Secondary structure and disorder prediction

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Sequence		M	F	L	D	Y	F	A	L	G	V	L	I	F	V	F	L	V	I	F	Y	G	I	I	I	L	H	D	I	P	Y	L	I	A	K	K	R	N	H	P	H	A	D	A	I	H	V	A	G	W	V	S	L	F	T	L	H	V	I	W	P
Secondary structure
SS confidence
Disorder		?																																			?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.
Sequence		F	L	W	I	W	A	T	L	Y	R	P	E	R	G	W	G	M	Q	S	H	D	S	S	V	M	Q	L	Q	Q	R	I	A	G	L	E	K	Q	L	A	D	I	K	S	S	S	A	E
Secondary structure
SS confidence
Disorder													?	?	?	?	?	?	?	?	?																								?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2zt9 chain H Region: 43 - 64 Aligned: 21 Modelled: 22 Confidence: 62.0% Identity: 38% PDB header:photosynthesis Chain: H: PDB Molecule:cytochrome b6-f complex subunit 8; PDBTitle: crystal structure of the cytochrome b6f complex from nostoc sp. pcc2 7120 Phyre2 PDB 2e76 chain H Region: 44 - 64 Aligned: 20 Modelled: 21 Confidence: 42.9% Identity: 35% PDB header:photosynthesis Chain: H: PDB Molecule:cytochrome b6-f complex subunit 8; PDBTitle: crystal structure of the cytochrome b6f complex with tridecyl-2 stigmatellin (tds) from m.laminosus Phyre2 PDB 2e74 chain H Region: 44 - 64 Aligned: 20 Modelled: 21 Confidence: 42.9% Identity: 35% PDB header:photosynthesis Chain: H: PDB Molecule:cytochrome b6-f complex subunit 8; PDBTitle: crystal structure of the cytochrome b6f complex from m.laminosus Phyre2 PDB 2e75 chain H Region: 44 - 64 Aligned: 20 Modelled: 21 Confidence: 42.9% Identity: 35% PDB header:photosynthesis Chain: H: PDB Molecule:cytochrome b6-f complex subunit 8; PDBTitle: crystal structure of the cytochrome b6f complex with 2-nonyl-4-2 hydroxyquinoline n-oxide (nqno) from m.laminosus Phyre2 PDB 2e74 chain H domain 1 Region: 44 - 64 Aligned: 20 Modelled: 21 Confidence: 38.4% Identity: 35% Fold: Single transmembrane helix Superfamily: PetN subunit of the cytochrome b6f complex Family: PetN subunit of the cytochrome b6f complex Phyre2 PDB 2pnv chain A Region: 84 - 104 Aligned: 21 Modelled: 21 Confidence: 35.1% Identity: 29% PDB header:membrane protein Chain: A: PDB Molecule:small conductance calcium-activated potassium PDBTitle: crystal structure of the leucine zipper domain of small-2 conductance ca2+-activated k+ (skca) channel from rattus3 norvegicus Phyre2 PDB 3m9h chain B Region: 80 - 101 Aligned: 22 Modelled: 22 Confidence: 34.9% Identity: 23% PDB header:chaperone Chain: B: PDB Molecule:proteasome-associated atpase; PDBTitle: crystal structure of the amino terminal coiled coil domain of the2 mycobacterium tuberculosis proteasomal atpase mpa Phyre2 PDB 1vf5 chain H Region: 44 - 64 Aligned: 20 Modelled: 21 Confidence: 30.6% Identity: 35% PDB header:photosynthesis Chain: H: PDB Molecule:protein pet n; PDBTitle: crystal structure of cytochrome b6f complex from m.laminosus Phyre2 PDB 1vf5 chain U Region: 44 - 64 Aligned: 20 Modelled: 21 Confidence: 27.5% Identity: 35% PDB header:photosynthesis Chain: U: PDB Molecule:protein pet n; PDBTitle: crystal structure of cytochrome b6f complex from m.laminosus Phyre2 PDB 2d2c chain U Region: 44 - 64 Aligned: 20 Modelled: 21 Confidence: 23.6% Identity: 35% PDB header:photosynthesis Chain: U: PDB Molecule:cytochrome b6-f complex subunit viii; PDBTitle: crystal structure of cytochrome b6f complex with dbmib from2 m. laminosus Phyre2 PDB 2d2c chain H Region: 44 - 64 Aligned: 20 Modelled: 21 Confidence: 23.6% Identity: 35% PDB header:photosynthesis Chain: H: PDB Molecule:cytochrome b6-f complex subunit viii; PDBTitle: crystal structure of cytochrome b6f complex with dbmib from2 m. laminosus Phyre2 PDB 3swf chain A Region: 81 - 99 Aligned: 19 Modelled: 19 Confidence: 21.8% Identity: 37% PDB header:transport protein Chain: A: PDB Molecule:cgmp-gated cation channel alpha-1; PDBTitle: cnga1 621-690 containing clz domain Phyre2 PDB 1ce0 chain B Region: 77 - 103 Aligned: 27 Modelled: 27 Confidence: 19.9% Identity: 19% PDB header:hiv-1 envelope protein Chain: B: PDB Molecule:protein (leucine zipper model h38-p1); PDBTitle: trimerization specificity in hiv-1 gp41: analysis with a2 gcn4 leucine zipper model Phyre2 PDB 1zta chain A Region: 76 - 103 Aligned: 28 Modelled: 28 Confidence: 19.4% Identity: 25% PDB header:dna-binding motif Chain: A: PDB Molecule:leucine zipper monomer; PDBTitle: the solution structure of a leucine-zipper motif peptide Phyre2 PDB 1zme chain D Region: 70 - 107 Aligned: 38 Modelled: 38 Confidence: 18.0% Identity: 16% PDB header:transcription/dna Chain: D: PDB Molecule:proline utilization transcription activator; PDBTitle: crystal structure of put3/dna complex Phyre2 PDB 1ij2 chain C Region: 76 - 103 Aligned: 28 Modelled: 28 Confidence: 17.2% Identity: 25% PDB header:transcription Chain: C: PDB Molecule:general control protein gcn4; PDBTitle: gcn4-pvtl coiled-coil trimer with threonine at the a(16)2 position Phyre2 PDB 1rb1 chain B Region: 76 - 103 Aligned: 28 Modelled: 28 Confidence: 16.9% Identity: 25% PDB header:dna binding protein Chain: B: PDB Molecule:general control protein gcn4; PDBTitle: gcn4-leucine zipper core mutant as n16a trigonal automatic2 solution Phyre2 PDB 3k7z chain A Region: 76 - 103 Aligned: 28 Modelled: 28 Confidence: 16.9% Identity: 25% PDB header:dna binding protein Chain: A: PDB Molecule:general control protein gcn4; PDBTitle: gcn4-leucine zipper core mutant as n16a trigonal automatic2 solution Phyre2 PDB 3k7z chain B Region: 76 - 103 Aligned: 28 Modelled: 28 Confidence: 16.9% Identity: 25% PDB header:dna binding protein Chain: B: PDB Molecule:general control protein gcn4; PDBTitle: gcn4-leucine zipper core mutant as n16a trigonal automatic2 solution Phyre2 PDB 1rb1 chain A Region: 76 - 103 Aligned: 28 Modelled: 28 Confidence: 16.9% Identity: 25% PDB header:dna binding protein Chain: A: PDB Molecule:general control protein gcn4; PDBTitle: gcn4-leucine zipper core mutant as n16a trigonal automatic2 solution Phyre2 1 c2zt9H_ 2 c2e76H_ 3 c2e74H_ 4 c2e75H_ 5 d2e74h1 6 c2pnvA_ 7 c3m9hB_ 8 c1vf5H_ 9 c1vf5U_ 10 c2d2cU_ 11 c2d2cH_ 12 c3swfA_ 13 c1ce0B_ 14 c1ztaA_ 15 c1zmeD_ 16 c1ij2C_ 17 c1rb1B_ 18 c3k7zA_ 19 c3k7zB_ 20 c1rb1A_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c2zt9H_ 62.0 38 PDB header:photosynthesis Chain: H: PDB Molecule:cytochrome b6-f complex subunit 8; PDBTitle: crystal structure of the cytochrome b6f complex from nostoc sp. pcc2 7120 2 c2e76H_ 42.9 35 PDB header:photosynthesis Chain: H: PDB Molecule:cytochrome b6-f complex subunit 8; PDBTitle: crystal structure of the cytochrome b6f complex with tridecyl-2 stigmatellin (tds) from m.laminosus 3 c2e74H_ 42.9 35 PDB header:photosynthesis Chain: H: PDB Molecule:cytochrome b6-f complex subunit 8; PDBTitle: crystal structure of the cytochrome b6f complex from m.laminosus 4 c2e75H_ 42.9 35 PDB header:photosynthesis Chain: H: PDB Molecule:cytochrome b6-f complex subunit 8; PDBTitle: crystal structure of the cytochrome b6f complex with 2-nonyl-4-2 hydroxyquinoline n-oxide (nqno) from m.laminosus 5 d2e74h1 38.4 35 Fold:Single transmembrane helix Superfamily:PetN subunit of the cytochrome b6f complex Family:PetN subunit of the cytochrome b6f complex 6 c2pnvA_ 35.1 29 PDB header:membrane protein Chain: A: PDB Molecule:small conductance calcium-activated potassium PDBTitle: crystal structure of the leucine zipper domain of small-2 conductance ca2+-activated k+ (skca) channel from rattus3 norvegicus 7 c3m9hB_ 34.9 23 PDB header:chaperone Chain: B: PDB Molecule:proteasome-associated atpase; PDBTitle: crystal structure of the amino terminal coiled coil domain of the2 mycobacterium tuberculosis proteasomal atpase mpa 8 c1vf5H_ 30.6 35 PDB header:photosynthesis Chain: H: PDB Molecule:protein pet n; PDBTitle: crystal structure of cytochrome b6f complex from m.laminosus 9 c1vf5U_ 27.5 35 PDB header:photosynthesis Chain: U: PDB Molecule:protein pet n; PDBTitle: crystal structure of cytochrome b6f complex from m.laminosus 10 c2d2cU_ 23.6 35 PDB header:photosynthesis Chain: U: PDB Molecule:cytochrome b6-f complex subunit viii; PDBTitle: crystal structure of cytochrome b6f complex with dbmib from2 m. laminosus 11 c2d2cH_ 23.6 35 PDB header:photosynthesis Chain: H: PDB Molecule:cytochrome b6-f complex subunit viii; PDBTitle: crystal structure of cytochrome b6f complex with dbmib from2 m. laminosus 12 c3swfA_ 21.8 37 PDB header:transport protein Chain: A: PDB Molecule:cgmp-gated cation channel alpha-1; PDBTitle: cnga1 621-690 containing clz domain 13 c1ce0B_ 19.9 19 PDB header:hiv-1 envelope protein Chain: B: PDB Molecule:protein (leucine zipper model h38-p1); PDBTitle: trimerization specificity in hiv-1 gp41: analysis with a2 gcn4 leucine zipper model 14 c1ztaA_ 19.4 25 PDB header:dna-binding motif Chain: A: PDB Molecule:leucine zipper monomer; PDBTitle: the solution structure of a leucine-zipper motif peptide 15 c1zmeD_ 18.0 16 PDB header:transcription/dna Chain: D: PDB Molecule:proline utilization transcription activator; PDBTitle: crystal structure of put3/dna complex 16 c1ij2C_ 17.2 25 PDB header:transcription Chain: C: PDB Molecule:general control protein gcn4; PDBTitle: gcn4-pvtl coiled-coil trimer with threonine at the a(16)2 position 17 c1rb1B_ 16.9 25 PDB header:dna binding protein Chain: B: PDB Molecule:general control protein gcn4; PDBTitle: gcn4-leucine zipper core mutant as n16a trigonal automatic2 solution 18 c3k7zA_ 16.9 25 PDB header:dna binding protein Chain: A: PDB Molecule:general control protein gcn4; PDBTitle: gcn4-leucine zipper core mutant as n16a trigonal automatic2 solution 19 c3k7zB_ 16.9 25 PDB header:dna binding protein Chain: B: PDB Molecule:general control protein gcn4; PDBTitle: gcn4-leucine zipper core mutant as n16a trigonal automatic2 solution 20 c1rb1A_ 16.9 25 PDB header:dna binding protein Chain: A: PDB Molecule:general control protein gcn4; PDBTitle: gcn4-leucine zipper core mutant as n16a trigonal automatic2 solution 21 c1rb6C_ not modelled 16.9 25 PDB header:dna binding protein Chain: C: PDB Molecule:general control protein gcn4; PDBTitle: antiparallel trimer of gcn4-leucine zipper core mutant as2 n16a tetragonal form 22 c1swiA_ not modelled 16.9 25 PDB header:leucine zipper Chain: A: PDB Molecule:gcn4p1; PDBTitle: gcn4-leucine zipper core mutant as n16a complexed with2 benzene 23 c2akfB_ not modelled 16.5 35 PDB header:protein binding Chain: B: PDB Molecule:coronin-1a; PDBTitle: crystal structure of the coiled-coil domain of coronin 1 24 c2akfC_ not modelled 16.5 35 PDB header:protein binding Chain: C: PDB Molecule:coronin-1a; PDBTitle: crystal structure of the coiled-coil domain of coronin 1 25 c2akfA_ not modelled 16.5 35 PDB header:protein binding Chain: A: PDB Molecule:coronin-1a; PDBTitle: crystal structure of the coiled-coil domain of coronin 1 26 c1ij3C_ not modelled 16.3 25 PDB header:transcription Chain: C: PDB Molecule:general control protein gcn4; PDBTitle: gcn4-pvsl coiled-coil trimer with serine at the a(16)2 position 27 c1ij3B_ not modelled 16.3 25 PDB header:transcription Chain: B: PDB Molecule:general control protein gcn4; PDBTitle: gcn4-pvsl coiled-coil trimer with serine at the a(16)2 position 28 c1ij2B_ not modelled 15.7 25 PDB header:transcription Chain: B: PDB Molecule:general control protein gcn4; PDBTitle: gcn4-pvtl coiled-coil trimer with threonine at the a(16)2 position 29 c1p9iA_ not modelled 15.6 32 PDB header:unknown function Chain: A: PDB Molecule:cortexillin i/gcn4 hybrid peptide; PDBTitle: coiled-coil x-ray structure at 1.17 a resolution 30 c1qcrD_ not modelled 14.1 17 PDB header: PDB COMPND: 31 c1junB_ not modelled 13.2 40 PDB header:transcription regulation Chain: B: PDB Molecule:c-jun homodimer; PDBTitle: nmr study of c-jun homodimer 32 c2ergA_ not modelled 12.5 13 PDB header:transcription activator/dna Chain: A: PDB Molecule:regulatory protein leu3; PDBTitle: crystal structure of leu3 dna-binding domain with a single2 h50c mutation complexed with a 15mer dna duplex 33 c2k21A_ not modelled 12.0 22 PDB header:membrane protein Chain: A: PDB Molecule:potassium voltage-gated channel subfamily e PDBTitle: nmr structure of human kcne1 in lmpg micelles at ph 6.0 and2 40 degree c 34 c3ci9B_ not modelled 11.2 43 PDB header:transcription Chain: B: PDB Molecule:heat shock factor-binding protein 1; PDBTitle: crystal structure of the human hsbp1 35 c3he5A_ not modelled 11.2 37 PDB header:de novo protein Chain: A: PDB Molecule:synzip1; PDBTitle: heterospecific coiled-coil pair synzip2:synzip1 36 c2y69Z_ not modelled 11.2 25 PDB header:electron transport Chain: Z: PDB Molecule:cytochrome c oxidase polypeptide 8h; PDBTitle: bovine heart cytochrome c oxidase re-refined with molecular2 oxygen 37 c1gk6B_ not modelled 10.4 15 PDB header:vimentin Chain: B: PDB Molecule:vimentin; PDBTitle: human vimentin coil 2b fragment linked to gcn4 leucine2 zipper (z2b) 38 c2o7hF_ not modelled 10.3 21 PDB header:transcription Chain: F: PDB Molecule:general control protein gcn4; PDBTitle: crystal structure of trimeric coiled coil gcn4 leucine zipper 39 c3p8cE_ not modelled 9.9 22 PDB header:protein binding Chain: E: PDB Molecule:probable protein brick1; PDBTitle: structure and control of the actin regulatory wave complex 40 d1v54m_ not modelled 9.9 25 Fold:Single transmembrane helix Superfamily:Mitochondrial cytochrome c oxidase subunit VIIIb (aka IX) Family:Mitochondrial cytochrome c oxidase subunit VIIIb (aka IX) 41 c1u0iA_ not modelled 9.4 37 PDB header:de novo protein Chain: A: PDB Molecule:iaal-e3; PDBTitle: iaal-e3/k3 heterodimer 42 c3rylB_ not modelled 8.8 45 PDB header:protein binding Chain: B: PDB Molecule:protein vpa1370; PDBTitle: dimerization domain of vibrio parahemolyticus vopl 43 c3nmdA_ not modelled 8.7 26 PDB header:transferase Chain: A: PDB Molecule:cgmp dependent protein kinase; PDBTitle: crystal structure of the leucine zipper domain of cgmp dependent2 protein kinase i beta 44 c2xzrA_ not modelled 7.8 16 PDB header:cell adhesion Chain: A: PDB Molecule:immunoglobulin-binding protein eibd; PDBTitle: escherichia coli immunoglobulin-binding protein eibd 391-438 fused2 to gcn4 adaptors 45 c2ke4A_ not modelled 7.8 15 PDB header:membrane protein Chain: A: PDB Molecule:cdc42-interacting protein 4; PDBTitle: the nmr structure of the tc10 and cdc42 interacting domain2 of cip4 46 c2xv5A_ not modelled 7.5 13 PDB header:structural protein Chain: A: PDB Molecule:lamin-a/c; PDBTitle: human lamin a coil 2b fragment 47 c1u2uA_ not modelled 7.4 40 PDB header:transcription Chain: A: PDB Molecule:general control protein gcn4; PDBTitle: nmr solution structure of a designed heterodimeric leucine2 zipper 48 d1grja1 not modelled 7.1 20 Fold:Long alpha-hairpin Superfamily:GreA transcript cleavage protein, N-terminal domain Family:GreA transcript cleavage protein, N-terminal domain 49 c1hwtC_ not modelled 7.1 39 PDB header:gene regulation/dna Chain: C: PDB Molecule:protein (heme activator protein); PDBTitle: structure of a hap1/dna complex reveals dramatically2 asymmetric dna binding by a homodimeric protein 50 c2yy0D_ not modelled 7.1 3 PDB header:transcription Chain: D: PDB Molecule:c-myc-binding protein; PDBTitle: crystal structure of ms0802, c-myc-1 binding protein domain2 from homo sapiens 51 c2lf0A_ not modelled 6.6 20 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein yibl; PDBTitle: solution structure of sf3636, a two-domain unknown function protein2 from shigella flexneri 2a, determined by joint refinement of nmr,3 residual dipolar couplings and small-angle x-ray scatting, nesg4 target sfr339/ocsp target sf3636 52 c1dipA_ not modelled 6.5 18 PDB header:acetylation Chain: A: PDB Molecule:delta-sleep-inducing peptide immunoreactive PDBTitle: the solution structure of porcine delta-sleep-inducing2 peptide immunoreactive peptide, nmr, 10 structures 53 d2f23a1 not modelled 6.0 25 Fold:Long alpha-hairpin Superfamily:GreA transcript cleavage protein, N-terminal domain Family:GreA transcript cleavage protein, N-terminal domain 54 c3n4xB_ not modelled 5.9 3 PDB header:replication Chain: B: PDB Molecule:monopolin complex subunit csm1; PDBTitle: structure of csm1 full-length 55 c3riaC_ not modelled 5.8 11 PDB header:transport protein/immune system Chain: C: PDB Molecule:avermectin-sensitive glutamate-gated chloride channel glucl PDBTitle: c. elegans glutamate-gated chloride channel (glucl) in complex with2 fab, ivermectin and iodide. 56 d1ioka2 not modelled 5.4 15 Fold:The "swivelling" beta/beta/alpha domain Superfamily:GroEL apical domain-like Family:GroEL-like chaperone, apical domain 57 c2zfcB_ not modelled 5.4 44 PDB header:viral protein Chain: B: PDB Molecule:hiv-1 gp41; PDBTitle: x-ray crystal structure of an engineered n-terminal hiv-12 gp41 trimer with enhanced stability and potency

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0