Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	F	T	I	N	A	E	V	R	K	E	Q	G	K	G	A	S	R	R	L	R	A	A	N	K	F	P	A	I	I	Y	G	G	K	E	A	P	L	A	I	E	L	D	H	D	K	V	M	N	M	Q	A	K	A	E	F	Y	S	E	V
Secondary structure
SS confidence
Disorder		?								?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.
Sequence		L	T	I	V	V	D	G	K	E	I	K	V	K	A	Q	D	V	Q	R	H	P	Y	K	P	K	L	Q	H	I	D	F	V	R	A
Secondary structure
SS confidence
Disorder																															?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1dfu chain P Region: 1 - 94 Aligned: 94 Modelled: 94 Confidence: 100.0% Identity: 100% Fold: Ribosomal protein L25-like Superfamily: Ribosomal protein L25-like Family: Ribosomal protein L25-like Phyre2 PDB 1feu chain A Region: 2 - 93 Aligned: 87 Modelled: 92 Confidence: 100.0% Identity: 18% Fold: Ribosomal protein L25-like Superfamily: Ribosomal protein L25-like Family: Ribosomal protein L25-like Phyre2 PDB 2zjr chain S domain 1 Region: 2 - 93 Aligned: 84 Modelled: 92 Confidence: 99.9% Identity: 19% Fold: Ribosomal protein L25-like Superfamily: Ribosomal protein L25-like Family: Ribosomal protein L25-like Phyre2 PDB 2b9n chain Z Region: 2 - 93 Aligned: 84 Modelled: 86 Confidence: 99.9% Identity: 20% PDB header:ribosome Chain: Z: PDB Molecule:50s ribosomal protein ctc; PDBTitle: 50s ribosomal subunit from a crystal structure of release factor rf2,2 trnas and mrna bound to the ribosome. this file contains the 50s3 subunit from a crystal structure of release factor rf1, trnas and4 mrna bound to the ribosome and is described in remark 400. Phyre2 PDB 1zak chain A domain 2 Region: 80 - 91 Aligned: 12 Modelled: 12 Confidence: 52.9% Identity: 25% Fold: Rubredoxin-like Superfamily: Microbial and mitochondrial ADK, insert "zinc finger" domain Family: Microbial and mitochondrial ADK, insert "zinc finger" domain Phyre2 PDB 1htw chain A Region: 73 - 93 Aligned: 19 Modelled: 21 Confidence: 47.9% Identity: 16% Fold: P-loop containing nucleoside triphosphate hydrolases Superfamily: P-loop containing nucleoside triphosphate hydrolases Family: YjeE-like Phyre2 PDB 1vho chain A Region: 4 - 52 Aligned: 48 Modelled: 49 Confidence: 24.0% Identity: 8% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:endoglucanase; PDBTitle: crystal structure of a putative peptidase/endoglucanase Phyre2 PDB 1q7l chain B Region: 13 - 37 Aligned: 24 Modelled: 25 Confidence: 18.0% Identity: 25% PDB header:hydrolase Chain: B: PDB Molecule:aminoacylase-1; PDBTitle: zn-binding domain of the t347g mutant of human aminoacylase-2 i Phyre2 PDB 3no8 chain A Region: 22 - 31 Aligned: 10 Modelled: 10 Confidence: 14.8% Identity: 20% PDB header:isomerase regulator Chain: A: PDB Molecule:btb/poz domain-containing protein 2; PDBTitle: crystal structure of the phr domain from human btbd2 protein Phyre2 PDB 1vix chain A Region: 4 - 39 Aligned: 35 Modelled: 36 Confidence: 14.8% Identity: 14% PDB header:hydrolase Chain: A: PDB Molecule:peptidase t; PDBTitle: crystal structure of a putative peptidase t Phyre2 PDB 2php chain A domain 1 Region: 15 - 38 Aligned: 24 Modelled: 23 Confidence: 12.8% Identity: 29% Fold: AraD/HMP-PK domain-like Superfamily: AraD/HMP-PK domain-like Family: Phosphomethylpyrimidine kinase C-terminal domain-like Phyre2 PDB 1a6c chain A domain 3 Region: 25 - 65 Aligned: 41 Modelled: 41 Confidence: 12.2% Identity: 10% Fold: Nucleoplasmin-like/VP (viral coat and capsid proteins) Superfamily: Positive stranded ssRNA viruses Family: Comoviridae-like VP Phyre2 PDB 3hwj chain A Region: 23 - 31 Aligned: 9 Modelled: 9 Confidence: 11.2% Identity: 33% PDB header:ligase Chain: A: PDB Molecule:e3 ubiquitin-protein ligase mycbp2; PDBTitle: crystal structure of the second phr domain of mouse myc-2 binding protein 2 (mycbp-2) Phyre2 PDB 3l7p chain A Region: 1 - 29 Aligned: 29 Modelled: 29 Confidence: 11.0% Identity: 17% PDB header:transcription Chain: A: PDB Molecule:putative nitrogen regulatory protein pii; PDBTitle: crystal structure of smu.1657c, putative nitrogen regulatory protein2 pii from streptococcus mutans Phyre2 PDB 1eth chain A domain 1 Region: 23 - 90 Aligned: 63 Modelled: 68 Confidence: 10.6% Identity: 14% Fold: Lipase/lipooxygenase domain (PLAT/LH2 domain) Superfamily: Lipase/lipooxygenase domain (PLAT/LH2 domain) Family: Colipase-binding domain Phyre2 PDB 3rza chain A Region: 11 - 52 Aligned: 41 Modelled: 42 Confidence: 9.6% Identity: 10% PDB header:hydrolase Chain: A: PDB Molecule:tripeptidase; PDBTitle: crystal structure of a tripeptidase (sav1512) from staphylococcus2 aureus subsp. aureus mu50 at 2.10 a resolution Phyre2 PDB 3na2 chain C Region: 28 - 82 Aligned: 55 Modelled: 55 Confidence: 9.5% Identity: 18% PDB header:structural genomics, unknown function Chain: C: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of protein of unknown function from mine drainage2 metagenome leptospirillum rubarum Phyre2 PDB 3ls8 chain A Region: 83 - 91 Aligned: 9 Modelled: 9 Confidence: 9.3% Identity: 67% PDB header:transferase Chain: A: PDB Molecule:phosphatidylinositol 3-kinase catalytic subunit PDBTitle: crystal structure of human pik3c3 in complex with 3-[4-(4-2 morpholinyl)thieno[3,2-d]pyrimidin-2-yl]-phenol Phyre2 PDB 1z2l chain A domain 1 Region: 4 - 34 Aligned: 30 Modelled: 31 Confidence: 9.3% Identity: 10% Fold: Phosphorylase/hydrolase-like Superfamily: Zn-dependent exopeptidases Family: Bacterial dinuclear zinc exopeptidases Phyre2 PDB 1vjn chain A Region: 15 - 78 Aligned: 62 Modelled: 64 Confidence: 8.9% Identity: 24% Fold: Metallo-hydrolase/oxidoreductase Superfamily: Metallo-hydrolase/oxidoreductase Family: Hypothetical protein TM0207 Phyre2 1 d1dfup_ 2 d1feua_ 3 d2zjrs1 4 c2b9nZ_ 5 d1zaka2 6 d1htwa_ 7 c1vhoA_ 8 c1q7lB_ 9 c3no8A_ 10 c1vixA_ 11 d2phpa1 12 d1a6ca3 13 c3hwjA_ 14 c3l7pA_ 15 d1etha1 16 c3rzaA_ 17 c3na2C_ 18 c3ls8A_ 19 d1z2la1 20 d1vjna_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d1dfup_ 100.0 100 Fold:Ribosomal protein L25-like Superfamily:Ribosomal protein L25-like Family:Ribosomal protein L25-like 2 d1feua_ 100.0 18 Fold:Ribosomal protein L25-like Superfamily:Ribosomal protein L25-like Family:Ribosomal protein L25-like 3 d2zjrs1 99.9 19 Fold:Ribosomal protein L25-like Superfamily:Ribosomal protein L25-like Family:Ribosomal protein L25-like 4 c2b9nZ_ 99.9 20 PDB header:ribosome Chain: Z: PDB Molecule:50s ribosomal protein ctc; PDBTitle: 50s ribosomal subunit from a crystal structure of release factor rf2,2 trnas and mrna bound to the ribosome. this file contains the 50s3 subunit from a crystal structure of release factor rf1, trnas and4 mrna bound to the ribosome and is described in remark 400. 5 d1zaka2 52.9 25 Fold:Rubredoxin-like Superfamily:Microbial and mitochondrial ADK, insert "zinc finger" domain Family:Microbial and mitochondrial ADK, insert "zinc finger" domain 6 d1htwa_ 47.9 16 Fold:P-loop containing nucleoside triphosphate hydrolases Superfamily:P-loop containing nucleoside triphosphate hydrolases Family:YjeE-like 7 c1vhoA_ 24.0 8 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:endoglucanase; PDBTitle: crystal structure of a putative peptidase/endoglucanase 8 c1q7lB_ 18.0 25 PDB header:hydrolase Chain: B: PDB Molecule:aminoacylase-1; PDBTitle: zn-binding domain of the t347g mutant of human aminoacylase-2 i 9 c3no8A_ 14.8 20 PDB header:isomerase regulator Chain: A: PDB Molecule:btb/poz domain-containing protein 2; PDBTitle: crystal structure of the phr domain from human btbd2 protein 10 c1vixA_ 14.8 14 PDB header:hydrolase Chain: A: PDB Molecule:peptidase t; PDBTitle: crystal structure of a putative peptidase t 11 d2phpa1 12.8 29 Fold:AraD/HMP-PK domain-like Superfamily:AraD/HMP-PK domain-like Family:Phosphomethylpyrimidine kinase C-terminal domain-like 12 d1a6ca3 12.2 10 Fold:Nucleoplasmin-like/VP (viral coat and capsid proteins) Superfamily:Positive stranded ssRNA viruses Family:Comoviridae-like VP 13 c3hwjA_ 11.2 33 PDB header:ligase Chain: A: PDB Molecule:e3 ubiquitin-protein ligase mycbp2; PDBTitle: crystal structure of the second phr domain of mouse myc-2 binding protein 2 (mycbp-2) 14 c3l7pA_ 11.0 17 PDB header:transcription Chain: A: PDB Molecule:putative nitrogen regulatory protein pii; PDBTitle: crystal structure of smu.1657c, putative nitrogen regulatory protein2 pii from streptococcus mutans 15 d1etha1 10.6 14 Fold:Lipase/lipooxygenase domain (PLAT/LH2 domain) Superfamily:Lipase/lipooxygenase domain (PLAT/LH2 domain) Family:Colipase-binding domain 16 c3rzaA_ 9.6 10 PDB header:hydrolase Chain: A: PDB Molecule:tripeptidase; PDBTitle: crystal structure of a tripeptidase (sav1512) from staphylococcus2 aureus subsp. aureus mu50 at 2.10 a resolution 17 c3na2C_ 9.5 18 PDB header:structural genomics, unknown function Chain: C: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of protein of unknown function from mine drainage2 metagenome leptospirillum rubarum 18 c3ls8A_ 9.3 67 PDB header:transferase Chain: A: PDB Molecule:phosphatidylinositol 3-kinase catalytic subunit PDBTitle: crystal structure of human pik3c3 in complex with 3-[4-(4-2 morpholinyl)thieno[3,2-d]pyrimidin-2-yl]-phenol 19 d1z2la1 9.3 10 Fold:Phosphorylase/hydrolase-like Superfamily:Zn-dependent exopeptidases Family:Bacterial dinuclear zinc exopeptidases 20 d1vjna_ 8.9 24 Fold:Metallo-hydrolase/oxidoreductase Superfamily:Metallo-hydrolase/oxidoreductase Family:Hypothetical protein TM0207 21 c3gbwA_ not modelled 8.8 33 PDB header:ligase Chain: A: PDB Molecule:e3 ubiquitin-protein ligase mycbp2; PDBTitle: crystal structure of the first phr domain of the mouse myc-2 binding protein 2 (mycbp-2) 22 c2j8aA_ not modelled 8.6 14 PDB header:transferase Chain: A: PDB Molecule:histone-lysine n-methyltransferase, h3 lysine-4 PDBTitle: x-ray structure of the n-terminus rrm domain of set1 23 d1e7ua4 not modelled 8.3 56 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Phoshoinositide 3-kinase (PI3K), catalytic domain 24 c2x6kB_ not modelled 7.5 67 PDB header:transferase Chain: B: PDB Molecule:phosphotidylinositol 3 kinase 59f; PDBTitle: the crystal structure of the drosophila class iii pi3-kinase2 vps34 in complex with pi-103 25 c3ifeA_ not modelled 7.4 11 PDB header:hydrolase Chain: A: PDB Molecule:peptidase t; PDBTitle: 1.55 angstrom resolution crystal structure of peptidase t (pept-1)2 from bacillus anthracis str. 'ames ancestor'. 26 d1qo5b_ not modelled 7.1 29 Fold:TIM beta/alpha-barrel Superfamily:Aldolase Family:Class I aldolase 27 c3mmtC_ not modelled 7.0 26 PDB header:hydrolase Chain: C: PDB Molecule:fructose-bisphosphate aldolase; PDBTitle: crystal structure of fructose bisphosphate aldolase from bartonella2 henselae, bound to fructose bisphosphate 28 d1fdja_ not modelled 6.6 29 Fold:TIM beta/alpha-barrel Superfamily:Aldolase Family:Class I aldolase 29 d1vixa1 not modelled 6.4 14 Fold:Phosphorylase/hydrolase-like Superfamily:Zn-dependent exopeptidases Family:Bacterial dinuclear zinc exopeptidases 30 d1xfba1 not modelled 6.4 19 Fold:TIM beta/alpha-barrel Superfamily:Aldolase Family:Class I aldolase 31 d1vkia_ not modelled 6.3 5 Fold:YbaK/ProRS associated domain Superfamily:YbaK/ProRS associated domain Family:YbaK/ProRS associated domain 32 d1zaia1 not modelled 6.2 16 Fold:TIM beta/alpha-barrel Superfamily:Aldolase Family:Class I aldolase 33 c2x0oA_ not modelled 6.2 21 PDB header:biosynthetic protein Chain: A: PDB Molecule:alcaligin biosynthesis protein; PDBTitle: apo structure of the alcaligin biosynthesis protein c (alcc)2 from bordetella bronchiseptica 34 c2pc4B_ not modelled 6.0 19 PDB header:lyase Chain: B: PDB Molecule:fructose-bisphosphate aldolase; PDBTitle: crystal structure of fructose-bisphosphate aldolase from plasmodium2 falciparum in complex with trap-tail determined at 2.4 angstrom3 resolution 35 d1a5ca_ not modelled 5.7 19 Fold:TIM beta/alpha-barrel Superfamily:Aldolase Family:Class I aldolase 36 c2rb7A_ not modelled 5.7 19 PDB header:hydrolase Chain: A: PDB Molecule:peptidase, m20/m25/m40 family; PDBTitle: crystal structure of co-catalytic metallopeptidase (yp_387682.1) from2 desulfovibrio desulfuricans g20 at 1.60 a resolution 37 d1fbaa_ not modelled 5.7 16 Fold:TIM beta/alpha-barrel Superfamily:Aldolase Family:Class I aldolase 38 d1f2ja_ not modelled 5.4 23 Fold:TIM beta/alpha-barrel Superfamily:Aldolase Family:Class I aldolase 39 d1nn7a_ not modelled 5.3 17 Fold:POZ domain Superfamily:POZ domain Family:Tetramerization domain of potassium channels 40 c2y3aA_ not modelled 5.1 56 PDB header:transferase Chain: A: PDB Molecule:phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic PDBTitle: crystal structure of p110beta in complex with icsh2 of p85beta and2 the drug gdc-0941 41 c3ic1A_ not modelled 5.1 9 PDB header:hydrolase Chain: A: PDB Molecule:succinyl-diaminopimelate desuccinylase; PDBTitle: crystal structure of zinc-bound succinyl-diaminopimelate desuccinylase2 from haemophilus influenzae 42 d1s1ga_ not modelled 5.1 19 Fold:POZ domain Superfamily:POZ domain Family:Tetramerization domain of potassium channels 43 c1e8zA_ not modelled 5.0 56 PDB header:transferase Chain: A: PDB Molecule:phosphatidylinositol 3-kinase catalytic subunit; PDBTitle: structure determinants of phosphoinositide 3-kinase2 inhibition by wortmannin, ly294002, quercetin, myricetin3 and staurosporine 44 d2hgca1 not modelled 5.0 16 Fold:DNA/RNA-binding 3-helical bundle Superfamily:"Winged helix" DNA-binding domain Family:YjcQ-like

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

---

Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0