PHYRE Protein Fold Recognition Server

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Protein Homology/analogY Recognition Engine V 2.2

Fold library entry viewer: c2ow7A_

Fold library id	PDB Header	Molecule	Title
c2ow7A_	PDB header: hydrolase	Chain: A: PDB Molecule: alpha-mannosidase 2;	PDBTitle: golgi alpha-mannosidase ii complex with (1r,6s,7r,8s)-1-2 thioniabicyclo[4.3.0]nonan-7,8-diol chloride

Links to external resources
Added to library: Tue Mar 16 12:33:21 2010

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60 . . . . . . . . . 70

Sequence Q C Q D V V Q D V P N V D V Q M L E L Y D R M S F K D I D G G V W K Q G W N I K Y D P L K Y N A H H K L K V F V V P H S H N D P G W I Q T F

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
S S S
S
S S S T T S
G G G S B T T B
S S S S S

. . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120 . . . . . . . . . 130 . . . . . . . . . 140

Sequence E E Y Y Q H D T K H I L S N A L R H L H D N P E M K F I W A E I S Y F A R F Y H D L G E N K K L Q M K S I V K N G Q L E F V T G G W V M P D

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T
T T
T T S
T T S S S
S S
B

. . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180 . . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210

Sequence E A N S H W R N V L L Q L T E G Q T W L K Q F M N V T P T A S W A I D P F G H S P T M P Y I L Q K S G F K N M L I Q R T H Y S V K K E L A Q

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) S S S
T
S S S S B
T T T T

. . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240 . . . . . . . . . 250 . . . . . . . . . 260 . . . . . . . . . 270 . . . . . . . . . 280

Sequence Q R Q L E F L W R Q I W D N K G D T A L F T H M M P F Y S Y D I P H T C G P D P K V C C Q F D F K R M G S F G L S C P W K V P P R T I S D Q

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T
S
T T
S S
T T
S S
S S G G G T S S S
G G G
G G G S S T T S
T T S
T T

. . . . . . . . . 290 . . . . . . . . . 300 . . . . . . . . . 310 . . . . . . . . . 320 . . . . . . . . . 330 . . . . . . . . . 340 . . . . . . . . . 350

Sequence N V A A R S D L L V D Q W K K K A E L Y R T N V L L I P L G D D F R F K Q N T E W D V Q R V N Y E R L F E H I N S Q A H F N V Q A Q F G T L

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T T S S S S T
S
S
G G G

. . . . . . . . . 360 . . . . . . . . . 370 . . . . . . . . . 380 . . . . . . . . . 390 . . . . . . . . . 400 . . . . . . . . . 410 . . . . . . . . . 420

Sequence Q E Y F D A V H Q A E R A G Q A E F P T L S G D F F T Y A D R S D N Y W S G Y Y T S R P Y H K R M D R V L M H Y V R A A E M L S A W H S W D

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T S
S
B
S
B S S T T
B
G G G T S S T S

. . . . . . . . . 430 . . . . . . . . . 440 . . . . . . . . . 450 . . . . . . . . . 460 . . . . . . . . . 470 . . . . . . . . . 480 . . . . . . . . . 490

Sequence G M A R I E E R L E Q A R R E L S L F Q H H D G I T G T A K T H V V V D Y E Q R M Q E A L K A C Q M V M Q Q S V Y R L L T K P S I Y S P D F

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) G G G
T B T T T T T S
S
T B
T T T
T

. . . . . . . . . 500 . . . . . . . . . 510 . . . . . . . . . 520 . . . . . . . . . 530 . . . . . . . . . 540 . . . . . . . . . 550 . . . . . . . . . 560

Sequence S F S Y F T L D D S R W P G S G V E D S R T T I I L G E D I L P S K H V V M H N T L P H W R E Q L V D F Y V S S P F V S V T D L A N N P V E

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T S
S
S T T T T T T T
B T T T B
S S S
S
S
T T

. . . . . . . . . 570 . . . . . . . . . 580 . . . . . . . . . 590 . . . . . . . . . 600 . . . . . . . . . 610 . . . . . . . . . 620 . . . . . . . . . 630

Sequence A Q V S P V W S W H H D T L T K T I H P Q G S T T K Y R I I F K A R V P P M G L A T Y V L T I S D S K P E H T S Y A S N L L L R K N P T S L

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T T T
T T
S S
T T
S S

. . . . . . . . . 640 . . . . . . . . . 650 . . . . . . . . . 660 . . . . . . . . . 670 . . . . . . . . . 680 . . . . . . . . . 690 . . . . . . . . . 700

Sequence P L G Q Y P E D V K F G D P R E I S L R V G N G P T L A F S E Q G L L K S I Q L T Q D S P H V P V H F K F L K Y G V R S H G D R S G A Y L F

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
T T
S S
S
T T S
T T S
S T T S
S S S
S S

. . . . . . . . . 710 . . . . . . . . . 720 . . . . . . . . . 730 . . . . . . . . . 740 . . . . . . . . . 750 . . . . . . . . . 760 . . . . . . . . . 770

Sequence L P N G P A S P V E L G Q P V V L V T K G K L E S S V S V G L P S V V H Q T I M R G G A P E I R N L V D I G S L D N T E I V M R L E T H I D

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
S S S
S
S S
T T S S S S
T T
T T

. . . . . . . . . 780 . . . . . . . . . 790 . . . . . . . . . 800 . . . . . . . . . 810 . . . . . . . . . 820 . . . . . . . . . 830 . . . . . . . . . 840

Sequence S G D I F Y T D L N G L Q F I K R R R L D K L P L Q A N Y Y P I P S G M F I E D A N T R L T L L T G Q P L G G S S L A S G E L E I M Q D R R

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
T T T T T
T T S
G G G G
S S
S S S S
S T T

. . . . . . . . . 850 . . . . . . . . . 860 . . . . . . . . . 870 . . . . . . . . . 880 . . . . . . . . . 890 . . . . . . . . . 900 . . . . . . . . . 910

Sequence L A S D D E R G L G Q G V L D N K P V L H I Y R L V L E K V N N C V R P S K L H P A G Y L T S A A H K A S Q S L L D P L D K F I F A E N E W

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) B S S
S S S
S
B
T T S
T T
S
S
S S

. . . . . . . . . 920 . . . . . . . . . 930 . . . . . . . . . 940 . . . . . . . . . 950 . . . . . . . . . 960 . . . . . . . . . 970 . . . . . . . . . 980

Sequence I G A Q G Q F G G D H P S A R E D L D V S V M R R L T K S S A K T Q R V G Y V L H R T N L M Q C G T P E E H T Q K L D V C H L L P N V A R C

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T B
S
T T S
T T
S
T T
S
S
G G G S S S S

. . . . . . . . . 990 . . . . . . . . . 1000 . . . . . . . . . 1010 . . . . . .

Sequence E R T T L T F L Q N L E H L D G M V A P E V C P M E T A A Y V S S H S S

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
T T S
S
G G G
T T

Download: PDB structure FASTA sequence
Hidden Markov model

Image coloured by rainbow N → C terminus

Interactive 3D view in JSmol

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Accessibility Statement

Please cite: Phyre2.2: A Community Resource for Template-based Protein Structure Prediction

Powell HR et al. Journal of Molecular Biology (2025) in press DOI: https://doi.org/10.1016/j.jmb.2025.168960

© Structural Bioinformatics Group, Imperial College, London

Michael Sternberg

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Phyre2 is part of Genome3D

	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70
Sequence	Q	C	Q	D	V	V	Q	D	V	P	N	V	D	V	Q	M	L	E	L	Y	D	R	M	S	F	K	D	I	D	G	G	V	W	K	Q	G	W	N	I	K	Y	D	P	L	K	Y	N	A	H	H	K	L	K	V	F	V	V	P	H	S	H	N	D	P	G	W	I	Q	T	F
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)					S	S	S						S																		S	S	S	T	T	S							G	G	G	S	B	T	T	B														S	S	S	S	S
	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140
Sequence	E	E	Y	Y	Q	H	D	T	K	H	I	L	S	N	A	L	R	H	L	H	D	N	P	E	M	K	F	I	W	A	E	I	S	Y	F	A	R	F	Y	H	D	L	G	E	N	K	K	L	Q	M	K	S	I	V	K	N	G	Q	L	E	F	V	T	G	G	W	V	M	P	D
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)							T																T	T																T	T	S														T	T	S				S	S			S	S		B
	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210
Sequence	E	A	N	S	H	W	R	N	V	L	L	Q	L	T	E	G	Q	T	W	L	K	Q	F	M	N	V	T	P	T	A	S	W	A	I	D	P	F	G	H	S	P	T	M	P	Y	I	L	Q	K	S	G	F	K	N	M	L	I	Q	R	T	H	Y	S	V	K	K	E	L	A	Q
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	S	S	S																					T											S	S	S	S	B		T								T	T	T
	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280
Sequence	Q	R	Q	L	E	F	L	W	R	Q	I	W	D	N	K	G	D	T	A	L	F	T	H	M	M	P	F	Y	S	Y	D	I	P	H	T	C	G	P	D	P	K	V	C	C	Q	F	D	F	K	R	M	G	S	F	G	L	S	C	P	W	K	V	P	P	R	T	I	S	D	Q
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	T	T		S							T	T		S	S		T	T									S	S		S	S	G	G	G	T	S	S	S						G	G	G		G	G	G	S	S	T	T	S				T	T	S								T	T
	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350
Sequence	N	V	A	A	R	S	D	L	L	V	D	Q	W	K	K	K	A	E	L	Y	R	T	N	V	L	L	I	P	L	G	D	D	F	R	F	K	Q	N	T	E	W	D	V	Q	R	V	N	Y	E	R	L	F	E	H	I	N	S	Q	A	H	F	N	V	Q	A	Q	F	G	T	L
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	T																	T	T	S	S	S	S										T		S		S																						G	G	G
	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence	Q	E	Y	F	D	A	V	H	Q	A	E	R	A	G	Q	A	E	F	P	T	L	S	G	D	F	F	T	Y	A	D	R	S	D	N	Y	W	S	G	Y	Y	T	S	R	P	Y	H	K	R	M	D	R	V	L	M	H	Y	V	R	A	A	E	M	L	S	A	W	H	S	W	D
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)													T	T	S								S		B		S		B	S	S	T	T		B			G	G	G	T	S	S																							T	S
	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480	.	.	.	.	.	.	.	.	.	490
Sequence	G	M	A	R	I	E	E	R	L	E	Q	A	R	R	E	L	S	L	F	Q	H	H	D	G	I	T	G	T	A	K	T	H	V	V	V	D	Y	E	Q	R	M	Q	E	A	L	K	A	C	Q	M	V	M	Q	Q	S	V	Y	R	L	L	T	K	P	S	I	Y	S	P	D	F
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	G	G	G																	T	B	T	T	T	T	T	S		S																															T	B		T	T	T					T
	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540	.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560
Sequence	S	F	S	Y	F	T	L	D	D	S	R	W	P	G	S	G	V	E	D	S	R	T	T	I	I	L	G	E	D	I	L	P	S	K	H	V	V	M	H	N	T	L	P	H	W	R	E	Q	L	V	D	F	Y	V	S	S	P	F	V	S	V	T	D	L	A	N	N	P	V	E
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	T	S		S						S	T	T	T	T	T	T	T										B	T	T	T	B											S	S	S											S		S							T	T
	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600	.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630
Sequence	A	Q	V	S	P	V	W	S	W	H	H	D	T	L	T	K	T	I	H	P	Q	G	S	T	T	K	Y	R	I	I	F	K	A	R	V	P	P	M	G	L	A	T	Y	V	L	T	I	S	D	S	K	P	E	H	T	S	Y	A	S	N	L	L	L	R	K	N	P	T	S	L
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)													T	T	T	T																					T	T											S	S			T	T											S	S
	.	.	.	.	.	.	.	.	.	640	.	.	.	.	.	.	.	.	.	650	.	.	.	.	.	.	.	.	.	660	.	.	.	.	.	.	.	.	.	670	.	.	.	.	.	.	.	.	.	680	.	.	.	.	.	.	.	.	.	690	.	.	.	.	.	.	.	.	.	700
Sequence	P	L	G	Q	Y	P	E	D	V	K	F	G	D	P	R	E	I	S	L	R	V	G	N	G	P	T	L	A	F	S	E	Q	G	L	L	K	S	I	Q	L	T	Q	D	S	P	H	V	P	V	H	F	K	F	L	K	Y	G	V	R	S	H	G	D	R	S	G	A	Y	L	F
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)			T	T		S	S							S								T	T	S							T	T	S								S	T	T	S																S	S	S					S	S
	.	.	.	.	.	.	.	.	.	710	.	.	.	.	.	.	.	.	.	720	.	.	.	.	.	.	.	.	.	730	.	.	.	.	.	.	.	.	.	740	.	.	.	.	.	.	.	.	.	750	.	.	.	.	.	.	.	.	.	760	.	.	.	.	.	.	.	.	.	770
Sequence	L	P	N	G	P	A	S	P	V	E	L	G	Q	P	V	V	L	V	T	K	G	K	L	E	S	S	V	S	V	G	L	P	S	V	V	H	Q	T	I	M	R	G	G	A	P	E	I	R	N	L	V	D	I	G	S	L	D	N	T	E	I	V	M	R	L	E	T	H	I	D
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)			S	S	S								S									S	S									T	T								S	S	S	S										T	T		T	T
	.	.	.	.	.	.	.	.	.	780	.	.	.	.	.	.	.	.	.	790	.	.	.	.	.	.	.	.	.	800	.	.	.	.	.	.	.	.	.	810	.	.	.	.	.	.	.	.	.	820	.	.	.	.	.	.	.	.	.	830	.	.	.	.	.	.	.	.	.	840
Sequence	S	G	D	I	F	Y	T	D	L	N	G	L	Q	F	I	K	R	R	R	L	D	K	L	P	L	Q	A	N	Y	Y	P	I	P	S	G	M	F	I	E	D	A	N	T	R	L	T	L	L	T	G	Q	P	L	G	G	S	S	L	A	S	G	E	L	E	I	M	Q	D	R	R
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)		T	T							T	T	T									T	T	S		G	G	G	G					S	S							S	S								S	S								S	T	T
	.	.	.	.	.	.	.	.	.	850	.	.	.	.	.	.	.	.	.	860	.	.	.	.	.	.	.	.	.	870	.	.	.	.	.	.	.	.	.	880	.	.	.	.	.	.	.	.	.	890	.	.	.	.	.	.	.	.	.	900	.	.	.	.	.	.	.	.	.	910
Sequence	L	A	S	D	D	E	R	G	L	G	Q	G	V	L	D	N	K	P	V	L	H	I	Y	R	L	V	L	E	K	V	N	N	C	V	R	P	S	K	L	H	P	A	G	Y	L	T	S	A	A	H	K	A	S	Q	S	L	L	D	P	L	D	K	F	I	F	A	E	N	E	W
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	B	S	S			S	S	S			S		B																		T	T	S					T	T		S																	S									S	S
	.	.	.	.	.	.	.	.	.	920	.	.	.	.	.	.	.	.	.	930	.	.	.	.	.	.	.	.	.	940	.	.	.	.	.	.	.	.	.	950	.	.	.	.	.	.	.	.	.	960	.	.	.	.	.	.	.	.	.	970	.	.	.	.	.	.	.	.	.	980
Sequence	I	G	A	Q	G	Q	F	G	G	D	H	P	S	A	R	E	D	L	D	V	S	V	M	R	R	L	T	K	S	S	A	K	T	Q	R	V	G	Y	V	L	H	R	T	N	L	M	Q	C	G	T	P	E	E	H	T	Q	K	L	D	V	C	H	L	L	P	N	V	A	R	C
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	T	T	B		S				T	T	S					T	T										S		T	T		S																	S											G	G	G	S	S	S	S
	.	.	.	.	.	.	.	.	.	990	.	.	.	.	.	.	.	.	.	1000	.	.	.	.	.	.	.	.	.	1010	.	.	.	.	.	.
Sequence	E	R	T	T	L	T	F	L	Q	N	L	E	H	L	D	G	M	V	A	P	E	V	C	P	M	E	T	A	A	Y	V	S	S	H	S	S
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)					T	T	S		S						G	G	G							T	T