Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	V	E	D	I	L	A	P	G	L	R	V	V	F	C	G	I	N	P	G	L	S	S	A	G	T	G	F	P	F	A	H	P	A	N	R	F	W	K	V	I	Y	Q	A	G	F	T	D	R	Q	L	K	P	Q	E	A	Q	H	L	L
Secondary structure
SS confidence
Disorder		?	?	?	?	?																								?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		D	Y	R	C	G	V	T	K	L	V	D	R	P	T	V	Q	A	N	E	V	S	K	Q	E	L	H	A	G	G	R	K	L	I	E	K	I	E	D	Y	Q	P	Q	A	L	A	I	L	G	K	Q	A	Y	E	Q	G	F	S	Q	R	G
Secondary structure
SS confidence
Disorder														?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.
Sequence		A	Q	W	G	K	Q	T	L	T	I	G	S	T	Q	I	W	V	L	P	N	P	S	G	L	S	R	V	S	L	E	K	L	V	E	A	Y	R	E	L	D	Q	A	L	V	V	R	G	R
Secondary structure
SS confidence
Disorder																										?																				?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1mug chain A Region: 1 - 164 Aligned: 164 Modelled: 164 Confidence: 100.0% Identity: 100% Fold: Uracil-DNA glycosylase-like Superfamily: Uracil-DNA glycosylase-like Family: Mug-like Phyre2 PDB 2d07 chain A Region: 2 - 168 Aligned: 164 Modelled: 167 Confidence: 100.0% Identity: 33% PDB header:hydrolase Chain: A: PDB Molecule:g/t mismatch-specific thymine dna glycosylase; PDBTitle: crystal structure of sumo-3-modified thymine-dna glycosylase Phyre2 PDB 2rba chain B Region: 2 - 168 Aligned: 167 Modelled: 167 Confidence: 100.0% Identity: 32% PDB header:hydrolase/dna Chain: B: PDB Molecule:g/t mismatch-specific thymine dna glycosylase; PDBTitle: structure of human thymine dna glycosylase bound to abasic and2 undamaged dna Phyre2 PDB 2c2p chain A Region: 1 - 165 Aligned: 161 Modelled: 165 Confidence: 100.0% Identity: 29% PDB header:hydrolase Chain: A: PDB Molecule:g/u mismatch-specific dna glycosylase; PDBTitle: the crystal structure of mismatch specific uracil-dna2 glycosylase (mug) from deinococcus radiodurans Phyre2 PDB 2l3f chain A Region: 2 - 163 Aligned: 151 Modelled: 162 Confidence: 100.0% Identity: 16% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: solution nmr structure of a putative uracil dna glycosylase from2 methanosarcina acetivorans, northeast structural genomics consortium3 target mvr76 Phyre2 PDB 1vk2 chain A Region: 1 - 162 Aligned: 149 Modelled: 149 Confidence: 100.0% Identity: 23% Fold: Uracil-DNA glycosylase-like Superfamily: Uracil-DNA glycosylase-like Family: Mug-like Phyre2 PDB 2d3y chain A Region: 2 - 162 Aligned: 159 Modelled: 161 Confidence: 99.9% Identity: 21% PDB header:hydrolase Chain: A: PDB Molecule:uracil-dna glycosylase; PDBTitle: crystal structure of uracil-dna glycosylase from thermus thermophilus2 hb8 Phyre2 PDB 1ui0 chain A Region: 1 - 163 Aligned: 150 Modelled: 150 Confidence: 99.9% Identity: 19% Fold: Uracil-DNA glycosylase-like Superfamily: Uracil-DNA glycosylase-like Family: Mug-like Phyre2 PDB 3ikb chain B Region: 2 - 167 Aligned: 157 Modelled: 164 Confidence: 99.9% Identity: 12% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:uncharacterized conserved protein; PDBTitle: the structure of a conserved protein from streptococcus2 mutans ua159. Phyre2 PDB 1oe4 chain A Region: 5 - 158 Aligned: 138 Modelled: 148 Confidence: 99.5% Identity: 21% Fold: Uracil-DNA glycosylase-like Superfamily: Uracil-DNA glycosylase-like Family: Single-strand selective monofunctional uracil-DNA glycosylase SMUG1 Phyre2 PDB 2owr chain D Region: 8 - 168 Aligned: 140 Modelled: 161 Confidence: 96.5% Identity: 19% PDB header:hydrolase Chain: D: PDB Molecule:uracil-dna glycosylase; PDBTitle: crystal structure of vaccinia virus uracil-dna glycosylase Phyre2 PDB 3cxm chain A Region: 8 - 168 Aligned: 152 Modelled: 152 Confidence: 95.8% Identity: 16% PDB header:hydrolase Chain: A: PDB Molecule:uracil-dna glycosylase; PDBTitle: leishmania naiffi uracil-dna glycosylase in complex with 5-bromouracil Phyre2 PDB 3tr7 chain A Region: 8 - 168 Aligned: 150 Modelled: 158 Confidence: 95.5% Identity: 19% PDB header:hydrolase Chain: A: PDB Molecule:uracil-dna glycosylase; PDBTitle: structure of a uracil-dna glycosylase (ung) from coxiella burnetii Phyre2 PDB 3eug chain A Region: 9 - 168 Aligned: 150 Modelled: 151 Confidence: 95.3% Identity: 13% Fold: Uracil-DNA glycosylase-like Superfamily: Uracil-DNA glycosylase-like Family: Uracil-DNA glycosylase Phyre2 PDB 2hxm chain A domain 1 Region: 8 - 168 Aligned: 151 Modelled: 160 Confidence: 94.6% Identity: 11% Fold: Uracil-DNA glycosylase-like Superfamily: Uracil-DNA glycosylase-like Family: Uracil-DNA glycosylase Phyre2 PDB 2zhx chain G Region: 8 - 168 Aligned: 149 Modelled: 161 Confidence: 94.5% Identity: 17% PDB header:hydrolase/hydrolase inhibitor Chain: G: PDB Molecule:uracil-dna glycosylase; PDBTitle: crystal structure of uracil-dna glycosylase from mycobacterium2 tuberculosis in complex with a proteinaceous inhibitor Phyre2 PDB 2j8x chain A domain 1 Region: 9 - 144 Aligned: 127 Modelled: 136 Confidence: 94.0% Identity: 10% Fold: Uracil-DNA glycosylase-like Superfamily: Uracil-DNA glycosylase-like Family: Uracil-DNA glycosylase Phyre2 PDB 2boo chain A Region: 9 - 168 Aligned: 150 Modelled: 151 Confidence: 93.5% Identity: 14% PDB header:hydrolase Chain: A: PDB Molecule:uracil-dna glycosylase; PDBTitle: the crystal structure of uracil-dna n-glycosylase (ung)2 from deinococcus radiodurans. Phyre2 PDB 1okb chain A Region: 8 - 168 Aligned: 150 Modelled: 150 Confidence: 93.1% Identity: 14% Fold: Uracil-DNA glycosylase-like Superfamily: Uracil-DNA glycosylase-like Family: Uracil-DNA glycosylase Phyre2 PDB 1lau chain E Region: 8 - 168 Aligned: 148 Modelled: 150 Confidence: 93.1% Identity: 17% Fold: Uracil-DNA glycosylase-like Superfamily: Uracil-DNA glycosylase-like Family: Uracil-DNA glycosylase Phyre2 1 d1muga_ 2 c2d07A_ 3 c2rbaB_ 4 c2c2pA_ 5 c2l3fA_ 6 d1vk2a_ 7 c2d3yA_ 8 d1ui0a_ 9 c3ikbB_ 10 d1oe4a_ 11 c2owrD_ 12 c3cxmA_ 13 c3tr7A_ 14 d3euga_ 15 d2hxma1 16 c2zhxG_ 17 d2j8xa1 18 c2booA_ 19 d1okba_ 20 d1laue_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d1muga_ 100.0 100 Fold:Uracil-DNA glycosylase-like Superfamily:Uracil-DNA glycosylase-like Family:Mug-like 2 c2d07A_ 100.0 33 PDB header:hydrolase Chain: A: PDB Molecule:g/t mismatch-specific thymine dna glycosylase; PDBTitle: crystal structure of sumo-3-modified thymine-dna glycosylase 3 c2rbaB_ 100.0 32 PDB header:hydrolase/dna Chain: B: PDB Molecule:g/t mismatch-specific thymine dna glycosylase; PDBTitle: structure of human thymine dna glycosylase bound to abasic and2 undamaged dna 4 c2c2pA_ 100.0 29 PDB header:hydrolase Chain: A: PDB Molecule:g/u mismatch-specific dna glycosylase; PDBTitle: the crystal structure of mismatch specific uracil-dna2 glycosylase (mug) from deinococcus radiodurans 5 c2l3fA_ 100.0 16 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: solution nmr structure of a putative uracil dna glycosylase from2 methanosarcina acetivorans, northeast structural genomics consortium3 target mvr76 6 d1vk2a_ 100.0 23 Fold:Uracil-DNA glycosylase-like Superfamily:Uracil-DNA glycosylase-like Family:Mug-like 7 c2d3yA_ 99.9 21 PDB header:hydrolase Chain: A: PDB Molecule:uracil-dna glycosylase; PDBTitle: crystal structure of uracil-dna glycosylase from thermus thermophilus2 hb8 8 d1ui0a_ 99.9 19 Fold:Uracil-DNA glycosylase-like Superfamily:Uracil-DNA glycosylase-like Family:Mug-like 9 c3ikbB_ 99.9 12 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:uncharacterized conserved protein; PDBTitle: the structure of a conserved protein from streptococcus2 mutans ua159. 10 d1oe4a_ 99.5 21 Fold:Uracil-DNA glycosylase-like Superfamily:Uracil-DNA glycosylase-like Family:Single-strand selective monofunctional uracil-DNA glycosylase SMUG1 11 c2owrD_ 96.5 19 PDB header:hydrolase Chain: D: PDB Molecule:uracil-dna glycosylase; PDBTitle: crystal structure of vaccinia virus uracil-dna glycosylase 12 c3cxmA_ 95.8 16 PDB header:hydrolase Chain: A: PDB Molecule:uracil-dna glycosylase; PDBTitle: leishmania naiffi uracil-dna glycosylase in complex with 5-bromouracil 13 c3tr7A_ 95.5 19 PDB header:hydrolase Chain: A: PDB Molecule:uracil-dna glycosylase; PDBTitle: structure of a uracil-dna glycosylase (ung) from coxiella burnetii 14 d3euga_ 95.3 13 Fold:Uracil-DNA glycosylase-like Superfamily:Uracil-DNA glycosylase-like Family:Uracil-DNA glycosylase 15 d2hxma1 94.6 11 Fold:Uracil-DNA glycosylase-like Superfamily:Uracil-DNA glycosylase-like Family:Uracil-DNA glycosylase 16 c2zhxG_ 94.5 17 PDB header:hydrolase/hydrolase inhibitor Chain: G: PDB Molecule:uracil-dna glycosylase; PDBTitle: crystal structure of uracil-dna glycosylase from mycobacterium2 tuberculosis in complex with a proteinaceous inhibitor 17 d2j8xa1 94.0 10 Fold:Uracil-DNA glycosylase-like Superfamily:Uracil-DNA glycosylase-like Family:Uracil-DNA glycosylase 18 c2booA_ 93.5 14 PDB header:hydrolase Chain: A: PDB Molecule:uracil-dna glycosylase; PDBTitle: the crystal structure of uracil-dna n-glycosylase (ung)2 from deinococcus radiodurans. 19 d1okba_ 93.1 14 Fold:Uracil-DNA glycosylase-like Superfamily:Uracil-DNA glycosylase-like Family:Uracil-DNA glycosylase 20 d1laue_ 93.1 17 Fold:Uracil-DNA glycosylase-like Superfamily:Uracil-DNA glycosylase-like Family:Uracil-DNA glycosylase 21 c3fpjA_ not modelled 25.4 32 PDB header:biosynthetic protein, transferase Chain: A: PDB Molecule:putative uncharacterized protein; PDBTitle: crystal structure of e81q mutant of mtnas in complex with s-2 adenosylmethionine 22 c3absD_ not modelled 18.2 24 PDB header:lyase Chain: D: PDB Molecule:ethanolamine ammonia-lyase light chain; PDBTitle: crystal structure of ethanolamine ammonia-lyase from escherichia coli2 complexed with adeninylpentylcobalamin and ethanolamine 23 c1v39A_ not modelled 16.3 35 PDB header:methyltransferase Chain: A: PDB Molecule:vp39; PDBTitle: dc26 mutant of vaccinia virus protein vp39 in complex with s-2 adenosylhomocysteine and m7g(5')pppg 24 c1vp3A_ not modelled 16.3 35 PDB header:methyltransferase Chain: A: PDB Molecule:vp39; PDBTitle: vaccinia virus protein vp39 in complex with s-adenosylhomocysteine 25 d1vpta_ not modelled 16.2 32 Fold:S-adenosyl-L-methionine-dependent methyltransferases Superfamily:S-adenosyl-L-methionine-dependent methyltransferases Family:mRNA cap methylase 26 c3anyB_ not modelled 15.9 24 PDB header:lyase Chain: B: PDB Molecule:ethanolamine ammonia-lyase light chain; PDBTitle: crystal structure of ethanolamine ammonia-lyase from escherichia coli2 complexed with cn-cbl and (r)-2-amino-1-propanol 27 c2plwA_ not modelled 10.7 24 PDB header:transferase Chain: A: PDB Molecule:ribosomal rna methyltransferase, putative; PDBTitle: crystal structure of a ribosomal rna methyltransferase, putative, from2 plasmodium falciparum (pf13_0052). 28 c3jqoV_ not modelled 8.8 15 PDB header:transport protein Chain: V: PDB Molecule:traf protein; PDBTitle: crystal structure of the outer membrane complex of a type iv2 secretion system 29 d2i7pa2 not modelled 8.3 23 Fold:Ribonuclease H-like motif Superfamily:Actin-like ATPase domain Family:Fumble-like 30 d1iv0a_ not modelled 8.3 8 Fold:Ribonuclease H-like motif Superfamily:Ribonuclease H-like Family:Putative Holliday junction resolvase RuvX 31 d2cyja1 not modelled 7.6 25 Fold:MTH938-like Superfamily:MTH938-like Family:MTH938-like 32 c2h4bD_ not modelled 6.7 38 PDB header:de novo protein Chain: D: PDB Molecule:pancreatic hormone; PDBTitle: cis-4-aminomethylphenylazobenzoic acid-avian pancreatic2 polypeptide 33 c2h4bC_ not modelled 6.7 38 PDB header:de novo protein Chain: C: PDB Molecule:pancreatic hormone; PDBTitle: cis-4-aminomethylphenylazobenzoic acid-avian pancreatic2 polypeptide 34 c2h3sB_ not modelled 6.7 38 PDB header:de novo protein Chain: B: PDB Molecule:pancreatic hormone; PDBTitle: cis-azobenzene-avian pancreatic polypeptide bound to dpc2 micelles 35 c2h3tB_ not modelled 6.7 38 PDB header:de novo protein Chain: B: PDB Molecule:pancreatic hormone; PDBTitle: trans-(4-aminomethyl)phenylazobenzoic acid-app bound to dpc2 micelles 36 d1ihna_ not modelled 6.5 14 Fold:MTH938-like Superfamily:MTH938-like Family:MTH938-like 37 d1jvaa2 not modelled 5.5 25 Fold:Homing endonuclease-like Superfamily:Homing endonucleases Family:Intein endonuclease 38 d2q4qa1 not modelled 5.3 15 Fold:MTH938-like Superfamily:MTH938-like Family:MTH938-like

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0