Secondary structure and disorder prediction

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Sequence		M	K	I	F	Q	R	Y	N	P	L	Q	V	A	K	Y	V	K	I	L	F	R	G	R	L	Y	I	K	D	V	G	A	F	E	F	D	K	G	K	I	L	I	P	K	V	K	D	K	L	H	L	S	V	M	S	E	V	N	R	Q	V
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.
Sequence		M	R	L	Q	T	E	M	A
Secondary structure
SS confidence
Disorder						?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2jro chain A Region: 1 - 67 Aligned: 67 Modelled: 67 Confidence: 100.0% Identity: 27% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: solution nmr structure of so0334 from shewanella oneidensis. northeast2 structural genomics target sor75 Phyre2 PDB 1t0h chain B Region: 15 - 63 Aligned: 45 Modelled: 49 Confidence: 36.1% Identity: 29% Fold: P-loop containing nucleoside triphosphate hydrolases Superfamily: P-loop containing nucleoside triphosphate hydrolases Family: Nucleotide and nucleoside kinases Phyre2 PDB 1njh chain A Region: 22 - 41 Aligned: 20 Modelled: 19 Confidence: 24.0% Identity: 20% Fold: Hypothetical protein YojF Superfamily: Hypothetical protein YojF Family: Hypothetical protein YojF Phyre2 PDB 2ow7 chain A Region: 30 - 56 Aligned: 27 Modelled: 27 Confidence: 17.6% Identity: 22% PDB header:hydrolase Chain: A: PDB Molecule:alpha-mannosidase 2; PDBTitle: golgi alpha-mannosidase ii complex with (1r,6s,7r,8s)-1-2 thioniabicyclo[4.3.0]nonan-7,8-diol chloride Phyre2 PDB 1hty chain A Region: 30 - 56 Aligned: 27 Modelled: 27 Confidence: 16.0% Identity: 22% PDB header:hydrolase Chain: A: PDB Molecule:alpha-mannosidase ii; PDBTitle: golgi alpha-mannosidase ii Phyre2 PDB 1o7d chain A Region: 30 - 66 Aligned: 37 Modelled: 37 Confidence: 13.6% Identity: 14% PDB header:hydrolase Chain: A: PDB Molecule:lysosomal alpha-mannosidase; PDBTitle: the structure of the bovine lysosomal a-mannosidase2 suggests a novel mechanism for low ph activation Phyre2 PDB 3bvu chain A domain 3 Region: 30 - 66 Aligned: 37 Modelled: 37 Confidence: 13.5% Identity: 19% Fold: 7-stranded beta/alpha barrel Superfamily: Glycoside hydrolase/deacetylase Family: alpha-mannosidase Phyre2 PDB 1ve2 chain A domain 1 Region: 21 - 31 Aligned: 11 Modelled: 11 Confidence: 12.5% Identity: 36% Fold: Tetrapyrrole methylase Superfamily: Tetrapyrrole methylase Family: Tetrapyrrole methylase Phyre2 PDB 2b1k chain A Region: 36 - 68 Aligned: 33 Modelled: 33 Confidence: 12.5% Identity: 18% PDB header:oxidoreductase Chain: A: PDB Molecule:thiol:disulfide interchange protein dsbe; PDBTitle: crystal structure of e. coli ccmg protein Phyre2 PDB 3i0y chain C Region: 23 - 40 Aligned: 18 Modelled: 18 Confidence: 11.6% Identity: 17% PDB header:isomerase Chain: C: PDB Molecule:putative polyketide cyclase; PDBTitle: crystal structure of a putative polyketide cyclase (xcc0381) from2 xanthomonas campestris pv. campestris at 1.50 a resolution Phyre2 PDB 3jx9 chain B Region: 22 - 34 Aligned: 13 Modelled: 13 Confidence: 11.2% Identity: 38% PDB header:isomerase Chain: B: PDB Molecule:putative phosphoheptose isomerase; PDBTitle: crystal structure of putative phosphoheptose isomerase2 (yp_001815198.1) from exiguobacterium sp. 255-15 at 1.95 a resolution Phyre2 PDB 1v3y chain A Region: 36 - 67 Aligned: 32 Modelled: 32 Confidence: 10.9% Identity: 13% Fold: Peptide deformylase Superfamily: Peptide deformylase Family: Peptide deformylase Phyre2 PDB 1o12 chain A domain 1 Region: 30 - 40 Aligned: 11 Modelled: 11 Confidence: 10.7% Identity: 45% Fold: Composite domain of metallo-dependent hydrolases Superfamily: Composite domain of metallo-dependent hydrolases Family: N-acetylglucosamine-6-phosphate deacetylase, NagA Phyre2 PDB 1cbf chain A Region: 21 - 31 Aligned: 11 Modelled: 11 Confidence: 10.4% Identity: 36% PDB header:methyltransferase Chain: A: PDB Molecule:cobalt-precorrin-4 transmethylase; PDBTitle: the x-ray structure of a cobalamin biosynthetic enzyme, cobalt2 precorrin-4 methyltransferase, cbif Phyre2 PDB 1cbf chain A Region: 21 - 31 Aligned: 11 Modelled: 11 Confidence: 10.4% Identity: 36% Fold: Tetrapyrrole methylase Superfamily: Tetrapyrrole methylase Family: Tetrapyrrole methylase Phyre2 PDB 1oh4 chain A Region: 20 - 38 Aligned: 19 Modelled: 19 Confidence: 10.2% Identity: 21% Fold: Galactose-binding domain-like Superfamily: Galactose-binding domain-like Family: Family 27 carbohydrate binding module, CBM27 Phyre2 PDB 2e0k chain A Region: 21 - 31 Aligned: 11 Modelled: 11 Confidence: 10.2% Identity: 18% PDB header:transferase Chain: A: PDB Molecule:precorrin-2 c20-methyltransferase; PDBTitle: crystal structure of cbil, a methyltransferase involved in anaerobic2 vitamin b12 biosynthesis Phyre2 PDB 1x4t chain A domain 1 Region: 53 - 66 Aligned: 14 Modelled: 14 Confidence: 10.0% Identity: 21% Fold: Long alpha-hairpin Superfamily: ISY1 domain-like Family: ISY1 N-terminal domain-like Phyre2 PDB 2gex chain A domain 1 Region: 23 - 40 Aligned: 18 Modelled: 18 Confidence: 9.9% Identity: 17% Fold: Cystatin-like Superfamily: NTF2-like Family: SnoaL-like polyketide cyclase Phyre2 PDB 2qbu chain A Region: 21 - 31 Aligned: 11 Modelled: 11 Confidence: 9.8% Identity: 36% PDB header:transferase Chain: A: PDB Molecule:precorrin-2 methyltransferase; PDBTitle: crystal structure of methanothermobacter thermautotrophicus cbil Phyre2 1 c2jroA_ 2 d1t0hb_ 3 d1njha_ 4 c2ow7A_ 5 c1htyA_ 6 c1o7dA_ 7 d3bvua3 8 d1ve2a1 9 c2b1kA_ 10 c3i0yC_ 11 c3jx9B_ 12 d1v3ya_ 13 d1o12a1 14 c1cbfA_ 15 d1cbfa_ 16 d1oh4a_ 17 c2e0kA_ 18 d1x4ta1 19 d2gexa1 20 c2qbuA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c2jroA_ 100.0 27 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: solution nmr structure of so0334 from shewanella oneidensis. northeast2 structural genomics target sor75 2 d1t0hb_ 36.1 29 Fold:P-loop containing nucleoside triphosphate hydrolases Superfamily:P-loop containing nucleoside triphosphate hydrolases Family:Nucleotide and nucleoside kinases 3 d1njha_ 24.0 20 Fold:Hypothetical protein YojF Superfamily:Hypothetical protein YojF Family:Hypothetical protein YojF 4 c2ow7A_ 17.6 22 PDB header:hydrolase Chain: A: PDB Molecule:alpha-mannosidase 2; PDBTitle: golgi alpha-mannosidase ii complex with (1r,6s,7r,8s)-1-2 thioniabicyclo[4.3.0]nonan-7,8-diol chloride 5 c1htyA_ 16.0 22 PDB header:hydrolase Chain: A: PDB Molecule:alpha-mannosidase ii; PDBTitle: golgi alpha-mannosidase ii 6 c1o7dA_ 13.6 14 PDB header:hydrolase Chain: A: PDB Molecule:lysosomal alpha-mannosidase; PDBTitle: the structure of the bovine lysosomal a-mannosidase2 suggests a novel mechanism for low ph activation 7 d3bvua3 13.5 19 Fold:7-stranded beta/alpha barrel Superfamily:Glycoside hydrolase/deacetylase Family:alpha-mannosidase 8 d1ve2a1 12.5 36 Fold:Tetrapyrrole methylase Superfamily:Tetrapyrrole methylase Family:Tetrapyrrole methylase 9 c2b1kA_ 12.5 18 PDB header:oxidoreductase Chain: A: PDB Molecule:thiol:disulfide interchange protein dsbe; PDBTitle: crystal structure of e. coli ccmg protein 10 c3i0yC_ 11.6 17 PDB header:isomerase Chain: C: PDB Molecule:putative polyketide cyclase; PDBTitle: crystal structure of a putative polyketide cyclase (xcc0381) from2 xanthomonas campestris pv. campestris at 1.50 a resolution 11 c3jx9B_ 11.2 38 PDB header:isomerase Chain: B: PDB Molecule:putative phosphoheptose isomerase; PDBTitle: crystal structure of putative phosphoheptose isomerase2 (yp_001815198.1) from exiguobacterium sp. 255-15 at 1.95 a resolution 12 d1v3ya_ 10.9 13 Fold:Peptide deformylase Superfamily:Peptide deformylase Family:Peptide deformylase 13 d1o12a1 10.7 45 Fold:Composite domain of metallo-dependent hydrolases Superfamily:Composite domain of metallo-dependent hydrolases Family:N-acetylglucosamine-6-phosphate deacetylase, NagA 14 c1cbfA_ 10.4 36 PDB header:methyltransferase Chain: A: PDB Molecule:cobalt-precorrin-4 transmethylase; PDBTitle: the x-ray structure of a cobalamin biosynthetic enzyme, cobalt2 precorrin-4 methyltransferase, cbif 15 d1cbfa_ 10.4 36 Fold:Tetrapyrrole methylase Superfamily:Tetrapyrrole methylase Family:Tetrapyrrole methylase 16 d1oh4a_ 10.2 21 Fold:Galactose-binding domain-like Superfamily:Galactose-binding domain-like Family:Family 27 carbohydrate binding module, CBM27 17 c2e0kA_ 10.2 18 PDB header:transferase Chain: A: PDB Molecule:precorrin-2 c20-methyltransferase; PDBTitle: crystal structure of cbil, a methyltransferase involved in anaerobic2 vitamin b12 biosynthesis 18 d1x4ta1 10.0 21 Fold:Long alpha-hairpin Superfamily:ISY1 domain-like Family:ISY1 N-terminal domain-like 19 d2gexa1 9.9 17 Fold:Cystatin-like Superfamily:NTF2-like Family:SnoaL-like polyketide cyclase 20 c2qbuA_ 9.8 36 PDB header:transferase Chain: A: PDB Molecule:precorrin-2 methyltransferase; PDBTitle: crystal structure of methanothermobacter thermautotrophicus cbil 21 d2geya1 not modelled 9.2 28 Fold:Cystatin-like Superfamily:NTF2-like Family:SnoaL-like polyketide cyclase 22 d1zyba1 not modelled 9.2 35 Fold:DNA/RNA-binding 3-helical bundle Superfamily:"Winged helix" DNA-binding domain Family:CAP C-terminal domain-like 23 d2k54a1 not modelled 8.8 21 Fold:Cystatin-like Superfamily:NTF2-like Family:Atu0742-like 24 c1g2cN_ not modelled 8.7 30 PDB header:viral protein Chain: N: PDB Molecule:fusion protein (f); PDBTitle: human respiratory syncytial virus fusion protein core 25 d1pjqa2 not modelled 8.6 20 Fold:Tetrapyrrole methylase Superfamily:Tetrapyrrole methylase Family:Tetrapyrrole methylase 26 c3hh1D_ not modelled 8.4 27 PDB header:transferase Chain: D: PDB Molecule:tetrapyrrole methylase family protein; PDBTitle: the structure of a tetrapyrrole methylase family protein domain from2 chlorobium tepidum tls 27 c3ff2A_ not modelled 8.4 20 PDB header:unknown function Chain: A: PDB Molecule:uncharacterized cystatin fold protein (yp_497570.1) from PDBTitle: crystal structure of an uncharacterized cystatin fold protein2 (saro_2299) from novosphingobium aromaticivorans dsm at 1.90 a3 resolution 28 d1s4da_ not modelled 7.9 18 Fold:Tetrapyrrole methylase Superfamily:Tetrapyrrole methylase Family:Tetrapyrrole methylase 29 c3f7xA_ not modelled 7.7 22 PDB header:unknown function Chain: A: PDB Molecule:putative polyketide cyclase; PDBTitle: crystal structure of a putative polyketide cyclase (pp0894) from2 pseudomonas putida kt2440 at 1.24 a resolution 30 c3k0zB_ not modelled 7.5 16 PDB header:lyase Chain: B: PDB Molecule:putative polyketide cyclase; PDBTitle: crystal structure of putative polyketide cyclase (np_977253.1) from2 bacillus cereus atcc 10987 at 1.91 a resolution 31 c3f14A_ not modelled 7.5 11 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized ntf2-like protein; PDBTitle: crystal structure of ntf2-like protein of unknown function2 (yp_680363.1) from cytophaga hutchinsonii atcc 33406 at 1.45 a3 resolution 32 c3f8hA_ not modelled 7.5 17 PDB header:unknown function Chain: A: PDB Molecule:putative polyketide cyclase; PDBTitle: crystal structure of a putative polyketide cyclase (tm1040_3560) from2 silicibacter sp. tm1040 at 2.00 a resolution 33 c3myuB_ not modelled 7.2 18 PDB header:vib binding protein Chain: B: PDB Molecule:high affinity transport system protein p37; PDBTitle: mycoplasma genitalium mg289 34 d1va0a1 not modelled 7.1 40 Fold:Tetrapyrrole methylase Superfamily:Tetrapyrrole methylase Family:Tetrapyrrole methylase 35 c2hw2A_ not modelled 7.1 55 PDB header:transferase Chain: A: PDB Molecule:rifampin adp-ribosyl transferase; PDBTitle: crystal structure of rifampin adp-ribosyl transferase in2 complex with rifampin 36 d1rk8b_ not modelled 6.8 35 Fold:Mago nashi protein Superfamily:Mago nashi protein Family:Mago nashi protein 37 c1t3jA_ not modelled 6.8 14 PDB header:membrane protein Chain: A: PDB Molecule:mitofusin 1; PDBTitle: mitofusin domain hr2 v686m/i708m mutant 38 c2zvbA_ not modelled 6.6 30 PDB header:transferase Chain: A: PDB Molecule:precorrin-3 c17-methyltransferase; PDBTitle: crystal structure of tt0207 from thermus thermophilus hb8 39 c1no1C_ not modelled 6.6 36 PDB header:replication Chain: C: PDB Molecule:replisome organizer; PDBTitle: structure of truncated variant of b.subtilis spp1 phage g39p helicase2 loader/inhibitor protein 40 d1no1a_ not modelled 6.6 36 Fold:Replisome organizer (g39p helicase loader/inhibitor protein) Superfamily:Replisome organizer (g39p helicase loader/inhibitor protein) Family:Replisome organizer (g39p helicase loader/inhibitor protein) 41 d1t3la2 not modelled 6.5 18 Fold:P-loop containing nucleoside triphosphate hydrolases Superfamily:P-loop containing nucleoside triphosphate hydrolases Family:Nucleotide and nucleoside kinases 42 c1r48A_ not modelled 6.4 11 PDB header:transport protein Chain: A: PDB Molecule:proline/betaine transporter; PDBTitle: solution structure of the c-terminal cytoplasmic domain2 residues 468-497 of escherichia coli protein prop 43 d2ih2a2 not modelled 6.3 33 Fold:DNA methylase specificity domain Superfamily:DNA methylase specificity domain Family:TaqI C-terminal domain-like 44 d2ba0a2 not modelled 6.0 20 Fold:Barrel-sandwich hybrid Superfamily:Ribosomal L27 protein-like Family:ECR1 N-terminal domain-like 45 c2l3bA_ not modelled 6.0 24 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:conserved protein found in conjugate transposon; PDBTitle: solution nmr structure of the bt_0084 lipoprotein from bacteroides2 thetaiotaomicron, northeast structural genomics consortium target3 btr376 46 c2qg8A_ not modelled 5.8 33 PDB header:transferase Chain: A: PDB Molecule:acyl carrier protein synthase py06285; PDBTitle: plasmodium yoelii acyl carrier protein synthase py06285 with adp bound 47 d1w6sb_ not modelled 5.7 43 Fold:Non-globular all-alpha subunits of globular proteins Superfamily:Methanol dehydrogenase subunit Family:Methanol dehydrogenase subunit 48 c1w25B_ not modelled 5.6 16 PDB header:signaling protein Chain: B: PDB Molecule:stalked-cell differentiation controlling protein; PDBTitle: response regulator pled in complex with c-digmp 49 c3ot2B_ not modelled 5.6 24 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of a putative nuclease belonging to duf8202 (ava_3926) from anabaena variabilis atcc 29413 at 1.96 a resolution 50 c3ot2A_ not modelled 5.6 24 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of a putative nuclease belonging to duf8202 (ava_3926) from anabaena variabilis atcc 29413 at 1.96 a resolution 51 d2ad6b1 not modelled 5.6 35 Fold:Non-globular all-alpha subunits of globular proteins Superfamily:Methanol dehydrogenase subunit Family:Methanol dehydrogenase subunit 52 c3dluA_ not modelled 5.5 15 PDB header:rna binding protein Chain: A: PDB Molecule:signal recognition particle 19 kda protein; PDBTitle: structures of srp54 and srp19, the two proteins assembling2 the ribonucleic core of the signal recognition particle3 from the archaeon pyrococcus furiosus. 53 c2rfpA_ not modelled 5.5 24 PDB header:hydrolase Chain: A: PDB Molecule:putative ntp pyrophosphohydrolase; PDBTitle: crystal structure of putative ntp pyrophosphohydrolase2 (yp_001813558.1) from exiguobacterium sibiricum 255-15 at 1.74 a3 resolution 54 c1tuhA_ not modelled 5.4 32 PDB header:unknown function Chain: A: PDB Molecule:hypothetical protein egc068; PDBTitle: structure of bal32a from a soil-derived mobile gene cassette 55 d1tuha_ not modelled 5.4 32 Fold:Cystatin-like Superfamily:NTF2-like Family:Hypothetical protein egc068 from a soil-derived mobile gene cassette 56 c2kkmA_ not modelled 5.4 27 PDB header:translation Chain: A: PDB Molecule:translation machinery-associated protein 16; PDBTitle: solution nmr structure of yeast protein yor252w [residues2 38-178]: northeast structural genomics consortium target3 yt654 57 c3kkgA_ not modelled 5.4 22 PDB header:lyase Chain: A: PDB Molecule:putative snoal-like polyketide cyclase; PDBTitle: crystal structure of putative snoal-like polyketide cyclase2 (yp_509242.1) from jannaschia sp. ccs1 at 1.40 a resolution 58 c3e79A_ not modelled 5.2 36 PDB header:tpp binding protein Chain: A: PDB Molecule:high affinity transport system protein p37; PDBTitle: structure determination of the cancer-associated mycoplasma2 hyorhinis protein mh-p37 59 d1h5oa_ not modelled 5.1 41 Fold:Defensin-like Superfamily:Defensin-like Family:Myotoxin 60 d1iw4a_ not modelled 5.1 50 Fold:Kazal-type serine protease inhibitors Superfamily:Kazal-type serine protease inhibitors Family:Ovomucoid domain III-like 61 c3hk4B_ not modelled 5.1 33 PDB header:lyase Chain: B: PDB Molecule:mlr7391 protein; PDBTitle: crystal structure of a putative snoal-like polyketide cyclase2 [carbohydrate phosphatase] (mlr7391) from mesorhizobium loti at 1.963 a resolution

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0