Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	I	T	Y	H	D	A	F	A	K	A	N	H	Y	L	D	D	A	D	L	P	V	V	I	T	L	H	G	R	F	S	Q	G	W	Y	F	C	F	E	A	R	E	F	L	E	T	G	D	E	A	A	R	L	A	G	N	A	P	F	I
Secondary structure
SS confidence
Disorder		?	?	?																																														?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.
Sequence		I	D	K	D	S	G	E	I	H	S	L	G	T	A	K	P	L	E	E	Y	L	Q	D	Y	E	I	K	K	A	T	F	G	L	P
Secondary structure
SS confidence
Disorder											?	?	?																?	?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 3cgi chain D Region: 60 - 83 Aligned: 24 Modelled: 24 Confidence: 48.2% Identity: 21% PDB header:unknown function Chain: D: PDB Molecule:propanediol utilization protein pduu; PDBTitle: crystal structure of the pduu shell protein from the pdu2 microcompartment Phyre2 PDB 3ia0 chain C Region: 60 - 83 Aligned: 24 Modelled: 24 Confidence: 46.0% Identity: 29% PDB header:structural protein Chain: C: PDB Molecule:ethanolamine utilization protein euts; PDBTitle: ethanolamine utilization microcompartment shell subunit,2 euts-g39v mutant Phyre2 PDB 1uli chain A domain 1 Region: 30 - 76 Aligned: 47 Modelled: 47 Confidence: 42.1% Identity: 19% Fold: ISP domain Superfamily: ISP domain Family: Ring hydroxylating alpha subunit ISP domain Phyre2 PDB 2odk chain D Region: 2 - 29 Aligned: 28 Modelled: 28 Confidence: 35.3% Identity: 25% PDB header:structural genomics, unknown function Chain: D: PDB Molecule:hypothetical protein; PDBTitle: putative prevent-host-death protein from nitrosomonas europaea Phyre2 PDB 3hry chain A Region: 2 - 29 Aligned: 28 Modelled: 28 Confidence: 31.4% Identity: 29% PDB header:antitoxin Chain: A: PDB Molecule:prevent host death protein; PDBTitle: crystal structure of phd in a trigonal space group and partially2 disordered Phyre2 PDB 2odk chain A domain 1 Region: 1 - 29 Aligned: 29 Modelled: 29 Confidence: 30.5% Identity: 24% Fold: YefM-like Superfamily: YefM-like Family: YefM-like Phyre2 PDB 2bmo chain A domain 1 Region: 17 - 76 Aligned: 60 Modelled: 60 Confidence: 26.0% Identity: 15% Fold: ISP domain Superfamily: ISP domain Family: Ring hydroxylating alpha subunit ISP domain Phyre2 PDB 1o7n chain A domain 1 Region: 13 - 76 Aligned: 64 Modelled: 64 Confidence: 24.9% Identity: 17% Fold: ISP domain Superfamily: ISP domain Family: Ring hydroxylating alpha subunit ISP domain Phyre2 PDB 3c5p chain F Region: 26 - 63 Aligned: 37 Modelled: 38 Confidence: 24.6% Identity: 30% PDB header:structural genomics, unknown function Chain: F: PDB Molecule:protein bas0735 of unknown function; PDBTitle: crystal structure of bas0735, a protein of unknown function from2 bacillus anthracis str. sterne Phyre2 PDB 3gkq chain B Region: 30 - 71 Aligned: 41 Modelled: 42 Confidence: 23.6% Identity: 15% PDB header:oxidoreductase Chain: B: PDB Molecule:terminal oxygenase component of carbazole 1,9a- PDBTitle: terminal oxygenase of carbazole 1,9a-dioxygenase from2 novosphingobium sp. ka1 Phyre2 PDB 3gcf chain C Region: 30 - 71 Aligned: 41 Modelled: 42 Confidence: 20.9% Identity: 20% PDB header:oxidoreductase Chain: C: PDB Molecule:terminal oxygenase component of carbazole 1,9a- PDBTitle: terminal oxygenase of carbazole 1,9a-dioxygenase from2 nocardioides aromaticivorans ic177 Phyre2 PDB 2b1x chain A domain 1 Region: 30 - 76 Aligned: 47 Modelled: 47 Confidence: 20.1% Identity: 32% Fold: ISP domain Superfamily: ISP domain Family: Ring hydroxylating alpha subunit ISP domain Phyre2 PDB 2a6q chain B domain 1 Region: 2 - 29 Aligned: 28 Modelled: 28 Confidence: 20.0% Identity: 29% Fold: YefM-like Superfamily: YefM-like Family: YefM-like Phyre2 PDB 3hs2 chain H Region: 2 - 29 Aligned: 28 Modelled: 28 Confidence: 19.3% Identity: 29% PDB header:antitoxin Chain: H: PDB Molecule:prevent host death protein; PDBTitle: crystal structure of phd truncated to residue 57 in an orthorhombic2 space group Phyre2 PDB 2jx8 chain A Region: 32 - 67 Aligned: 23 Modelled: 36 Confidence: 18.7% Identity: 39% PDB header:transcription Chain: A: PDB Molecule:phosphorylated ctd-interacting factor 1; PDBTitle: solution structure of hpcif1 ww domain Phyre2 PDB 2de6 chain A domain 1 Region: 30 - 71 Aligned: 41 Modelled: 42 Confidence: 17.6% Identity: 17% Fold: ISP domain Superfamily: ISP domain Family: Ring hydroxylating alpha subunit ISP domain Phyre2 PDB 2jso chain A Region: 39 - 83 Aligned: 44 Modelled: 45 Confidence: 16.1% Identity: 18% PDB header:signaling protein Chain: A: PDB Molecule:polymyxin resistance protein pmrd; PDBTitle: antimicrobial resistance protein Phyre2 PDB 1wql chain A domain 1 Region: 30 - 76 Aligned: 47 Modelled: 47 Confidence: 13.5% Identity: 17% Fold: ISP domain Superfamily: ISP domain Family: Ring hydroxylating alpha subunit ISP domain Phyre2 PDB 2ckc chain A Region: 60 - 84 Aligned: 25 Modelled: 25 Confidence: 13.3% Identity: 24% PDB header:hydrolase Chain: A: PDB Molecule:chromodomain-helicase-dna-binding protein 7; PDBTitle: solution structures of the brk domains of the human chromo2 helicase domain 7 and 8, reveals structural similarity3 with gyf domain suggesting a role in protein interaction Phyre2 PDB 2ckc chain A domain 1 Region: 60 - 84 Aligned: 25 Modelled: 25 Confidence: 13.3% Identity: 24% Fold: GYF/BRK domain-like Superfamily: BRK domain-like Family: BRK domain-like Phyre2 1 c3cgiD_ 2 c3ia0c_ 3 d1ulia1 4 c2odkD_ 5 c3hryA_ 6 d2odka1 7 d2bmoa1 8 d1o7na1 9 c3c5pF_ 10 c3gkqB_ 11 c3gcfC_ 12 d2b1xa1 13 d2a6qb1 14 c3hs2H_ 15 c2jx8A_ 16 d2de6a1 17 c2jsoA_ 18 d1wqla1 19 c2ckcA_ 20 d2ckca1 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c3cgiD_ 48.2 21 PDB header:unknown function Chain: D: PDB Molecule:propanediol utilization protein pduu; PDBTitle: crystal structure of the pduu shell protein from the pdu2 microcompartment 2 c3ia0c_ 46.0 29 PDB header:structural protein Chain: C: PDB Molecule:ethanolamine utilization protein euts; PDBTitle: ethanolamine utilization microcompartment shell subunit,2 euts-g39v mutant 3 d1ulia1 42.1 19 Fold:ISP domain Superfamily:ISP domain Family:Ring hydroxylating alpha subunit ISP domain 4 c2odkD_ 35.3 25 PDB header:structural genomics, unknown function Chain: D: PDB Molecule:hypothetical protein; PDBTitle: putative prevent-host-death protein from nitrosomonas europaea 5 c3hryA_ 31.4 29 PDB header:antitoxin Chain: A: PDB Molecule:prevent host death protein; PDBTitle: crystal structure of phd in a trigonal space group and partially2 disordered 6 d2odka1 30.5 24 Fold:YefM-like Superfamily:YefM-like Family:YefM-like 7 d2bmoa1 26.0 15 Fold:ISP domain Superfamily:ISP domain Family:Ring hydroxylating alpha subunit ISP domain 8 d1o7na1 24.9 17 Fold:ISP domain Superfamily:ISP domain Family:Ring hydroxylating alpha subunit ISP domain 9 c3c5pF_ 24.6 30 PDB header:structural genomics, unknown function Chain: F: PDB Molecule:protein bas0735 of unknown function; PDBTitle: crystal structure of bas0735, a protein of unknown function from2 bacillus anthracis str. sterne 10 c3gkqB_ 23.6 15 PDB header:oxidoreductase Chain: B: PDB Molecule:terminal oxygenase component of carbazole 1,9a- PDBTitle: terminal oxygenase of carbazole 1,9a-dioxygenase from2 novosphingobium sp. ka1 11 c3gcfC_ 20.9 20 PDB header:oxidoreductase Chain: C: PDB Molecule:terminal oxygenase component of carbazole 1,9a- PDBTitle: terminal oxygenase of carbazole 1,9a-dioxygenase from2 nocardioides aromaticivorans ic177 12 d2b1xa1 20.1 32 Fold:ISP domain Superfamily:ISP domain Family:Ring hydroxylating alpha subunit ISP domain 13 d2a6qb1 20.0 29 Fold:YefM-like Superfamily:YefM-like Family:YefM-like 14 c3hs2H_ 19.3 29 PDB header:antitoxin Chain: H: PDB Molecule:prevent host death protein; PDBTitle: crystal structure of phd truncated to residue 57 in an orthorhombic2 space group 15 c2jx8A_ 18.7 39 PDB header:transcription Chain: A: PDB Molecule:phosphorylated ctd-interacting factor 1; PDBTitle: solution structure of hpcif1 ww domain 16 d2de6a1 17.6 17 Fold:ISP domain Superfamily:ISP domain Family:Ring hydroxylating alpha subunit ISP domain 17 c2jsoA_ 16.1 18 PDB header:signaling protein Chain: A: PDB Molecule:polymyxin resistance protein pmrd; PDBTitle: antimicrobial resistance protein 18 d1wqla1 13.5 17 Fold:ISP domain Superfamily:ISP domain Family:Ring hydroxylating alpha subunit ISP domain 19 c2ckcA_ 13.3 24 PDB header:hydrolase Chain: A: PDB Molecule:chromodomain-helicase-dna-binding protein 7; PDBTitle: solution structures of the brk domains of the human chromo2 helicase domain 7 and 8, reveals structural similarity3 with gyf domain suggesting a role in protein interaction 20 d2ckca1 13.3 24 Fold:GYF/BRK domain-like Superfamily:BRK domain-like Family:BRK domain-like 21 d2a6qa1 not modelled 11.0 30 Fold:YefM-like Superfamily:YefM-like Family:YefM-like 22 d2fbaa1 not modelled 10.8 16 Fold:alpha/alpha toroid Superfamily:Six-hairpin glycosidases Family:Glucoamylase 23 c1ncgA_ not modelled 10.3 27 PDB header:cell adhesion protein Chain: A: PDB Molecule:n-cadherin; PDBTitle: structural basis of cell-cell adhesion by cadherins 24 d1z01a1 not modelled 10.2 22 Fold:ISP domain Superfamily:ISP domain Family:Ring hydroxylating alpha subunit ISP domain 25 c1zvnA_ not modelled 9.9 32 PDB header:---- Chain: A: PDB Molecule:mn-cadherin; PDBTitle: crystal structure of chick mn-cadherin ec1 26 d1tdha3 not modelled 9.9 28 Fold:Glucocorticoid receptor-like (DNA-binding domain) Superfamily:Glucocorticoid receptor-like (DNA-binding domain) Family:C-terminal, Zn-finger domain of MutM-like DNA repair proteins 27 c2rqxA_ not modelled 9.5 21 PDB header:signaling protein Chain: A: PDB Molecule:polymyxin b resistance protein; PDBTitle: solution nmr structure of pmrd from klebsiella pneumoniae 28 c2e9qA_ not modelled 9.4 18 PDB header:plant protein Chain: A: PDB Molecule:11s globulin subunit beta; PDBTitle: recombinant pro-11s globulin of pumpkin 29 d2idaa1 not modelled 9.0 14 Fold:RING/U-box Superfamily:RING/U-box Family:Zf-UBP 30 d2pbka1 not modelled 9.0 18 Fold:Herpes virus serine proteinase, assemblin Superfamily:Herpes virus serine proteinase, assemblin Family:Herpes virus serine proteinase, assemblin 31 d1njha_ not modelled 8.8 22 Fold:Hypothetical protein YojF Superfamily:Hypothetical protein YojF Family:Hypothetical protein YojF 32 c3ff7B_ not modelled 8.1 27 PDB header:cell adhesion/immunue system Chain: B: PDB Molecule:epithelial cadherin; PDBTitle: structure of nk cell receptor klrg1 bound to e-cadherin 33 d1aa7a_ not modelled 8.1 35 Fold:Influenza virus matrix protein M1 Superfamily:Influenza virus matrix protein M1 Family:Influenza virus matrix protein M1 34 d1o6ea_ not modelled 8.0 13 Fold:Herpes virus serine proteinase, assemblin Superfamily:Herpes virus serine proteinase, assemblin Family:Herpes virus serine proteinase, assemblin 35 c2b1xE_ not modelled 7.9 26 PDB header:oxidoreductase Chain: E: PDB Molecule:naphthalene dioxygenase large subunit; PDBTitle: crystal structure of naphthalene 1,2-dioxygenase from rhodococcus sp. 36 c3g5oA_ not modelled 7.4 21 PDB header:toxin/antitoxin Chain: A: PDB Molecule:uncharacterized protein rv2865; PDBTitle: the crystal structure of the toxin-antitoxin complex relbe2 (rv2865-2 2866) from mycobacterium tuberculosis 37 d1y0pa3 not modelled 7.1 17 Fold:Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain Superfamily:Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain Family:Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain 38 c3entB_ not modelled 7.0 20 PDB header:structural protein Chain: B: PDB Molecule:putative uncharacterized protein; PDBTitle: crystal structure of nitrollin, a betagamma-crystallin from2 nitrosospira multiformis-in alternate space group (p65) 39 d1ynha1 not modelled 7.0 16 Fold:Pentein, beta/alpha-propeller Superfamily:Pentein Family:Succinylarginine dihydrolase-like 40 d1r76a_ not modelled 6.9 33 Fold:alpha/alpha toroid Superfamily:Family 10 polysaccharide lyase Family:Family 10 polysaccharide lyase 41 d2omzb1 not modelled 6.9 29 Fold:Immunoglobulin-like beta-sandwich Superfamily:Cadherin-like Family:Cadherin 42 c3jr7A_ not modelled 6.5 9 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized egv family protein cog1307; PDBTitle: the crystal structure of the protein of degv family cog1307 with2 unknown function from ruminococcus gnavus atcc 29149 43 d1vr5a1 not modelled 6.5 11 Fold:Periplasmic binding protein-like II Superfamily:Periplasmic binding protein-like II Family:Phosphate binding protein-like 44 c1uljA_ not modelled 6.5 19 PDB header:oxidoreductase Chain: A: PDB Molecule:biphenyl dioxygenase large subunit; PDBTitle: biphenyl dioxygenase (bpha1a2) in complex with the substrate 45 d1iega_ not modelled 6.1 19 Fold:Herpes virus serine proteinase, assemblin Superfamily:Herpes virus serine proteinase, assemblin Family:Herpes virus serine proteinase, assemblin 46 c3gteB_ not modelled 6.0 21 PDB header:electron transport, oxidoreductase Chain: B: PDB Molecule:ddmc; PDBTitle: crystal structure of dicamba monooxygenase with non-heme2 iron 47 c2hjjA_ not modelled 6.0 15 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical protein ykff; PDBTitle: solution nmr structure of protein ykff from escherichia coli.2 northeast structural genomics target er397. 48 d2hjja1 not modelled 6.0 15 Fold:dsRBD-like Superfamily:YcfA/nrd intein domain Family:YkfF-like 49 c2o7jA_ not modelled 5.9 11 PDB header:sugar binding protein Chain: A: PDB Molecule:oligopeptide abc transporter, periplasmic PDBTitle: the x-ray crystal structure of a thermophilic cellobiose2 binding protein bound with cellopentaose 50 c2js3B_ not modelled 5.9 28 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:uncharacterized protein; PDBTitle: nmr structure of protein q6n9a4_rhopa. northeast structural genomics2 consortium target rpt8 51 c2de7B_ not modelled 5.5 17 PDB header:oxidoreductase Chain: B: PDB Molecule:terminal oxygenase component of carbazole; PDBTitle: the substrate-bound complex between oxygenase and2 ferredoxin in carbazole 1,9a-dioxygenase 52 d1at3a_ not modelled 5.3 16 Fold:Herpes virus serine proteinase, assemblin Superfamily:Herpes virus serine proteinase, assemblin Family:Herpes virus serine proteinase, assemblin 53 d1smye_ not modelled 5.3 30 Fold:RPB6/omega subunit-like Superfamily:RPB6/omega subunit-like Family:RNA polymerase omega subunit 54 d1vkza1 not modelled 5.3 21 Fold:Barrel-sandwich hybrid Superfamily:Rudiment single hybrid motif Family:BC C-terminal domain-like 55 c1nchB_ not modelled 5.3 27 PDB header:cell adhesion protein Chain: B: PDB Molecule:n-cadherin; PDBTitle: structural basis of cell-cell adhesion by cadherins 56 c1nciB_ not modelled 5.2 30 PDB header:cell adhesion protein Chain: B: PDB Molecule:n-cadherin; PDBTitle: structural basis of cell-cell adhesion by cadherins

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0