Phyre 2 Results for P72358

Email	l.a.kelley@imperial.ac.uk
Description	P72358
Date	Tue Jul 17 17:05:13 BST 2012
Unique Job ID	c27a6a3e0d9c09fc

Summary

Top model

Image coloured by rainbow N → C terminus

Model (left) based on template c2kncA_

Top template information

PDB header:cell adhesion
Chain: A: PDB Molecule:integrin alpha-iib;
PDBTitle: platelet integrin alfaiib-beta3 transmembrane-cytoplasmic2 heterocomplex

Confidence and coverage

Confidence:

32.3%

Coverage:

29%

43 residues ( 29% of your sequence) have been modelled with 32.3% confidence by the single highest scoring template.

You may wish to submit your sequence to Phyrealarm. This will automatically scan your sequence every week for new potential templates as they appear in the Phyre2 library.

Please note: You must be registered and logged in to use Phyrealarm.

3D viewing

Interactive 3D view in Jmol

Sequence analysis

Secondary structure and disorder prediction

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60

Sequence M V V K Q Q K D A S K P A H F F H Q V I V I A L V L F V S K I I E S F M P I P M P A S V I G L V L L F V L L C T G A V K

Secondary structure

SS confidence

Disorder ? ?

Disorder confidence

. . . . . . . . . 70 . . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120

Sequence L G E V E K V G T T L T N N I G L L F V P A G I S V V N S L G V I S Q A P F L I I G L I I V S T I L L L I C T G Y V T Q

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 130 . . . . . . . . . 140 . . . . . . .

Sequence I I M K V T S R S K G D K V T K K I K I E E A Q A H D

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ?
? ? ? ? ?
? ? ? ?

Disorder confidence

Confidence Key
High(9) Low (0)

? Disordered

Alpha helix

Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank	Aligned region

PDB 2knc chain A

Region: 97 - 139
Aligned: 43
Modelled: 43
Confidence: 32.3%
Identity: 9%
PDB header:cell adhesion
Chain: A: PDB Molecule:integrin alpha-iib;
PDBTitle: platelet integrin alfaiib-beta3 transmembrane-cytoplasmic2 heterocomplex

Phyre2

PDB 1iwg chain A domain 8

Region: 75 - 129
Aligned: 55
Modelled: 55
Confidence: 23.8%
Identity: 18%
Fold: Multidrug efflux transporter AcrB transmembrane domain
Superfamily: Multidrug efflux transporter AcrB transmembrane domain
Family: Multidrug efflux transporter AcrB transmembrane domain

Phyre2

PDB 1fft chain B domain 2

Region: 94 - 141
Aligned: 48
Modelled: 48
Confidence: 23.6%
Identity: 13%
Fold: Transmembrane helix hairpin
Superfamily: Cytochrome c oxidase subunit II-like, transmembrane region
Family: Cytochrome c oxidase subunit II-like, transmembrane region

Phyre2

PDB 2yev chain B

Region: 100 - 142
Aligned: 43
Modelled: 43
Confidence: 18.1%
Identity: 14%
PDB header:electron transport
Chain: B: PDB Molecule:cytochrome c oxidase subunit 2;
PDBTitle: structure of caa3-type cytochrome oxidase

Phyre2

PDB 2knc chain B

Region: 101 - 145
Aligned: 45
Modelled: 45
Confidence: 11.0%
Identity: 22%
PDB header:cell adhesion
Chain: B: PDB Molecule:integrin beta-3;
PDBTitle: platelet integrin alfaiib-beta3 transmembrane-cytoplasmic2 heterocomplex

Phyre2

PDB 1oy8 chain A

Region: 19 - 129
Aligned: 111
Modelled: 111
Confidence: 10.1%
Identity: 15%
PDB header:membrane protein
Chain: A: PDB Molecule:acriflavine resistance protein b;
PDBTitle: structural basis of multiple drug binding capacity of the acrb2 multidrug efflux pump

Phyre2

PDB 3g5u chain B

Region: 62 - 146
Aligned: 84
Modelled: 85
Confidence: 10.0%
Identity: 15%
PDB header:membrane protein
Chain: B: PDB Molecule:multidrug resistance protein 1a;
PDBTitle: structure of p-glycoprotein reveals a molecular basis for2 poly-specific drug binding

Phyre2

PDB 2hyd chain A domain 2

Region: 79 - 143
Aligned: 65
Modelled: 65
Confidence: 9.6%
Identity: 8%
Fold: ABC transporter transmembrane region
Superfamily: ABC transporter transmembrane region
Family: ABC transporter transmembrane region

Phyre2

PDB 2oar chain A domain 1

Region: 105 - 142
Aligned: 38
Modelled: 38
Confidence: 7.0%
Identity: 5%
Fold: Gated mechanosensitive channel
Superfamily: Gated mechanosensitive channel
Family: Gated mechanosensitive channel

Phyre2

PDB 2l2t chain A

Region: 99 - 132
Aligned: 34
Modelled: 34
Confidence: 6.5%
Identity: 15%
PDB header:membrane protein
Chain: A: PDB Molecule:receptor tyrosine-protein kinase erbb-4;
PDBTitle: solution nmr structure of the erbb4 dimeric membrane domain

Phyre2

PDB 3ehb chain B domain 2

Region: 102 - 140
Aligned: 39
Modelled: 39
Confidence: 5.9%
Identity: 8%
Fold: Transmembrane helix hairpin
Superfamily: Cytochrome c oxidase subunit II-like, transmembrane region
Family: Cytochrome c oxidase subunit II-like, transmembrane region

Phyre2

PDB 3kcv chain G

Region: 10 - 147
Aligned: 131
Modelled: 138
Confidence: 5.6%
Identity: 11%
PDB header:transport protein
Chain: G: PDB Molecule:probable formate transporter 1;
PDBTitle: structure of formate channel

Phyre2

PDB 1vek chain A

Region: 64 - 75
Aligned: 12
Modelled: 12
Confidence: 5.3%
Identity: 25%
Fold: RuvA C-terminal domain-like
Superfamily: UBA-like
Family: UBA domain

Phyre2

	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence	M	V	V	K	Q	Q	K	D	A	S	K	P	A	H	F	F	H	Q	V	I	V	I	A	L	V	L	F	V	S	K	I	I	E	S	F	M	P	I	P	M	P	A	S	V	I	G	L	V	L	L	F	V	L	L	C	T	G	A	V	K
Secondary structure
SS confidence
Disorder	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence	L	G	E	V	E	K	V	G	T	T	L	T	N	N	I	G	L	L	F	V	P	A	G	I	S	V	V	N	S	L	G	V	I	S	Q	A	P	F	L	I	I	G	L	I	I	V	S	T	I	L	L	L	I	C	T	G	Y	V	T	Q
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.
Sequence	I	I	M	K	V	T	S	R	S	K	G	D	K	V	T	K	K	I	K	I	E	E	A	Q	A	H	D
Secondary structure
SS confidence
Disorder						?	?	?	?	?	?	?	?				?	?	?	?	?			?	?	?	?
Disorder confidence