Secondary structure and disorder prediction

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Sequence		M	Q	K	R	E	P	V	I	I	A	P	D	Y	T	D	D	E	L	Y	E	W	M	R	Q	K	I	N	A	A	Q	D	L	K	W	A	N	E	A	R	A	K	Q	A	E	N	L	S	A	L	E	Q	D	I	T	N	L	E	K	A	A
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.
Sequence		A	L	S	I	A	R	M	I	T	Y	P	R
Secondary structure
SS confidence
Disorder										?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1pkx chain A domain 2 Region: 7 - 25 Aligned: 19 Modelled: 19 Confidence: 40.6% Identity: 37% Fold: Cytidine deaminase-like Superfamily: Cytidine deaminase-like Family: AICAR transformylase domain of bifunctional purine biosynthesis enzyme ATIC Phyre2 PDB 1zcz chain A Region: 7 - 25 Aligned: 18 Modelled: 19 Confidence: 39.0% Identity: 39% PDB header:transferase/hydrolase Chain: A: PDB Molecule:bifunctional purine biosynthesis protein purh; PDBTitle: crystal structure of phosphoribosylaminoimidazolecarboxamide2 formyltransferase / imp cyclohydrolase (tm1249) from thermotoga3 maritima at 1.88 a resolution Phyre2 PDB 1g8m chain A domain 2 Region: 7 - 25 Aligned: 19 Modelled: 19 Confidence: 33.2% Identity: 26% Fold: Cytidine deaminase-like Superfamily: Cytidine deaminase-like Family: AICAR transformylase domain of bifunctional purine biosynthesis enzyme ATIC Phyre2 PDB 1zcz chain A domain 2 Region: 7 - 18 Aligned: 12 Modelled: 12 Confidence: 29.4% Identity: 42% Fold: Cytidine deaminase-like Superfamily: Cytidine deaminase-like Family: AICAR transformylase domain of bifunctional purine biosynthesis enzyme ATIC Phyre2 PDB 1thz chain A Region: 7 - 25 Aligned: 19 Modelled: 19 Confidence: 29.0% Identity: 26% PDB header:transferase, hydrolase Chain: A: PDB Molecule:bifunctional purine biosynthesis protein purh; PDBTitle: crystal structure of avian aicar transformylase in complex2 with a novel inhibitor identified by virtual ligand3 screening Phyre2 PDB 2kw0 chain A Region: 9 - 25 Aligned: 17 Modelled: 17 Confidence: 28.6% Identity: 12% PDB header:oxidoreductase Chain: A: PDB Molecule:ccmh protein; PDBTitle: solution structure of n-terminal domain of ccmh from escherichia.coli Phyre2 PDB 1cy9 chain A Region: 45 - 72 Aligned: 28 Modelled: 28 Confidence: 27.4% Identity: 36% Fold: Prokaryotic type I DNA topoisomerase Superfamily: Prokaryotic type I DNA topoisomerase Family: Prokaryotic type I DNA topoisomerase Phyre2 PDB 2hl7 chain A Region: 12 - 25 Aligned: 14 Modelled: 14 Confidence: 26.5% Identity: 21% PDB header:oxidoreductase Chain: A: PDB Molecule:cytochrome c-type biogenesis protein ccmh; PDBTitle: crystal structure of the periplasmic domain of ccmh from pseudomonas2 aeruginosa Phyre2 PDB 4a1o chain B Region: 7 - 18 Aligned: 12 Modelled: 12 Confidence: 24.1% Identity: 50% PDB header:transferase-hydrolase Chain: B: PDB Molecule:bifunctional purine biosynthesis protein purh; PDBTitle: crystal structure of mycobacterium tuberculosis purh complexed with2 aicar and a novel nucleotide cfair, at 2.48 a resolution. Phyre2 PDB 3c4m chain D Region: 17 - 33 Aligned: 17 Modelled: 16 Confidence: 23.9% Identity: 29% PDB header:membrane protein Chain: D: PDB Molecule:parathyroid hormone; PDBTitle: structure of human parathyroid hormone in complex with the2 extracellular domain of its g-protein-coupled receptor (pth1r) Phyre2 PDB 3c4m chain C Region: 17 - 33 Aligned: 17 Modelled: 16 Confidence: 23.9% Identity: 29% PDB header:membrane protein Chain: C: PDB Molecule:parathyroid hormone; PDBTitle: structure of human parathyroid hormone in complex with the2 extracellular domain of its g-protein-coupled receptor (pth1r) Phyre2 PDB 1z4h chain A Region: 13 - 30 Aligned: 18 Modelled: 18 Confidence: 23.3% Identity: 11% PDB header:protein binding, dna binding protein Chain: A: PDB Molecule:tor inhibition protein; PDBTitle: the response regulator tori belongs to a new family of2 atypical excisionase Phyre2 PDB 3jza chain B Region: 22 - 46 Aligned: 25 Modelled: 25 Confidence: 23.3% Identity: 32% PDB header:transport protein Chain: B: PDB Molecule:uncharacterized protein drra; PDBTitle: crystal structure of human rab1b in complex with the gef domain of2 drra/sidm from legionella pneumophila Phyre2 PDB 3gyq chain B Region: 18 - 28 Aligned: 11 Modelled: 11 Confidence: 23.3% Identity: 27% PDB header:transferase Chain: B: PDB Molecule:rrna (adenosine-2'-o-)-methyltransferase; PDBTitle: structure of the thiostrepton-resistance methyltransferase2 s-adenosyl-l-methionine complex Phyre2 PDB 2rmi chain A Region: 32 - 43 Aligned: 12 Modelled: 12 Confidence: 22.3% Identity: 50% PDB header:neuropeptide Chain: A: PDB Molecule:astressin; PDBTitle: 3d nmr structure of astressin Phyre2 PDB 1mw9 chain X Region: 45 - 72 Aligned: 28 Modelled: 28 Confidence: 19.0% Identity: 32% Fold: Prokaryotic type I DNA topoisomerase Superfamily: Prokaryotic type I DNA topoisomerase Family: Prokaryotic type I DNA topoisomerase Phyre2 PDB 3tj6 chain B Region: 16 - 37 Aligned: 22 Modelled: 22 Confidence: 18.9% Identity: 36% PDB header:protein binding/toxin Chain: B: PDB Molecule:protein ps 120; PDBTitle: human vinculin head domain (vh1, residues 1-258) in complex with the2 vinculin binding site of the surface cell antigen 4 (sca4-vbs-c;3 residues 812-835) from rickettsia rickettsii Phyre2 PDB 2a07 chain F domain 1 Region: 10 - 39 Aligned: 30 Modelled: 30 Confidence: 17.2% Identity: 27% Fold: DNA/RNA-binding 3-helical bundle Superfamily: "Winged helix" DNA-binding domain Family: Forkhead DNA-binding domain Phyre2 PDB 3g73 chain A Region: 14 - 39 Aligned: 26 Modelled: 26 Confidence: 16.9% Identity: 23% PDB header:transcription/dna Chain: A: PDB Molecule:forkhead box protein m1; PDBTitle: structure of the foxm1 dna binding Phyre2 PDB 1zwg chain A Region: 17 - 26 Aligned: 10 Modelled: 10 Confidence: 16.5% Identity: 50% PDB header:hormone Chain: A: PDB Molecule:parathyroid hormone; PDBTitle: succinyl human parathyroid hormone 4-37, nmr, 10 structures Phyre2 1 d1pkxa2 2 c1zczA_ 3 d1g8ma2 4 d1zcza2 5 c1thzA_ 6 c2kw0A_ 7 d1cy9a_ 8 c2hl7A_ 9 c4a1oB_ 10 c3c4mD_ 11 c3c4mC_ 12 c1z4hA_ 13 c3jzaB_ 14 c3gyqB_ 15 c2rmiA_ 16 d1mw9x_ 17 c3tj6B_ 18 d2a07f1 19 c3g73A_ 20 c1zwgA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d1pkxa2 40.6 37 Fold:Cytidine deaminase-like Superfamily:Cytidine deaminase-like Family:AICAR transformylase domain of bifunctional purine biosynthesis enzyme ATIC 2 c1zczA_ 39.0 39 PDB header:transferase/hydrolase Chain: A: PDB Molecule:bifunctional purine biosynthesis protein purh; PDBTitle: crystal structure of phosphoribosylaminoimidazolecarboxamide2 formyltransferase / imp cyclohydrolase (tm1249) from thermotoga3 maritima at 1.88 a resolution 3 d1g8ma2 33.2 26 Fold:Cytidine deaminase-like Superfamily:Cytidine deaminase-like Family:AICAR transformylase domain of bifunctional purine biosynthesis enzyme ATIC 4 d1zcza2 29.4 42 Fold:Cytidine deaminase-like Superfamily:Cytidine deaminase-like Family:AICAR transformylase domain of bifunctional purine biosynthesis enzyme ATIC 5 c1thzA_ 29.0 26 PDB header:transferase, hydrolase Chain: A: PDB Molecule:bifunctional purine biosynthesis protein purh; PDBTitle: crystal structure of avian aicar transformylase in complex2 with a novel inhibitor identified by virtual ligand3 screening 6 c2kw0A_ 28.6 12 PDB header:oxidoreductase Chain: A: PDB Molecule:ccmh protein; PDBTitle: solution structure of n-terminal domain of ccmh from escherichia.coli 7 d1cy9a_ 27.4 36 Fold:Prokaryotic type I DNA topoisomerase Superfamily:Prokaryotic type I DNA topoisomerase Family:Prokaryotic type I DNA topoisomerase 8 c2hl7A_ 26.5 21 PDB header:oxidoreductase Chain: A: PDB Molecule:cytochrome c-type biogenesis protein ccmh; PDBTitle: crystal structure of the periplasmic domain of ccmh from pseudomonas2 aeruginosa 9 c4a1oB_ 24.1 50 PDB header:transferase-hydrolase Chain: B: PDB Molecule:bifunctional purine biosynthesis protein purh; PDBTitle: crystal structure of mycobacterium tuberculosis purh complexed with2 aicar and a novel nucleotide cfair, at 2.48 a resolution. 10 c3c4mD_ 23.9 29 PDB header:membrane protein Chain: D: PDB Molecule:parathyroid hormone; PDBTitle: structure of human parathyroid hormone in complex with the2 extracellular domain of its g-protein-coupled receptor (pth1r) 11 c3c4mC_ 23.9 29 PDB header:membrane protein Chain: C: PDB Molecule:parathyroid hormone; PDBTitle: structure of human parathyroid hormone in complex with the2 extracellular domain of its g-protein-coupled receptor (pth1r) 12 c1z4hA_ 23.3 11 PDB header:protein binding, dna binding protein Chain: A: PDB Molecule:tor inhibition protein; PDBTitle: the response regulator tori belongs to a new family of2 atypical excisionase 13 c3jzaB_ 23.3 32 PDB header:transport protein Chain: B: PDB Molecule:uncharacterized protein drra; PDBTitle: crystal structure of human rab1b in complex with the gef domain of2 drra/sidm from legionella pneumophila 14 c3gyqB_ 23.3 27 PDB header:transferase Chain: B: PDB Molecule:rrna (adenosine-2'-o-)-methyltransferase; PDBTitle: structure of the thiostrepton-resistance methyltransferase2 s-adenosyl-l-methionine complex 15 c2rmiA_ 22.3 50 PDB header:neuropeptide Chain: A: PDB Molecule:astressin; PDBTitle: 3d nmr structure of astressin 16 d1mw9x_ 19.0 32 Fold:Prokaryotic type I DNA topoisomerase Superfamily:Prokaryotic type I DNA topoisomerase Family:Prokaryotic type I DNA topoisomerase 17 c3tj6B_ 18.9 36 PDB header:protein binding/toxin Chain: B: PDB Molecule:protein ps 120; PDBTitle: human vinculin head domain (vh1, residues 1-258) in complex with the2 vinculin binding site of the surface cell antigen 4 (sca4-vbs-c;3 residues 812-835) from rickettsia rickettsii 18 d2a07f1 17.2 27 Fold:DNA/RNA-binding 3-helical bundle Superfamily:"Winged helix" DNA-binding domain Family:Forkhead DNA-binding domain 19 c3g73A_ 16.9 23 PDB header:transcription/dna Chain: A: PDB Molecule:forkhead box protein m1; PDBTitle: structure of the foxm1 dna binding 20 c1zwgA_ 16.5 50 PDB header:hormone Chain: A: PDB Molecule:parathyroid hormone; PDBTitle: succinyl human parathyroid hormone 4-37, nmr, 10 structures 21 c2fjlA_ not modelled 16.2 29 PDB header:hydrolase Chain: A: PDB Molecule:1-phosphatidylinositol-4,5-bisphosphate PDBTitle: solution structure of the split ph domain in phospholipase2 c-gamma1 22 c2o59B_ not modelled 16.2 43 PDB header:isomerase/dna Chain: B: PDB Molecule:dna topoisomerase 3; PDBTitle: structure of e. coli topoisomerase iii in complex with an 8-2 base single stranded oligonucleotide. frozen in glycerol3 ph 8.0 23 c2ha8A_ not modelled 15.5 27 PDB header:rna binding protein Chain: A: PDB Molecule:tar (hiv-1) rna loop binding protein; PDBTitle: methyltransferase domain of human tar (hiv-1) rna binding2 protein 1 24 c1gl9B_ not modelled 15.5 25 PDB header:topoisomerase Chain: B: PDB Molecule:reverse gyrase; PDBTitle: archaeoglobus fulgidus reverse gyrase complexed with adpnp 25 c3n6oB_ not modelled 15.4 32 PDB header:signaling protein Chain: B: PDB Molecule:guanine nucleotide exchange factor; PDBTitle: crystal structure of the gef and p4m domain of drra/sidm from2 legionella pneumophila 26 c3swfA_ not modelled 15.3 32 PDB header:transport protein Chain: A: PDB Molecule:cgmp-gated cation channel alpha-1; PDBTitle: cnga1 621-690 containing clz domain 27 c1x7pB_ not modelled 15.2 60 PDB header:transferase Chain: B: PDB Molecule:rrna methyltransferase; PDBTitle: crystal structure of the spou methyltransferase avirb from2 streptomyces viridochromogenes in complex with the cofactor adomet 28 d1gkub3 not modelled 14.7 29 Fold:Prokaryotic type I DNA topoisomerase Superfamily:Prokaryotic type I DNA topoisomerase Family:Prokaryotic type I DNA topoisomerase 29 c2pihA_ not modelled 14.4 7 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:protein ymca; PDBTitle: crystal structure of protein ymca from bacillus subtilis,2 northeast structural genomics target sr375 30 d2piha1 not modelled 14.4 7 Fold:YheA-like Superfamily:YheA/YmcA-like Family:YmcA-like 31 c2l1nA_ not modelled 14.3 20 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: solution nmr structure of the protein yp_399305.1 32 d2vgna2 not modelled 14.3 15 Fold:Ribonuclease H-like motif Superfamily:Translational machinery components Family:ERF1/Dom34 middle domain-like 33 c3omdB_ not modelled 14.3 9 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of unknown function protein from leptospirillum2 rubarum 34 d3bpya1 not modelled 13.6 36 Fold:DNA/RNA-binding 3-helical bundle Superfamily:"Winged helix" DNA-binding domain Family:Forkhead DNA-binding domain 35 d1ipaa1 not modelled 13.3 56 Fold:alpha/beta knot Superfamily:alpha/beta knot Family:SpoU-like RNA 2'-O ribose methyltransferase 36 c1zhcA_ not modelled 13.2 28 PDB header:unknown function Chain: A: PDB Molecule:hypothetical protein hp1242; PDBTitle: solution structure of hp1242 from helicobacter pylori 37 d2c6ya1 not modelled 12.0 17 Fold:DNA/RNA-binding 3-helical bundle Superfamily:"Winged helix" DNA-binding domain Family:Forkhead DNA-binding domain 38 c1e17A_ not modelled 11.4 38 PDB header:dna binding domain Chain: A: PDB Molecule:afx; PDBTitle: solution structure of the dna binding domain of the human2 forkhead transcription factor afx (foxo4) 39 c3co7C_ not modelled 10.8 42 PDB header:transcription/dna Chain: C: PDB Molecule:forkhead box protein o1; PDBTitle: crystal structure of foxo1 dbd bound to dbe2 dna 40 d2hfha_ not modelled 10.4 14 Fold:DNA/RNA-binding 3-helical bundle Superfamily:"Winged helix" DNA-binding domain Family:Forkhead DNA-binding domain 41 c1kq8A_ not modelled 10.4 29 PDB header:transcription Chain: A: PDB Molecule:hepatocyte nuclear factor 3 forkhead homolog 1; PDBTitle: solution structure of winged helix protein hfh-1 42 d1kq8a_ not modelled 10.4 29 Fold:DNA/RNA-binding 3-helical bundle Superfamily:"Winged helix" DNA-binding domain Family:Forkhead DNA-binding domain 43 d1d5va_ not modelled 10.1 14 Fold:DNA/RNA-binding 3-helical bundle Superfamily:"Winged helix" DNA-binding domain Family:Forkhead DNA-binding domain 44 c1mofA_ not modelled 10.1 24 PDB header:viral protein Chain: A: PDB Molecule:moloney murine leukemia virus p15; PDBTitle: coat protein 45 c2eboB_ not modelled 10.0 15 PDB header:envelope glycoprotein Chain: B: PDB Molecule:ebola virus envelope glycoprotein; PDBTitle: core structure of gp2 from ebola virus 46 d2c4ka2 not modelled 9.1 17 Fold:PRTase-like Superfamily:PRTase-like Family:Phosphoribosylpyrophosphate synthetase-like 47 d2j5ya1 not modelled 9.1 33 Fold:immunoglobulin/albumin-binding domain-like Superfamily:Bacterial immunoglobulin/albumin-binding domains Family:GA module, an albumin-binding domain 48 c2gajA_ not modelled 9.0 18 PDB header:isomerase Chain: A: PDB Molecule:dna topoisomerase i; PDBTitle: structure of full length topoisomerase i from thermotoga maritima in2 monoclinic crystal form 49 d1i7da_ not modelled 8.6 29 Fold:Prokaryotic type I DNA topoisomerase Superfamily:Prokaryotic type I DNA topoisomerase Family:Prokaryotic type I DNA topoisomerase 50 d1whqa_ not modelled 8.5 38 Fold:dsRBD-like Superfamily:dsRNA-binding domain-like Family:Double-stranded RNA-binding domain (dsRBD) 51 d1jb0b_ not modelled 8.4 24 Fold:Photosystem I subunits PsaA/PsaB Superfamily:Photosystem I subunits PsaA/PsaB Family:Photosystem I subunits PsaA/PsaB 52 c1fvyA_ not modelled 8.0 50 PDB header:hormone/growth factor Chain: A: PDB Molecule:parathyroid hormone; PDBTitle: solution structure of the osteogenic 1-31 fragment of the2 human parathyroid hormone 53 d2qi2a2 not modelled 7.5 21 Fold:Ribonuclease H-like motif Superfamily:Translational machinery components Family:ERF1/Dom34 middle domain-like 54 c2kjmA_ not modelled 7.3 30 PDB header:rna binding protein Chain: A: PDB Molecule:histone rna hairpin-binding protein; PDBTitle: solution structure of slbp rna binding domain fragment 55 d1v4sa1 not modelled 7.3 19 Fold:Ribonuclease H-like motif Superfamily:Actin-like ATPase domain Family:Hexokinase 56 c3he4A_ not modelled 7.1 39 PDB header:de novo protein Chain: A: PDB Molecule:synzip6; PDBTitle: heterospecific coiled-coil pair synzip5:synzip6 57 c2wttL_ not modelled 7.0 28 PDB header:transcription Chain: L: PDB Molecule:tumor protein p73; PDBTitle: structure of the human p73 tetramerization domain (crystal2 form ii) 58 d1gz0a1 not modelled 6.9 50 Fold:alpha/beta knot Superfamily:alpha/beta knot Family:SpoU-like RNA 2'-O ribose methyltransferase 59 c1gz0G_ not modelled 6.9 50 PDB header:transferase Chain: G: PDB Molecule:hypothetical trna/rrna methyltransferase yjfh; PDBTitle: 23s ribosomal rna g2251 2'o-methyltransferase rlmb 60 d1ig8a1 not modelled 6.6 23 Fold:Ribonuclease H-like motif Superfamily:Actin-like ATPase domain Family:Hexokinase 61 c3bkhA_ not modelled 6.5 33 PDB header:hydrolase Chain: A: PDB Molecule:lytic transglycosylase; PDBTitle: crystal structure of the bacteriophage phikz lytic2 transglycosylase, gp144 62 d1dkua2 not modelled 6.5 17 Fold:PRTase-like Superfamily:PRTase-like Family:Phosphoribosylpyrophosphate synthetase-like 63 d2eyqa6 not modelled 6.5 17 Fold:TRCF domain-like Superfamily:TRCF domain-like Family:TRCF domain 64 d1meka_ not modelled 6.3 12 Fold:Thioredoxin fold Superfamily:Thioredoxin-like Family:PDI-like 65 c1u0iA_ not modelled 6.3 50 PDB header:de novo protein Chain: A: PDB Molecule:iaal-e3; PDBTitle: iaal-e3/k3 heterodimer 66 c4a9zD_ not modelled 6.1 36 PDB header:transcription Chain: D: PDB Molecule:tumor protein 63; PDBTitle: crystal structure of human p63 tetramerization domain 67 c1ipaA_ not modelled 5.9 56 PDB header:transferase Chain: A: PDB Molecule:rna 2'-o-ribose methyltransferase; PDBTitle: crystal structure of rna 2'-o ribose methyltransferase 68 c3dlaD_ not modelled 5.6 21 PDB header:ligase Chain: D: PDB Molecule:glutamine-dependent nad(+) synthetase; PDBTitle: x-ray crystal structure of glutamine-dependent nad+ synthetase from2 mycobacterium tuberculosis bound to naad+ and don 69 c1eboE_ not modelled 5.5 15 PDB header:viral protein Chain: E: PDB Molecule:ebola virus envelope protein chimera consisting PDBTitle: crystal structure of the ebola virus membrane-fusion2 subunit, gp2, from the envelope glycoprotein ectodomain 70 c2qjvB_ not modelled 5.2 33 PDB header:isomerase Chain: B: PDB Molecule:uncharacterized iolb-like protein; PDBTitle: crystal structure of an iolb-like protein (stm4420) from salmonella2 typhimurium lt2 at 1.90 a resolution 71 d1z1za1 not modelled 5.1 38 Fold:Phage tail protein-like Superfamily:Phage tail protein-like Family:Lambda phage gpU-like

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0