Phyre Home Retrieve Phyre Job Id
Emaill.a.kelley@imperial.ac.uk
DescriptionP39196
DateThu Jan 5 11:58:27 GMT 2012
Unique Job ID4fef362045539b3f

Summary 

Top model
Image coloured by rainbow N → C terminus
Model (left) based on template d1pv7a_
Top template information
Fold:MFS general substrate transporter
Superfamily:MFS general substrate transporter
Family:LacY-like proton/sugar symporter
Confidence and coverage
Confidence:100.0% Coverage: 97%
387 residues ( 97% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.
3D viewing
Interactive 3D view in Jmol

Sequence analysis 

Secondary structure and disorder prediction 

   1........10.........20.........30.........40.........50.........60
Sequence  MSESVHTNTSLWSKGMKAVIVAQFLSAFGDNALLFATLALLKAQFYPEWSQPILQMVFVG
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Disorder  ????????????















































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   .........70.........80.........90.........100.........110.........120
Sequence  AYILFAPFVGQVADSFAKGRVMMFANGLKLLGAASICFGINPFLGYTLVGVGAAAYSPAK
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   .........130.........140.........150.........160.........170.........180
Sequence  YGILGELTTGSKLVKANGLMEASTIAAILLGSVAGGVLADWHVLVALAACALAYGGAVVA
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   .........190.........200.........210.........220.........230.........240
Sequence  NIYIPKLAAARPGQSWNLINMTRSFLNACTSLWRNGETRFSLVGTSLFWGAGVTLRFLLV
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   .........250.........260.........270.........280.........290.........300
Sequence  LWVPVALGITDNATPTYLNAMVAIGIVVGAGAAAKLVTLETVSRCMPAGILIGVVVLIFS
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   .........310.........320.........330.........340.........350.........360
Sequence  LQHELLPAYALLMLIGVMGGFFVVPLNALLQERGKKSVGAGNAIAVQNLGENSAMLLMLG
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   .........370.........380.........390.......
Sequence  IYSLAVMIGIPVVPIGIGFGALFALAITALWIWQRRH
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????
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Confidence Key
High(9)                    Low (0)
?Disordered
Alpha helix
Beta strand

Domain analysis 

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

RankAligned region

PDB 1pv7 chain A

3D model

Region: 11 - 397
Aligned: 387
Modelled: 387
Confidence: 100.0%
Identity: 11%
Fold: MFS general substrate transporter
Superfamily: MFS general substrate transporter
Family: LacY-like proton/sugar symporter

Phyre2

PDB 1pw4 chain A

3D model

Region: 2 - 396
Aligned: 393
Modelled: 395
Confidence: 100.0%
Identity: 10%
Fold: MFS general substrate transporter
Superfamily: MFS general substrate transporter
Family: Glycerol-3-phosphate transporter

Phyre2

PDB 2gfp chain A

3D model

Region: 16 - 385
Aligned: 368
Modelled: 370
Confidence: 100.0%
Identity: 9%
PDB header:membrane protein
Chain: A: PDB Molecule:multidrug resistance protein d;
PDBTitle: structure of the multidrug transporter emrd from2 escherichia coli

Phyre2

PDB 3o7p chain A

3D model

Region: 14 - 395
Aligned: 379
Modelled: 379
Confidence: 99.9%
Identity: 12%
PDB header:transport protein
Chain: A: PDB Molecule:l-fucose-proton symporter;
PDBTitle: crystal structure of the e.coli fucose:proton symporter, fucp (n162a)

Phyre2

PDB 2xut chain C

3D model

Region: 18 - 392
Aligned: 374
Modelled: 375
Confidence: 99.9%
Identity: 11%
PDB header:transport protein
Chain: C: PDB Molecule:proton/peptide symporter family protein;
PDBTitle: crystal structure of a proton dependent oligopeptide (pot)2 family transporter.

Phyre2

PDB 2w8a chain C

3D model

Region: 17 - 214
Aligned: 198
Modelled: 198
Confidence: 11.8%
Identity: 13%
PDB header:membrane protein
Chain: C: PDB Molecule:glycine betaine transporter betp;
PDBTitle: crystal structure of the sodium-coupled glycine betaine2 symporter betp from corynebacterium glutamicum with bound3 substrate

Phyre2

PDB 2g9p chain A

3D model

Region: 68 - 81
Aligned: 14
Modelled: 14
Confidence: 11.8%
Identity: 14%
PDB header:antimicrobial protein
Chain: A: PDB Molecule:antimicrobial peptide latarcin 2a;
PDBTitle: nmr structure of a novel antimicrobial peptide, latarcin 2a,2 from spider (lachesana tarabaevi) venom

Phyre2

PDB 2xq2 chain A

3D model

Region: 47 - 210
Aligned: 162
Modelled: 164
Confidence: 8.7%
Identity: 7%
PDB header:transport protein
Chain: A: PDB Molecule:sodium/glucose cotransporter;
PDBTitle: structure of the k294a mutant of vsglt

Phyre2

PDB 2ks1 chain B

3D model

Region: 373 - 397
Aligned: 25
Modelled: 25
Confidence: 8.4%
Identity: 20%
PDB header:transferase
Chain: B: PDB Molecule:epidermal growth factor receptor;
PDBTitle: heterodimeric association of transmembrane domains of erbb1 and erbb22 receptors enabling kinase activation

Phyre2

PDB 2bbj chain B

3D model

Region: 337 - 396
Aligned: 58
Modelled: 60
Confidence: 8.0%
Identity: 9%
PDB header:metal transport/membrane protein
Chain: B: PDB Molecule:divalent cation transport-related protein;
PDBTitle: crystal structure of the cora mg2+ transporter

Phyre2

PDB 2vut chain I domain 1

3D model

Region: 6 - 15
Aligned: 10
Modelled: 10
Confidence: 7.2%
Identity: 30%
Fold: Glucocorticoid receptor-like (DNA-binding domain)
Superfamily: Glucocorticoid receptor-like (DNA-binding domain)
Family: Erythroid transcription factor GATA-1

Phyre2

PDB 1y0j chain A domain 1

3D model

Region: 6 - 15
Aligned: 10
Modelled: 10
Confidence: 5.9%
Identity: 40%
Fold: Glucocorticoid receptor-like (DNA-binding domain)
Superfamily: Glucocorticoid receptor-like (DNA-binding domain)
Family: Erythroid transcription factor GATA-1

Phyre2
1

d1pv7a_
2

d1pw4a_
3

c2gfpA_
4

c3o7pA_
5

c2xutC_
6

c2w8aC_
7

c2g9pA_
8

c2xq2A_
9

c2ks1B_
10

c2bbjB_
11

d2vuti1
12

d1y0ja1



Detailed template information 

#
Template Alignment Coverage3D Model Confidence
% i.d. Template Information
1d1pv7a_



100.0 11 Fold:MFS general substrate transporter
Superfamily:MFS general substrate transporter
Family:LacY-like proton/sugar symporter
2d1pw4a_



100.0 10 Fold:MFS general substrate transporter
Superfamily:MFS general substrate transporter
Family:Glycerol-3-phosphate transporter
3c2gfpA_



100.0 9 PDB header:membrane protein
Chain: A: PDB Molecule:multidrug resistance protein d;
PDBTitle: structure of the multidrug transporter emrd from2 escherichia coli
4c3o7pA_



99.9 12 PDB header:transport protein
Chain: A: PDB Molecule:l-fucose-proton symporter;
PDBTitle: crystal structure of the e.coli fucose:proton symporter, fucp (n162a)
5c2xutC_



99.9 11 PDB header:transport protein
Chain: C: PDB Molecule:proton/peptide symporter family protein;
PDBTitle: crystal structure of a proton dependent oligopeptide (pot)2 family transporter.
6c2w8aC_



11.8 13 PDB header:membrane protein
Chain: C: PDB Molecule:glycine betaine transporter betp;
PDBTitle: crystal structure of the sodium-coupled glycine betaine2 symporter betp from corynebacterium glutamicum with bound3 substrate
7c2g9pA_



11.8 14 PDB header:antimicrobial protein
Chain: A: PDB Molecule:antimicrobial peptide latarcin 2a;
PDBTitle: nmr structure of a novel antimicrobial peptide, latarcin 2a,2 from spider (lachesana tarabaevi) venom
8c2xq2A_



8.7 7 PDB header:transport protein
Chain: A: PDB Molecule:sodium/glucose cotransporter;
PDBTitle: structure of the k294a mutant of vsglt
9c2ks1B_



8.4 20 PDB header:transferase
Chain: B: PDB Molecule:epidermal growth factor receptor;
PDBTitle: heterodimeric association of transmembrane domains of erbb1 and erbb22 receptors enabling kinase activation
10c2bbjB_



8.0 9 PDB header:metal transport/membrane protein
Chain: B: PDB Molecule:divalent cation transport-related protein;
PDBTitle: crystal structure of the cora mg2+ transporter
11d2vuti1



7.2 30 Fold:Glucocorticoid receptor-like (DNA-binding domain)
Superfamily:Glucocorticoid receptor-like (DNA-binding domain)
Family:Erythroid transcription factor GATA-1
12d1y0ja1



5.9 40 Fold:Glucocorticoid receptor-like (DNA-binding domain)
Superfamily:Glucocorticoid receptor-like (DNA-binding domain)
Family:Erythroid transcription factor GATA-1

Binding site prediction 

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite



Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
 
© Structural Bioinformatics Group
Imperial College London
Lawrence Kelley, Benjamin Jefferys
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Terms and Conditions
Component software
Template detection: HHpred 1.51
Secondary structure prediction: Psi-pred 2.5
Disorder prediction: Disopred 2.4
Transmembrane prediction: Memsat_SVM
Multi-template modelling and ab initio: Poing 1.0