Phyre Home Retrieve Phyre Job Id
Emaill.a.kelley@imperial.ac.uk
DescriptionP76612
DateThu Jan 5 12:24:58 GMT 2012
Unique Job ID5a4e04757bb0036f

Summary 

Top model
Image coloured by rainbow N → C terminus
Model (left) based on template c2yztA_
Top template information
PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:putative uncharacterized protein ttha1756;
PDBTitle: crystal structure of uncharacterized conserved protein from thermus2 thermophilus hb8
Confidence and coverage
Confidence: 35.9% Coverage: 10%
27 residues ( 10% of your sequence) have been modelled with 35.9% confidence by the single highest scoring template.
You may wish to submit your sequence to Phyrealarm. This will automatically scan your sequence every week for new potential templates as they appear in the Phyre2 library.
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3D viewing
Interactive 3D view in Jmol

Sequence analysis 

Secondary structure and disorder prediction 

   1........10.........20.........30.........40.........50.........60
Sequence  MESRNSYENKIDEISSLSESKEHPIDIQEKKDAFVNEFKGVLFDKNTRSSELLFNFYECC
Secondary structure 

















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Disorder  ??????????



???
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   .........70.........80.........90.........100.........110.........120
Sequence  YKFLPRAQPQDKIDSYNSALQAFSIFCSSTLTHNNIGFDFKLFPEVKLSGEHLETVFKYK
Secondary structure 
















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?


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   .........130.........140.........150.........160.........170.........180
Sequence  NGDDVREIAKINITLQKEEGGLYNLRGLDFKGCFFSGQNFSNYDIQYVNWGTSLFDVDTP
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   .........190.........200.........210.........220.........230.........240
Sequence  CIFNAPAYNKSNEKSLKPVSENGLSGVLTDRNNKIKLITGVAPFDDILFMDDDFDDSSSE
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Disorder 





?

??
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?

























?????
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   .........250.........260...
Sequence  DDPVENSPVVTSPVVSSSKSSFQ
Secondary structure 


















SS confidence 






















Disorder  ??????


??



????????
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Confidence Key
High(9)                    Low (0)
?Disordered
Alpha helix
Beta strand

Domain analysis 

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

RankAligned region

PDB 2yzt chain A

3D model

Region: 133 - 160
Aligned: 27
Modelled: 28
Confidence: 35.9%
Identity: 15%
PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:putative uncharacterized protein ttha1756;
PDBTitle: crystal structure of uncharacterized conserved protein from thermus2 thermophilus hb8

Phyre2

PDB 2j8k chain A domain 1

3D model

Region: 141 - 176
Aligned: 36
Modelled: 36
Confidence: 31.0%
Identity: 14%
Fold: Single-stranded right-handed beta-helix
Superfamily: Pentapeptide repeat-like
Family: Pentapeptide repeats

Phyre2

PDB 3pss chain B

3D model

Region: 144 - 175
Aligned: 32
Modelled: 32
Confidence: 28.3%
Identity: 38%
PDB header:cell cycle
Chain: B: PDB Molecule:qnr;
PDBTitle: crystal structure of ahqnr, the qnr protein from aeromonas hydrophila2 (p21 crystal form)

Phyre2

PDB 2g0y chain A

3D model

Region: 144 - 176
Aligned: 33
Modelled: 33
Confidence: 28.1%
Identity: 27%
PDB header:unknown function
Chain: A: PDB Molecule:pentapeptide repeat protein;
PDBTitle: crystal structure of a lumenal pentapeptide repeat protein from2 cyanothece sp 51142 at 2.3 angstrom resolution. tetragonal crystal3 form

Phyre2

PDB 3du1 chain X

3D model

Region: 135 - 175
Aligned: 41
Modelled: 41
Confidence: 24.2%
Identity: 12%
PDB header:structural protein
Chain: X: PDB Molecule:all3740 protein;
PDBTitle: the 2.0 angstrom resolution crystal structure of hetl, a pentapeptide2 repeat protein involved in heterocyst differentiation regulation from3 the cyanobacterium nostoc sp. strain pcc 7120

Phyre2

PDB 3n90 chain A

3D model

Region: 144 - 175
Aligned: 32
Modelled: 32
Confidence: 20.2%
Identity: 31%
PDB header:unknown function
Chain: A: PDB Molecule:thylakoid lumenal 15 kda protein 1, chloroplastic;
PDBTitle: the 1.7 angstrom resolution crystal structure of at2g44920, a2 pentapeptide repeat protein from arabidopsis thaliana thylakoid3 lumen.

Phyre2

PDB 2vy2 chain A

3D model

Region: 51 - 72
Aligned: 22
Modelled: 22
Confidence: 20.2%
Identity: 41%
PDB header:transcription
Chain: A: PDB Molecule:protein leafy;
PDBTitle: structure of leafy transcription factor from arabidopsis2 thaliana in complex with dna from ag-i promoter

Phyre2

PDB 2j8i chain A domain 1

3D model

Region: 144 - 175
Aligned: 32
Modelled: 32
Confidence: 19.9%
Identity: 13%
Fold: Single-stranded right-handed beta-helix
Superfamily: Pentapeptide repeat-like
Family: Pentapeptide repeats

Phyre2

PDB 2xt4 chain A

3D model

Region: 144 - 176
Aligned: 33
Modelled: 33
Confidence: 19.4%
Identity: 21%
PDB header:cell cycle
Chain: A: PDB Molecule:mcbg-like protein;
PDBTitle: structure of the pentapeptide repeat protein albg, a2 resistance factor for the topoisomerase poison albicidin.

Phyre2

PDB 3cuc chain B

3D model

Region: 44 - 84
Aligned: 41
Modelled: 41
Confidence: 18.9%
Identity: 24%
PDB header:signaling protein
Chain: B: PDB Molecule:protein of unknown function with a fic domain;
PDBTitle: crystal structure of a fic domain containing signaling protein2 (bt_2513) from bacteroides thetaiotaomicron vpi-5482 at 2.71 a3 resolution

Phyre2

PDB 3k1i chain A

3D model

Region: 30 - 84
Aligned: 55
Modelled: 55
Confidence: 18.4%
Identity: 16%
PDB header:chaperone
Chain: A: PDB Molecule:flagellar protein;
PDBTitle: crystal strcture of flis-hp1076 complex in h. pylori

Phyre2

PDB 2xtw chain B

3D model

Region: 129 - 175
Aligned: 47
Modelled: 47
Confidence: 17.8%
Identity: 17%
PDB header:cell cycle
Chain: B: PDB Molecule:qnrb1;
PDBTitle: structure of qnrb1 (full length), a plasmid-mediated2 fluoroquinolone resistance protein

Phyre2

PDB 2xt4 chain B

3D model

Region: 144 - 176
Aligned: 33
Modelled: 33
Confidence: 15.0%
Identity: 18%
PDB header:cell cycle
Chain: B: PDB Molecule:mcbg-like protein;
PDBTitle: structure of the pentapeptide repeat protein albg, a2 resistance factor for the topoisomerase poison albicidin.

Phyre2

PDB 1u4r chain A

3D model

Region: 59 - 76
Aligned: 18
Modelled: 18
Confidence: 14.5%
Identity: 33%
Fold: IL8-like
Superfamily: Interleukin 8-like chemokines
Family: Interleukin 8-like chemokines

Phyre2

PDB 3oiq chain B

3D model

Region: 242 - 250
Aligned: 9
Modelled: 9
Confidence: 13.7%
Identity: 89%
PDB header:protein binding
Chain: B: PDB Molecule:dna polymerase alpha catalytic subunit a;
PDBTitle: crystal structure of yeast telomere protein cdc13 ob1 and the2 catalytic subunit of dna polymerase alpha pol1

Phyre2

PDB 2w7z chain B

3D model

Region: 144 - 176
Aligned: 33
Modelled: 33
Confidence: 13.6%
Identity: 18%
PDB header:inhibitor
Chain: B: PDB Molecule:pentapeptide repeat family protein;
PDBTitle: structure of the pentapeptide repeat protein efsqnr, a dna2 gyrase inhibitor. free amines modified by cyclic3 pentylation with glutaraldehyde.

Phyre2

PDB 3gb8 chain B

3D model

Region: 115 - 183
Aligned: 66
Modelled: 69
Confidence: 13.4%
Identity: 18%
PDB header:transport protein
Chain: B: PDB Molecule:snurportin-1;
PDBTitle: crystal structure of crm1/snurportin-1 complex

Phyre2

PDB 1m8a chain A

3D model

Region: 58 - 76
Aligned: 19
Modelled: 19
Confidence: 13.4%
Identity: 21%
Fold: IL8-like
Superfamily: Interleukin 8-like chemokines
Family: Interleukin 8-like chemokines

Phyre2

PDB 2j8k chain A

3D model

Region: 144 - 176
Aligned: 33
Modelled: 33
Confidence: 12.9%
Identity: 18%
PDB header:toxin
Chain: A: PDB Molecule:np275-np276;
PDBTitle: structure of the fusion of np275 and np276, pentapeptide2 repeat proteins from nostoc punctiforme

Phyre2

PDB 3lkf chain A

3D model

Region: 74 - 178
Aligned: 98
Modelled: 105
Confidence: 11.9%
Identity: 21%
Fold: Leukocidin-like
Superfamily: Leukocidin-like
Family: Leukocidin (pore-forming toxin)

Phyre2
1

c2yztA_
2

d2j8ka1
3

c3pssB_
4

c2g0yA_
5

c3du1X_
6

c3n90A_
7

c2vy2A_
8

d2j8ia1
9

c2xt4A_
10

c3cucB_
11

c3k1iA_
12

c2xtwB_
13

c2xt4B_
14

d1u4ra_
15

c3oiqB_
16

c2w7zB_
17

c3gb8B_
18

d1m8aa_
19

c2j8kA_
20

d3lkfa_
21



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48



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68






Detailed template information 

#
Template Alignment Coverage3D Model Confidence
% i.d. Template Information
1c2yztA_



35.9 15 PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:putative uncharacterized protein ttha1756;
PDBTitle: crystal structure of uncharacterized conserved protein from thermus2 thermophilus hb8
2d2j8ka1



31.0 14 Fold:Single-stranded right-handed beta-helix
Superfamily:Pentapeptide repeat-like
Family:Pentapeptide repeats
3c3pssB_



28.3 38 PDB header:cell cycle
Chain: B: PDB Molecule:qnr;
PDBTitle: crystal structure of ahqnr, the qnr protein from aeromonas hydrophila2 (p21 crystal form)
4c2g0yA_



28.1 27 PDB header:unknown function
Chain: A: PDB Molecule:pentapeptide repeat protein;
PDBTitle: crystal structure of a lumenal pentapeptide repeat protein from2 cyanothece sp 51142 at 2.3 angstrom resolution. tetragonal crystal3 form
5c3du1X_



24.2 12 PDB header:structural protein
Chain: X: PDB Molecule:all3740 protein;
PDBTitle: the 2.0 angstrom resolution crystal structure of hetl, a pentapeptide2 repeat protein involved in heterocyst differentiation regulation from3 the cyanobacterium nostoc sp. strain pcc 7120
6c3n90A_



20.2 31 PDB header:unknown function
Chain: A: PDB Molecule:thylakoid lumenal 15 kda protein 1, chloroplastic;
PDBTitle: the 1.7 angstrom resolution crystal structure of at2g44920, a2 pentapeptide repeat protein from arabidopsis thaliana thylakoid3 lumen.
7c2vy2A_



20.2 41 PDB header:transcription
Chain: A: PDB Molecule:protein leafy;
PDBTitle: structure of leafy transcription factor from arabidopsis2 thaliana in complex with dna from ag-i promoter
8d2j8ia1



19.9 13 Fold:Single-stranded right-handed beta-helix
Superfamily:Pentapeptide repeat-like
Family:Pentapeptide repeats
9c2xt4A_



19.4 21 PDB header:cell cycle
Chain: A: PDB Molecule:mcbg-like protein;
PDBTitle: structure of the pentapeptide repeat protein albg, a2 resistance factor for the topoisomerase poison albicidin.
10c3cucB_



18.9 24 PDB header:signaling protein
Chain: B: PDB Molecule:protein of unknown function with a fic domain;
PDBTitle: crystal structure of a fic domain containing signaling protein2 (bt_2513) from bacteroides thetaiotaomicron vpi-5482 at 2.71 a3 resolution
11c3k1iA_



18.4 16 PDB header:chaperone
Chain: A: PDB Molecule:flagellar protein;
PDBTitle: crystal strcture of flis-hp1076 complex in h. pylori
12c2xtwB_



17.8 17 PDB header:cell cycle
Chain: B: PDB Molecule:qnrb1;
PDBTitle: structure of qnrb1 (full length), a plasmid-mediated2 fluoroquinolone resistance protein
13c2xt4B_



15.0 18 PDB header:cell cycle
Chain: B: PDB Molecule:mcbg-like protein;
PDBTitle: structure of the pentapeptide repeat protein albg, a2 resistance factor for the topoisomerase poison albicidin.
14d1u4ra_



14.5 33 Fold:IL8-like
Superfamily:Interleukin 8-like chemokines
Family:Interleukin 8-like chemokines
15c3oiqB_



13.7 89 PDB header:protein binding
Chain: B: PDB Molecule:dna polymerase alpha catalytic subunit a;
PDBTitle: crystal structure of yeast telomere protein cdc13 ob1 and the2 catalytic subunit of dna polymerase alpha pol1
16c2w7zB_



13.6 18 PDB header:inhibitor
Chain: B: PDB Molecule:pentapeptide repeat family protein;
PDBTitle: structure of the pentapeptide repeat protein efsqnr, a dna2 gyrase inhibitor. free amines modified by cyclic3 pentylation with glutaraldehyde.
17c3gb8B_



13.4 18 PDB header:transport protein
Chain: B: PDB Molecule:snurportin-1;
PDBTitle: crystal structure of crm1/snurportin-1 complex
18d1m8aa_



13.4 21 Fold:IL8-like
Superfamily:Interleukin 8-like chemokines
Family:Interleukin 8-like chemokines
19c2j8kA_



12.9 18 PDB header:toxin
Chain: A: PDB Molecule:np275-np276;
PDBTitle: structure of the fusion of np275 and np276, pentapeptide2 repeat proteins from nostoc punctiforme
20d3lkfa_



11.9 21 Fold:Leukocidin-like
Superfamily:Leukocidin-like
Family:Leukocidin (pore-forming toxin)
21d2hcca_



not modelled 11.8 28 Fold:IL8-like
Superfamily:Interleukin 8-like chemokines
Family:Interleukin 8-like chemokines
22c3h6sE_



not modelled 11.6 63 PDB header:hydrolase/hydrolase inhibitor
Chain: E: PDB Molecule:clitocypin analog;
PDBTitle: strucure of clitocypin - cathepsin v complex
23d1g91a_



not modelled 11.2 39 Fold:IL8-like
Superfamily:Interleukin 8-like chemokines
Family:Interleukin 8-like chemokines
24d1ex0a2



not modelled 10.9 17 Fold:Immunoglobulin-like beta-sandwich
Superfamily:Transglutaminase, two C-terminal domains
Family:Transglutaminase, two C-terminal domains
25d2g03a1



not modelled 10.9 13 Fold:Fic-like
Superfamily:Fic-like
Family:Fic-like
26c3oc5A_



not modelled 10.4 36 PDB header:cell adhesion
Chain: A: PDB Molecule:toxin coregulated pilus biosynthesis protein f;
PDBTitle: crystal structure of the vibrio cholerae secreted colonization factor2 tcpf
27d1j8ia_



not modelled 10.3 22 Fold:IL8-like
Superfamily:Interleukin 8-like chemokines
Family:Interleukin 8-like chemokines
28c2l4nA_



not modelled 10.1 39 PDB header:cytokine
Chain: A: PDB Molecule:c-c motif chemokine 21;
PDBTitle: solution structure of the chemokine ccl21
29d2eota_



not modelled 10.1 33 Fold:IL8-like
Superfamily:Interleukin 8-like chemokines
Family:Interleukin 8-like chemokines
30c2o6wA_



not modelled 10.0 15 PDB header:unknown function
Chain: A: PDB Molecule:repeat five residue (rfr) protein or
PDBTitle: crystal structure of a pentapeptide repeat protein (rfr23)2 from the cyanobacterium cyanothece 51142
31d2f3la1



not modelled 9.5 28 Fold:Single-stranded right-handed beta-helix
Superfamily:Pentapeptide repeat-like
Family:Pentapeptide repeats
32d1bo0a_



not modelled 9.4 39 Fold:IL8-like
Superfamily:Interleukin 8-like chemokines
Family:Interleukin 8-like chemokines
33c2ra4B_



not modelled 9.4 28 PDB header:cytokine
Chain: B: PDB Molecule:small-inducible cytokine a13;
PDBTitle: crystal structure of human monocyte chemoattractant protein 4 (mcp-2 4/ccl13)
34d1huna_



not modelled 9.1 28 Fold:IL8-like
Superfamily:Interleukin 8-like chemokines
Family:Interleukin 8-like chemokines
35d1eiga_



not modelled 8.9 33 Fold:IL8-like
Superfamily:Interleukin 8-like chemokines
Family:Interleukin 8-like chemokines
36d1c8za_



not modelled 8.7 67 Fold:Tubby C-terminal domain-like
Superfamily:Tubby C-terminal domain-like
Family:Transcriptional factor tubby, C-terminal domain
37d2bm5a1



not modelled 8.1 24 Fold:Single-stranded right-handed beta-helix
Superfamily:Pentapeptide repeat-like
Family:Pentapeptide repeats
38c2j8iB_



not modelled 7.9 16 PDB header:toxin
Chain: B: PDB Molecule:np275;
PDBTitle: structure of np275, a pentapeptide repeat protein from2 nostoc punctiforme
39d1el0a_



not modelled 7.9 33 Fold:IL8-like
Superfamily:Interleukin 8-like chemokines
Family:Interleukin 8-like chemokines
40d1nr4a_



not modelled 7.9 28 Fold:IL8-like
Superfamily:Interleukin 8-like chemokines
Family:Interleukin 8-like chemokines
41c3bq9A_



not modelled 7.8 32 PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:predicted rossmann fold nucleotide-binding domain-
PDBTitle: crystal structure of predicted nucleotide-binding protein from2 idiomarina baltica os145
42d1nr4b_



not modelled 7.7 28 Fold:IL8-like
Superfamily:Interleukin 8-like chemokines
Family:Interleukin 8-like chemokines
43d1b50a_



not modelled 7.5 39 Fold:IL8-like
Superfamily:Interleukin 8-like chemokines
Family:Interleukin 8-like chemokines
44d1n28a_



not modelled 7.4 22 Fold:Phospholipase A2, PLA2
Superfamily:Phospholipase A2, PLA2
Family:Vertebrate phospholipase A2
45d1doka_



not modelled 7.2 39 Fold:IL8-like
Superfamily:Interleukin 8-like chemokines
Family:Interleukin 8-like chemokines
46d1iaza_



not modelled 7.1 21 Fold:Cytolysin/lectin
Superfamily:Cytolysin/lectin
Family:Anemone pore-forming cytolysin
47d1tg7a4



not modelled 7.0 27 Fold:Glycosyl hydrolase domain
Superfamily:Glycosyl hydrolase domain
Family:Beta-galactosidase LacA, domain 2
48d1eaqa_



not modelled 7.0 35 Fold:Common fold of diphtheria toxin/transcription factors/cytochrome f
Superfamily:p53-like transcription factors
Family:RUNT domain
49d2pbea2



not modelled 7.0 50 Fold:Nucleotidyltransferase
Superfamily:Nucleotidyltransferase
Family:AadK N-terminal domain-like
50d1jltb_



not modelled 6.9 20 Fold:Phospholipase A2, PLA2
Superfamily:Phospholipase A2, PLA2
Family:Vertebrate phospholipase A2
51d1g2ta_



not modelled 6.9 28 Fold:IL8-like
Superfamily:Interleukin 8-like chemokines
Family:Interleukin 8-like chemokines
52c2q8rF_



not modelled 6.7 28 PDB header:cytokine
Chain: F: PDB Molecule:ccl14;
PDBTitle: structural and functional characterization of cc chemokine ccl14
53c1zxtD_



not modelled 6.7 28 PDB header:signaling protein
Chain: D: PDB Molecule:functional macrophage inflammatory protein 1-alpha homolog;
PDBTitle: crystal structure of a viral chemokine
54c2cazF_



not modelled 6.6 31 PDB header:protein transport
Chain: F: PDB Molecule:protein srn2;
PDBTitle: escrt-i core
55d1b3aa_



not modelled 6.6 33 Fold:IL8-like
Superfamily:Interleukin 8-like chemokines
Family:Interleukin 8-like chemokines
56d1ddba_



not modelled 6.5 27 Fold:Toxins' membrane translocation domains
Superfamily:Bcl-2 inhibitors of programmed cell death
Family:Bcl-2 inhibitors of programmed cell death
57c3n3vA_



not modelled 6.4 14 PDB header:transferase
Chain: A: PDB Molecule:adenosine monophosphate-protein transferase ibpa;
PDBTitle: crystal structure of ibpafic2-h3717a in complex with adenylylated2 cdc42
58d2nz1d1



not modelled 6.2 39 Fold:IL8-like
Superfamily:Interleukin 8-like chemokines
Family:Interleukin 8-like chemokines
59d1ljma_



not modelled 6.2 35 Fold:Common fold of diphtheria toxin/transcription factors/cytochrome f
Superfamily:p53-like transcription factors
Family:RUNT domain
60d1gmza_



not modelled 5.8 17 Fold:Phospholipase A2, PLA2
Superfamily:Phospholipase A2, PLA2
Family:Vertebrate phospholipase A2
61d1nxza1



not modelled 5.5 23 Fold:PUA domain-like
Superfamily:PUA domain-like
Family:YggJ N-terminal domain-like
62d1g2xa_



not modelled 5.5 26 Fold:Phospholipase A2, PLA2
Superfamily:Phospholipase A2, PLA2
Family:Vertebrate phospholipase A2
63d2fhta1



not modelled 5.3 33 Fold:IL8-like
Superfamily:Interleukin 8-like chemokines
Family:Interleukin 8-like chemokines
64d1oari_



not modelled 5.3 40 Fold:Immunoglobulin-like beta-sandwich
Superfamily:Immunoglobulin
Family:V set domains (antibody variable domain-like)
65d1mg7a1



not modelled 5.2 33 Fold:Ribosomal protein S5 domain 2-like
Superfamily:Ribosomal protein S5 domain 2-like
Family:Early switch protein XOL-1, N-terminal domain
66c3q13A_



not modelled 5.1 21 PDB header:cell adhesion
Chain: A: PDB Molecule:spondin-1;
PDBTitle: the structure of the ca2+-binding, glycosylated f-spondin domain of f-2 spondin, a c2-domain variant from extracellular matrix
67c3oqlA_



not modelled 5.1 27 PDB header:transcription
Chain: A: PDB Molecule:tena homolog;
PDBTitle: crystal structure of a tena homolog (pspto1738) from pseudomonas2 syringae pv. tomato str. dc3000 at 2.54 a resolution
68d1buna_



not modelled 5.1 17 Fold:Phospholipase A2, PLA2
Superfamily:Phospholipase A2, PLA2
Family:Vertebrate phospholipase A2

Binding site prediction 

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

Transmembrane helix prediction 

Transmembrane helices have been predicted in your sequence to adopt the topology shown below



Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
 
© Structural Bioinformatics Group
Imperial College London
Lawrence Kelley, Benjamin Jefferys
Disclaimer
Terms and Conditions
Component software
Template detection: HHpred 1.51
Secondary structure prediction: Psi-pred 2.5
Disorder prediction: Disopred 2.4
Transmembrane prediction: Memsat_SVM
Multi-template modelling and ab initio: Poing 1.0