|Structural Bioinformatics Group|
Division of Molecular Biosciences
Faculty of Natural Sciences
ConFunc - Conserved residue Function Prediction Server
ConFunc HelpSubmission Options
There are 3 submission options:
1- submit a sequnece and let conFunc do the rest
2- submit a Swiss-Prot accession - conFunc will extract the sequence from Swiss-Prot and make predictions of its function
3- TO BE IMPLEMENTED: submit a multiple sequence alignment containing your chosen query sequence and the other sequences that you would like to used for the prediction process. Note that if you do not provide an accession for the sequence that is to be used then the first sequence in the alignment will be chosen as the query
conFunc uses Gene Ontology annotations for Swiss-Prot from the EBI, therefore only sequences in the alignemnt will be used for prediction if they have Swiss-Prot accessions.
|submitted||Job submitted not running yet|
|running||job started - initial setup running|
|running PSI-BLAST||PSI-BLAST being run to identify homologues|
|muscle alignment||annotated sequences are being aligned|
|generating GO subalignments and e-values||conFunc prediction process|
|analysing GO e-value||final conFunc prediction|
|finished||Job completed and results displayed below|
|error||An error has occured|
conFunc Function Predictions
Each GO has an associated sub-alignment that is used for identifying conserved residues associated with each GO term. These subalignments can be viewed by clicking on the relevant GO term.
Please note that some terms have exactly the same e-value, frequency and subalignment, this occurs when the same terms have exactly the same sequences associated with them, this often happens for related terms.
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