25.2 19 PDB header:membrane protein
Chain: E: PDB Molecule:lipid a export atp-binding/permease protein msba;
PDBTitle: crystal structure of eschericia coli msba
12c2xu8B_



22.5 27 PDB header:structural genomics
Chain: B: PDB Molecule:pa1645;
PDBTitle: structure of pa1645
13d2e74d1



22.5 23 Fold:ISP domain
Superfamily:ISP domain
Family:Rieske iron-sulfur protein (ISP)
14c3so4C_



21.0 27 PDB header:transferase
Chain: C: PDB Molecule:methionine-adenosyltransferase;
PDBTitle: methionine-adenosyltransferase from entamoeba histolytica
15c3hvnA_



20.2 20 PDB header:toxin
Chain: A: PDB Molecule:hemolysin;
PDBTitle: crystal structure of cytotoxin protein suilysin from2 streptococcus suis
16c2e5yA_



19.9 18 PDB header:hydrolase
Chain: A: PDB Molecule:atp synthase epsilon chain;
PDBTitle: epsilon subunit and atp complex of f1f0-atp synthase from2 the thermophilic bacillus ps3
17d1v58a2



19.8 44 Fold:Cystatin-like
Superfamily:DsbC/DsbG N-terminal domain-like
Family:DsbC/DsbG N-terminal domain-like
18c2obvA_



19.7 30 PDB header:transferase
Chain: A: PDB Molecule:s-adenosylmethionine synthetase isoform type-1;
PDBTitle: crystal structure of the human s-adenosylmethionine synthetase 1 in2 complex with the product
19c1rg9D_



19.2 34 PDB header:transferase
Chain: D: PDB Molecule:s-adenosylmethionine synthetase;
PDBTitle: s-adenosylmethionine synthetase complexed with sam and ppnp
20c3imlB_



18.9 24 PDB header:transferase
Chain: B: PDB Molecule:s-adenosylmethionine synthetase;
PDBTitle: crystal structure of s-adenosylmethionine synthetase from burkholderia2 pseudomallei
21c3rv2B_



not modelled 17.6 27 PDB header:transferase
Chain: B: PDB Molecule:s-adenosylmethionine synthase;
PDBTitle: crystal structure of s-adenosylmethionine synthetase from2 mycobacterium marinum
22c2wanA_



not modelled 16.2 25 PDB header:hydrolase
Chain: A: PDB Molecule:pullulanase;
PDBTitle: pullulanase from bacillus acidopullulyticus
23c2l92A_



not modelled 13.6 50 PDB header:dna binding protein
Chain: A: PDB Molecule:histone family protein nucleoid-structuring protein h-ns;
PDBTitle: solution structure of the c-terminal domain of h-ns like protein bv3f
24c1h8eH_



not modelled 13.3 14 PDB header:hydrolase
Chain: H: PDB Molecule:bovine mitochondrial f1-atpase;
PDBTitle: (adp.alf4)2(adp.so4) bovine f1-atpase2 (all three catalytic sites occupied)
25c3ebeA_



not modelled 11.8 24 PDB header:replication
Chain: A: PDB Molecule:protein mcm10 homolog;
PDBTitle: crystal structure of xenopus laevis replication initiation factor2 mcm10 internal domain
26d2j07a1



not modelled 11.8 23 Fold:Cryptochrome/photolyase FAD-binding domain
Superfamily:Cryptochrome/photolyase FAD-binding domain
Family:Cryptochrome/photolyase FAD-binding domain
27d1ig4a_



not modelled 10.6 50 Fold:DNA-binding domain
Superfamily:DNA-binding domain
Family:Methyl-CpG-binding domain, MBD
28d1e6vb2



not modelled 10.5 18 Fold:Ferredoxin-like
Superfamily:Methyl-coenzyme M reductase subunits
Family:Methyl-coenzyme M reductase alpha and beta chain N-terminal domain
29c2qe7H_



not modelled 10.3 27 PDB header:hydrolase
Chain: H: PDB Molecule:atp synthase subunit epsilon;
PDBTitle: crystal structure of the f1-atpase from the thermoalkaliphilic2 bacterium bacillus sp. ta2.a1
30d1ik0a_



not modelled 9.9 35 Fold:4-helical cytokines
Superfamily:4-helical cytokines
Family:Short-chain cytokines
31d1hbnb2



not modelled 9.4 45 Fold:Ferredoxin-like
Superfamily:Methyl-coenzyme M reductase subunits
Family:Methyl-coenzyme M reductase alpha and beta chain N-terminal domain
32d1mxaa3



not modelled 9.2 30 Fold:S-adenosylmethionine synthetase
Superfamily:S-adenosylmethionine synthetase
Family:S-adenosylmethionine synthetase
33d1jaea1



not modelled 9.1 26 Fold:Glycosyl hydrolase domain
Superfamily:Glycosyl hydrolase domain
Family:alpha-Amylases, C-terminal beta-sheet domain
34c1dvaY_



not modelled 8.9 40 PDB header:hydrolase/hydrolase inhibitor
Chain: Y: PDB Molecule:peptide e-76;
PDBTitle: crystal structure of the complex between the peptide exosite inhibitor2 e-76 and coagulation factor viia
35c1dvaX_



not modelled 8.9 40 PDB header:hydrolase/hydrolase inhibitor
Chain: X: PDB Molecule:peptide e-76;
PDBTitle: crystal structure of the complex between the peptide exosite inhibitor2 e-76 and coagulation factor viia
36d1r44a_



not modelled 8.8 20 Fold:Hedgehog/DD-peptidase
Superfamily:Hedgehog/DD-peptidase
Family:VanX-like
37d2j2ja1



not modelled 8.6 33 Fold:Virus attachment protein globular domain
Superfamily:Virus attachment protein globular domain
Family:Adenovirus fiber protein "knob" domain
38c2e76D_



not modelled 8.6 25 PDB header:photosynthesis
Chain: D: PDB Molecule:cytochrome b6-f complex iron-sulfur subunit;
PDBTitle: crystal structure of the cytochrome b6f complex with tridecyl-2 stigmatellin (tds) from m.laminosus
39c3ideD_



not modelled 8.5 21 PDB header:virus like particle
Chain: D: PDB Molecule:capsid protein vp2;
PDBTitle: structure of ipnv subviral particle
40c2df7H_



not modelled 8.5 43 PDB header:virus like particle
Chain: H: PDB Molecule:structural polyprotein vp2;
PDBTitle: crystal structure of infectious bursal disease virus vp2 subviral2 particle
41c2wstE_



not modelled 8.4 50 PDB header:viral protein
Chain: E: PDB Molecule:putative fiber protein;
PDBTitle: head domain of porcine adenovirus type 4 nadc-1 isolate2 fibre
42d2df7a1



not modelled 8.3 43 Fold:Nucleoplasmin-like/VP (viral coat and capsid proteins)
Superfamily:Positive stranded ssRNA viruses
Family:Birnaviridae-like VP
43c2rkcA_



not modelled 8.2 20 PDB header:viral protein
Chain: A: PDB Molecule:hemagglutinin;
PDBTitle: crystal structure of the measles virus hemagglutinin
44c3m05A_



not modelled 8.0 29 PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:uncharacterized protein pepe_1480;
PDBTitle: the crystal structure of a functionally unknown protein2 pepe_1480 from pediococcus pentosaceus atcc 25745
45c2ky8A_



not modelled 7.7 60 PDB header:transcription/dna
Chain: A: PDB Molecule:methyl-cpg-binding domain protein 2;
PDBTitle: solution structure and dynamic analysis of chicken mbd2 methyl binding2 domain bound to a target methylated dna sequence
46d1v1ha1



not modelled 7.6 25 Fold:Triple beta-spiral
Superfamily:Fibre shaft of virus attachment proteins
Family:Adenovirus
47c2yxhB_



not modelled 7.4 75 PDB header:structural genomics, unknown function
Chain: B: PDB Molecule:mazg-related protein;
PDBTitle: crystal structure of mazg-related protein from thermotoga maritima
48d1ua7a1



not modelled 7.4 17 Fold:Glycosyl hydrolase domain
Superfamily:Glycosyl hydrolase domain
Family:alpha-Amylases, C-terminal beta-sheet domain
49d1wi9a_



not modelled 7.4 24 Fold:DNA/RNA-binding 3-helical bundle
Superfamily:"Winged helix" DNA-binding domain
Family:PCI domain (PINT motif)
50c3oqcB_



not modelled 7.3 25 PDB header:hydrolase
Chain: B: PDB Molecule:ufm1-specific protease 2;
PDBTitle: ubiquitin-fold modifier 1 specific protease, ufsp2
51c1z8rA_



not modelled 7.3 34 PDB header:hydrolase
Chain: A: PDB Molecule:coxsackievirus b4 polyprotein;
PDBTitle: 2a cysteine proteinase from human coxsackievirus b4 (strain2 jvb / benschoten / new york / 51)
52c2z84A_



not modelled 7.2 67 PDB header:hydrolase
Chain: A: PDB Molecule:ufm1-specific protease 1;
PDBTitle: insights from crystal and solution structures of mouse ufsp1
53c3crcB_



not modelled 7.0 25 PDB header:hydrolase
Chain: B: PDB Molecule:protein mazg;
PDBTitle: crystal structure of escherichia coli mazg, the regulator2 of nutritional stress response
54d2j4wd1



not modelled 6.7 80 Fold:Apical membrane antigen 1
Superfamily:Apical membrane antigen 1
Family:Apical membrane antigen 1
55c2j4wD_



not modelled 6.7 80 PDB header:immune system
Chain: D: PDB Molecule:apical membrane antigen 1;
PDBTitle: structure of a plasmodium vivax apical membrane antigen 1-2 fab f8.12.19 complex
56d2ysca1



not modelled 6.0 71 Fold:WW domain-like
Superfamily:WW domain
Family:WW domain
57c2i5pO_



not modelled 5.9 21 PDB header:oxidoreductase
Chain: O: PDB Molecule:glyceraldehyde-3-phosphate dehydrogenase 1;
PDBTitle: crystal structure of glyceraldehyde-3-phosphate2 dehydrogenase isoform 1 from k. marxianus
58c2l1qA_



not modelled 5.9 42 PDB header:antimicrobial protein
Chain: A: PDB Molecule:liver-expressed antimicrobial peptide 2;
PDBTitle: solution structure of human liver expressed antimicrobial peptide 2
59c3obhA_



not modelled 5.9 28 PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:uncharacterized protein;
PDBTitle: x-ray crystal structure of protein sp_0782 (7-79) from streptococcus2 pneumoniae. northeast structural genomics consortium target spr104
60c2pbdV_



not modelled 5.9 75 PDB header:structural protein
Chain: V: PDB Molecule:vasodilator-stimulated phosphoprotein;
PDBTitle: ternary complex of profilin-actin with the poly-pro-gab2 domain of vasp*
61c2yyyB_



not modelled 5.9 23 PDB header:oxidoreductase
Chain: B: PDB Molecule:glyceraldehyde-3-phosphate dehydrogenase;
PDBTitle: crystal structure of glyceraldehyde-3-phosphate2 dehydrogenase
62c2j5lA_



not modelled 5.7 100 PDB header:immune system
Chain: A: PDB Molecule:apical membrane antigen 1;
PDBTitle: structure of a plasmodium falciparum apical membrane2 antigen 1-fab f8.12.19 complex
63d2j5la1



not modelled 5.7 100 Fold:Apical membrane antigen 1
Superfamily:Apical membrane antigen 1
Family:Apical membrane antigen 1
64d1obfo2



not modelled 5.7 21 Fold:FwdE/GAPDH domain-like
Superfamily:Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
Family:GAPDH-like
65d1rm4a2



not modelled 5.2 27 Fold:FwdE/GAPDH domain-like
Superfamily:Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
Family:GAPDH-like

Binding site prediction 

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite



Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
 
© Structural Bioinformatics Group
Imperial College London
Lawrence Kelley, Benjamin Jefferys
Disclaimer
Terms and Conditions
Component software
Template detection: HHpred 1.51
Secondary structure prediction: Psi-pred 2.5
Disorder prediction: Disopred 2.4
Transmembrane prediction: Memsat_SVM
Multi-template modelling and ab initio: Poing 1.0