Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	L	S	P	L	L	K	R	Y	T	W	N	S	A	W	L	Y	Y	A	R	I	F	I	A	L	C	G	T	T	A	F	P	W	W	L	G	D	V	K	L	T	I	P	L	T	L	G	M	V	A	A	A	L	T	D	L	D	D	R	L
Secondary structure
SS confidence
Disorder		?	?	?																																																			?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	G	R	L	R	N	L	I	I	T	L	F	C	F	F	I	A	S	A	S	V	E	L	L	F	P	W	P	W	L	F	A	I	G	L	T	L	S	T	S	G	F	I	L	L	G	G	L	G	Q	R	Y	A	T	I	A	F	G	A	L
Secondary structure
SS confidence
Disorder																																																		?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		L	I	A	I	Y	T	M	L	G	T	S	L	Y	E	H	W	Y	Q	Q	P	M	Y	L	L	A	G	A	V	W	Y	N	V	L	T	L	I	G	H	L	L	F	P	V	R	P	L	Q	D	N	L	A	R	C	Y	E	Q	L	A	R	Y
Secondary structure
SS confidence
Disorder									?					?																											?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		L	E	L	K	S	R	M	F	D	P	D	I	E	D	Q	S	Q	A	P	L	Y	D	L	A	L	A	N	G	L	L	M	A	T	L	N	Q	T	K	L	S	L	L	T	R	L	R	G	D	R	G	Q	R	G	T	R	R	T	L	H	Y
Secondary structure
SS confidence
Disorder													?	?	?	?	?	?																												?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		Y	F	V	A	Q	D	I	H	E	R	A	S	S	S	H	I	Q	Y	Q	T	L	R	E	H	F	R	H	S	D	V	L	F	R	F	Q	R	L	M	S	M	Q	G	Q	A	C	Q	Q	L	S	R	C	I	L	L	R	Q	P	Y	Q	H
Secondary structure
SS confidence
Disorder															?																																										?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		D	P	H	F	E	R	A	F	T	H	I	D	A	A	L	E	R	M	R	D	N	G	A	P	A	D	L	L	K	T	L	G	F	L	L	N	N	L	R	A	I	D	A	Q	L	A	T	I	E	S	E	Q	A	Q	A	L	P	H	N	N
Secondary structure
SS confidence
Disorder																					?	?		?																															?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		D	E	N	E	L	A	D	D	S	P	H	G	L	S	D	I	W	L	R	L	S	R	H	F	T	P	E	S	A	L	F	R	H	A	V	R	M	S	L	V	L	C	F	G	Y	A	I	I	Q	I	T	G	M	H	H	G	Y	W	I	L
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		L	T	S	L	F	V	C	Q	P	N	Y	N	A	T	R	H	R	L	K	L	R	I	I	G	T	L	V	G	I	A	I	G	I	P	V	L	W	F	V	P	S	L	E	G	Q	L	V	L	L	V	I	T	G	V	L	F	F	A	F	R
Secondary structure
SS confidence
Disorder										?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence		N	V	Q	Y	A	H	A	T	M	F	I	T	L	L	V	L	L	C	F	N	L	L	G	E	G	F	E	V	A	L	P	R	V	I	D	T	L	I	G	C	A	I	A	W	A	A	V	S	Y	I	W	P	D	W	Q	F	R	N	L	P
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600
Sequence		R	M	L	E	R	A	T	E	A	N	C	R	Y	L	D	A	I	L	E	Q	Y	H	Q	G	R	D	N	R	L	A	Y	R	I	A	R	R	D	A	H	N	R	D	A	E	L	A	S	V	V	S	N	M	S	S	E	P	N	V	T	P
Secondary structure
SS confidence
Disorder																							?	?	?	?	?	?																											?		?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630	.	.	.	.	.	.	.	.	.	640	.	.	.	.	.	.	.	.	.	650	.	.	.	.	.	.	.	.	.	660
Sequence		Q	I	R	E	A	A	F	R	L	L	C	L	N	H	T	F	T	S	Y	I	S	A	L	G	A	H	R	E	Q	L	T	N	P	E	I	L	A	F	L	D	D	A	V	C	Y	V	D	D	A	L	H	H	Q	P	A	D	E	E	R	V
Secondary structure
SS confidence
Disorder		?																										?	?	?	?	?	?	?																			?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	670	.	.	.	.	.	.	.	.	.	680	.	.	.	.	.	.	.	.	.	690	.	.	.	.	.	.	.	.	.	700	.	.	.	.	.	.	.	.	.	710	.	.	.	.	.	.	.
Sequence		N	E	A	L	A	S	L	K	Q	R	M	Q	Q	L	E	P	R	A	D	S	K	E	P	L	V	V	Q	Q	V	G	L	L	I	A	L	L	P	E	I	G	R	L	Q	R	Q	I	T	Q	V	P	Q	E	T	P	V	S	A
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?																																										?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2ht2 chain B Region: 442 - 545 Aligned: 93 Modelled: 104 Confidence: 52.5% Identity: 18% PDB header:membrane protein Chain: B: PDB Molecule:h(+)/cl(-) exchange transporter clca; PDBTitle: structure of the escherichia coli clc chloride channel2 y445h mutant and fab complex Phyre2 PDB 3k3g chain A Region: 25 - 111 Aligned: 87 Modelled: 87 Confidence: 36.9% Identity: 13% PDB header:transport protein Chain: A: PDB Molecule:urea transporter; PDBTitle: crystal structure of the urea transporter from desulfovibrio vulgaris2 bound to 1,3-dimethylurea Phyre2 PDB 3cvf chain A Region: 648 - 714 Aligned: 67 Modelled: 67 Confidence: 16.6% Identity: 12% PDB header:signaling protein Chain: A: PDB Molecule:homer protein homolog 3; PDBTitle: crystal structure of the carboxy terminus of homer3 Phyre2 PDB 1ots chain A Region: 442 - 549 Aligned: 97 Modelled: 108 Confidence: 16.3% Identity: 16% Fold: Clc chloride channel Superfamily: Clc chloride channel Family: Clc chloride channel Phyre2 PDB 1hlo chain A Region: 658 - 712 Aligned: 55 Modelled: 55 Confidence: 14.5% Identity: 11% Fold: HLH-like Superfamily: HLH, helix-loop-helix DNA-binding domain Family: HLH, helix-loop-helix DNA-binding domain Phyre2 PDB 1nlw chain E Region: 658 - 712 Aligned: 55 Modelled: 55 Confidence: 14.5% Identity: 11% Fold: HLH-like Superfamily: HLH, helix-loop-helix DNA-binding domain Family: HLH, helix-loop-helix DNA-binding domain Phyre2 PDB 2r6g chain F domain 1 Region: 63 - 125 Aligned: 63 Modelled: 63 Confidence: 14.3% Identity: 8% Fold: MalF N-terminal region-like Superfamily: MalF N-terminal region-like Family: MalF N-terminal region-like Phyre2 PDB 3dtu chain A domain 1 Region: 31 - 180 Aligned: 143 Modelled: 150 Confidence: 14.1% Identity: 10% Fold: Cytochrome c oxidase subunit I-like Superfamily: Cytochrome c oxidase subunit I-like Family: Cytochrome c oxidase subunit I-like Phyre2 PDB 1kpl chain A Region: 442 - 549 Aligned: 97 Modelled: 97 Confidence: 13.2% Identity: 18% Fold: Clc chloride channel Superfamily: Clc chloride channel Family: Clc chloride channel Phyre2 PDB 1ei3 chain E Region: 634 - 708 Aligned: 75 Modelled: 75 Confidence: 12.6% Identity: 11% PDB header: PDB COMPND: Phyre2 PDB 3nd0 chain A Region: 442 - 543 Aligned: 91 Modelled: 102 Confidence: 12.5% Identity: 16% PDB header:transport protein Chain: A: PDB Molecule:sll0855 protein; PDBTitle: x-ray crystal structure of a slow cyanobacterial cl-/h+ antiporter Phyre2 PDB 1pw4 chain A Region: 40 - 172 Aligned: 133 Modelled: 133 Confidence: 12.5% Identity: 11% Fold: MFS general substrate transporter Superfamily: MFS general substrate transporter Family: Glycerol-3-phosphate transporter Phyre2 PDB 1m56 chain G Region: 31 - 180 Aligned: 143 Modelled: 150 Confidence: 12.2% Identity: 10% PDB header:oxidoreductase Chain: G: PDB Molecule:cytochrome c oxidase; PDBTitle: structure of cytochrome c oxidase from rhodobactor2 sphaeroides (wild type) Phyre2 PDB 1nkp chain B Region: 658 - 712 Aligned: 55 Modelled: 55 Confidence: 10.1% Identity: 11% Fold: HLH-like Superfamily: HLH, helix-loop-helix DNA-binding domain Family: HLH, helix-loop-helix DNA-binding domain Phyre2 PDB 1deq chain F Region: 634 - 712 Aligned: 79 Modelled: 79 Confidence: 9.7% Identity: 10% PDB header: PDB COMPND: Phyre2 PDB 1an2 chain A Region: 658 - 712 Aligned: 55 Modelled: 55 Confidence: 9.7% Identity: 11% Fold: HLH-like Superfamily: HLH, helix-loop-helix DNA-binding domain Family: HLH, helix-loop-helix DNA-binding domain Phyre2 PDB 1k8k chain D domain 2 Region: 526 - 596 Aligned: 62 Modelled: 70 Confidence: 9.5% Identity: 11% Fold: Secretion chaperone-like Superfamily: Arp2/3 complex subunits Family: Arp2/3 complex subunits Phyre2 PDB 1r05 chain A Region: 658 - 712 Aligned: 55 Modelled: 55 Confidence: 9.3% Identity: 13% Fold: HLH-like Superfamily: HLH, helix-loop-helix DNA-binding domain Family: HLH, helix-loop-helix DNA-binding domain Phyre2 PDB 2knc chain A Region: 126 - 159 Aligned: 34 Modelled: 34 Confidence: 8.3% Identity: 15% PDB header:cell adhesion Chain: A: PDB Molecule:integrin alpha-iib; PDBTitle: platelet integrin alfaiib-beta3 transmembrane-cytoplasmic2 heterocomplex Phyre2 PDB 1st6 chain A domain 5 Region: 635 - 717 Aligned: 74 Modelled: 83 Confidence: 8.0% Identity: 14% Fold: Four-helical up-and-down bundle Superfamily: alpha-catenin/vinculin-like Family: alpha-catenin/vinculin Phyre2 1 c2ht2B_ 2 c3k3gA_ 3 c3cvfA_ 4 d1otsa_ 5 d1hloa_ 6 d1nlwe_ 7 d2r6gf1 8 d3dtua1 9 d1kpla_ 10 c1ei3E_ 11 c3nd0A_ 12 d1pw4a_ 13 c1m56G_ 14 d1nkpb_ 15 c1deqF_ 16 d1an2a_ 17 d1k8kd2 18 d1r05a_ 19 c2kncA_ 20 d1st6a5 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58