Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	R	K	N	T	Y	A	M	R	Y	V	A	G	Q	P	A	E	R	I	L	P	P	G	S	F	A	S	I	G	Q	A	L	P	P	G	E	P	L	S	T	E	E	R	I	R	I	L	V	W	N	I	Y	K	Q	Q	R	A	E	W	L
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?										?					?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?														?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		S	V	L	K	N	Y	G	K	D	A	H	L	V	L	L	Q	E	A	Q	T	T	P	E	L	V	Q	F	A	T	A	N	Y	L	A	A	D	Q	V	P	A	F	V	L	P	Q	H	P	S	G	V	M	T	L	S	A	A	H	P	V	Y
Secondary structure
SS confidence
Disorder																																																													?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		C	C	P	L	R	E	R	E	P	I	L	R	L	A	K	S	A	L	V	T	V	Y	P	L	P	D	T	R	L	L	M	V	V	N	I	H	A	V	N	F	S	L	G	V	D	V	Y	S	K	Q	L	L	P	I	G	D	Q	I	A	H
Secondary structure
SS confidence
Disorder				?																																					?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		H	S	G	P	V	I	M	A	G	D	F	N	A	W	S	R	R	R	M	N	A	L	Y	R	F	A	R	E	M	S	L	R	Q	V	R	F	T	D	D	Q	R	R	R	A	F	G	R	P	L	D	F	V	F	Y	R	G	L	N	V	S
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.
Sequence		E	A	S	V	L	V	T	R	A	S	D	H	N	P	L	L	V	E	F	S	P	G	K	P	D	K
Secondary structure
SS confidence
Disorder																						?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2j63 chain B Region: 34 - 262 Aligned: 229 Modelled: 229 Confidence: 100.0% Identity: 16% PDB header:lyase Chain: B: PDB Molecule:ap-endonuclease; PDBTitle: crystal structure of ap endonuclease lmap from leishmania2 major Phyre2 PDB 3mpr chain B Region: 40 - 262 Aligned: 219 Modelled: 223 Confidence: 100.0% Identity: 16% PDB header:hydrolase Chain: B: PDB Molecule:putative endonuclease/exonuclease/phosphatase family PDBTitle: crystal structure of endonuclease/exonuclease/phosphatase family2 protein from bacteroides thetaiotaomicron, northeast structural3 genomics consortium target btr318a Phyre2 PDB 1e9n chain B Region: 28 - 261 Aligned: 228 Modelled: 233 Confidence: 100.0% Identity: 13% PDB header:dna repair Chain: B: PDB Molecule:dna-(apurinic or apyrimidinic site) lyase; PDBTitle: a second divalent metal ion in the active site of a new2 crystal form of human apurinic/apyrimidinic endonuclease,3 ape1, and its implications for the catalytic mechanism Phyre2 PDB 3teb chain A Region: 44 - 260 Aligned: 215 Modelled: 216 Confidence: 100.0% Identity: 15% PDB header:hydrolase Chain: A: PDB Molecule:endonuclease/exonuclease/phosphatase; PDBTitle: endonuclease/exonuclease/phosphatase family protein from leptotrichia2 buccalis c-1013-b Phyre2 PDB 3ngo chain A Region: 20 - 261 Aligned: 237 Modelled: 242 Confidence: 100.0% Identity: 19% PDB header:hydrolase/dna Chain: A: PDB Molecule:ccr4-not transcription complex subunit 6-like; PDBTitle: crystal structure of the human cnot6l nuclease domain in complex with2 poly(a) dna Phyre2 PDB 3mtc chain A Region: 43 - 262 Aligned: 219 Modelled: 220 Confidence: 100.0% Identity: 16% PDB header:hydrolase/hydrolase inhibitor Chain: A: PDB Molecule:type ii inositol-1,4,5-trisphosphate 5-phosphatase; PDBTitle: crystal structure of inpp5b in complex with phosphatidylinositol 4-2 phosphate Phyre2 PDB 3g6s chain A Region: 42 - 261 Aligned: 218 Modelled: 220 Confidence: 100.0% Identity: 17% PDB header:hydrolase Chain: A: PDB Molecule:putative endonuclease/exonuclease/phosphatase PDBTitle: crystal structure of the2 endonuclease/exonuclease/phosphatase (bvu_0621) from3 bacteroides vulgatus. northeast structural genomics4 consortium target bvr56d Phyre2 PDB 3l1w chain E Region: 45 - 262 Aligned: 215 Modelled: 218 Confidence: 100.0% Identity: 17% PDB header:structural genomics, unknown function Chain: E: PDB Molecule:uncharacterized protein; PDBTitle: the crystal structure of a functionally unknown conserved2 protein from enterococcus faecalis v583 Phyre2 PDB 2imq chain X domain 1 Region: 43 - 261 Aligned: 218 Modelled: 219 Confidence: 100.0% Identity: 15% Fold: DNase I-like Superfamily: DNase I-like Family: Inositol polyphosphate 5-phosphatase (IPP5) Phyre2 PDB 3g0r chain A Region: 44 - 261 Aligned: 212 Modelled: 212 Confidence: 100.0% Identity: 19% PDB header:hydrolase/dna Chain: A: PDB Molecule:exodeoxyribonuclease; PDBTitle: complex of mth0212 and an 8bp dsdna with distorted ends Phyre2 PDB 1vyb chain A Region: 40 - 260 Aligned: 210 Modelled: 217 Confidence: 100.0% Identity: 17% Fold: DNase I-like Superfamily: DNase I-like Family: DNase I-like Phyre2 PDB 2f1n chain A domain 1 Region: 40 - 258 Aligned: 206 Modelled: 219 Confidence: 99.9% Identity: 16% Fold: DNase I-like Superfamily: DNase I-like Family: DNase I-like Phyre2 PDB 2jc5 chain A Region: 44 - 263 Aligned: 214 Modelled: 220 Confidence: 99.9% Identity: 16% PDB header:hydrolase Chain: A: PDB Molecule:exodeoxyribonuclease; PDBTitle: apurinic apyrimidinic (ap) endonuclease (nape) from2 neisseria meningitidis Phyre2 PDB 1wdu chain A Region: 43 - 263 Aligned: 203 Modelled: 213 Confidence: 99.9% Identity: 14% Fold: DNase I-like Superfamily: DNase I-like Family: DNase I-like Phyre2 PDB 1ako chain A Region: 44 - 260 Aligned: 211 Modelled: 215 Confidence: 99.9% Identity: 12% Fold: DNase I-like Superfamily: DNase I-like Family: DNase I-like Phyre2 PDB 2ddr chain A domain 1 Region: 41 - 261 Aligned: 218 Modelled: 219 Confidence: 99.9% Identity: 19% Fold: DNase I-like Superfamily: DNase I-like Family: Sphingomyelin phosphodiesterase-like Phyre2 PDB 1zwx chain A domain 1 Region: 41 - 259 Aligned: 218 Modelled: 219 Confidence: 99.9% Identity: 17% Fold: DNase I-like Superfamily: DNase I-like Family: Sphingomyelin phosphodiesterase-like Phyre2 PDB 3nr8 chain A Region: 43 - 261 Aligned: 216 Modelled: 219 Confidence: 99.9% Identity: 15% PDB header:hydrolase Chain: A: PDB Molecule:phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2; PDBTitle: crystal structure of human ship2 Phyre2 PDB 1sr4 chain B Region: 42 - 260 Aligned: 212 Modelled: 219 Confidence: 99.9% Identity: 14% Fold: DNase I-like Superfamily: DNase I-like Family: DNase I-like Phyre2 PDB 2ei9 chain A Region: 43 - 260 Aligned: 191 Modelled: 197 Confidence: 99.9% Identity: 18% PDB header:gene regulation Chain: A: PDB Molecule:non-ltr retrotransposon r1bmks orf2 protein; PDBTitle: crystal structure of r1bm endonuclease domain Phyre2 1 c2j63B_ 2 c3mprB_ 3 c1e9nB_ 4 c3tebA_ 5 c3ngoA_ 6 c3mtcA_ 7 c3g6sA_ 8 c3l1wE_ 9 d2imqx1 10 c3g0rA_ 11 d1vyba_ 12 d2f1na1 13 c2jc5A_ 14 d1wdua_ 15 d1akoa_ 16 d2ddra1 17 d1zwxa1 18 c3nr8A_ 19 d1sr4b_ 20 c2ei9A_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c2j63B_ 100.0 16 PDB header:lyase Chain: B: PDB Molecule:ap-endonuclease; PDBTitle: crystal structure of ap endonuclease lmap from leishmania2 major 2 c3mprB_ 100.0 16 PDB header:hydrolase Chain: B: PDB Molecule:putative endonuclease/exonuclease/phosphatase family PDBTitle: crystal structure of endonuclease/exonuclease/phosphatase family2 protein from bacteroides thetaiotaomicron, northeast structural3 genomics consortium target btr318a 3 c1e9nB_ 100.0 13 PDB header:dna repair Chain: B: PDB Molecule:dna-(apurinic or apyrimidinic site) lyase; PDBTitle: a second divalent metal ion in the active site of a new2 crystal form of human apurinic/apyrimidinic endonuclease,3 ape1, and its implications for the catalytic mechanism 4 c3tebA_ 100.0 15 PDB header:hydrolase Chain: A: PDB Molecule:endonuclease/exonuclease/phosphatase; PDBTitle: endonuclease/exonuclease/phosphatase family protein from leptotrichia2 buccalis c-1013-b 5 c3ngoA_ 100.0 19 PDB header:hydrolase/dna Chain: A: PDB Molecule:ccr4-not transcription complex subunit 6-like; PDBTitle: crystal structure of the human cnot6l nuclease domain in complex with2 poly(a) dna 6 c3mtcA_ 100.0 16 PDB header:hydrolase/hydrolase inhibitor Chain: A: PDB Molecule:type ii inositol-1,4,5-trisphosphate 5-phosphatase; PDBTitle: crystal structure of inpp5b in complex with phosphatidylinositol 4-2 phosphate 7 c3g6sA_ 100.0 17 PDB header:hydrolase Chain: A: PDB Molecule:putative endonuclease/exonuclease/phosphatase PDBTitle: crystal structure of the2 endonuclease/exonuclease/phosphatase (bvu_0621) from3 bacteroides vulgatus. northeast structural genomics4 consortium target bvr56d 8 c3l1wE_ 100.0 17 PDB header:structural genomics, unknown function Chain: E: PDB Molecule:uncharacterized protein; PDBTitle: the crystal structure of a functionally unknown conserved2 protein from enterococcus faecalis v583 9 d2imqx1 100.0 15 Fold:DNase I-like Superfamily:DNase I-like Family:Inositol polyphosphate 5-phosphatase (IPP5) 10 c3g0rA_ 100.0 19 PDB header:hydrolase/dna Chain: A: PDB Molecule:exodeoxyribonuclease; PDBTitle: complex of mth0212 and an 8bp dsdna with distorted ends 11 d1vyba_ 100.0 17 Fold:DNase I-like Superfamily:DNase I-like Family:DNase I-like 12 d2f1na1 99.9 16 Fold:DNase I-like Superfamily:DNase I-like Family:DNase I-like 13 c2jc5A_ 99.9 16 PDB header:hydrolase Chain: A: PDB Molecule:exodeoxyribonuclease; PDBTitle: apurinic apyrimidinic (ap) endonuclease (nape) from2 neisseria meningitidis 14 d1wdua_ 99.9 14 Fold:DNase I-like Superfamily:DNase I-like Family:DNase I-like 15 d1akoa_ 99.9 12 Fold:DNase I-like Superfamily:DNase I-like Family:DNase I-like 16 d2ddra1 99.9 19 Fold:DNase I-like Superfamily:DNase I-like Family:Sphingomyelin phosphodiesterase-like 17 d1zwxa1 99.9 17 Fold:DNase I-like Superfamily:DNase I-like Family:Sphingomyelin phosphodiesterase-like 18 c3nr8A_ 99.9 15 PDB header:hydrolase Chain: A: PDB Molecule:phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2; PDBTitle: crystal structure of human ship2 19 d1sr4b_ 99.9 14 Fold:DNase I-like Superfamily:DNase I-like Family:DNase I-like 20 c2ei9A_ 99.9 18 PDB header:gene regulation Chain: A: PDB Molecule:non-ltr retrotransposon r1bmks orf2 protein; PDBTitle: crystal structure of r1bm endonuclease domain 21 d2a40b1 not modelled 99.9 15 Fold:DNase I-like Superfamily:DNase I-like Family:DNase I-like 22 c2voaB_ not modelled 99.9 14 PDB header:lyase Chain: B: PDB Molecule:exodeoxyribonuclease iii; PDBTitle: structure of an ap endonuclease from archaeoglobus fulgidus 23 d1hd7a_ not modelled 99.9 16 Fold:DNase I-like Superfamily:DNase I-like Family:DNase I-like 24 c3i46B_ not modelled 99.9 15 PDB header:toxin Chain: B: PDB Molecule:beta-hemolysin; PDBTitle: crystal structure of beta toxin from staphylococcus aureus f277a,2 p278a mutant with bound calcium ions 25 c2jc4A_ not modelled 99.9 17 PDB header:hydrolase Chain: A: PDB Molecule:exodeoxyribonuclease iii; PDBTitle: 3'-5' exonuclease (nexo) from neisseria meningitidis 26 c2xswB_ not modelled 99.8 15 PDB header:hydrolase Chain: B: PDB Molecule:72 kda inositol polyphosphate 5-phosphatase; PDBTitle: crystal structure of human inpp5e 27 d1i9za_ not modelled 99.8 16 Fold:DNase I-like Superfamily:DNase I-like Family:Inositol polyphosphate 5-phosphatase (IPP5) 28 d2qlvb1 not modelled 41.4 21 Fold:Immunoglobulin-like beta-sandwich Superfamily:E set domains Family:AMPK-beta glycogen binding domain-like 29 c2qlvB_ not modelled 36.1 20 PDB header:transferase/protein binding Chain: B: PDB Molecule:protein sip2; PDBTitle: crystal structure of the heterotrimer core of the s.2 cerevisiae ampk homolog snf1 30 d1z0na1 not modelled 27.7 31 Fold:Immunoglobulin-like beta-sandwich Superfamily:E set domains Family:AMPK-beta glycogen binding domain-like 31 d2f15a1 not modelled 26.6 29 Fold:Immunoglobulin-like beta-sandwich Superfamily:E set domains Family:AMPK-beta glycogen binding domain-like 32 d1q6za1 not modelled 23.3 23 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:Pyruvate oxidase and decarboxylase, middle domain 33 c3nmeA_ not modelled 23.1 25 PDB header:hydrolase Chain: A: PDB Molecule:sex4 glucan phosphatase; PDBTitle: structure of a plant phosphatase 34 d1z0mb1 not modelled 20.4 35 Fold:Immunoglobulin-like beta-sandwich Superfamily:E set domains Family:AMPK-beta glycogen binding domain-like 35 d2ez9a1 not modelled 19.3 14 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:Pyruvate oxidase and decarboxylase, middle domain 36 d1uf3a_ not modelled 19.1 12 Fold:Metallo-dependent phosphatases Superfamily:Metallo-dependent phosphatases Family:TT1561-like 37 d1emsa2 not modelled 19.1 14 Fold:Carbon-nitrogen hydrolase Superfamily:Carbon-nitrogen hydrolase Family:Nitrilase 38 c2w1vA_ not modelled 18.1 17 PDB header:hydrolase Chain: A: PDB Molecule:nitrilase homolog 2; PDBTitle: crystal structure of mouse nitrilase-2 at 1.4a resolution 39 d2ji7a1 not modelled 18.0 32 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:Pyruvate oxidase and decarboxylase, middle domain 40 d1ybha1 not modelled 17.3 26 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:Pyruvate oxidase and decarboxylase, middle domain 41 d2djia1 not modelled 15.9 23 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:Pyruvate oxidase and decarboxylase, middle domain 42 c2jzfA_ not modelled 15.4 33 PDB header:viral protein Chain: A: PDB Molecule:replicase polyprotein 1ab; PDBTitle: nmr conformer closest to the mean coordinates of the domain 513-651 of2 the sars-cov nonstructural protein nsp3 43 d2ihta1 not modelled 15.2 22 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:Pyruvate oxidase and decarboxylase, middle domain 44 d3d03a1 not modelled 15.0 16 Fold:Metallo-dependent phosphatases Superfamily:Metallo-dependent phosphatases Family:GpdQ-like 45 d1ovma1 not modelled 14.6 9 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:Pyruvate oxidase and decarboxylase, middle domain 46 d1ozha1 not modelled 13.1 19 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:Pyruvate oxidase and decarboxylase, middle domain 47 d1xm7a_ not modelled 13.0 11 Fold:Metallo-dependent phosphatases Superfamily:Metallo-dependent phosphatases Family:Hypothetical protein aq 1666 48 d2yvta1 not modelled 12.7 19 Fold:Metallo-dependent phosphatases Superfamily:Metallo-dependent phosphatases Family:TT1561-like 49 d1j31a_ not modelled 11.3 23 Fold:Carbon-nitrogen hydrolase Superfamily:Carbon-nitrogen hydrolase Family:Carbamilase 50 d1f89a_ not modelled 10.4 19 Fold:Carbon-nitrogen hydrolase Superfamily:Carbon-nitrogen hydrolase Family:Nitrilase 51 d1pvda1 not modelled 10.4 11 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:Pyruvate oxidase and decarboxylase, middle domain 52 c2e11B_ not modelled 8.6 21 PDB header:hydrolase Chain: B: PDB Molecule:hydrolase; PDBTitle: the crystal structure of xc1258 from xanthomonas campestris: a cn-2 hydrolase superfamily protein with an arsenic adduct in the active3 site 53 c3ilvA_ not modelled 8.3 18 PDB header:ligase Chain: A: PDB Molecule:glutamine-dependent nad(+) synthetase; PDBTitle: crystal structure of a glutamine-dependent nad(+) synthetase2 from cytophaga hutchinsonii 54 d1edqa1 not modelled 8.0 17 Fold:Immunoglobulin-like beta-sandwich Superfamily:E set domains Family:E-set domains of sugar-utilizing enzymes 55 c3av0A_ not modelled 7.9 16 PDB header:recombination Chain: A: PDB Molecule:dna double-strand break repair protein mre11; PDBTitle: crystal structure of mre11-rad50 bound to atp s 56 d2vzsa2 not modelled 7.8 22 Fold:Immunoglobulin-like beta-sandwich Superfamily:beta-Galactosidase/glucuronidase domain Family:beta-Galactosidase/glucuronidase domain 57 c3rl4A_ not modelled 6.8 13 PDB header:hydrolase Chain: A: PDB Molecule:metallophosphoesterase mpped2; PDBTitle: rat metallophosphodiesterase mpped2 g252h mutant 58 d1zpda1 not modelled 6.0 10 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:Pyruvate oxidase and decarboxylase, middle domain 59 d1o51a_ not modelled 5.9 10 Fold:Ferredoxin-like Superfamily:GlnB-like Family:DUF190/COG1993 60 c3jvvA_ not modelled 5.6 8 PDB header:atp binding protein Chain: A: PDB Molecule:twitching mobility protein; PDBTitle: crystal structure of p. aeruginosa pilt with bound amp-pcp 61 c3n05B_ not modelled 5.6 21 PDB header:ligase Chain: B: PDB Molecule:nh(3)-dependent nad(+) synthetase; PDBTitle: crystal structure of nh3-dependent nad+ synthetase from streptomyces2 avermitilis 62 d2fvta1 not modelled 5.4 13 Fold:MTH938-like Superfamily:MTH938-like Family:MTH938-like 63 c3auzA_ not modelled 5.4 18 PDB header:recombination Chain: A: PDB Molecule:dna double-strand break repair protein mre11; PDBTitle: crystal structure of mre11 with manganese 64 c3dnfB_ not modelled 5.2 18 PDB header:oxidoreductase Chain: B: PDB Molecule:4-hydroxy-3-methylbut-2-enyl diphosphate reductase; PDBTitle: structure of (e)-4-hydroxy-3-methyl-but-2-enyl diphosphate reductase,2 the terminal enzyme of the non-mevalonate pathway

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0