Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	Q	K	L	K	Q	Q	V	F	E	A	N	M	E	L	P	R	Y	G	L	V	T	F	T	W	G	N	V	S	A	I	D	R	E	R	G	L	V	V	I	K	P	S	G	V	A	Y	E	T	M	K	A	A	D	M	V	V	V	D	M
Secondary structure
SS confidence
Disorder		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		S	G	K	V	V	E	G	E	Y	R	P	S	S	D	T	A	T	H	L	E	L	Y	R	R	Y	P	S	L	G	G	I	V	H	T	H	S	T	H	A	T	A	W	A	Q	A	G	L	A	I	P	A	L	G	T	T	H	A	D	Y	F
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		F	G	D	I	P	C	T	R	G	L	S	E	E	E	V	Q	G	E	Y	E	L	N	T	G	K	V	I	I	E	T	L	G	N	A	E	P	L	H	T	P	G	I	V	V	Y	Q	H	G	P	F	A	W	G	K	D	A	H	D	A	V
Secondary structure
SS confidence
Disorder																																			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.
Sequence		H	N	A	V	V	M	E	E	V	A	K	M	A	W	I	A	R	G	I	N	P	Q	L	N	H	I	D	S	F	L	M	N	K	H	F	M	R	K	H	G	P	N	A	Y	Y	G	Q	K
Secondary structure
SS confidence
Disorder																					?	?	?	?	?	?	?	?												?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1k0w chain A Region: 1 - 219 Aligned: 219 Modelled: 219 Confidence: 100.0% Identity: 61% Fold: AraD/HMP-PK domain-like Superfamily: AraD/HMP-PK domain-like Family: AraD-like aldolase/epimerase Phyre2 PDB 3ocr chain A Region: 2 - 226 Aligned: 214 Modelled: 222 Confidence: 100.0% Identity: 15% PDB header:lyase Chain: A: PDB Molecule:class ii aldolase/adducin domain protein; PDBTitle: crystal structure of aldolase ii superfamily protein from pseudomonas2 syringae Phyre2 PDB 1e4c chain P Region: 2 - 217 Aligned: 202 Modelled: 211 Confidence: 100.0% Identity: 27% Fold: AraD/HMP-PK domain-like Superfamily: AraD/HMP-PK domain-like Family: AraD-like aldolase/epimerase Phyre2 PDB 2z7b chain A Region: 2 - 213 Aligned: 207 Modelled: 212 Confidence: 100.0% Identity: 15% PDB header:lyase Chain: A: PDB Molecule:mlr6791 protein; PDBTitle: crystal structure of mesorhizobium loti 3-hydroxy-2-methylpyridine-4,2 5-dicarboxylate decarboxylase Phyre2 PDB 1ojr chain A Region: 6 - 217 Aligned: 201 Modelled: 212 Confidence: 100.0% Identity: 18% Fold: AraD/HMP-PK domain-like Superfamily: AraD/HMP-PK domain-like Family: AraD-like aldolase/epimerase Phyre2 PDB 1pvt chain A Region: 2 - 204 Aligned: 192 Modelled: 203 Confidence: 100.0% Identity: 23% Fold: AraD/HMP-PK domain-like Superfamily: AraD/HMP-PK domain-like Family: AraD-like aldolase/epimerase Phyre2 PDB 2opi chain B Region: 2 - 218 Aligned: 204 Modelled: 217 Confidence: 100.0% Identity: 18% PDB header:lyase Chain: B: PDB Molecule:l-fuculose-1-phosphate aldolase; PDBTitle: crystal structure of l-fuculose-1-phosphate aldolase from bacteroides2 thetaiotaomicron Phyre2 PDB 2fk5 chain B Region: 2 - 204 Aligned: 186 Modelled: 195 Confidence: 100.0% Identity: 25% PDB header:lyase Chain: B: PDB Molecule:fuculose-1-phosphate aldolase; PDBTitle: crystal structure of l-fuculose-1-phosphate aldolase from thermus2 thermophilus hb8 Phyre2 PDB 2irp chain A Region: 2 - 199 Aligned: 195 Modelled: 198 Confidence: 100.0% Identity: 20% PDB header:lyase Chain: A: PDB Molecule:putative aldolase class 2 protein aq_1979; PDBTitle: crystal structure of the l-fuculose-1-phosphate aldolase (aq_1979)2 from aquifex aeolicus vf5 Phyre2 PDB 3m4r chain A Region: 6 - 194 Aligned: 168 Modelled: 178 Confidence: 100.0% Identity: 20% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: structure of the n-terminal class ii aldolase domain of a conserved2 protein from thermoplasma acidophilum Phyre2 PDB 2yzt chain A Region: 168 - 186 Aligned: 19 Modelled: 19 Confidence: 43.3% Identity: 0% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:putative uncharacterized protein ttha1756; PDBTitle: crystal structure of uncharacterized conserved protein from thermus2 thermophilus hb8 Phyre2 PDB 1gph chain 1 Region: 49 - 167 Aligned: 99 Modelled: 107 Confidence: 22.4% Identity: 7% PDB header:transferase(glutamine amidotransferase) Chain: 1: PDB Molecule:glutamine phosphoribosyl-pyrophosphate amidotransferase; PDBTitle: structure of the allosteric regulatory enzyme of purine biosynthesis Phyre2 PDB 1jw3 chain A Region: 168 - 183 Aligned: 16 Modelled: 16 Confidence: 22.4% Identity: 38% Fold: MTH1598-like Superfamily: MTH1598-like Family: MTH1598-like Phyre2 PDB 1chd chain A Region: 34 - 92 Aligned: 59 Modelled: 59 Confidence: 20.1% Identity: 17% Fold: Methylesterase CheB, C-terminal domain Superfamily: Methylesterase CheB, C-terminal domain Family: Methylesterase CheB, C-terminal domain Phyre2 PDB 1j5u chain A Region: 168 - 186 Aligned: 19 Modelled: 19 Confidence: 19.3% Identity: 11% Fold: MTH1598-like Superfamily: MTH1598-like Family: MTH1598-like Phyre2 PDB 1mqo chain A Region: 26 - 176 Aligned: 151 Modelled: 151 Confidence: 16.7% Identity: 13% Fold: Metallo-hydrolase/oxidoreductase Superfamily: Metallo-hydrolase/oxidoreductase Family: Zn metallo-beta-lactamase Phyre2 PDB 1ecj chain B Region: 49 - 100 Aligned: 50 Modelled: 52 Confidence: 16.0% Identity: 12% PDB header:transferase Chain: B: PDB Molecule:glutamine phosphoribosylpyrophosphate PDBTitle: escherichia coli glutamine phosphoribosylpyrophosphate2 (prpp) amidotransferase complexed with 2 amp per tetramer Phyre2 PDB 3p04 chain A Region: 10 - 46 Aligned: 35 Modelled: 37 Confidence: 15.1% Identity: 14% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized bcr; PDBTitle: crystal structure of the bcr protein from corynebacterium glutamicum.2 northeast structural genomics consortium target cgr8 Phyre2 PDB 3p04 chain B Region: 10 - 46 Aligned: 35 Modelled: 37 Confidence: 13.4% Identity: 14% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:uncharacterized bcr; PDBTitle: crystal structure of the bcr protein from corynebacterium glutamicum.2 northeast structural genomics consortium target cgr8 Phyre2 PDB 3sft chain A Region: 34 - 92 Aligned: 59 Modelled: 59 Confidence: 13.1% Identity: 14% PDB header:hydrolase Chain: A: PDB Molecule:chemotaxis response regulator protein-glutamate PDBTitle: crystal structure of thermotoga maritima cheb methylesterase catalytic2 domain Phyre2 1 d1k0wa_ 2 c3ocrA_ 3 d1e4cp_ 4 c2z7bA_ 5 d1ojra_ 6 d1pvta_ 7 c2opiB_ 8 c2fk5B_ 9 c2irpA_ 10 c3m4rA_ 11 c2yztA_ 12 c1gph1_ 13 d1jw3a_ 14 d1chda_ 15 d1j5ua_ 16 d1mqoa_ 17 c1ecjB_ 18 c3p04A_ 19 c3p04B_ 20 c3sftA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d1k0wa_ 100.0 61 Fold:AraD/HMP-PK domain-like Superfamily:AraD/HMP-PK domain-like Family:AraD-like aldolase/epimerase 2 c3ocrA_ 100.0 15 PDB header:lyase Chain: A: PDB Molecule:class ii aldolase/adducin domain protein; PDBTitle: crystal structure of aldolase ii superfamily protein from pseudomonas2 syringae 3 d1e4cp_ 100.0 27 Fold:AraD/HMP-PK domain-like Superfamily:AraD/HMP-PK domain-like Family:AraD-like aldolase/epimerase 4 c2z7bA_ 100.0 15 PDB header:lyase Chain: A: PDB Molecule:mlr6791 protein; PDBTitle: crystal structure of mesorhizobium loti 3-hydroxy-2-methylpyridine-4,2 5-dicarboxylate decarboxylase 5 d1ojra_ 100.0 18 Fold:AraD/HMP-PK domain-like Superfamily:AraD/HMP-PK domain-like Family:AraD-like aldolase/epimerase 6 d1pvta_ 100.0 23 Fold:AraD/HMP-PK domain-like Superfamily:AraD/HMP-PK domain-like Family:AraD-like aldolase/epimerase 7 c2opiB_ 100.0 18 PDB header:lyase Chain: B: PDB Molecule:l-fuculose-1-phosphate aldolase; PDBTitle: crystal structure of l-fuculose-1-phosphate aldolase from bacteroides2 thetaiotaomicron 8 c2fk5B_ 100.0 25 PDB header:lyase Chain: B: PDB Molecule:fuculose-1-phosphate aldolase; PDBTitle: crystal structure of l-fuculose-1-phosphate aldolase from thermus2 thermophilus hb8 9 c2irpA_ 100.0 20 PDB header:lyase Chain: A: PDB Molecule:putative aldolase class 2 protein aq_1979; PDBTitle: crystal structure of the l-fuculose-1-phosphate aldolase (aq_1979)2 from aquifex aeolicus vf5 10 c3m4rA_ 100.0 20 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: structure of the n-terminal class ii aldolase domain of a conserved2 protein from thermoplasma acidophilum 11 c2yztA_ 43.3 0 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:putative uncharacterized protein ttha1756; PDBTitle: crystal structure of uncharacterized conserved protein from thermus2 thermophilus hb8 12 c1gph1_ 22.4 7 PDB header:transferase(glutamine amidotransferase) Chain: 1: PDB Molecule:glutamine phosphoribosyl-pyrophosphate amidotransferase; PDBTitle: structure of the allosteric regulatory enzyme of purine biosynthesis 13 d1jw3a_ 22.4 38 Fold:MTH1598-like Superfamily:MTH1598-like Family:MTH1598-like 14 d1chda_ 20.1 17 Fold:Methylesterase CheB, C-terminal domain Superfamily:Methylesterase CheB, C-terminal domain Family:Methylesterase CheB, C-terminal domain 15 d1j5ua_ 19.3 11 Fold:MTH1598-like Superfamily:MTH1598-like Family:MTH1598-like 16 d1mqoa_ 16.7 13 Fold:Metallo-hydrolase/oxidoreductase Superfamily:Metallo-hydrolase/oxidoreductase Family:Zn metallo-beta-lactamase 17 c1ecjB_ 16.0 12 PDB header:transferase Chain: B: PDB Molecule:glutamine phosphoribosylpyrophosphate PDBTitle: escherichia coli glutamine phosphoribosylpyrophosphate2 (prpp) amidotransferase complexed with 2 amp per tetramer 18 c3p04A_ 15.1 14 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized bcr; PDBTitle: crystal structure of the bcr protein from corynebacterium glutamicum.2 northeast structural genomics consortium target cgr8 19 c3p04B_ 13.4 14 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:uncharacterized bcr; PDBTitle: crystal structure of the bcr protein from corynebacterium glutamicum.2 northeast structural genomics consortium target cgr8 20 c3sftA_ 13.1 14 PDB header:hydrolase Chain: A: PDB Molecule:chemotaxis response regulator protein-glutamate PDBTitle: crystal structure of thermotoga maritima cheb methylesterase catalytic2 domain 21 d1eexg_ not modelled 12.4 14 Fold:Open three-helical up-and-down bundle Superfamily:Diol dehydratase, gamma subunit Family:Diol dehydratase, gamma subunit 22 c1uc5M_ not modelled 12.4 14 PDB header:lyase Chain: M: PDB Molecule:diol dehydrase gamma subunit; PDBTitle: structure of diol dehydratase complexed with (r)-1,2-2 propanediol 23 c7mdhA_ not modelled 11.1 9 PDB header:chloroplastic malate dehydrogenase Chain: A: PDB Molecule:protein (malate dehydrogenase); PDBTitle: structural basis for light acitvation of a chloroplast enzyme. the2 structure of sorghum nadp-malate dehydrogenase in its oxidized form 24 d1iwpg_ not modelled 10.7 22 Fold:Open three-helical up-and-down bundle Superfamily:Diol dehydratase, gamma subunit Family:Diol dehydratase, gamma subunit 25 c3da4B_ not modelled 10.1 22 PDB header:antibiotic Chain: B: PDB Molecule:colicin-m; PDBTitle: crystal structure of colicin m, a novel phosphatase2 specifically imported by escherichia coli 26 c1zq1B_ not modelled 9.9 14 PDB header:lyase Chain: B: PDB Molecule:glutamyl-trna(gln) amidotransferase subunit d; PDBTitle: structure of gatde trna-dependent amidotransferase from2 pyrococcus abyssi 27 c1a2oB_ not modelled 9.9 17 PDB header:bacterial chemotaxis Chain: B: PDB Molecule:cheb methylesterase; PDBTitle: structural basis for methylesterase cheb regulation by a2 phosphorylation-activated domain 28 c2vf7B_ not modelled 9.2 25 PDB header:dna-binding protein Chain: B: PDB Molecule:excinuclease abc, subunit a.; PDBTitle: crystal structure of uvra2 from deinococcus radiodurans 29 c3ikbB_ not modelled 7.2 3 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:uncharacterized conserved protein; PDBTitle: the structure of a conserved protein from streptococcus2 mutans ua159. 30 d2czra1 not modelled 6.8 11 Fold:Restriction endonuclease-like Superfamily:TBP-interacting protein-like Family:TBP-interacting protein-like 31 c3q2oB_ not modelled 6.5 15 PDB header:lyase Chain: B: PDB Molecule:phosphoribosylaminoimidazole carboxylase, atpase subunit; PDBTitle: crystal structure of purk: n5-carboxyaminoimidazole ribonucleotide2 synthetase 32 d1a9xa5 not modelled 6.4 19 Fold:ATP-grasp Superfamily:Glutathione synthetase ATP-binding domain-like Family:BC ATP-binding domain-like 33 c2ra9A_ not modelled 6.3 15 PDB header:unknown function Chain: A: PDB Molecule:uncharacterized protein duf1285; PDBTitle: crystal structure of a duf1285 family protein (sbal_2486) from2 shewanella baltica os155 at 1.40 a resolution 34 c2p09A_ not modelled 5.7 27 PDB header:de novo protein Chain: A: PDB Molecule:a non-biological atp binding protein with two mutations PDBTitle: structural insights into the evolution of a non-biological protein 35 c2kouA_ not modelled 5.5 24 PDB header:hydrolase Chain: A: PDB Molecule:dicer-like protein 4; PDBTitle: dicer like protein 36 d3e9va1 not modelled 5.3 27 Fold:BTG domain-like Superfamily:BTG domain-like Family:BTG domain-like 37 d1iuqa_ not modelled 5.1 4 Fold:Glycerol-3-phosphate (1)-acyltransferase Superfamily:Glycerol-3-phosphate (1)-acyltransferase Family:Glycerol-3-phosphate (1)-acyltransferase

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

---

Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0