Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	L	E	D	L	K	R	Q	V	L	E	A	N	L	A	L	P	K	H	N	L	V	T	L	T	W	G	N	V	S	A	V	D	R	E	R	G	V	F	V	I	K	P	S	G	V	D	Y	S	V	M	T	A	D	D	M	V	V	V	S
Secondary structure
SS confidence
Disorder		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		I	E	T	G	E	V	V	E	G	T	K	K	P	S	S	D	T	P	T	H	R	L	L	Y	Q	A	F	P	S	I	G	G	I	V	H	T	H	S	R	H	A	T	I	W	A	Q	A	G	Q	S	I	P	A	T	G	T	T	H	A	D
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		Y	F	Y	G	T	I	P	C	T	R	K	M	T	D	A	E	I	N	G	E	Y	E	W	E	T	G	N	V	I	V	E	T	F	E	K	Q	G	I	D	A	A	Q	M	P	G	V	L	V	H	S	H	G	P	F	A	W	G	K	N	A
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.
Sequence		E	D	A	V	H	N	A	I	V	L	E	E	V	A	Y	M	G	I	F	C	R	Q	L	A	P	Q	L	P	D	M	Q	Q	T	L	L	D	K	H	Y	L	R	K	H	G	A	K	A	Y	Y	G	Q
Secondary structure
SS confidence
Disorder																									?	?	?	?		?	?													?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1k0w chain A Region: 1 - 223 Aligned: 223 Modelled: 223 Confidence: 100.0% Identity: 98% Fold: AraD/HMP-PK domain-like Superfamily: AraD/HMP-PK domain-like Family: AraD-like aldolase/epimerase Phyre2 PDB 3ocr chain A Region: 3 - 230 Aligned: 214 Modelled: 228 Confidence: 100.0% Identity: 16% PDB header:lyase Chain: A: PDB Molecule:class ii aldolase/adducin domain protein; PDBTitle: crystal structure of aldolase ii superfamily protein from pseudomonas2 syringae Phyre2 PDB 1e4c chain P Region: 3 - 222 Aligned: 203 Modelled: 218 Confidence: 100.0% Identity: 26% Fold: AraD/HMP-PK domain-like Superfamily: AraD/HMP-PK domain-like Family: AraD-like aldolase/epimerase Phyre2 PDB 1ojr chain A Region: 4 - 226 Aligned: 209 Modelled: 223 Confidence: 100.0% Identity: 15% Fold: AraD/HMP-PK domain-like Superfamily: AraD/HMP-PK domain-like Family: AraD-like aldolase/epimerase Phyre2 PDB 2z7b chain A Region: 3 - 217 Aligned: 204 Modelled: 215 Confidence: 100.0% Identity: 18% PDB header:lyase Chain: A: PDB Molecule:mlr6791 protein; PDBTitle: crystal structure of mesorhizobium loti 3-hydroxy-2-methylpyridine-4,2 5-dicarboxylate decarboxylase Phyre2 PDB 2opi chain B Region: 3 - 220 Aligned: 202 Modelled: 216 Confidence: 100.0% Identity: 17% PDB header:lyase Chain: B: PDB Molecule:l-fuculose-1-phosphate aldolase; PDBTitle: crystal structure of l-fuculose-1-phosphate aldolase from bacteroides2 thetaiotaomicron Phyre2 PDB 1pvt chain A Region: 3 - 209 Aligned: 194 Modelled: 207 Confidence: 100.0% Identity: 25% Fold: AraD/HMP-PK domain-like Superfamily: AraD/HMP-PK domain-like Family: AraD-like aldolase/epimerase Phyre2 PDB 2irp chain A Region: 2 - 203 Aligned: 198 Modelled: 202 Confidence: 100.0% Identity: 23% PDB header:lyase Chain: A: PDB Molecule:putative aldolase class 2 protein aq_1979; PDBTitle: crystal structure of the l-fuculose-1-phosphate aldolase (aq_1979)2 from aquifex aeolicus vf5 Phyre2 PDB 2fk5 chain B Region: 3 - 208 Aligned: 186 Modelled: 203 Confidence: 100.0% Identity: 25% PDB header:lyase Chain: B: PDB Molecule:fuculose-1-phosphate aldolase; PDBTitle: crystal structure of l-fuculose-1-phosphate aldolase from thermus2 thermophilus hb8 Phyre2 PDB 3m4r chain A Region: 5 - 198 Aligned: 170 Modelled: 194 Confidence: 100.0% Identity: 21% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: structure of the n-terminal class ii aldolase domain of a conserved2 protein from thermoplasma acidophilum Phyre2 PDB 2yzt chain A Region: 165 - 190 Aligned: 26 Modelled: 26 Confidence: 35.6% Identity: 8% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:putative uncharacterized protein ttha1756; PDBTitle: crystal structure of uncharacterized conserved protein from thermus2 thermophilus hb8 Phyre2 PDB 1j5u chain A Region: 172 - 190 Aligned: 19 Modelled: 19 Confidence: 23.2% Identity: 16% Fold: MTH1598-like Superfamily: MTH1598-like Family: MTH1598-like Phyre2 PDB 2cfu chain A Region: 146 - 231 Aligned: 81 Modelled: 86 Confidence: 20.2% Identity: 14% PDB header:hydrolase Chain: A: PDB Molecule:sdsa1; PDBTitle: crystal structure of sdsa1, an alkylsulfatase from2 pseudomonas aeruginosa, in complex with 1-decane-sulfonic-3 acid. Phyre2 PDB 3euh chain F Region: 3 - 44 Aligned: 35 Modelled: 42 Confidence: 18.1% Identity: 20% PDB header:cell cycle Chain: F: PDB Molecule:muke; PDBTitle: crystal structure of the muke-mukf complex Phyre2 PDB 1jw3 chain A Region: 172 - 190 Aligned: 19 Modelled: 19 Confidence: 16.9% Identity: 32% Fold: MTH1598-like Superfamily: MTH1598-like Family: MTH1598-like Phyre2 PDB 2yz3 chain B Region: 27 - 98 Aligned: 72 Modelled: 72 Confidence: 10.0% Identity: 14% PDB header:hydrolase Chain: B: PDB Molecule:metallo-beta-lactamase; PDBTitle: crystallographic investigation of inhibition mode of the2 vim-2 metallo-beta-lactamase from pseudomonas aeruginosa3 with mercaptocarboxylate inhibitor Phyre2 PDB 3e9v chain A domain 1 Region: 21 - 41 Aligned: 19 Modelled: 19 Confidence: 9.6% Identity: 26% Fold: BTG domain-like Superfamily: BTG domain-like Family: BTG domain-like Phyre2 PDB 2w3p chain B Region: 139 - 182 Aligned: 44 Modelled: 44 Confidence: 8.5% Identity: 11% PDB header:lyase Chain: B: PDB Molecule:benzoyl-coa-dihydrodiol lyase; PDBTitle: boxc crystal structure Phyre2 PDB 7mdh chain A Region: 41 - 172 Aligned: 111 Modelled: 113 Confidence: 8.0% Identity: 9% PDB header:chloroplastic malate dehydrogenase Chain: A: PDB Molecule:protein (malate dehydrogenase); PDBTitle: structural basis for light acitvation of a chloroplast enzyme. the2 structure of sorghum nadp-malate dehydrogenase in its oxidized form Phyre2 PDB 3da4 chain B Region: 21 - 45 Aligned: 23 Modelled: 25 Confidence: 7.7% Identity: 22% PDB header:antibiotic Chain: B: PDB Molecule:colicin-m; PDBTitle: crystal structure of colicin m, a novel phosphatase2 specifically imported by escherichia coli Phyre2 1 d1k0wa_ 2 c3ocrA_ 3 d1e4cp_ 4 d1ojra_ 5 c2z7bA_ 6 c2opiB_ 7 d1pvta_ 8 c2irpA_ 9 c2fk5B_ 10 c3m4rA_ 11 c2yztA_ 12 d1j5ua_ 13 c2cfuA_ 14 c3euhF_ 15 d1jw3a_ 16 c2yz3B_ 17 d3e9va1 18 c2w3pB_ 19 c7mdhA_ 20 c3da4B_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d1k0wa_ 100.0 98 Fold:AraD/HMP-PK domain-like Superfamily:AraD/HMP-PK domain-like Family:AraD-like aldolase/epimerase 2 c3ocrA_ 100.0 16 PDB header:lyase Chain: A: PDB Molecule:class ii aldolase/adducin domain protein; PDBTitle: crystal structure of aldolase ii superfamily protein from pseudomonas2 syringae 3 d1e4cp_ 100.0 26 Fold:AraD/HMP-PK domain-like Superfamily:AraD/HMP-PK domain-like Family:AraD-like aldolase/epimerase 4 d1ojra_ 100.0 15 Fold:AraD/HMP-PK domain-like Superfamily:AraD/HMP-PK domain-like Family:AraD-like aldolase/epimerase 5 c2z7bA_ 100.0 18 PDB header:lyase Chain: A: PDB Molecule:mlr6791 protein; PDBTitle: crystal structure of mesorhizobium loti 3-hydroxy-2-methylpyridine-4,2 5-dicarboxylate decarboxylase 6 c2opiB_ 100.0 17 PDB header:lyase Chain: B: PDB Molecule:l-fuculose-1-phosphate aldolase; PDBTitle: crystal structure of l-fuculose-1-phosphate aldolase from bacteroides2 thetaiotaomicron 7 d1pvta_ 100.0 25 Fold:AraD/HMP-PK domain-like Superfamily:AraD/HMP-PK domain-like Family:AraD-like aldolase/epimerase 8 c2irpA_ 100.0 23 PDB header:lyase Chain: A: PDB Molecule:putative aldolase class 2 protein aq_1979; PDBTitle: crystal structure of the l-fuculose-1-phosphate aldolase (aq_1979)2 from aquifex aeolicus vf5 9 c2fk5B_ 100.0 25 PDB header:lyase Chain: B: PDB Molecule:fuculose-1-phosphate aldolase; PDBTitle: crystal structure of l-fuculose-1-phosphate aldolase from thermus2 thermophilus hb8 10 c3m4rA_ 100.0 21 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: structure of the n-terminal class ii aldolase domain of a conserved2 protein from thermoplasma acidophilum 11 c2yztA_ 35.6 8 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:putative uncharacterized protein ttha1756; PDBTitle: crystal structure of uncharacterized conserved protein from thermus2 thermophilus hb8 12 d1j5ua_ 23.2 16 Fold:MTH1598-like Superfamily:MTH1598-like Family:MTH1598-like 13 c2cfuA_ 20.2 14 PDB header:hydrolase Chain: A: PDB Molecule:sdsa1; PDBTitle: crystal structure of sdsa1, an alkylsulfatase from2 pseudomonas aeruginosa, in complex with 1-decane-sulfonic-3 acid. 14 c3euhF_ 18.1 20 PDB header:cell cycle Chain: F: PDB Molecule:muke; PDBTitle: crystal structure of the muke-mukf complex 15 d1jw3a_ 16.9 32 Fold:MTH1598-like Superfamily:MTH1598-like Family:MTH1598-like 16 c2yz3B_ 10.0 14 PDB header:hydrolase Chain: B: PDB Molecule:metallo-beta-lactamase; PDBTitle: crystallographic investigation of inhibition mode of the2 vim-2 metallo-beta-lactamase from pseudomonas aeruginosa3 with mercaptocarboxylate inhibitor 17 d3e9va1 9.6 26 Fold:BTG domain-like Superfamily:BTG domain-like Family:BTG domain-like 18 c2w3pB_ 8.5 11 PDB header:lyase Chain: B: PDB Molecule:benzoyl-coa-dihydrodiol lyase; PDBTitle: boxc crystal structure 19 c7mdhA_ 8.0 9 PDB header:chloroplastic malate dehydrogenase Chain: A: PDB Molecule:protein (malate dehydrogenase); PDBTitle: structural basis for light acitvation of a chloroplast enzyme. the2 structure of sorghum nadp-malate dehydrogenase in its oxidized form 20 c3da4B_ 7.7 22 PDB header:antibiotic Chain: B: PDB Molecule:colicin-m; PDBTitle: crystal structure of colicin m, a novel phosphatase2 specifically imported by escherichia coli 21 c1b8vA_ not modelled 7.7 7 PDB header:oxidoreductase Chain: A: PDB Molecule:protein (malate dehydrogenase); PDBTitle: malate dehydrogenase from aquaspirillum arcticum 22 d1w96c1 not modelled 7.1 28 Fold:Barrel-sandwich hybrid Superfamily:Rudiment single hybrid motif Family:BC C-terminal domain-like 23 c3ikbB_ not modelled 6.7 16 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:uncharacterized conserved protein; PDBTitle: the structure of a conserved protein from streptococcus2 mutans ua159. 24 d1q0qa3 not modelled 6.7 16 Fold:FwdE/GAPDH domain-like Superfamily:Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain Family:Dihydrodipicolinate reductase-like 25 d1r0ka3 not modelled 6.6 21 Fold:FwdE/GAPDH domain-like Superfamily:Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain Family:Dihydrodipicolinate reductase-like 26 d1a9xa5 not modelled 6.5 17 Fold:ATP-grasp Superfamily:Glutathione synthetase ATP-binding domain-like Family:BC ATP-binding domain-like 27 d1ulza1 not modelled 5.9 17 Fold:Barrel-sandwich hybrid Superfamily:Rudiment single hybrid motif Family:BC C-terminal domain-like 28 c2atmA_ not modelled 5.9 13 PDB header:hydrolase Chain: A: PDB Molecule:hyaluronoglucosaminidase; PDBTitle: crystal structure of the recombinant allergen ves v 2 29 d2z15a1 not modelled 5.8 17 Fold:BTG domain-like Superfamily:BTG domain-like Family:BTG domain-like 30 d2j9ga1 not modelled 5.6 17 Fold:Barrel-sandwich hybrid Superfamily:Rudiment single hybrid motif Family:BC C-terminal domain-like 31 c1gph1_ not modelled 5.6 10 PDB header:transferase(glutamine amidotransferase) Chain: 1: PDB Molecule:glutamine phosphoribosyl-pyrophosphate amidotransferase; PDBTitle: structure of the allosteric regulatory enzyme of purine biosynthesis 32 c3q2oB_ not modelled 5.4 30 PDB header:lyase Chain: B: PDB Molecule:phosphoribosylaminoimidazole carboxylase, atpase subunit; PDBTitle: crystal structure of purk: n5-carboxyaminoimidazole ribonucleotide2 synthetase 33 d2cfua2 not modelled 5.4 8 Fold:Metallo-hydrolase/oxidoreductase Superfamily:Metallo-hydrolase/oxidoreductase Family:Alkylsulfatase-like 34 c1fcuA_ not modelled 5.4 11 PDB header:hydrolase Chain: A: PDB Molecule:hyaluronoglucosaminidase; PDBTitle: crystal structure (trigonal) of bee venom hyaluronidase 35 d1k75a_ not modelled 5.4 10 Fold:ALDH-like Superfamily:ALDH-like Family:L-histidinol dehydrogenase HisD 36 c1k5hB_ not modelled 5.3 12 PDB header:oxidoreductase Chain: B: PDB Molecule:1-deoxy-d-xylulose-5-phosphate reductoisomerase; PDBTitle: 1-deoxy-d-xylulose-5-phosphate reductoisomerase 37 c3pqeD_ not modelled 5.3 12 PDB header:oxidoreductase Chain: D: PDB Molecule:l-lactate dehydrogenase; PDBTitle: crystal structure of l-lactate dehydrogenase from bacillus subtilis2 with h171c mutation 38 d1y67a2 not modelled 5.2 10 Fold:Fe,Mn superoxide dismutase (SOD), C-terminal domain Superfamily:Fe,Mn superoxide dismutase (SOD), C-terminal domain Family:Fe,Mn superoxide dismutase (SOD), C-terminal domain 39 c1gn4B_ not modelled 5.2 7 PDB header:oxidoreductase Chain: B: PDB Molecule:superoxide dismutase; PDBTitle: h145e mutant of mycobacterium tuberculosis iron-superoxide2 dismutase.

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0