Phyre Home Retrieve Phyre Job Id
Emaill.a.kelley@imperial.ac.uk
DescriptionP0AEC3
DateThu Jan 5 11:22:59 GMT 2012
Unique Job IDa2079f6f10b94eea

Summary 

Top model
Image coloured by rainbow N → C terminus
Model (left) based on template c2c2aA_
Top template information
PDB header:transferase
Chain: A: PDB Molecule:sensor histidine kinase;
PDBTitle: structure of the entire cytoplasmic portion of a sensor2 histidine kinase protein
Confidence and coverage
Confidence:100.0% Coverage: 30%
233 residues ( 30% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.
Additional confident templates have been detected (see Domain analysis) which cover other regions of your sequence.
610 residues ( 78%) could be modelled at >90% confidence using multiple-templates.
You may wish to try resubmitting your sequence in "intensive" mode to model more of your sequence.
3D viewing
Interactive 3D view in Jmol

Sequence analysis 

Secondary structure and disorder prediction 

   1........10.........20.........30.........40.........50.........60
Sequence  MKQIRLLAQYYVDLMMKLGLVRFSMLLALALVVLAIVVQMAVTMVLHGQVESIDVIRSIF
Secondary structure 







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Disorder  ???















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   .........70.........80.........90.........100.........110.........120
Sequence  FGLLITPWAVYFLSVVVEQLEESRQRLSRLVQKLEEMRERDLSLNVQLKDNIAQLNQEIA
Secondary structure 





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???
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?
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   .........130.........140.........150.........160.........170.........180
Sequence  VREKAEAELQETFGQLKIEIKEREETQIQLEQQSSFLRSFLDASPDLVFYRNEDKEFSGC
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   .........190.........200.........210.........220.........230.........240
Sequence  NRAMELLTGKSEKQLVHLKPADVYSPEAAAKVIETDEKVFRHNVSLTYEQWLDYPDGRKA
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?
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   .........250.........260.........270.........280.........290.........300
Sequence  CFEIRKVPYYDRVGKRHGLMGFGRDITERKRYQDALERASRDKTTFISTISHELRTPLNG
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   .........310.........320.........330.........340.........350.........360
Sequence  IVGLSRILLDTELTAEQEKYLKTIHVSAVTLGNIFNDIIDMDKMERRKVQLDNQPVDFTS
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   .........370.........380.........390.........400.........410.........420
Sequence  FLADLENLSALQAQQKGLRFNLEPTLPLPHQVITDGTRLRQILWNLISNAVKFTQQGQVT
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   .........430.........440.........450.........460.........470.........480
Sequence  VRVRYDEGDMLHFEVEDSGIGIPQDELDKIFAMYYQVKDSHGGKPATGTGIGLAVSRRLA
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??






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   .........490.........500.........510.........520.........530.........540
Sequence  KNMGGDITVTSEQGKGSTFTLTIHAPSVAEEVDDAFDEDDMPLPALNVLLVEDIELNVIV
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   .........550.........560.........570.........580.........590.........600
Sequence  ARSVLEKLGNSVDVAMTGKAALEMFKPGEYDLVLLDIQLPDMTGLDISRELTKRYPREDL
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?
?????
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   .........610.........620.........630.........640.........650.........660
Sequence  PPLVALTANVLKDKQEYLNAGMDDVLSKPLSVPALTAMIKKFWDTQDDEESTVTTEENSK
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????????????????
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   .........670.........680.........690.........700.........710.........720
Sequence  SEALLDIPMLEQYLELVGPKLITDGLAVFEKMMPGYVSVLESNLTAQDKKGIVEEGHKIK
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   .........730.........740.........750.........760.........770........
Sequence  GAAGSVGLRHLQQLGQQIQSPDLPAWEDNVGEWIEEMKEEWRHDVEVLKAWVAKATKK
Secondary structure 








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?????


























?????
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Confidence Key
High(9)                    Low (0)
?Disordered
Alpha helix
Beta strand

Domain analysis 

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

RankAligned region

PDB 2c2a chain A

3D model

Region: 263 - 506
Aligned: 233
Modelled: 244
Confidence: 100.0%
Identity: 33%
PDB header:transferase
Chain: A: PDB Molecule:sensor histidine kinase;
PDBTitle: structure of the entire cytoplasmic portion of a sensor2 histidine kinase protein

Phyre2

PDB 3a0r chain A

3D model

Region: 156 - 510
Aligned: 329
Modelled: 355
Confidence: 100.0%
Identity: 20%
PDB header:transferase
Chain: A: PDB Molecule:sensor protein;
PDBTitle: crystal structure of histidine kinase thka (tm1359) in complex with2 response regulator protein trra (tm1360)

Phyre2

PDB 3d36 chain B

3D model

Region: 276 - 507
Aligned: 219
Modelled: 232
Confidence: 100.0%
Identity: 21%
PDB header:transferase/transferase inhibitor
Chain: B: PDB Molecule:sporulation kinase b;
PDBTitle: how to switch off a histidine kinase: crystal structure of2 geobacillus stearothermophilus kinb with the inhibitor sda

Phyre2

PDB 3d2r chain B

3D model

Region: 268 - 515
Aligned: 244
Modelled: 248
Confidence: 100.0%
Identity: 18%
PDB header:transferase
Chain: B: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 4;
PDBTitle: crystal structure of pyruvate dehydrogenase kinase isoform 4 in2 complex with adp

Phyre2

PDB 2q8f chain A

3D model

Region: 268 - 510
Aligned: 242
Modelled: 243
Confidence: 100.0%
Identity: 19%
PDB header:transferase
Chain: A: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 1;
PDBTitle: structure of pyruvate dehydrogenase kinase isoform 1

Phyre2

PDB 1y8o chain A

3D model

Region: 267 - 533
Aligned: 257
Modelled: 267
Confidence: 100.0%
Identity: 16%
PDB header:transferase
Chain: A: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 3;
PDBTitle: crystal structure of the pdk3-l2 complex

Phyre2

PDB 2bu8 chain A

3D model

Region: 268 - 516
Aligned: 241
Modelled: 249
Confidence: 100.0%
Identity: 17%
PDB header:transferase
Chain: A: PDB Molecule:pyruvate dehydrogenase kinase isoenzyme 2;
PDBTitle: crystal structures of human pyruvate dehydrogenase kinase 22 containing physiological and synthetic ligands

Phyre2

PDB 1gjv chain A

3D model

Region: 269 - 511
Aligned: 233
Modelled: 243
Confidence: 100.0%
Identity: 18%
PDB header:transferase
Chain: A: PDB Molecule:[3-methyl-2-oxobutanoate dehydrogenase
PDBTitle: branched-chain alpha-ketoacid dehydrogenase kinase (bck)2 complxed with atp-gamma-s

Phyre2

PDB 2ayx chain A

3D model

Region: 416 - 643
Aligned: 224
Modelled: 228
Confidence: 99.9%
Identity: 19%
PDB header:transferase
Chain: A: PDB Molecule:sensor kinase protein rcsc;
PDBTitle: solution structure of the e.coli rcsc c-terminus (residues2 700-949) containing linker region and phosphoreceiver3 domain

Phyre2

PDB 2c2a chain A domain 2

3D model

Region: 350 - 506
Aligned: 147
Modelled: 157
Confidence: 99.9%
Identity: 33%
Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family: Histidine kinase

Phyre2

PDB 3a0t chain A

3D model

Region: 351 - 510
Aligned: 152
Modelled: 160
Confidence: 99.9%
Identity: 22%
PDB header:transferase
Chain: A: PDB Molecule:sensor protein;
PDBTitle: catalytic domain of histidine kinase thka (tm1359) in2 complex with adp and mg ion (trigonal)

Phyre2

PDB 1b3q chain A

3D model

Region: 291 - 507
Aligned: 208
Modelled: 217
Confidence: 99.9%
Identity: 18%
PDB header:transferase
Chain: A: PDB Molecule:protein (chemotaxis protein chea);
PDBTitle: crystal structure of chea-289, a signal transducing histidine kinase

Phyre2

PDB 1gkz chain A domain 2

3D model

Region: 354 - 511
Aligned: 151
Modelled: 158
Confidence: 99.9%
Identity: 23%
Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family: alpha-ketoacid dehydrogenase kinase, C-terminal domain

Phyre2

PDB 1id0 chain A

3D model

Region: 353 - 507
Aligned: 146
Modelled: 155
Confidence: 99.9%
Identity: 23%
Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family: Histidine kinase

Phyre2

PDB 1bxd chain A

3D model

Region: 346 - 516
Aligned: 160
Modelled: 170
Confidence: 99.9%
Identity: 18%
Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family: Histidine kinase

Phyre2

PDB 1jm6 chain A domain 2

3D model

Region: 354 - 515
Aligned: 156
Modelled: 162
Confidence: 99.9%
Identity: 21%
Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family: alpha-ketoacid dehydrogenase kinase, C-terminal domain

Phyre2

PDB 3jz3 chain B

3D model

Region: 321 - 504
Aligned: 149
Modelled: 154
Confidence: 99.9%
Identity: 22%
PDB header:transferase
Chain: B: PDB Molecule:sensor protein qsec;
PDBTitle: structure of the cytoplasmic segment of histidine kinase qsec

Phyre2

PDB 1ysr chain A domain 1

3D model

Region: 352 - 507
Aligned: 136
Modelled: 141
Confidence: 99.9%
Identity: 24%
Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family: Histidine kinase

Phyre2

PDB 2ch4 chain A

3D model

Region: 356 - 511
Aligned: 153
Modelled: 156
Confidence: 99.9%
Identity: 22%
PDB header:transferase/chemotaxis
Chain: A: PDB Molecule:chemotaxis protein chea;
PDBTitle: complex between bacterial chemotaxis histidine kinase chea2 domains p4 and p5 and receptor-adaptor protein chew

Phyre2

PDB 1w25 chain B

3D model

Region: 525 - 643
Aligned: 118
Modelled: 119
Confidence: 99.9%
Identity: 31%
PDB header:signaling protein
Chain: B: PDB Molecule:stalked-cell differentiation controlling protein;
PDBTitle: response regulator pled in complex with c-digmp

Phyre2

PDB 1zn2 chain A

3D model

Region: 525 - 718
Aligned: 191
Modelled: 191
Confidence: 99.8%
Identity: 21%
PDB header:transcription regulator
Chain: A: PDB Molecule:response regulatory protein;
PDBTitle: low resolution structure of response regulator styr

Phyre2

PDB 2a0b chain A

3D model

Region: 659 - 776
Aligned: 118
Modelled: 118
Confidence: 99.7%
Identity: 100%
Fold: Four-helical up-and-down bundle
Superfamily: Histidine-containing phosphotransfer domain, HPT domain
Family: Aerobic respiration control sensor protein, ArcB

Phyre2
1

c2c2aA_
2

c3a0rA_
3

c3d36B_
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c3d2rB_
5

c2q8fA_
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c1y8oA_
7

c2bu8A_
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c1gjvA_
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c2ayxA_
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d2c2aa2
11

c3a0tA_
12

c1b3qA_
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d1gkza2
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d1id0a_
15

d1bxda_
16

d1jm6a2
17

c3jz3B_
18

d1ysra1
19

c2ch4A_
20

c1w25B_
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c1zn2A_
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d2a0ba_
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Detailed template information 

#
Template Alignment Coverage3D Model Confidence
% i.d. Template Information
1c2c2aA_



100.0 33 PDB header:transferase
Chain: A: PDB Molecule:sensor histidine kinase;
PDBTitle: structure of the entire cytoplasmic portion of a sensor2 histidine kinase protein
2c3a0rA_



100.0 20 PDB header:transferase
Chain: A: PDB Molecule:sensor protein;
PDBTitle: crystal structure of histidine kinase thka (tm1359) in complex with2 response regulator protein trra (tm1360)
3c3d36B_



100.0 21 PDB header:transferase/transferase inhibitor
Chain: B: PDB Molecule:sporulation kinase b;
PDBTitle: how to switch off a histidine kinase: crystal structure of2 geobacillus stearothermophilus kinb with the inhibitor sda
4c3d2rB_



100.0 18 PDB header:transferase
Chain: B: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 4;
PDBTitle: crystal structure of pyruvate dehydrogenase kinase isoform 4 in2 complex with adp
5c2q8fA_



100.0 19 PDB header:transferase
Chain: A: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 1;
PDBTitle: structure of pyruvate dehydrogenase kinase isoform 1
6c1y8oA_



100.0 16 PDB header:transferase
Chain: A: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 3;
PDBTitle: crystal structure of the pdk3-l2 complex
7c2bu8A_



100.0 17 PDB header:transferase
Chain: A: PDB Molecule:pyruvate dehydrogenase kinase isoenzyme 2;
PDBTitle: crystal structures of human pyruvate dehydrogenase kinase 22 containing physiological and synthetic ligands
8c1gjvA_



100.0 18 PDB header:transferase
Chain: A: PDB Molecule:[3-methyl-2-oxobutanoate dehydrogenase
PDBTitle: branched-chain alpha-ketoacid dehydrogenase kinase (bck)2 complxed with atp-gamma-s
9c2ayxA_



99.9 19 PDB header:transferase
Chain: A: PDB Molecule:sensor kinase protein rcsc;
PDBTitle: solution structure of the e.coli rcsc c-terminus (residues2 700-949) containing linker region and phosphoreceiver3 domain
10d2c2aa2



99.9 33 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Histidine kinase
11c3a0tA_



99.9 22 PDB header:transferase
Chain: A: PDB Molecule:sensor protein;
PDBTitle: catalytic domain of histidine kinase thka (tm1359) in2 complex with adp and mg ion (trigonal)
12c1b3qA_



99.9 18 PDB header:transferase
Chain: A: PDB Molecule:protein (chemotaxis protein chea);
PDBTitle: crystal structure of chea-289, a signal transducing histidine kinase
13d1gkza2



99.9 23 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:alpha-ketoacid dehydrogenase kinase, C-terminal domain
14d1id0a_



99.9 23 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Histidine kinase
15d1bxda_



99.9 18 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Histidine kinase
16d1jm6a2



99.9 21 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:alpha-ketoacid dehydrogenase kinase, C-terminal domain
17c3jz3B_



99.9 22 PDB header:transferase
Chain: B: PDB Molecule:sensor protein qsec;
PDBTitle: structure of the cytoplasmic segment of histidine kinase qsec
18d1ysra1



99.9 24 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Histidine kinase
19c2ch4A_



99.9 22 PDB header:transferase/chemotaxis
Chain: A: PDB Molecule:chemotaxis protein chea;
PDBTitle: complex between bacterial chemotaxis histidine kinase chea2 domains p4 and p5 and receptor-adaptor protein chew
20c1w25B_



99.9 31 PDB header:signaling protein
Chain: B: PDB Molecule:stalked-cell differentiation controlling protein;
PDBTitle: response regulator pled in complex with c-digmp
21c3breA_



not modelled 99.9 23 PDB header:signaling protein
Chain: A: PDB Molecule:probable two-component response regulator;
PDBTitle: crystal structure of p.aeruginosa pa3702
22c3eq2A_



not modelled 99.9 28 PDB header:signaling protein
Chain: A: PDB Molecule:probable two-component response regulator;
PDBTitle: structure of hexagonal crystal form of pseudomonas2 aeruginosa rssb
23d1i58a_



not modelled 99.9 24 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Histidine kinase
24c3i5aA_



not modelled 99.9 23 PDB header:signaling protein
Chain: A: PDB Molecule:response regulator/ggdef domain protein;
PDBTitle: crystal structure of full-length wpsr from pseudomonas syringae
25c3gt7A_



not modelled 99.9 24 PDB header:hydrolase
Chain: A: PDB Molecule:sensor protein;
PDBTitle: crystal structure of signal receiver domain of signal2 transduction histidine kinase from syntrophus3 aciditrophicus
26c3lteH_



not modelled 99.9 24 PDB header:transcription
Chain: H: PDB Molecule:response regulator;
PDBTitle: crystal structure of response regulator (signal receiver domain) from2 bermanella marisrubri
27d1mb3a_



not modelled 99.8 34 Fold:Flavodoxin-like
Superfamily:CheY-like
Family:CheY-related
28d1k66a_



not modelled 99.8 25 Fold:Flavodoxin-like
Superfamily:CheY-like
Family:CheY-related
29c2zayA_



not modelled 99.8 22 PDB header:signaling protein
Chain: A: PDB Molecule:response regulator receiver protein;
PDBTitle: crystal structure of response regulator from desulfuromonas2 acetoxidans
30c3t6kB_



not modelled 99.8 25 PDB header:signaling protein
Chain: B: PDB Molecule:response regulator receiver;
PDBTitle: crystal structure of a hypothetical response regulator (caur_3799)2 from chloroflexus aurantiacus j-10-fl at 1.86 a resolution
31d1w25a1



not modelled 99.8 32 Fold:Flavodoxin-like
Superfamily:CheY-like
Family:CheY-related
32d2ayxa1



not modelled 99.8 28 Fold:Flavodoxin-like
Superfamily:CheY-like
Family:CheY-related
33d1p6qa_



not modelled 99.8 22 Fold:Flavodoxin-like
Superfamily:CheY-like
Family:CheY-related
34d1heya_



not modelled 99.8 26 Fold:Flavodoxin-like
Superfamily:CheY-like
Family:CheY-related
35c3h1gA_



not modelled 99.8 23 PDB header:signaling protein
Chain: A: PDB Molecule:chemotaxis protein chey homolog;
PDBTitle: crystal structure of chey mutant t84a of helicobacter pylori
36d1peya_



not modelled 99.8 26 Fold:Flavodoxin-like
Superfamily:CheY-like
Family:CheY-related
37d2pl1a1



not modelled 99.8 31 Fold:Flavodoxin-like
Superfamily:CheY-like
Family:CheY-related
38d1jbea_



not modelled 99.8 26 Fold:Flavodoxin-like
Superfamily:CheY-like
Family:CheY-related
39d2r25b1



not modelled 99.8 29 Fold:Flavodoxin-like
Superfamily:CheY-like
Family:CheY-related
40c3n0rA_



not modelled 99.8 23 PDB header:signaling protein
Chain: A: PDB Molecule:response regulator;
PDBTitle: structure of the phyr stress response regulator at 1.25 angstrom2 resolution
41c3gl9B_



not modelled 99.8 28 PDB header:signaling protein
Chain: B: PDB Molecule:response regulator;
PDBTitle: the structure of a histidine kinase-response regulator2 complex sheds light into two-component signaling and3 reveals a novel cis autophosphorylation mechanism
42d1u0sy_



not modelled 99.8 27 Fold:Flavodoxin-like
Superfamily:CheY-like
Family:CheY-related
43c3cnbC_



not modelled 99.8 21 PDB header:dna binding protein
Chain: C: PDB Molecule:dna-binding response regulator, merr family;
PDBTitle: crystal structure of signal receiver domain of dna binding response2 regulator protein (merr) from colwellia psychrerythraea 34h
44c1ny5A_



not modelled 99.8 30 PDB header:transcription
Chain: A: PDB Molecule:transcriptional regulator (ntrc family);
PDBTitle: crystal structure of sigm54 activator (aaa+ atpase) in the inactive2 state
45d1s8na_



not modelled 99.8 28 Fold:Flavodoxin-like
Superfamily:CheY-like
Family:CheY-related
46c3lufB_



not modelled 99.8 22 PDB header:signaling protein
Chain: B: PDB Molecule:two-component system response regulator/ggdef
PDBTitle: structure of probable two-component system response2 regulator/ggdef domain protein
47d1ny5a1



not modelled 99.8 30 Fold:Flavodoxin-like
Superfamily:CheY-like
Family:CheY-related
48d1qkka_



not modelled 99.8 23 Fold:Flavodoxin-like
Superfamily:CheY-like
Family:CheY-related
49c2zwmA_



not modelled 99.8 37 PDB header:transcription
Chain: A: PDB Molecule:transcriptional regulatory protein yycf;
PDBTitle: crystal structure of yycf receiver domain from bacillus2 subtilis
50c3c3mA_



not modelled 99.8 26 PDB header:signaling protein
Chain: A: PDB Molecule:response regulator receiver protein;
PDBTitle: crystal structure of the n-terminal domain of response regulator2 receiver protein from methanoculleus marisnigri jr1
51c3cfyA_



not modelled 99.8 23 PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:putative luxo repressor protein;
PDBTitle: crystal structure of signal receiver domain of putative luxo2 repressor protein from vibrio parahaemolyticus
52d1zesa1



not modelled 99.8 32 Fold:Flavodoxin-like
Superfamily:CheY-like
Family:CheY-related
53c3ilhA_



not modelled 99.8 18 PDB header:transcription regulator
Chain: A: PDB Molecule:two component response regulator;
PDBTitle: crystal structure of two component response regulator from cytophaga2 hutchinsonii
54c3mmnA_



not modelled 99.8 33 PDB header:transferase
Chain: A: PDB Molecule:histidine kinase homolog;
PDBTitle: crystal structure of the receiver domain of the histidine kinase cki12 from arabidopsis thaliana complexed with mg2+
55c2qvgA_



not modelled 99.8 27 PDB header:transferase
Chain: A: PDB Molecule:two component response regulator;
PDBTitle: the crystal structure of a two-component response regulator2 from legionella pneumophila
56c2rjnA_



not modelled 99.8 23 PDB header:hydrolase
Chain: A: PDB Molecule:response regulator receiver:metal-dependent
PDBTitle: crystal structure of an uncharacterized protein q2bku2 from2 neptuniibacter caesariensis
57d1mvoa_



not modelled 99.8 31 Fold:Flavodoxin-like
Superfamily:CheY-like
Family:CheY-related
58c3i42A_



not modelled 99.8 27 PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:response regulator receiver domain protein (chey-
PDBTitle: structure of response regulator receiver domain (chey-like)2 from methylobacillus flagellatus
59c3r0jA_



not modelled 99.8 31 PDB header:dna binding protein
Chain: A: PDB Molecule:possible two component system response transcriptional
PDBTitle: structure of phop from mycobacterium tuberculosis
60d1zh2a1



not modelled 99.8 35 Fold:Flavodoxin-like
Superfamily:CheY-like
Family:CheY-related
61c3nhzA_



not modelled 99.8 32 PDB header:dna binding protein
Chain: A: PDB Molecule:two component system transcriptional regulator mtra;
PDBTitle: structure of n-terminal domain of mtra
62d1i3ca_



not modelled 99.8 21 Fold:Flavodoxin-like
Superfamily:CheY-like
Family:CheY-related
63d2a9pa1



not modelled 99.8 31 Fold:Flavodoxin-like
Superfamily:CheY-like
Family:CheY-related
64c2qzjC_



not modelled 99.8 29 PDB header:transcription
Chain: C: PDB Molecule:two-component response regulator;
PDBTitle: crystal structure of a two-component response regulator from2 clostridium difficile
65c3hdgE_



not modelled 99.8 22 PDB header:structural genomics, unknown function
Chain: E: PDB Molecule:uncharacterized protein;
PDBTitle: crystal structure of the n-terminal domain of an2 uncharacterized protein (ws1339) from wolinella3 succinogenes
66d1zgza1



not modelled 99.8 30 Fold:Flavodoxin-like
Superfamily:CheY-like
Family:CheY-related
67c3cg4A_



not modelled 99.8 25 PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:response regulator receiver domain protein (chey-like);
PDBTitle: crystal structure of response regulator receiver domain protein (chey-2 like) from methanospirillum hungatei jf-1
68c3khtA_



not modelled 99.8 28 PDB header:signaling protein
Chain: A: PDB Molecule:response regulator;
PDBTitle: crystal structure of response regulator from hahella chejuensis
69d1ys7a2



not modelled 99.8 29 Fold:Flavodoxin-like
Superfamily:CheY-like
Family:CheY-related
70d1dcfa_



not modelled 99.8 24 Fold:Flavodoxin-like
Superfamily:CheY-like
Family:Receiver domain of the ethylene receptor
71d1dbwa_



not modelled 99.8 21 Fold:Flavodoxin-like
Superfamily:CheY-like
Family:CheY-related
72c3m6mF_



not modelled 99.8 27 PDB header:lyase/transferase
Chain: F: PDB Molecule:sensory/regulatory protein rpfc;
PDBTitle: crystal structure of rpff complexed with rec domain of rpfc
73c3hv2B_



not modelled 99.8 26 PDB header:signaling protein
Chain: B: PDB Molecule:response regulator/hd domain protein;
PDBTitle: crystal structure of signal receiver domain of hd domain-2 containing protein from pseudomonas fluorescens pf-5
74c3c97A_



not modelled 99.8 31 PDB header:signaling protein, transferase
Chain: A: PDB Molecule:signal transduction histidine kinase;
PDBTitle: crystal structure of the response regulator receiver domain2 of a signal transduction histidine kinase from aspergillus3 oryzae
75c3hebB_



not modelled 99.8 25 PDB header:transcription regulator
Chain: B: PDB Molecule:response regulator receiver domain protein (chey);
PDBTitle: crystal structure of response regulator receiver domain from2 rhodospirillum rubrum
76c3b2nA_



not modelled 99.8 20 PDB header:transcription
Chain: A: PDB Molecule:uncharacterized protein q99uf4;
PDBTitle: crystal structure of dna-binding response regulator, luxr family, from2 staphylococcus aureus
77c2jrlA_



not modelled 99.8 25 PDB header:transcription
Chain: A: PDB Molecule:transcriptional regulator (ntrc family);
PDBTitle: solution structure of the beryllofluoride-activated ntrc4 receiver2 domain dimer
78d1kgsa2



not modelled 99.8 28 Fold:Flavodoxin-like
Superfamily:CheY-like
Family:CheY-related
79c3jteA_



not modelled 99.8 26 PDB header:protein binding
Chain: A: PDB Molecule:response regulator receiver protein;
PDBTitle: crystal structure of response regulator receiver domain2 protein from clostridium thermocellum
80d1yioa2



not modelled 99.8 25 Fold:Flavodoxin-like
Superfamily:CheY-like
Family:CheY-related
81c2qr3A_



not modelled 99.8 19 PDB header:transcription
Chain: A: PDB Molecule:two-component system response regulator;
PDBTitle: crystal structure of the n-terminal signal receiver domain of two-2 component system response regulator from bacteroides fragilis
82c3grcD_



not modelled 99.8 25 PDB header:transferase
Chain: D: PDB Molecule:sensor protein, kinase;
PDBTitle: crystal structure of a sensor protein from polaromonas sp.2 js666
83d1dz3a_



not modelled 99.8 20 Fold:Flavodoxin-like
Superfamily:CheY-like
Family:CheY-related
84d1xhfa1



not modelled 99.8 29 Fold:Flavodoxin-like
Superfamily:CheY-like
Family:CheY-related
85c3hdvB_



not modelled 99.8 18 PDB header:transcription regulator
Chain: B: PDB Molecule:response regulator;
PDBTitle: crystal structure of response regulator receiver protein from2 pseudomonas putida
86d1krwa_



not modelled 99.8 23 Fold:Flavodoxin-like
Superfamily:CheY-like
Family:CheY-related
87c1a2oB_



not modelled 99.8 22 PDB header:bacterial chemotaxis
Chain: B: PDB Molecule:cheb methylesterase;
PDBTitle: structural basis for methylesterase cheb regulation by a2 phosphorylation-activated domain
88d1a04a2



not modelled 99.8 20 Fold:Flavodoxin-like
Superfamily:CheY-like
Family:CheY-related
89d2hkja3



not modelled 99.8 17 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:DNA gyrase/MutL, N-terminal domain
90c2gwrA_



not modelled 99.8 31 PDB header:signaling protein
Chain: A: PDB Molecule:dna-binding response regulator mtra;
PDBTitle: crystal structure of the response regulator protein mtra from2 mycobacterium tuberculosis
91c3dzdA_



not modelled 99.8 22 PDB header:transcription regulator
Chain: A: PDB Molecule:transcriptional regulator (ntrc family);
PDBTitle: crystal structure of sigma54 activator ntrc4 in the inactive2 state
92c3crnA_



not modelled 99.8 28 PDB header:signaling protein
Chain: A: PDB Molecule:response regulator receiver domain protein, chey-like;
PDBTitle: crystal structure of response regulator receiver domain protein (chey-2 like) from methanospirillum hungatei jf-1
93c2qxyB_



not modelled 99.8 24 PDB header:transcription
Chain: B: PDB Molecule:response regulator;
PDBTitle: crystal structure of a response regulator from thermotoga2 maritima
94c1ys7B_



not modelled 99.8 27 PDB header:transcription regulator
Chain: B: PDB Molecule:transcriptional regulatory protein prra;
PDBTitle: crystal structure of the response regulator protein prra comlexed with2 mg2+
95c3eulB_



not modelled 99.8 21 PDB header:transcription
Chain: B: PDB Molecule:possible nitrate/nitrite response transcriptional
PDBTitle: structure of the signal receiver domain of the putative2 response regulator narl from mycobacterium tuberculosis
96c2qv0A_



not modelled 99.8 21 PDB header:transcription
Chain: A: PDB Molecule:protein mrke;
PDBTitle: crystal structure of the response regulatory domain of2 protein mrke from klebsiella pneumoniae
97c3cu5B_



not modelled 99.8 18 PDB header:transcription regulator
Chain: B: PDB Molecule:two component transcriptional regulator, arac family;
PDBTitle: crystal structure of a two component transcriptional regulator arac2 from clostridium phytofermentans isdg
98c3luaA_



not modelled 99.8 18 PDB header:transcription regulator
Chain: A: PDB Molecule:response regulator receiver protein;
PDBTitle: crystal structure of a signal receiver domain of two component signal2 transduction (histidine kinase) from clostridium thermocellum
99c2j48A_



not modelled 99.8 23 PDB header:transferase
Chain: A: PDB Molecule:two-component sensor kinase;
PDBTitle: nmr structure of the pseudo-receiver domain of the cika2 protein.
100d1r62a_



not modelled 99.8 19 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Histidine kinase
101c3f6cB_



not modelled 99.8 19 PDB header:dna binding protein
Chain: B: PDB Molecule:positive transcription regulator evga;
PDBTitle: crystal structure of n-terminal domain of positive transcription2 regulator evga from escherichia coli
102c3nhmA_



not modelled 99.8 19 PDB header:signaling protein
Chain: A: PDB Molecule:response regulator;
PDBTitle: crystal structure of a response regulator from myxococcus xanthus
103c3rqiA_



not modelled 99.8 23 PDB header:transcription
Chain: A: PDB Molecule:response regulator protein;
PDBTitle: crystal structure of a response regulator protein from burkholderia2 pseudomallei with a phosphorylated aspartic acid, calcium ion and3 citrate
104c3cz5B_



not modelled 99.8 18 PDB header:transcription regulator
Chain: B: PDB Molecule:two-component response regulator, luxr family;
PDBTitle: crystal structure of two-component response regulator, luxr family,2 from aurantimonas sp. si85-9a1
105c3cg0A_



not modelled 99.8 26 PDB header:lyase
Chain: A: PDB Molecule:response regulator receiver modulated diguanylate cyclase
PDBTitle: crystal structure of signal receiver domain of modulated diguanylate2 cyclase from desulfovibrio desulfuricans g20, an example of alternate3 folding
106c2jk1A_



not modelled 99.8 23 PDB header:dna-binding
Chain: A: PDB Molecule:hydrogenase transcriptional regulatory protein hupr1;
PDBTitle: crystal structure of the wild-type hupr receiver domain
107c3hzhA_



not modelled 99.8 17 PDB header:signaling protein
Chain: A: PDB Molecule:chemotaxis response regulator (chey-3);
PDBTitle: crystal structure of the chex-chey-bef3-mg+2 complex from2 borrelia burgdorferi
108c1p2fA_



not modelled 99.8 28 PDB header:transcription
Chain: A: PDB Molecule:response regulator;
PDBTitle: crystal structure analysis of response regulator drrb, a2 thermotoga maritima ompr/phob homolog
109c2nt3A_



not modelled 99.8 25 PDB header:signaling protein
Chain: A: PDB Molecule:response regulator homolog;
PDBTitle: receiver domain from myxococcus xanthus social motility protein frzs2 (y102a mutant)
110c3kcnA_



not modelled 99.8 23 PDB header:lyase
Chain: A: PDB Molecule:adenylate cyclase homolog;
PDBTitle: the crystal structure of adenylate cyclase from2 rhodopirellula baltica
111d1k68a_



not modelled 99.8 18 Fold:Flavodoxin-like
Superfamily:CheY-like
Family:CheY-related
112d1p2fa2



not modelled 99.8 27 Fold:Flavodoxin-like
Superfamily:CheY-like
Family:CheY-related
113c2rdmB_



not modelled 99.8 21 PDB header:structural genomics, unknown function
Chain: B: PDB Molecule:response regulator receiver protein;
PDBTitle: crystal structure of response regulator receiver protein from2 sinorhizobium medicae wsm419
114d2b4aa1



not modelled 99.8 24 Fold:Flavodoxin-like
Superfamily:CheY-like
Family:CheY-related
115c3a0rB_



not modelled 99.8 28 PDB header:transferase
Chain: B: PDB Molecule:response regulator;
PDBTitle: crystal structure of histidine kinase thka (tm1359) in complex with2 response regulator protein trra (tm1360)
116d1w25a2



not modelled 99.8 21 Fold:Flavodoxin-like
Superfamily:CheY-like
Family:CheY-related
117c1zn2A_



99.8 21 PDB header:transcription regulator
Chain: A: PDB Molecule:response regulatory protein;
PDBTitle: low resolution structure of response regulator styr
118c3eodA_



not modelled 99.8 29 PDB header:signaling protein
Chain: A: PDB Molecule:protein hnr;
PDBTitle: crystal structure of n-terminal domain of e. coli rssb
119c1kgsA_



not modelled 99.7 29 PDB header:dna binding protein
Chain: A: PDB Molecule:dna binding response regulator d;
PDBTitle: crystal structure at 1.50 a of an ompr/phob homolog from thermotoga2 maritima
120c3h5iA_



not modelled 99.7 28 PDB header:transcription
Chain: A: PDB Molecule:response regulator/sensory box protein/ggdef
PDBTitle: crystal structure of the n-terminal domain of a response2 regulator/sensory box/ggdef 3-domain protein from3 carboxydothermus hydrogenoformans

Binding site prediction 

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite



Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
 
© Structural Bioinformatics Group
Imperial College London
Lawrence Kelley, Benjamin Jefferys
Disclaimer
Terms and Conditions
Component software
Template detection: HHpred 1.51
Secondary structure prediction: Psi-pred 2.5
Disorder prediction: Disopred 2.4
Transmembrane prediction: Memsat_SVM
Multi-template modelling and ab initio: Poing 1.0