Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	F	S	P	Q	S	R	L	R	H	A	V	A	D	T	F	A	M	V	V	Y	C	S	V	V	N	M	C	I	E	V	F	L	S	G	M	S	F	E	Q	S	F	Y	S	R	L	V	A	I	P	V	N	I	L	I	A	W	P	Y	G
Secondary structure
SS confidence
Disorder		?	?	?																															?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		M	Y	R	D	L	F	M	R	A	A	R	K	V	S	P	S	G	W	I	K	N	L	A	D	I	L	A	Y	V	T	F	Q	S	P	V	Y	V	A	I	L	L	V	V	G	A	D	W	H	Q	I	M	A	A	V	S	S	N	I	V	V
Secondary structure
SS confidence
Disorder													?	?	?	?	?	?																													?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.
Sequence		S	M	L	M	G	A	V	Y	G	Y	F	L	D	Y	C	R	R	L	F	K	V	S	R	Y	Q	Q	V	K	A
Secondary structure
SS confidence
Disorder																								?			?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1z9h chain A domain 1 Region: 7 - 56 Aligned: 50 Modelled: 50 Confidence: 56.9% Identity: 14% Fold: GST C-terminal domain-like Superfamily: GST C-terminal domain-like Family: Glutathione S-transferase (GST), C-terminal domain Phyre2 PDB 1nku chain A Region: 27 - 45 Aligned: 19 Modelled: 19 Confidence: 40.1% Identity: 26% Fold: DNA-glycosylase Superfamily: DNA-glycosylase Family: 3-Methyladenine DNA glycosylase I (Tag) Phyre2 PDB 2jg6 chain A Region: 27 - 45 Aligned: 19 Modelled: 19 Confidence: 32.6% Identity: 16% PDB header:hydrolase Chain: A: PDB Molecule:dna-3-methyladenine glycosidase; PDBTitle: crystal structure of a 3-methyladenine dna glycosylase i2 from staphylococcus aureus Phyre2 PDB 2xf5 chain C Region: 128 - 133 Aligned: 6 Modelled: 6 Confidence: 20.1% Identity: 100% PDB header:viral protein Chain: C: PDB Molecule:gp23.1; PDBTitle: crystal structure of bacillus subtilis spp1 phage gp23.1, a2 putative chaperone. Phyre2 PDB 2ntk chain A domain 1 Region: 25 - 48 Aligned: 24 Modelled: 24 Confidence: 17.6% Identity: 17% Fold: Ntn hydrolase-like Superfamily: Archaeal IMP cyclohydrolase PurO Family: Archaeal IMP cyclohydrolase PurO Phyre2 PDB 1wyp chain A Region: 129 - 145 Aligned: 16 Modelled: 17 Confidence: 14.5% Identity: 19% PDB header:structural protein Chain: A: PDB Molecule:calponin 1; PDBTitle: solution structure of the ch domain of human calponin 1 Phyre2 PDB 2csh chain A domain 2 Region: 61 - 68 Aligned: 8 Modelled: 8 Confidence: 13.3% Identity: 63% Fold: beta-beta-alpha zinc fingers Superfamily: beta-beta-alpha zinc fingers Family: Classic zinc finger, C2H2 Phyre2 PDB 1ei5 chain A Region: 22 - 47 Aligned: 25 Modelled: 26 Confidence: 13.0% Identity: 16% PDB header:hydrolase Chain: A: PDB Molecule:d-aminopeptidase; PDBTitle: crystal structure of a d-aminopeptidase from ochrobactrum2 anthropi Phyre2 PDB 3br8 chain A Region: 62 - 84 Aligned: 23 Modelled: 23 Confidence: 12.7% Identity: 35% PDB header:hydrolase Chain: A: PDB Molecule:probable acylphosphatase; PDBTitle: crystal structure of acylphosphatase from bacillus subtilis Phyre2 PDB 2acy chain A Region: 62 - 84 Aligned: 23 Modelled: 23 Confidence: 11.9% Identity: 22% Fold: Ferredoxin-like Superfamily: Acylphosphatase/BLUF domain-like Family: Acylphosphatase-like Phyre2 PDB 1e7l chain A domain 2 Region: 60 - 86 Aligned: 27 Modelled: 27 Confidence: 11.8% Identity: 30% Fold: His-Me finger endonucleases Superfamily: His-Me finger endonucleases Family: Recombination endonuclease VII, N-terminal domain Phyre2 PDB 2bje chain A Region: 62 - 84 Aligned: 23 Modelled: 23 Confidence: 11.0% Identity: 30% PDB header:hydrolase Chain: A: PDB Molecule:acylphosphatase; PDBTitle: acylphosphatase from sulfolobus solfataricus. monclinic p212 space group Phyre2 PDB 2d86 chain A Region: 129 - 145 Aligned: 17 Modelled: 17 Confidence: 10.9% Identity: 24% PDB header:signaling protein, protein binding Chain: A: PDB Molecule:vav-3 protein; PDBTitle: solution structure of the ch domain from human vav-3 protein Phyre2 PDB 1w2i chain A Region: 62 - 84 Aligned: 23 Modelled: 23 Confidence: 10.1% Identity: 43% Fold: Ferredoxin-like Superfamily: Acylphosphatase/BLUF domain-like Family: Acylphosphatase-like Phyre2 PDB 1bmx chain A Region: 131 - 146 Aligned: 16 Modelled: 16 Confidence: 9.9% Identity: 44% PDB header:viral protein Chain: A: PDB Molecule:human immunodeficiency virus type 1 capsid; PDBTitle: hiv-1 capsid protein major homology region peptide analog,2 nmr, 8 structures Phyre2 PDB 3o3v chain B Region: 22 - 47 Aligned: 25 Modelled: 26 Confidence: 9.9% Identity: 28% PDB header:hydrolase Chain: B: PDB Molecule:beta-lactamase; PDBTitle: crystal structure of clbp peptidase domain Phyre2 PDB 1ulr chain A Region: 62 - 84 Aligned: 23 Modelled: 23 Confidence: 9.6% Identity: 35% Fold: Ferredoxin-like Superfamily: Acylphosphatase/BLUF domain-like Family: Acylphosphatase-like Phyre2 PDB 1i8y chain A Region: 58 - 62 Aligned: 5 Modelled: 5 Confidence: 9.5% Identity: 60% PDB header:cytokine Chain: A: PDB Molecule:granulin-1; PDBTitle: semi-automatic structure determination of the cg1 3-302 peptide based on aria Phyre2 PDB 1i8y chain A Region: 58 - 62 Aligned: 5 Modelled: 5 Confidence: 9.5% Identity: 60% Fold: Knottins (small inhibitors, toxins, lectins) Superfamily: Granulin repeat Family: Granulin repeat Phyre2 PDB 1gxu chain A Region: 62 - 84 Aligned: 23 Modelled: 23 Confidence: 8.8% Identity: 22% Fold: Ferredoxin-like Superfamily: Acylphosphatase/BLUF domain-like Family: Acylphosphatase-like Phyre2 1 d1z9ha1 2 d1nkua_ 3 c2jg6A_ 4 c2xf5C_ 5 d2ntka1 6 c1wypA_ 7 d2csha2 8 c1ei5A_ 9 c3br8A_ 10 d2acya_ 11 d1e7la2 12 c2bjeA_ 13 c2d86A_ 14 d1w2ia_ 15 c1bmxA_ 16 c3o3vB_ 17 d1ulra_ 18 c1i8yA_ 19 d1i8ya_ 20 d1gxua_ 21 22 23 24 25 26 27 28 29 30 31 32

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d1z9ha1 56.9 14 Fold:GST C-terminal domain-like Superfamily:GST C-terminal domain-like Family:Glutathione S-transferase (GST), C-terminal domain 2 d1nkua_ 40.1 26 Fold:DNA-glycosylase Superfamily:DNA-glycosylase Family:3-Methyladenine DNA glycosylase I (Tag) 3 c2jg6A_ 32.6 16 PDB header:hydrolase Chain: A: PDB Molecule:dna-3-methyladenine glycosidase; PDBTitle: crystal structure of a 3-methyladenine dna glycosylase i2 from staphylococcus aureus 4 c2xf5C_ 20.1 100 PDB header:viral protein Chain: C: PDB Molecule:gp23.1; PDBTitle: crystal structure of bacillus subtilis spp1 phage gp23.1, a2 putative chaperone. 5 d2ntka1 17.6 17 Fold:Ntn hydrolase-like Superfamily:Archaeal IMP cyclohydrolase PurO Family:Archaeal IMP cyclohydrolase PurO 6 c1wypA_ 14.5 19 PDB header:structural protein Chain: A: PDB Molecule:calponin 1; PDBTitle: solution structure of the ch domain of human calponin 1 7 d2csha2 13.3 63 Fold:beta-beta-alpha zinc fingers Superfamily:beta-beta-alpha zinc fingers Family:Classic zinc finger, C2H2 8 c1ei5A_ 13.0 16 PDB header:hydrolase Chain: A: PDB Molecule:d-aminopeptidase; PDBTitle: crystal structure of a d-aminopeptidase from ochrobactrum2 anthropi 9 c3br8A_ 12.7 35 PDB header:hydrolase Chain: A: PDB Molecule:probable acylphosphatase; PDBTitle: crystal structure of acylphosphatase from bacillus subtilis 10 d2acya_ 11.9 22 Fold:Ferredoxin-like Superfamily:Acylphosphatase/BLUF domain-like Family:Acylphosphatase-like 11 d1e7la2 11.8 30 Fold:His-Me finger endonucleases Superfamily:His-Me finger endonucleases Family:Recombination endonuclease VII, N-terminal domain 12 c2bjeA_ 11.0 30 PDB header:hydrolase Chain: A: PDB Molecule:acylphosphatase; PDBTitle: acylphosphatase from sulfolobus solfataricus. monclinic p212 space group 13 c2d86A_ 10.9 24 PDB header:signaling protein, protein binding Chain: A: PDB Molecule:vav-3 protein; PDBTitle: solution structure of the ch domain from human vav-3 protein 14 d1w2ia_ 10.1 43 Fold:Ferredoxin-like Superfamily:Acylphosphatase/BLUF domain-like Family:Acylphosphatase-like 15 c1bmxA_ 9.9 44 PDB header:viral protein Chain: A: PDB Molecule:human immunodeficiency virus type 1 capsid; PDBTitle: hiv-1 capsid protein major homology region peptide analog,2 nmr, 8 structures 16 c3o3vB_ 9.9 28 PDB header:hydrolase Chain: B: PDB Molecule:beta-lactamase; PDBTitle: crystal structure of clbp peptidase domain 17 d1ulra_ 9.6 35 Fold:Ferredoxin-like Superfamily:Acylphosphatase/BLUF domain-like Family:Acylphosphatase-like 18 c1i8yA_ 9.5 60 PDB header:cytokine Chain: A: PDB Molecule:granulin-1; PDBTitle: semi-automatic structure determination of the cg1 3-302 peptide based on aria 19 d1i8ya_ 9.5 60 Fold:Knottins (small inhibitors, toxins, lectins) Superfamily:Granulin repeat Family:Granulin repeat 20 d1gxua_ 8.8 22 Fold:Ferredoxin-like Superfamily:Acylphosphatase/BLUF domain-like Family:Acylphosphatase-like 21 d1urra_ not modelled 8.7 26 Fold:Ferredoxin-like Superfamily:Acylphosphatase/BLUF domain-like Family:Acylphosphatase-like 22 d1h67a_ not modelled 8.7 25 Fold:CH domain-like Superfamily:Calponin-homology domain, CH-domain Family:Calponin-homology domain, CH-domain 23 d2hkua2 not modelled 8.6 23 Fold:Tetracyclin repressor-like, C-terminal domain Superfamily:Tetracyclin repressor-like, C-terminal domain Family:Tetracyclin repressor-like, C-terminal domain 24 c3o59X_ not modelled 8.0 31 PDB header:transferase Chain: X: PDB Molecule:dna polymerase ii large subunit; PDBTitle: dna polymerase d large subunit dp2(1-300) from pyrococcus horikoshii 25 c3a7kD_ not modelled 7.9 19 PDB header:membrane protein Chain: D: PDB Molecule:halorhodopsin; PDBTitle: crystal structure of halorhodopsin from natronomonas2 pharaonis 26 c3tg9A_ not modelled 7.7 16 PDB header:penicillin binding protein Chain: A: PDB Molecule:penicillin-binding protein; PDBTitle: the crystal structure of penicillin binding protein from bacillus2 halodurans 27 d1ujoa_ not modelled 7.2 21 Fold:CH domain-like Superfamily:Calponin-homology domain, CH-domain Family:Calponin-homology domain, CH-domain 28 d1ui5a2 not modelled 6.0 9 Fold:Tetracyclin repressor-like, C-terminal domain Superfamily:Tetracyclin repressor-like, C-terminal domain Family:Tetracyclin repressor-like, C-terminal domain 29 c1zbhA_ not modelled 5.9 18 PDB header:hydrolase/rna Chain: A: PDB Molecule:3'-5' exonuclease eri1; PDBTitle: 3'-end specific recognition of histone mrna stem-loop by 3'-2 exonuclease 30 c1wymA_ not modelled 5.6 19 PDB header:structural protein Chain: A: PDB Molecule:transgelin-2; PDBTitle: solution structure of the ch domain of human transgelin-2 31 c2wnmA_ not modelled 5.6 38 PDB header:hydrolase Chain: A: PDB Molecule:gene 2; PDBTitle: solution structure of gp2 32 c3i6xC_ not modelled 5.4 6 PDB header:calmodulin-binding, membrane protein Chain: C: PDB Molecule:ras gtpase-activating-like protein iqgap1; PDBTitle: crystal structure of the calponin homology domain of iqgap1

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0