Phyre Home Retrieve Phyre Job Id
Emaill.a.kelley@imperial.ac.uk
DescriptionP14376
DateThu Jan 5 11:34:01 GMT 2012
Unique Job ID574fdd0481bd17f4

Summary 

Top model
Image coloured by rainbow N → C terminus
Model (left) based on template c2c2aA_
Top template information
PDB header:transferase
Chain: A: PDB Molecule:sensor histidine kinase;
PDBTitle: structure of the entire cytoplasmic portion of a sensor2 histidine kinase protein
Confidence and coverage
Confidence:100.0% Coverage: 25%
233 residues ( 25% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.
Additional confident templates have been detected (see Domain analysis) which cover other regions of your sequence.
860 residues ( 91%) could be modelled at >90% confidence using multiple-templates.
You may wish to try resubmitting your sequence in "intensive" mode to model more of your sequence.
3D viewing
Interactive 3D view in Jmol

Sequence analysis 

Secondary structure and disorder prediction 

   1........10.........20.........30.........40.........50.........60
Sequence  MKYLASFRTTLKASRYMFRALALVLWLLIAFSSVFYIVNALHQRESEIRQEFNLSSDQAQ
Secondary structure 









SS confidence 



























































Disorder  ?????????


















































Disorder confidence 



























































 
   .........70.........80.........90.........100.........110.........120
Sequence  RFIQRTSDVMKELKYIAENRLSAENGVLSPRGRETQADVPAFEPLFADSDCSAMSNTWRG
Secondary structure 
































SS confidence 



























































Disorder 
















??????????????????????????????????????????
Disorder confidence 



























































 
   .........130.........140.........150.........160.........170.........180
Sequence  SLESLAWFMRYWRDNFSAAYDLNRVFLIGSDNLCMANFGLRDMPVERDTALKALHERINK
Secondary structure 






















SS confidence 



























































Disorder 












??















?????????????????










?
Disorder confidence 



























































 
   .........190.........200.........210.........220.........230.........240
Sequence  YRNAPQDDSGSNLYWISEGPRPGVGYFYALTPVYLANRLQALLGVEQTIRMENFFLPGTL
Secondary structure 




























SS confidence 



























































Disorder  ????????????








?






















?????????????

Disorder confidence 



























































 
   .........250.........260.........270.........280.........290.........300
Sequence  PMGVTILDENGHTLISLTGPESKIKGDPRWMQERSWFGYTEGFRELVLKKNLPPSSLSIV
Secondary structure 







































SS confidence 



























































Disorder 

















?????????????????
























Disorder confidence 



























































 
   .........310.........320.........330.........340.........350.........360
Sequence  YSVPVDKVLERIRMLILNAILLNVLAGAALFTLARMYERRIFIPAESDALRLEEHEQFNR
Secondary structure 
SS confidence 



























































Disorder 



























































Disorder confidence 



























































 
   .........370.........380.........390.........400.........410.........420
Sequence  KIVASAPVGICILRTADGVNILSNELAHTYLNMLTHEDRQRLTQIICGQQVNFVDVLTSN
Secondary structure 

























SS confidence 



























































Disorder 














































????








Disorder confidence 



























































 
   .........430.........440.........450.........460.........470.........480
Sequence  NTNLQISFVHSRYRNENVAICVLVDVSSRVKMEESLQEMAQAAEQASQSKSMFLATVSHE
Secondary structure 





SS confidence 



























































Disorder 



























































Disorder confidence 



























































 
   .........490.........500.........510.........520.........530.........540
Sequence  LRTPLYGIIGNLDLLQTKELPKGVDRLVTAMNNSSSLLLKIISDILDFSKIESEQLKIEP
Secondary structure 










SS confidence 



























































Disorder 















?????






































Disorder confidence 



























































 
   .........550.........560.........570.........580.........590.........600
Sequence  REFSPREVMNHITANYLPLVVRKQLGLYCFIEPDVPVALNGDPMRLQQVISNLLSNAIKF
Secondary structure 



















SS confidence 



























































Disorder 



























































Disorder confidence 



























































 
   .........610.........620.........630.........640.........650.........660
Sequence  TDTGCIVLHVRADGDYLSIRVRDTGVGIPAKEVVRLFDPFFQVGTGVQRNFQGTGLGLAI
Secondary structure 




























SS confidence 



























































Disorder 

































??























Disorder confidence 



























































 
   .........670.........680.........690.........700.........710.........720
Sequence  CEKLISMMDGDISVDSEPGMGSQFTVRIPLYGAQYPQKKGVEGLSGKRCWLAVRNASLCQ
Secondary structure 



























SS confidence 



























































Disorder 





























??????????????















Disorder confidence 



























































 
   .........730.........740.........750.........760.........770.........780
Sequence  FLETSLQRSGIVVTTYEGQEPTPEDVLITDEVVSKKWQGRAVVTFCRRHIGIPLEKAPGE
Secondary structure 





















SS confidence 



























































Disorder 

































?











?????????????
Disorder confidence 



























































 
   .........790.........800.........810.........820.........830.........840
Sequence  WVHSVAAPHELPALLARIYLIEMESDDPANALPSTDKAVSDNDDMMILVVDDHPINRRLL
Secondary structure 































SS confidence 



























































Disorder  ?????
??
?








?????????????????????????















Disorder confidence 



























































 
   .........850.........860.........870.........880.........890.........900
Sequence  ADQLGSLGYQCKTANDGVDALNVLSKNHIDIVLSDVNMPNMDGYRLTQRIRQLGLTLPVI
Secondary structure 






















SS confidence 



























































Disorder 



























































Disorder confidence 



























































 
   .........910.........920.........930.........940.........
Sequence  GVTANALAEEKQRCLESGMDSCLSKPVTLDVIKQTLTLYAERVRKSRDS
Secondary structure 



















SS confidence 
















































Disorder 







































?????????
Disorder confidence 
















































 

Confidence Key
High(9)                    Low (0)
?Disordered
Alpha helix
Beta strand

Domain analysis 

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

RankAligned region

PDB 2c2a chain A

3D model

Region: 443 - 692
Aligned: 233
Modelled: 250
Confidence: 100.0%
Identity: 28%
PDB header:transferase
Chain: A: PDB Molecule:sensor histidine kinase;
PDBTitle: structure of the entire cytoplasmic portion of a sensor2 histidine kinase protein

Phyre2

PDB 3d2r chain B

3D model

Region: 447 - 733
Aligned: 266
Modelled: 268
Confidence: 100.0%
Identity: 16%
PDB header:transferase
Chain: B: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 4;
PDBTitle: crystal structure of pyruvate dehydrogenase kinase isoform 4 in2 complex with adp

Phyre2

PDB 2ayx chain A

3D model

Region: 699 - 949
Aligned: 251
Modelled: 251
Confidence: 100.0%
Identity: 100%
PDB header:transferase
Chain: A: PDB Molecule:sensor kinase protein rcsc;
PDBTitle: solution structure of the e.coli rcsc c-terminus (residues2 700-949) containing linker region and phosphoreceiver3 domain

Phyre2

PDB 3d36 chain B

3D model

Region: 468 - 692
Aligned: 213
Modelled: 225
Confidence: 100.0%
Identity: 25%
PDB header:transferase/transferase inhibitor
Chain: B: PDB Molecule:sporulation kinase b;
PDBTitle: how to switch off a histidine kinase: crystal structure of2 geobacillus stearothermophilus kinb with the inhibitor sda

Phyre2

PDB 2q8f chain A

3D model

Region: 448 - 703
Aligned: 252
Modelled: 252
Confidence: 100.0%
Identity: 18%
PDB header:transferase
Chain: A: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 1;
PDBTitle: structure of pyruvate dehydrogenase kinase isoform 1

Phyre2

PDB 1y8o chain A

3D model

Region: 448 - 700
Aligned: 244
Modelled: 253
Confidence: 100.0%
Identity: 15%
PDB header:transferase
Chain: A: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 3;
PDBTitle: crystal structure of the pdk3-l2 complex

Phyre2

PDB 2bu8 chain A

3D model

Region: 448 - 703
Aligned: 250
Modelled: 256
Confidence: 100.0%
Identity: 16%
PDB header:transferase
Chain: A: PDB Molecule:pyruvate dehydrogenase kinase isoenzyme 2;
PDBTitle: crystal structures of human pyruvate dehydrogenase kinase 22 containing physiological and synthetic ligands

Phyre2

PDB 3a0r chain A

3D model

Region: 358 - 694
Aligned: 313
Modelled: 336
Confidence: 100.0%
Identity: 25%
PDB header:transferase
Chain: A: PDB Molecule:sensor protein;
PDBTitle: crystal structure of histidine kinase thka (tm1359) in complex with2 response regulator protein trra (tm1360)

Phyre2

PDB 1gjv chain A

3D model

Region: 467 - 696
Aligned: 222
Modelled: 230
Confidence: 100.0%
Identity: 19%
PDB header:transferase
Chain: A: PDB Molecule:[3-methyl-2-oxobutanoate dehydrogenase
PDBTitle: branched-chain alpha-ketoacid dehydrogenase kinase (bck)2 complxed with atp-gamma-s

Phyre2

PDB 2c2a chain A domain 2

3D model

Region: 537 - 692
Aligned: 147
Modelled: 156
Confidence: 100.0%
Identity: 30%
Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family: Histidine kinase

Phyre2

PDB 1b3q chain A

3D model

Region: 478 - 691
Aligned: 206
Modelled: 214
Confidence: 100.0%
Identity: 20%
PDB header:transferase
Chain: A: PDB Molecule:protein (chemotaxis protein chea);
PDBTitle: crystal structure of chea-289, a signal transducing histidine kinase

Phyre2

PDB 3a0t chain A

3D model

Region: 538 - 694
Aligned: 150
Modelled: 157
Confidence: 100.0%
Identity: 27%
PDB header:transferase
Chain: A: PDB Molecule:sensor protein;
PDBTitle: catalytic domain of histidine kinase thka (tm1359) in2 complex with adp and mg ion (trigonal)

Phyre2

PDB 3luf chain B

3D model

Region: 707 - 945
Aligned: 234
Modelled: 239
Confidence: 100.0%
Identity: 16%
PDB header:signaling protein
Chain: B: PDB Molecule:two-component system response regulator/ggdef
PDBTitle: structure of probable two-component system response2 regulator/ggdef domain protein

Phyre2

PDB 1gkz chain A domain 2

3D model

Region: 541 - 696
Aligned: 151
Modelled: 156
Confidence: 100.0%
Identity: 23%
Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family: alpha-ketoacid dehydrogenase kinase, C-terminal domain

Phyre2

PDB 2ayx chain A domain 1

3D model

Region: 817 - 949
Aligned: 133
Modelled: 133
Confidence: 100.0%
Identity: 100%
Fold: Flavodoxin-like
Superfamily: CheY-like
Family: CheY-related

Phyre2

PDB 1id0 chain A

3D model

Region: 540 - 692
Aligned: 146
Modelled: 153
Confidence: 100.0%
Identity: 23%
Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family: Histidine kinase

Phyre2

PDB 1w25 chain B

3D model

Region: 825 - 948
Aligned: 124
Modelled: 124
Confidence: 100.0%
Identity: 31%
PDB header:signaling protein
Chain: B: PDB Molecule:stalked-cell differentiation controlling protein;
PDBTitle: response regulator pled in complex with c-digmp

Phyre2

PDB 3eq2 chain A

3D model

Region: 826 - 948
Aligned: 120
Modelled: 123
Confidence: 100.0%
Identity: 25%
PDB header:signaling protein
Chain: A: PDB Molecule:probable two-component response regulator;
PDBTitle: structure of hexagonal crystal form of pseudomonas2 aeruginosa rssb

Phyre2

PDB 1jm6 chain A domain 2

3D model

Region: 541 - 702
Aligned: 158
Modelled: 162
Confidence: 100.0%
Identity: 21%
Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family: alpha-ketoacid dehydrogenase kinase, C-terminal domain

Phyre2

PDB 1bxd chain A

3D model

Region: 533 - 701
Aligned: 160
Modelled: 169
Confidence: 100.0%
Identity: 19%
Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family: Histidine kinase

Phyre2

PDB 3lib chain A

3D model

Region: 43 - 313
Aligned: 245
Modelled: 245
Confidence: 98.1%
Identity: 11%
PDB header:signaling protein
Chain: A: PDB Molecule:hypothetical sensory transduction histidine kinase;
PDBTitle: crystal structure of the extracellular domain of the putative2 histidine kinase mmhk1s-z3

Phyre2

PDB 3lic chain A

3D model

Region: 37 - 312
Aligned: 246
Modelled: 244
Confidence: 98.0%
Identity: 11%
PDB header:signaling protein
Chain: A: PDB Molecule:sensor protein;
PDBTitle: crystal structure of the extracellular domain of the putative2 histidine kinase sohk1s-z6

Phyre2

PDB 2p7j chain A

3D model

Region: 44 - 308
Aligned: 235
Modelled: 233
Confidence: 97.9%
Identity: 10%
PDB header:transcription
Chain: A: PDB Molecule:putative sensory box/ggdef family protein;
PDBTitle: crystal structure of the domain of putative sensory box/ggdef family2 protein from vibrio parahaemolyticus

Phyre2

PDB 3by9 chain A

3D model

Region: 42 - 304
Aligned: 225
Modelled: 223
Confidence: 97.8%
Identity: 12%
PDB header:transferase
Chain: A: PDB Molecule:sensor protein;
PDBTitle: crystal structure of the v. cholerae histidine kinase dctb2 sensor domain

Phyre2
1

c2c2aA_
2

c3d2rB_
3

c2ayxA_
4

c3d36B_
5

c2q8fA_
6

c1y8oA_
7

c2bu8A_
8

c3a0rA_
9

c1gjvA_
10

d2c2aa2
11

c1b3qA_
12

c3a0tA_
13

c3lufB_
14

d1gkza2
15

d2ayxa1
16

d1id0a_
17

c1w25B_
18

c3eq2A_
19

d1jm6a2
20

d1bxda_
21



22



23



24



25



26



27



28



29



30



31



32



33



34



35



36



37



38



39



40



41



42



43



44



45



46



47



48



49



50



51



52



53



54



55



56



57



58



59



60



61



62



63



64



65



66



67



68



69



70



71



72



73



74



75



76



77



78



79



80



81



82



83



84



85



86



87



88



89



90



91



92



93



94



95



96



97



98



99



100



101



102



103



104



105



106



107



108



109



110



111



112



113



114



115



116



117



118



119



120



121



122



123



124



125



126



127



128



129



130



131



132



133



134



135



136



137



138



139



140



141



142



143



144



145



146



147



148



149



150



151



152



153



154



155



156



157



158



159



160



161



162



163



164



165



166



167



168



169



170



171



172



173



174



175



176



177



178



179



180



181



182



183



184



185

c3libA_
186

c3licA_
187



188



189



190



191

c2p7jA_
192



193



194



195



196



197



198

c3by9A_
199



200



201



202



203



204



205



206



207



208



209



210



211



212



213



214



215



216



217



218



219



220



221



222



223



224



225



226



227



228



229



230



231



232



233



234



235



236



237



238



239



240



241



242



243



244



245



246



247



248



249



250



251



252



253



254



255



256



257



258



259



260



261



262



263



264



265



266



267



268



269



270



271



272



273



274



275



276



277



278



279



280



281



282



283



284



285



286



287



288



289



290



291



292



293



294



295



296



297



298



299



300



301



302



303



304



305



306



307



308



309



310



311



312



313



314



315



316



317



318



319



320



321



322



323



324



325



326



327



328



329



330



331



332



333



334



335



336



337



338



339



340



341



342



343



344



345



346



347



348



349



350



351



352



353



354



355



356



357



358



359



360



361



362



363



364



365



366



367



368



369



370



371



372



373



374



375



376



377



378



379



380



381



382



383



384



385



386



387



388



389



390



391



392



393



394



395



396



397



398



399



400



401



402



403



404



405



406



407



408



409



410



411



412



413



414



415



416



417



418



419



420



421



422



423



424



425



426



427



428



429



430



431



432



433



434



435



436



437



438



439



440



441



442



443



444



445



446



447



448



449



450



451



452



453



454



455



456



457



458



459



460



461



462



463



464



465



466



467



468



469



470



471



472



473



474



475



476



477



478



479



480



481



482



483



484



485



486



487



488



489



490



491



492



493



494



495



496



497



498



499






Detailed template information 

#
Template Alignment Coverage3D Model Confidence
% i.d. Template Information
1c2c2aA_



100.0 28 PDB header:transferase
Chain: A: PDB Molecule:sensor histidine kinase;
PDBTitle: structure of the entire cytoplasmic portion of a sensor2 histidine kinase protein
2c3d2rB_



100.0 16 PDB header:transferase
Chain: B: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 4;
PDBTitle: crystal structure of pyruvate dehydrogenase kinase isoform 4 in2 complex with adp
3c2ayxA_



100.0 100 PDB header:transferase
Chain: A: PDB Molecule:sensor kinase protein rcsc;
PDBTitle: solution structure of the e.coli rcsc c-terminus (residues2 700-949) containing linker region and phosphoreceiver3 domain
4c3d36B_



100.0 25 PDB header:transferase/transferase inhibitor
Chain: B: PDB Molecule:sporulation kinase b;
PDBTitle: how to switch off a histidine kinase: crystal structure of2 geobacillus stearothermophilus kinb with the inhibitor sda
5c2q8fA_



100.0 18 PDB header:transferase
Chain: A: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 1;
PDBTitle: structure of pyruvate dehydrogenase kinase isoform 1
6c1y8oA_



100.0 15 PDB header:transferase
Chain: A: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 3;
PDBTitle: crystal structure of the pdk3-l2 complex
7c2bu8A_



100.0 16 PDB header:transferase
Chain: A: PDB Molecule:pyruvate dehydrogenase kinase isoenzyme 2;
PDBTitle: crystal structures of human pyruvate dehydrogenase kinase 22 containing physiological and synthetic ligands
8c3a0rA_



100.0 25 PDB header:transferase
Chain: A: PDB Molecule:sensor protein;
PDBTitle: crystal structure of histidine kinase thka (tm1359) in complex with2 response regulator protein trra (tm1360)
9c1gjvA_



100.0 19 PDB header:transferase
Chain: A: PDB Molecule:[3-methyl-2-oxobutanoate dehydrogenase
PDBTitle: branched-chain alpha-ketoacid dehydrogenase kinase (bck)2 complxed with atp-gamma-s
10d2c2aa2



100.0 30 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Histidine kinase
11c1b3qA_



100.0 20 PDB header:transferase
Chain: A: PDB Molecule:protein (chemotaxis protein chea);
PDBTitle: crystal structure of chea-289, a signal transducing histidine kinase
12c3a0tA_



100.0 27 PDB header:transferase
Chain: A: PDB Molecule:sensor protein;
PDBTitle: catalytic domain of histidine kinase thka (tm1359) in2 complex with adp and mg ion (trigonal)
13c3lufB_



100.0 16 PDB header:signaling protein
Chain: B: PDB Molecule:two-component system response regulator/ggdef
PDBTitle: structure of probable two-component system response2 regulator/ggdef domain protein
14d1gkza2



100.0 23 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:alpha-ketoacid dehydrogenase kinase, C-terminal domain
15d2ayxa1



100.0 100 Fold:Flavodoxin-like
Superfamily:CheY-like
Family:CheY-related
16d1id0a_



100.0 23 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Histidine kinase
17c1w25B_



100.0 31 PDB header:signaling protein
Chain: B: PDB Molecule:stalked-cell differentiation controlling protein;
PDBTitle: response regulator pled in complex with c-digmp
18c3eq2A_



100.0 25 PDB header:signaling protein
Chain: A: PDB Molecule:probable two-component response regulator;
PDBTitle: structure of hexagonal crystal form of pseudomonas2 aeruginosa rssb
19d1jm6a2



100.0 21 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:alpha-ketoacid dehydrogenase kinase, C-terminal domain
20d1bxda_



100.0 19 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Histidine kinase
21c3breA_



not modelled 100.0 20 PDB header:signaling protein
Chain: A: PDB Molecule:probable two-component response regulator;
PDBTitle: crystal structure of p.aeruginosa pa3702
22c3i5aA_



not modelled 99.9 18 PDB header:signaling protein
Chain: A: PDB Molecule:response regulator/ggdef domain protein;
PDBTitle: crystal structure of full-length wpsr from pseudomonas syringae
23c3jz3B_



not modelled 99.9 20 PDB header:transferase
Chain: B: PDB Molecule:sensor protein qsec;
PDBTitle: structure of the cytoplasmic segment of histidine kinase qsec
24d1ny5a1



not modelled 99.9 26 Fold:Flavodoxin-like
Superfamily:CheY-like
Family:CheY-related
25c3cfyA_



not modelled 99.9 21 PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:putative luxo repressor protein;
PDBTitle: crystal structure of signal receiver domain of putative luxo2 repressor protein from vibrio parahaemolyticus
26c3gt7A_



not modelled 99.9 32 PDB header:hydrolase
Chain: A: PDB Molecule:sensor protein;
PDBTitle: crystal structure of signal receiver domain of signal2 transduction histidine kinase from syntrophus3 aciditrophicus
27d1qkka_



not modelled 99.9 27 Fold:Flavodoxin-like
Superfamily:CheY-like
Family:CheY-related
28c1ny5A_



not modelled 99.9 26 PDB header:transcription
Chain: A: PDB Molecule:transcriptional regulator (ntrc family);
PDBTitle: crystal structure of sigm54 activator (aaa+ atpase) in the inactive2 state
29d1jbea_



not modelled 99.9 37 Fold:Flavodoxin-like
Superfamily:CheY-like
Family:CheY-related
30c2ch4A_



not modelled 99.9 24 PDB header:transferase/chemotaxis
Chain: A: PDB Molecule:chemotaxis protein chea;
PDBTitle: complex between bacterial chemotaxis histidine kinase chea2 domains p4 and p5 and receptor-adaptor protein chew
31d2pl1a1



not modelled 99.9 28 Fold:Flavodoxin-like
Superfamily:CheY-like
Family:CheY-related
32d1w25a1



not modelled 99.9 32 Fold:Flavodoxin-like
Superfamily:CheY-like
Family:CheY-related
33c2rjnA_



not modelled 99.9 19 PDB header:hydrolase
Chain: A: PDB Molecule:response regulator receiver:metal-dependent
PDBTitle: crystal structure of an uncharacterized protein q2bku2 from2 neptuniibacter caesariensis
34d1ysra1



not modelled 99.9 22 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Histidine kinase
35d1yioa2



not modelled 99.9 21 Fold:Flavodoxin-like
Superfamily:CheY-like
Family:CheY-related
36d1k66a_



not modelled 99.9 24 Fold:Flavodoxin-like
Superfamily:CheY-like
Family:CheY-related
37d1peya_



not modelled 99.9 31 Fold:Flavodoxin-like
Superfamily:CheY-like
Family:CheY-related
38c2zayA_



not modelled 99.9 21 PDB header:signaling protein
Chain: A: PDB Molecule:response regulator receiver protein;
PDBTitle: crystal structure of response regulator from desulfuromonas2 acetoxidans
39d1s8na_



not modelled 99.9 26 Fold:Flavodoxin-like
Superfamily:CheY-like
Family:CheY-related
40c3t6kB_



not modelled 99.9 31 PDB header:signaling protein
Chain: B: PDB Molecule:response regulator receiver;
PDBTitle: crystal structure of a hypothetical response regulator (caur_3799)2 from chloroflexus aurantiacus j-10-fl at 1.86 a resolution
41d1mvoa_



not modelled 99.9 31 Fold:Flavodoxin-like
Superfamily:CheY-like
Family:CheY-related
42d1u0sy_



not modelled 99.9 23 Fold:Flavodoxin-like
Superfamily:CheY-like
Family:CheY-related
43c3r0jA_



not modelled 99.9 29 PDB header:dna binding protein
Chain: A: PDB Molecule:possible two component system response transcriptional
PDBTitle: structure of phop from mycobacterium tuberculosis
44d1ys7a2



not modelled 99.9 30 Fold:Flavodoxin-like
Superfamily:CheY-like
Family:CheY-related
45d1heya_



not modelled 99.9 36 Fold:Flavodoxin-like
Superfamily:CheY-like
Family:CheY-related
46c3cnbC_



not modelled 99.9 26 PDB header:dna binding protein
Chain: C: PDB Molecule:dna-binding response regulator, merr family;
PDBTitle: crystal structure of signal receiver domain of dna binding response2 regulator protein (merr) from colwellia psychrerythraea 34h
47d1i58a_



not modelled 99.9 26 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Histidine kinase
48c2zwmA_



not modelled 99.9 30 PDB header:transcription
Chain: A: PDB Molecule:transcriptional regulatory protein yycf;
PDBTitle: crystal structure of yycf receiver domain from bacillus2 subtilis
49c3jteA_



not modelled 99.9 24 PDB header:protein binding
Chain: A: PDB Molecule:response regulator receiver protein;
PDBTitle: crystal structure of response regulator receiver domain2 protein from clostridium thermocellum
50c3hv2B_



not modelled 99.9 27 PDB header:signaling protein
Chain: B: PDB Molecule:response regulator/hd domain protein;
PDBTitle: crystal structure of signal receiver domain of hd domain-2 containing protein from pseudomonas fluorescens pf-5
51c2qzjC_



not modelled 99.9 23 PDB header:transcription
Chain: C: PDB Molecule:two-component response regulator;
PDBTitle: crystal structure of a two-component response regulator from2 clostridium difficile
52d1dbwa_



not modelled 99.9 22 Fold:Flavodoxin-like
Superfamily:CheY-like
Family:CheY-related
53d1zh2a1



not modelled 99.9 26 Fold:Flavodoxin-like
Superfamily:CheY-like
Family:CheY-related
54d1krwa_



not modelled 99.9 29 Fold:Flavodoxin-like
Superfamily:CheY-like
Family:CheY-related
55d2a9pa1



not modelled 99.9 26 Fold:Flavodoxin-like
Superfamily:CheY-like
Family:CheY-related
56d2r25b1



not modelled 99.9 34 Fold:Flavodoxin-like
Superfamily:CheY-like
Family:CheY-related
57c3cu5B_



not modelled 99.9 26 PDB header:transcription regulator
Chain: B: PDB Molecule:two component transcriptional regulator, arac family;
PDBTitle: crystal structure of a two component transcriptional regulator arac2 from clostridium phytofermentans isdg
58c3lteH_



not modelled 99.9 27 PDB header:transcription
Chain: H: PDB Molecule:response regulator;
PDBTitle: crystal structure of response regulator (signal receiver domain) from2 bermanella marisrubri
59c3hdgE_



not modelled 99.9 21 PDB header:structural genomics, unknown function
Chain: E: PDB Molecule:uncharacterized protein;
PDBTitle: crystal structure of the n-terminal domain of an2 uncharacterized protein (ws1339) from wolinella3 succinogenes
60c3mmnA_



not modelled 99.9 29 PDB header:transferase
Chain: A: PDB Molecule:histidine kinase homolog;
PDBTitle: crystal structure of the receiver domain of the histidine kinase cki12 from arabidopsis thaliana complexed with mg2+
61d1zgza1



not modelled 99.9 24 Fold:Flavodoxin-like
Superfamily:CheY-like
Family:CheY-related
62c2qr3A_



not modelled 99.9 24 PDB header:transcription
Chain: A: PDB Molecule:two-component system response regulator;
PDBTitle: crystal structure of the n-terminal signal receiver domain of two-2 component system response regulator from bacteroides fragilis
63c3cg4A_



not modelled 99.9 21 PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:response regulator receiver domain protein (chey-like);
PDBTitle: crystal structure of response regulator receiver domain protein (chey-2 like) from methanospirillum hungatei jf-1
64d1kgsa2



not modelled 99.9 24 Fold:Flavodoxin-like
Superfamily:CheY-like
Family:CheY-related
65c3gl9B_



not modelled 99.9 26 PDB header:signaling protein
Chain: B: PDB Molecule:response regulator;
PDBTitle: the structure of a histidine kinase-response regulator2 complex sheds light into two-component signaling and3 reveals a novel cis autophosphorylation mechanism
66c3crnA_



not modelled 99.9 22 PDB header:signaling protein
Chain: A: PDB Molecule:response regulator receiver domain protein, chey-like;
PDBTitle: crystal structure of response regulator receiver domain protein (chey-2 like) from methanospirillum hungatei jf-1
67d1zesa1



not modelled 99.9 27 Fold:Flavodoxin-like
Superfamily:CheY-like
Family:CheY-related
68c3h1gA_



not modelled 99.9 32 PDB header:signaling protein
Chain: A: PDB Molecule:chemotaxis protein chey homolog;
PDBTitle: crystal structure of chey mutant t84a of helicobacter pylori
69d1p6qa_



not modelled 99.9 31 Fold:Flavodoxin-like
Superfamily:CheY-like
Family:CheY-related
70c3nhzA_



not modelled 99.9 27 PDB header:dna binding protein
Chain: A: PDB Molecule:two component system transcriptional regulator mtra;
PDBTitle: structure of n-terminal domain of mtra
71c3n0rA_



not modelled 99.9 15 PDB header:signaling protein
Chain: A: PDB Molecule:response regulator;
PDBTitle: structure of the phyr stress response regulator at 1.25 angstrom2 resolution
72c3dzdA_



not modelled 99.9 23 PDB header:transcription regulator
Chain: A: PDB Molecule:transcriptional regulator (ntrc family);
PDBTitle: crystal structure of sigma54 activator ntrc4 in the inactive2 state
73c2jrlA_



not modelled 99.9 24 PDB header:transcription
Chain: A: PDB Molecule:transcriptional regulator (ntrc family);
PDBTitle: solution structure of the beryllofluoride-activated ntrc4 receiver2 domain dimer
74d1xhfa1



not modelled 99.9 25 Fold:Flavodoxin-like
Superfamily:CheY-like
Family:CheY-related
75c3b2nA_



not modelled 99.9 19 PDB header:transcription
Chain: A: PDB Molecule:uncharacterized protein q99uf4;
PDBTitle: crystal structure of dna-binding response regulator, luxr family, from2 staphylococcus aureus
76d1mb3a_



not modelled 99.9 29 Fold:Flavodoxin-like
Superfamily:CheY-like
Family:CheY-related
77c3khtA_



not modelled 99.9 21 PDB header:signaling protein
Chain: A: PDB Molecule:response regulator;
PDBTitle: crystal structure of response regulator from hahella chejuensis
78c3rqiA_



not modelled 99.9 23 PDB header:transcription
Chain: A: PDB Molecule:response regulator protein;
PDBTitle: crystal structure of a response regulator protein from burkholderia2 pseudomallei with a phosphorylated aspartic acid, calcium ion and3 citrate
79d1a04a2



not modelled 99.9 23 Fold:Flavodoxin-like
Superfamily:CheY-like
Family:CheY-related
80c3c3mA_



not modelled 99.9 29 PDB header:signaling protein
Chain: A: PDB Molecule:response regulator receiver protein;
PDBTitle: crystal structure of the n-terminal domain of response regulator2 receiver protein from methanoculleus marisnigri jr1
81c3cg0A_



not modelled 99.9 26 PDB header:lyase
Chain: A: PDB Molecule:response regulator receiver modulated diguanylate cyclase
PDBTitle: crystal structure of signal receiver domain of modulated diguanylate2 cyclase from desulfovibrio desulfuricans g20, an example of alternate3 folding
82c1ys7B_



not modelled 99.9 29 PDB header:transcription regulator
Chain: B: PDB Molecule:transcriptional regulatory protein prra;
PDBTitle: crystal structure of the response regulator protein prra comlexed with2 mg2+
83c2jk1A_



not modelled 99.9 20 PDB header:dna-binding
Chain: A: PDB Molecule:hydrogenase transcriptional regulatory protein hupr1;
PDBTitle: crystal structure of the wild-type hupr receiver domain
84d1i3ca_



not modelled 99.9 23 Fold:Flavodoxin-like
Superfamily:CheY-like
Family:CheY-related
85c3m6mF_



not modelled 99.9 31 PDB header:lyase/transferase
Chain: F: PDB Molecule:sensory/regulatory protein rpfc;
PDBTitle: crystal structure of rpff complexed with rec domain of rpfc
86c2qvgA_



not modelled 99.9 19 PDB header:transferase
Chain: A: PDB Molecule:two component response regulator;
PDBTitle: the crystal structure of a two-component response regulator2 from legionella pneumophila
87c3ilhA_



not modelled 99.9 20 PDB header:transcription regulator
Chain: A: PDB Molecule:two component response regulator;
PDBTitle: crystal structure of two component response regulator from cytophaga2 hutchinsonii
88c2qxyB_



not modelled 99.9 22 PDB header:transcription
Chain: B: PDB Molecule:response regulator;
PDBTitle: crystal structure of a response regulator from thermotoga2 maritima
89c3hebB_



not modelled 99.9 24 PDB header:transcription regulator
Chain: B: PDB Molecule:response regulator receiver domain protein (chey);
PDBTitle: crystal structure of response regulator receiver domain from2 rhodospirillum rubrum
90c2gwrA_



not modelled 99.9 26 PDB header:signaling protein
Chain: A: PDB Molecule:dna-binding response regulator mtra;
PDBTitle: crystal structure of the response regulator protein mtra from2 mycobacterium tuberculosis
91c1a2oB_



not modelled 99.9 24 PDB header:bacterial chemotaxis
Chain: B: PDB Molecule:cheb methylesterase;
PDBTitle: structural basis for methylesterase cheb regulation by a2 phosphorylation-activated domain
92d1dz3a_



not modelled 99.9 25 Fold:Flavodoxin-like
Superfamily:CheY-like
Family:CheY-related
93d1dcfa_



not modelled 99.9 28 Fold:Flavodoxin-like
Superfamily:CheY-like
Family:Receiver domain of the ethylene receptor
94c3eulB_



not modelled 99.9 27 PDB header:transcription
Chain: B: PDB Molecule:possible nitrate/nitrite response transcriptional
PDBTitle: structure of the signal receiver domain of the putative2 response regulator narl from mycobacterium tuberculosis
95c3hdvB_



not modelled 99.9 26 PDB header:transcription regulator
Chain: B: PDB Molecule:response regulator;
PDBTitle: crystal structure of response regulator receiver protein from2 pseudomonas putida
96c2qv0A_



not modelled 99.9 24 PDB header:transcription
Chain: A: PDB Molecule:protein mrke;
PDBTitle: crystal structure of the response regulatory domain of2 protein mrke from klebsiella pneumoniae
97c3i42A_



not modelled 99.9 25 PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:response regulator receiver domain protein (chey-
PDBTitle: structure of response regulator receiver domain (chey-like)2 from methylobacillus flagellatus
98c3c97A_



not modelled 99.9 22 PDB header:signaling protein, transferase
Chain: A: PDB Molecule:signal transduction histidine kinase;
PDBTitle: crystal structure of the response regulator receiver domain2 of a signal transduction histidine kinase from aspergillus3 oryzae
99c3cz5B_



not modelled 99.9 23 PDB header:transcription regulator
Chain: B: PDB Molecule:two-component response regulator, luxr family;
PDBTitle: crystal structure of two-component response regulator, luxr family,2 from aurantimonas sp. si85-9a1
100c1p2fA_



not modelled 99.9 27 PDB header:transcription
Chain: A: PDB Molecule:response regulator;
PDBTitle: crystal structure analysis of response regulator drrb, a2 thermotoga maritima ompr/phob homolog
101c3kcnA_



not modelled 99.9 21 PDB header:lyase
Chain: A: PDB Molecule:adenylate cyclase homolog;
PDBTitle: the crystal structure of adenylate cyclase from2 rhodopirellula baltica
102c3h5iA_



not modelled 99.9 23 PDB header:transcription
Chain: A: PDB Molecule:response regulator/sensory box protein/ggdef
PDBTitle: crystal structure of the n-terminal domain of a response2 regulator/sensory box/ggdef 3-domain protein from3 carboxydothermus hydrogenoformans
103c3luaA_



not modelled 99.9 16 PDB header:transcription regulator
Chain: A: PDB Molecule:response regulator receiver protein;
PDBTitle: crystal structure of a signal receiver domain of two component signal2 transduction (histidine kinase) from clostridium thermocellum
104d1k68a_



not modelled 99.9 21 Fold:Flavodoxin-like
Superfamily:CheY-like
Family:CheY-related
105d1p2fa2



not modelled 99.9 28 Fold:Flavodoxin-like
Superfamily:CheY-like
Family:CheY-related
106c3nhmA_



not modelled 99.9 31 PDB header:signaling protein
Chain: A: PDB Molecule:response regulator;
PDBTitle: crystal structure of a response regulator from myxococcus xanthus
107c1kgsA_



not modelled 99.9 24 PDB header:dna binding protein
Chain: A: PDB Molecule:dna binding response regulator d;
PDBTitle: crystal structure at 1.50 a of an ompr/phob homolog from thermotoga2 maritima
108c3hzhA_



not modelled 99.9 24 PDB header:signaling protein
Chain: A: PDB Molecule:chemotaxis response regulator (chey-3);
PDBTitle: crystal structure of the chex-chey-bef3-mg+2 complex from2 borrelia burgdorferi
109c3grcD_



not modelled 99.9 23 PDB header:transferase
Chain: D: PDB Molecule:sensor protein, kinase;
PDBTitle: crystal structure of a sensor protein from polaromonas sp.2 js666
110c3eodA_



not modelled 99.9 30 PDB header:signaling protein
Chain: A: PDB Molecule:protein hnr;
PDBTitle: crystal structure of n-terminal domain of e. coli rssb
111d1w25a2



not modelled 99.9 21 Fold:Flavodoxin-like
Superfamily:CheY-like
Family:CheY-related
112c3gieA_



not modelled 99.9 16 PDB header:transferase
Chain: A: PDB Molecule:sensor histidine kinase desk;
PDBTitle: crystal structure of deskc_h188e in complex with amp-pcp
113c2rdmB_



not modelled 99.9 21 PDB header:structural genomics, unknown function
Chain: B: PDB Molecule:response regulator receiver protein;
PDBTitle: crystal structure of response regulator receiver protein from2 sinorhizobium medicae wsm419
114d1qo0d_



not modelled 99.9 10 Fold:Flavodoxin-like
Superfamily:CheY-like
Family:Positive regulator of the amidase operon AmiR
115c3snkA_



not modelled 99.9 18 PDB header:signaling protein
Chain: A: PDB Molecule:response regulator chey-like protein;
PDBTitle: crystal structure of a response regulator chey-like protein (mll6475)2 from mesorhizobium loti at 2.02 a resolution
116c3t8yA_



not modelled 99.9 25 PDB header:hydrolase
Chain: A: PDB Molecule:chemotaxis response regulator protein-glutamate
PDBTitle: crystal structure of the response regulator domain of thermotoga2 maritima cheb
117c3a0rB_



not modelled 99.9 28 PDB header:transferase
Chain: B: PDB Molecule:response regulator;
PDBTitle: crystal structure of histidine kinase thka (tm1359) in complex with2 response regulator protein trra (tm1360)
118d2b4aa1



not modelled 99.9 16 Fold:Flavodoxin-like
Superfamily:CheY-like
Family:CheY-related
119c3eqzB_



not modelled 99.9 23 PDB header:structural genomics, unknown function
Chain: B: PDB Molecule:response regulator;
PDBTitle: crystal structure of a response regulator from colwellia2 psychrerythraea
120c1zn2A_



not modelled 99.9 21 PDB header:transcription regulator
Chain: A: PDB Molecule:response regulatory protein;
PDBTitle: low resolution structure of response regulator styr

Binding site prediction 

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite



Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
 
© Structural Bioinformatics Group
Imperial College London
Lawrence Kelley, Benjamin Jefferys
Disclaimer
Terms and Conditions
Component software
Template detection: HHpred 1.51
Secondary structure prediction: Psi-pred 2.5
Disorder prediction: Disopred 2.4
Transmembrane prediction: Memsat_SVM
Multi-template modelling and ab initio: Poing 1.0