Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	L	P	R	I	R	H	N	N	F	I	G	A	V	E	L	F	V	K	S	S	Y	T	K	T	H	S	N	N	F	F	N	N	I	H	H	A	F	K	K	K	D	W	I	S	N	Y	D	S	L	L	T	L	R	E	F	F	R	C	A
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?																			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		T	Q	I	D	K	S	G	Y	Q	V	L	S	S	K	N	E	T	V	H	A	M	D	K	F	L	I	S	F	S	L	K	D	N	G	A	E	Y	T	M	T	L	R	G	S	G	F	E	Y	E	E	I	P	I	T	I	N	E	Y	N	S
Secondary structure
SS confidence
Disorder																	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		F	M	D	F	K	N	R	E	F	P	L	E	Q	N	R	R	L	Y	A	W	D	I	L	Q	K	K	Q	S	D	I	P	K	R	I	K	G	Y	I	H	Q	A	I	G	D	V	S	L	G	Y	A	L	L	E	D	I	V	S	K	L	K
Secondary structure
SS confidence
Disorder																										?	?	?	?	?	?	?																													?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		R	G	K	F	E	L	Q	I	P	G	G	G	I	K	E	C	D	G	W	Y	I	Y	E	K	I	I	D	D	N	F	A	I	V	I	E	S	L	G	F	A	L	K	I	Y	G	G	D	E	R	F	R	N	G	S	S	V	V	L	E	D
Secondary structure
SS confidence
Disorder		?	?					?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		E	D	Y	S	L	I	Y	N	F	L	V	N	A	G	C	Q	Q	V	E	L	A	E	Q	V	D	A	I	V	S	A	N	L	A	A	D	S	D	I	T	K	E	K	I	C	E	K	Y	K	S	T	I	E	A	F	K	K	E	Q	L	A
Secondary structure
SS confidence
Disorder																					?									?	?		?	?	?	?	?	?	?																		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.
Sequence		L	P	V	L	V	R	R	K	N	S	E	T
Secondary structure
SS confidence
Disorder							?	?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2eng chain A Region: 182 - 198 Aligned: 17 Modelled: 17 Confidence: 44.9% Identity: 53% Fold: Double psi beta-barrel Superfamily: Barwin-like endoglucanases Family: Eng V-like Phyre2 PDB 1l8f chain A Region: 179 - 198 Aligned: 20 Modelled: 20 Confidence: 42.4% Identity: 50% Fold: Double psi beta-barrel Superfamily: Barwin-like endoglucanases Family: Eng V-like Phyre2 PDB 1miu chain A domain 3 Region: 196 - 242 Aligned: 47 Modelled: 47 Confidence: 37.0% Identity: 23% Fold: OB-fold Superfamily: Nucleic acid-binding proteins Family: Single strand DNA-binding domain, SSB Phyre2 PDB 1iyj chain B domain 3 Region: 189 - 242 Aligned: 54 Modelled: 54 Confidence: 36.2% Identity: 22% Fold: OB-fold Superfamily: Nucleic acid-binding proteins Family: Single strand DNA-binding domain, SSB Phyre2 PDB 1j6x chain A Region: 170 - 200 Aligned: 23 Modelled: 29 Confidence: 34.2% Identity: 35% Fold: LuxS/MPP-like metallohydrolase Superfamily: LuxS/MPP-like metallohydrolase Family: Autoinducer-2 production protein LuxS Phyre2 PDB 1vje chain A Region: 170 - 200 Aligned: 24 Modelled: 31 Confidence: 29.7% Identity: 42% Fold: LuxS/MPP-like metallohydrolase Superfamily: LuxS/MPP-like metallohydrolase Family: Autoinducer-2 production protein LuxS Phyre2 PDB 1i5p chain A domain 1 Region: 88 - 116 Aligned: 29 Modelled: 29 Confidence: 25.6% Identity: 38% Fold: Galactose-binding domain-like Superfamily: Galactose-binding domain-like Family: delta-Endotoxin, C-terminal domain Phyre2 PDB 1j98 chain A Region: 187 - 200 Aligned: 13 Modelled: 14 Confidence: 24.0% Identity: 38% Fold: LuxS/MPP-like metallohydrolase Superfamily: LuxS/MPP-like metallohydrolase Family: Autoinducer-2 production protein LuxS Phyre2 PDB 1j6w chain A Region: 187 - 200 Aligned: 13 Modelled: 14 Confidence: 22.6% Identity: 46% Fold: LuxS/MPP-like metallohydrolase Superfamily: LuxS/MPP-like metallohydrolase Family: Autoinducer-2 production protein LuxS Phyre2 PDB 2qqp chain D Region: 143 - 165 Aligned: 23 Modelled: 23 Confidence: 22.4% Identity: 48% PDB header:virus Chain: D: PDB Molecule:small capsid protein; PDBTitle: crystal structure of authentic providence virus Phyre2 PDB 1wy5 chain A domain 2 Region: 158 - 201 Aligned: 41 Modelled: 44 Confidence: 21.3% Identity: 24% Fold: MesJ substrate recognition domain-like Superfamily: MesJ substrate recognition domain-like Family: MesJ substrate recognition domain-like Phyre2 PDB 1cfr chain A Region: 158 - 202 Aligned: 44 Modelled: 45 Confidence: 16.8% Identity: 23% Fold: Restriction endonuclease-like Superfamily: Restriction endonuclease-like Family: Cfr10I/Bse634I Phyre2 PDB 3na2 chain C Region: 192 - 245 Aligned: 54 Modelled: 54 Confidence: 14.0% Identity: 30% PDB header:structural genomics, unknown function Chain: C: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of protein of unknown function from mine drainage2 metagenome leptospirillum rubarum Phyre2 PDB 1tbf chain A Region: 126 - 189 Aligned: 64 Modelled: 64 Confidence: 13.4% Identity: 27% Fold: HD-domain/PDEase-like Superfamily: HD-domain/PDEase-like Family: PDEase Phyre2 PDB 2fvu chain A Region: 193 - 241 Aligned: 37 Modelled: 49 Confidence: 13.2% Identity: 41% PDB header:transcription Chain: A: PDB Molecule:regulatory protein sir3; PDBTitle: structure of the yeast sir3 bah domain Phyre2 PDB 1xoz chain A Region: 126 - 189 Aligned: 64 Modelled: 64 Confidence: 13.0% Identity: 27% PDB header:hydrolase Chain: A: PDB Molecule:cgmp-specific 3',5'-cyclic phosphodiesterase; PDBTitle: catalytic domain of human phosphodiesterase 5a in complex2 with tadalafil Phyre2 PDB 1qmj chain A Region: 94 - 140 Aligned: 41 Modelled: 47 Confidence: 12.4% Identity: 27% Fold: Concanavalin A-like lectins/glucanases Superfamily: Concanavalin A-like lectins/glucanases Family: Galectin (animal S-lectin) Phyre2 PDB 2cos chain A Region: 250 - 257 Aligned: 8 Modelled: 8 Confidence: 11.7% Identity: 88% PDB header:transferase Chain: A: PDB Molecule:serine/threonine protein kinase lats2; PDBTitle: solution structure of rsgi ruh-038, a uba domain from mouse2 lats2 (large tumor suppressor homolog 2) Phyre2 PDB 2vy8 chain A Region: 137 - 156 Aligned: 20 Modelled: 20 Confidence: 11.1% Identity: 40% PDB header:transcription Chain: A: PDB Molecule:polymerase basic protein 2; PDBTitle: the 627-domain from influenza a virus polymerase pb22 subunit with glu-627 Phyre2 PDB 1z0k chain B domain 1 Region: 154 - 161 Aligned: 8 Modelled: 8 Confidence: 9.9% Identity: 50% Fold: Long alpha-hairpin Superfamily: Rabenosyn-5 Rab-binding domain-like Family: Rabenosyn-5 Rab-binding domain-like Phyre2 1 d2enga_ 2 d1l8fa_ 3 d1miua3 4 d1iyjb3 5 d1j6xa_ 6 d1vjea_ 7 d1i5pa1 8 d1j98a_ 9 d1j6wa_ 10 c2qqpD_ 11 d1wy5a2 12 d1cfra_ 13 c3na2C_ 14 d1tbfa_ 15 c2fvuA_ 16 c1xozA_ 17 d1qmja_ 18 c2cosA_ 19 c2vy8A_ 20 d1z0kb1 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d2enga_ 44.9 53 Fold:Double psi beta-barrel Superfamily:Barwin-like endoglucanases Family:Eng V-like 2 d1l8fa_ 42.4 50 Fold:Double psi beta-barrel Superfamily:Barwin-like endoglucanases Family:Eng V-like 3 d1miua3 37.0 23 Fold:OB-fold Superfamily:Nucleic acid-binding proteins Family:Single strand DNA-binding domain, SSB 4 d1iyjb3 36.2 22 Fold:OB-fold Superfamily:Nucleic acid-binding proteins Family:Single strand DNA-binding domain, SSB 5 d1j6xa_ 34.2 35 Fold:LuxS/MPP-like metallohydrolase Superfamily:LuxS/MPP-like metallohydrolase Family:Autoinducer-2 production protein LuxS 6 d1vjea_ 29.7 42 Fold:LuxS/MPP-like metallohydrolase Superfamily:LuxS/MPP-like metallohydrolase Family:Autoinducer-2 production protein LuxS 7 d1i5pa1 25.6 38 Fold:Galactose-binding domain-like Superfamily:Galactose-binding domain-like Family:delta-Endotoxin, C-terminal domain 8 d1j98a_ 24.0 38 Fold:LuxS/MPP-like metallohydrolase Superfamily:LuxS/MPP-like metallohydrolase Family:Autoinducer-2 production protein LuxS 9 d1j6wa_ 22.6 46 Fold:LuxS/MPP-like metallohydrolase Superfamily:LuxS/MPP-like metallohydrolase Family:Autoinducer-2 production protein LuxS 10 c2qqpD_ 22.4 48 PDB header:virus Chain: D: PDB Molecule:small capsid protein; PDBTitle: crystal structure of authentic providence virus 11 d1wy5a2 21.3 24 Fold:MesJ substrate recognition domain-like Superfamily:MesJ substrate recognition domain-like Family:MesJ substrate recognition domain-like 12 d1cfra_ 16.8 23 Fold:Restriction endonuclease-like Superfamily:Restriction endonuclease-like Family:Cfr10I/Bse634I 13 c3na2C_ 14.0 30 PDB header:structural genomics, unknown function Chain: C: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of protein of unknown function from mine drainage2 metagenome leptospirillum rubarum 14 d1tbfa_ 13.4 27 Fold:HD-domain/PDEase-like Superfamily:HD-domain/PDEase-like Family:PDEase 15 c2fvuA_ 13.2 41 PDB header:transcription Chain: A: PDB Molecule:regulatory protein sir3; PDBTitle: structure of the yeast sir3 bah domain 16 c1xozA_ 13.0 27 PDB header:hydrolase Chain: A: PDB Molecule:cgmp-specific 3',5'-cyclic phosphodiesterase; PDBTitle: catalytic domain of human phosphodiesterase 5a in complex2 with tadalafil 17 d1qmja_ 12.4 27 Fold:Concanavalin A-like lectins/glucanases Superfamily:Concanavalin A-like lectins/glucanases Family:Galectin (animal S-lectin) 18 c2cosA_ 11.7 88 PDB header:transferase Chain: A: PDB Molecule:serine/threonine protein kinase lats2; PDBTitle: solution structure of rsgi ruh-038, a uba domain from mouse2 lats2 (large tumor suppressor homolog 2) 19 c2vy8A_ 11.1 40 PDB header:transcription Chain: A: PDB Molecule:polymerase basic protein 2; PDBTitle: the 627-domain from influenza a virus polymerase pb22 subunit with glu-627 20 d1z0kb1 9.9 50 Fold:Long alpha-hairpin Superfamily:Rabenosyn-5 Rab-binding domain-like Family:Rabenosyn-5 Rab-binding domain-like 21 c1mjeA_ not modelled 9.8 23 PDB header:gene regulation/antitumor protein/dna Chain: A: PDB Molecule:breast cancer 2; PDBTitle: structure of a brca2-dss1-ssdna complex 22 d1ddba_ not modelled 9.6 30 Fold:Toxins' membrane translocation domains Superfamily:Bcl-2 inhibitors of programmed cell death Family:Bcl-2 inhibitors of programmed cell death 23 d1yzma1 not modelled 9.5 50 Fold:Long alpha-hairpin Superfamily:Rabenosyn-5 Rab-binding domain-like Family:Rabenosyn-5 Rab-binding domain-like 24 c3cw4A_ not modelled 9.2 40 PDB header:transferase Chain: A: PDB Molecule:polymerase basic protein 2; PDBTitle: large c-terminal domain of influenza a virus rna-dependent polymerase2 pb2 25 c1x50A_ not modelled 9.0 16 PDB header:sugar binding protein Chain: A: PDB Molecule:galectin-4; PDBTitle: solution structure of the c-terminal gal-bind lectin domain2 from human galectin-4 26 c2q2kA_ not modelled 9.0 58 PDB header:dna binding protein/dna Chain: A: PDB Molecule:hypothetical protein; PDBTitle: structure of nucleic-acid binding protein 27 c3c8lB_ not modelled 8.8 29 PDB header:unknown function Chain: B: PDB Molecule:ftsz-like protein of unknown function; PDBTitle: crystal structure of a ftsz-like protein of unknown function2 (npun_r1471) from nostoc punctiforme pcc 73102 at 1.22 a resolution 28 c2wg6L_ not modelled 8.4 24 PDB header:transcription,hydrolase Chain: L: PDB Molecule:general control protein gcn4, PDBTitle: proteasome-activating nucleotidase (pan) n-domain (57-134)2 from archaeoglobus fulgidus fused to gcn4, p61a mutant 29 d1hlca_ not modelled 8.4 21 Fold:Concanavalin A-like lectins/glucanases Superfamily:Concanavalin A-like lectins/glucanases Family:Galectin (animal S-lectin) 30 c3duiB_ not modelled 7.5 20 PDB header:sugar binding protein Chain: B: PDB Molecule:beta-galactoside-binding lectin; PDBTitle: crystal structure of the oxidized cg-1b: an adhesion/growth-2 regulatory lectin from chicken 31 d2cosa1 not modelled 7.4 88 Fold:RuvA C-terminal domain-like Superfamily:UBA-like Family:UBA domain 32 d1ok7a2 not modelled 7.2 17 Fold:DNA clamp Superfamily:DNA clamp Family:DNA polymerase III, beta subunit 33 c3h6nA_ not modelled 6.7 21 PDB header:signaling protein Chain: A: PDB Molecule:plexin-d1; PDBTitle: crystal structure of the ubiquitin-like domain of plexin d1 34 c3bjcA_ not modelled 6.5 23 PDB header:hydrolase Chain: A: PDB Molecule:cgmp-specific 3',5'-cyclic phosphodiesterase; PDBTitle: crystal structure of the pde5a catalytic domain in complex2 with a novel inhibitor 35 c1iyjB_ not modelled 6.5 22 PDB header:gene regulation/antitumor protein Chain: B: PDB Molecule:breast cancer susceptibility; PDBTitle: structure of a brca2-dss1 complex 36 c3najA_ not modelled 6.3 18 PDB header:sugar binding protein Chain: A: PDB Molecule:galectin-8; PDBTitle: crystal structure of a protease-resistant mutant form of human2 galectin-8 37 c3zwfA_ not modelled 6.3 36 PDB header:hydrolase Chain: A: PDB Molecule:zinc phosphodiesterase elac protein 1; PDBTitle: crystal structure of human trnase z, short form (elac1). 38 c3bg4D_ not modelled 6.2 30 PDB header:hydrolase/hydrolase inhibitor Chain: D: PDB Molecule:guamerin; PDBTitle: the crystal structure of guamerin in complex with2 chymotrypsin and the development of an elastase-specific3 inhibitor 39 d1f3va_ not modelled 6.0 44 Fold:Ferredoxin-like Superfamily:TRADD, N-terminal domain Family:TRADD, N-terminal domain 40 c2l6pA_ not modelled 6.0 19 PDB header:structure genomics, unknown function Chain: A: PDB Molecule:phac1, phac2 and phad genes; PDBTitle: nmr solution structure of the protein np_253742.1 41 c4a0kB_ not modelled 5.9 83 PDB header:ligase/dna-binding protein/dna Chain: B: PDB Molecule:e3 ubiquitin-protein ligase rbx1; PDBTitle: structure of ddb1-ddb2-cul4a-rbx1 bound to a 12 bp abasic2 site containing dna-duplex 42 c3phfX_ not modelled 5.8 23 PDB header:viral protein Chain: X: PDB Molecule:envelope glycoprotein l; PDBTitle: crystal structure of the epstein-barr virus gh and gl complex 43 c1gl9B_ not modelled 5.7 22 PDB header:topoisomerase Chain: B: PDB Molecule:reverse gyrase; PDBTitle: archaeoglobus fulgidus reverse gyrase complexed with adpnp 44 c2jphA_ not modelled 5.7 21 PDB header:signaling protein, protein binding Chain: A: PDB Molecule:plexin-b1; PDBTitle: nmr solution structure of the rho gtpase binding domain of2 human plexin-b1 45 c1xtcC_ not modelled 5.6 47 PDB header:toxin Chain: C: PDB Molecule:cholera toxin; PDBTitle: cholera toxin 46 c3h43F_ not modelled 5.6 19 PDB header:hydrolase Chain: F: PDB Molecule:proteasome-activating nucleotidase; PDBTitle: n-terminal domain of the proteasome-activating nucleotidase2 of methanocaldococcus jannaschii 47 c2ounA_ not modelled 5.2 24 PDB header:hydrolase Chain: A: PDB Molecule:camp and camp-inhibited cgmp 3',5'-cyclic PDBTitle: crystal structure of pde10a2 in complex with amp

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

---

Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0