Phyre Home Retrieve Phyre Job Id
Emaill.a.kelley@imperial.ac.uk
DescriptionA2A5I3
DateTue Jul 30 13:02:03 BST 2013
Unique Job IDfa958de14c9bd80b
SequenceMPLLSSIVGL ... Download FASTA

Summary 

Top model
Image coloured by rainbow N → C terminus
Model dimensions (Å):X:54.973 Y:55.095 Z:47.688
Model (left) based on template c3u3uC_
Top template information
PDB header:protein binding
Chain: C: PDB Molecule:tablysin 15;
PDBTitle: crystal structure of the tablysin-15-leukotriene e4 complex
Confidence and coverage
Confidence:100.0% Coverage: 86%
217 residues ( 86% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.
3D viewing
Interactive 3D view in Jmol

Sequence analysis 

Secondary structure and disorder prediction 

   1........10.........20.........30.........40.........50.........60
Sequence  MPLLSSIVGLTGLLLWMGHTVGALRMPNTTLVQGRPKNTAVWPLSGLGVPRHRRKRHISA
Secondary structure 
SS confidence 
Disorder  ??
??
?
??
??
??????????
Disorder confidence 
 
   .........70.........80.........90.........100.........110.........120
Sequence  RDMSALLDYHNHIRASVHPPAANMEYMVWDEQLARSAEAWATQCIWTHGPSQLMKYVGQN
Secondary structure 
SS confidence 
Disorder 
?????
????
Disorder confidence 
 
   .........130.........140.........150.........160.........170.........180
Sequence  LSIHSGRFRSVVDLVRSWSEEKRHYSFPAPKDCTPHCPWLCSGPVCSHYTQMVWASSSRL
Secondary structure 
SS confidence 
Disorder 
??
?
?
???
????
Disorder confidence 
 
   .........190.........200.........210.........220.........230.........240
Sequence  GCAINTCSSINVWGNTWQQAVYLVCNYAIKGNWIGEAPYKAGKPCSACPPSYQGNCNSNM
Secondary structure 
SS confidence 
Disorder 
???
?
Disorder confidence 
 
   .........250...
Sequence  CFSGLKSNRLPWV
Secondary structure 
SS confidence 
Disorder 
??
?
Disorder confidence 
 

Confidence Key
High(9)                    Low (0)
?Disordered ( 18%)
Alpha helix ( 26%)
Beta strand ( 11%)

Domain analysis 

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

RankAligned region

PDB 3u3u chain C

3D model

Region: 24 - 250
Aligned: 217
Modelled: 226
Confidence: 100.0%
Identity: 16%
PDB header:protein binding
Chain: C: PDB Molecule:tablysin 15;
PDBTitle: crystal structure of the tablysin-15-leukotriene e4 complex

Phyre2

PDB 3nt8 chain A

3D model

Region: 27 - 242
Aligned: 198
Modelled: 216
Confidence: 100.0%
Identity: 26%
PDB header:immune system
Chain: A: PDB Molecule:ancylostoma secreted protein 1;
PDBTitle: crystal structure of na-asp-1

Phyre2

PDB 2vzn chain A

3D model

Region: 25 - 223
Aligned: 191
Modelled: 199
Confidence: 100.0%
Identity: 28%
PDB header:allergen
Chain: A: PDB Molecule:venom allergen 3;
PDBTitle: crystal structure of the major allergen from fire ant2 venom, sol i 3

Phyre2

PDB 1qnx chain A

3D model

Region: 20 - 221
Aligned: 187
Modelled: 202
Confidence: 100.0%
Identity: 29%
Fold: PR-1-like
Superfamily: PR-1-like
Family: PR-1-like

Phyre2

PDB 1xx5 chain B

3D model

Region: 57 - 242
Aligned: 167
Modelled: 186
Confidence: 100.0%
Identity: 33%
PDB header:toxin
Chain: B: PDB Molecule:natrin 1;
PDBTitle: crystal structure of natrin from naja atra snake venom

Phyre2

PDB 1u53 chain A

3D model

Region: 51 - 238
Aligned: 176
Modelled: 188
Confidence: 100.0%
Identity: 28%
PDB header:antibiotic
Chain: A: PDB Molecule:secreted protein asp-2;
PDBTitle: novel x-ray structure of na-asp-2, a pr-1 protein from the2 nematode parasite necator americanus and a vaccine antigen3 for human hookworm infection

Phyre2

PDB 4g2u chain A

3D model

Region: 48 - 246
Aligned: 181
Modelled: 199
Confidence: 100.0%
Identity: 22%
PDB header:immune system
Chain: A: PDB Molecule:ancylostoma-secreted protein-like protein;
PDBTitle: crystal structure analysis of ostertagia ostertagi asp-1

Phyre2

PDB 2epf chain D

3D model

Region: 62 - 248
Aligned: 165
Modelled: 187
Confidence: 100.0%
Identity: 34%
PDB header:toxin
Chain: D: PDB Molecule:pseudecin;
PDBTitle: crystal structure of zinc-bound pseudecin from pseudechis porphyriacus

Phyre2

PDB 3s6s chain B

3D model

Region: 46 - 243
Aligned: 154
Modelled: 174
Confidence: 100.0%
Identity: 19%
PDB header:unknown function
Chain: B: PDB Molecule:ac-asp-7;
PDBTitle: ancylostoma-secreted protein ac-asp-7

Phyre2

PDB 1rc9 chain A domain 1

3D model

Region: 51 - 222
Aligned: 157
Modelled: 164
Confidence: 100.0%
Identity: 31%
Fold: PR-1-like
Superfamily: PR-1-like
Family: PR-1-like

Phyre2

PDB 1cfe chain A

3D model

Region: 63 - 219
Aligned: 132
Modelled: 152
Confidence: 100.0%
Identity: 36%
Fold: PR-1-like
Superfamily: PR-1-like
Family: PR-1-like

Phyre2

PDB 1smb chain A

3D model

Region: 59 - 224
Aligned: 143
Modelled: 166
Confidence: 100.0%
Identity: 21%
Fold: PR-1-like
Superfamily: PR-1-like
Family: PR-1-like

Phyre2

PDB 4h0a chain B

3D model

Region: 45 - 185
Aligned: 109
Modelled: 116
Confidence: 98.8%
Identity: 17%
PDB header:unknown function
Chain: B: PDB Molecule:uncharacterized protein;
PDBTitle: crystal structure of a hypothetical protein (sav1118) from2 staphylococcus aureus subsp. aureus mu50 at 1.90 a resolution

Phyre2

PDB 4ifa chain A

3D model

Region: 58 - 185
Aligned: 96
Modelled: 104
Confidence: 98.6%
Identity: 22%
PDB header:unknown function
Chain: A: PDB Molecule:extracellular protein containing a scp domain;
PDBTitle: 1.5 angstrom resolution crystal structure of an extracellular protein2 containing a scp domain from bacillus anthracis str. ames

Phyre2

PDB 3ghg chain D

3D model

Region: 40 - 78
Aligned: 38
Modelled: 39
Confidence: 55.0%
Identity: 8%
PDB header:blood clotting
Chain: D: PDB Molecule:fibrinogen alpha chain;
PDBTitle: crystal structure of human fibrinogen

Phyre2

PDB 2a45 chain J

3D model

Region: 44 - 77
Aligned: 34
Modelled: 34
Confidence: 55.0%
Identity: 9%
PDB header:hydrolase/hydrolase inhibitor
Chain: J: PDB Molecule:fibrinogen alpha chain;
PDBTitle: crystal structure of the complex between thrombin and the central "e"2 region of fibrin

Phyre2

PDB 1m1j chain A

3D model

Region: 32 - 78
Aligned: 46
Modelled: 47
Confidence: 49.7%
Identity: 11%
PDB header:blood clotting
Chain: A: PDB Molecule:fibrinogen alpha subunit;
PDBTitle: crystal structure of native chicken fibrinogen with two different2 bound ligands

Phyre2

PDB 1rc9 chain A domain 2

3D model

Region: 223 - 241
Aligned: 15
Modelled: 19
Confidence: 37.3%
Identity: 40%
Fold: Crisp domain-like
Superfamily: Crisp domain-like
Family: Crisp domain

Phyre2

PDB 1t3t chain A domain 1

3D model

Region: 58 - 107
Aligned: 39
Modelled: 39
Confidence: 36.1%
Identity: 18%
Fold: RuvA C-terminal domain-like
Superfamily: FGAM synthase PurL, linker domain
Family: FGAM synthase PurL, linker domain

Phyre2

PDB 1ha8 chain A

3D model

Region: 219 - 241
Aligned: 23
Modelled: 23
Confidence: 31.2%
Identity: 30%
Fold: Pheromone ER-23
Superfamily: Pheromone ER-23
Family: Pheromone ER-23

Phyre2
1
c3u3uC_
2
c3nt8A_
3
c2vznA_
4
d1qnxa_
5
c1xx5B_
6
c1u53A_
7
c4g2uA_
8
c2epfD_
9
c3s6sB_
10
d1rc9a1
11
d1cfea_
12
d1smba_
13
c4h0aB_
14
c4ifaA_
15
c3ghgD_
16
c2a45J_
17
c1m1jA_
18
d1rc9a2
19
d1t3ta1
20
d1ha8a_
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45



Detailed template information 

#
Template Alignment Coverage3D Model Confidence
% i.d. Template Information
1c3u3uC_
100.0 16 PDB header:protein binding
Chain: C: PDB Molecule:tablysin 15;
PDBTitle: crystal structure of the tablysin-15-leukotriene e4 complex
2c3nt8A_
100.0 26 PDB header:immune system
Chain: A: PDB Molecule:ancylostoma secreted protein 1;
PDBTitle: crystal structure of na-asp-1
3c2vznA_
100.0 28 PDB header:allergen
Chain: A: PDB Molecule:venom allergen 3;
PDBTitle: crystal structure of the major allergen from fire ant2 venom, sol i 3
4d1qnxa_
100.0 29 Fold:PR-1-like
Superfamily:PR-1-like
Family:PR-1-like
5c1xx5B_
100.0 33 PDB header:toxin
Chain: B: PDB Molecule:natrin 1;
PDBTitle: crystal structure of natrin from naja atra snake venom
6c1u53A_
100.0 28 PDB header:antibiotic
Chain: A: PDB Molecule:secreted protein asp-2;
PDBTitle: novel x-ray structure of na-asp-2, a pr-1 protein from the2 nematode parasite necator americanus and a vaccine antigen3 for human hookworm infection
7c4g2uA_
100.0 22 PDB header:immune system
Chain: A: PDB Molecule:ancylostoma-secreted protein-like protein;
PDBTitle: crystal structure analysis of ostertagia ostertagi asp-1
8c2epfD_
100.0 34 PDB header:toxin
Chain: D: PDB Molecule:pseudecin;
PDBTitle: crystal structure of zinc-bound pseudecin from pseudechis porphyriacus
9c3s6sB_
100.0 19 PDB header:unknown function
Chain: B: PDB Molecule:ac-asp-7;
PDBTitle: ancylostoma-secreted protein ac-asp-7
10d1rc9a1
100.0 31 Fold:PR-1-like
Superfamily:PR-1-like
Family:PR-1-like
11d1cfea_
100.0 36 Fold:PR-1-like
Superfamily:PR-1-like
Family:PR-1-like
12d1smba_
100.0 21 Fold:PR-1-like
Superfamily:PR-1-like
Family:PR-1-like
13c4h0aB_
98.8 17 PDB header:unknown function
Chain: B: PDB Molecule:uncharacterized protein;
PDBTitle: crystal structure of a hypothetical protein (sav1118) from2 staphylococcus aureus subsp. aureus mu50 at 1.90 a resolution
14c4ifaA_
98.6 22 PDB header:unknown function
Chain: A: PDB Molecule:extracellular protein containing a scp domain;
PDBTitle: 1.5 angstrom resolution crystal structure of an extracellular protein2 containing a scp domain from bacillus anthracis str. ames
15c3ghgD_
55.0 8 PDB header:blood clotting
Chain: D: PDB Molecule:fibrinogen alpha chain;
PDBTitle: crystal structure of human fibrinogen
16c2a45J_
55.0 9 PDB header:hydrolase/hydrolase inhibitor
Chain: J: PDB Molecule:fibrinogen alpha chain;
PDBTitle: crystal structure of the complex between thrombin and the central "e"2 region of fibrin
17c1m1jA_
49.7 11 PDB header:blood clotting
Chain: A: PDB Molecule:fibrinogen alpha subunit;
PDBTitle: crystal structure of native chicken fibrinogen with two different2 bound ligands
18d1rc9a2
37.3 40 Fold:Crisp domain-like
Superfamily:Crisp domain-like
Family:Crisp domain
19d1t3ta1
36.1 18 Fold:RuvA C-terminal domain-like
Superfamily:FGAM synthase PurL, linker domain
Family:FGAM synthase PurL, linker domain
20d1ha8a_
31.2 30 Fold:Pheromone ER-23
Superfamily:Pheromone ER-23
Family:Pheromone ER-23
21c1decA_
not modelled 17.9 28 PDB header:blood coagulation
Chain: A: PDB Molecule:decorsin;
PDBTitle: structure of the rgd protein decorsin: conserved motif and2 distinct function in leech proteins that affect blood3 clotting
22d1deca_
not modelled 17.9 28 Fold:Knottins (small inhibitors, toxins, lectins)
Superfamily:Leech antihemostatic proteins
Family:Hirudin-like
23d1l6pa_
not modelled 17.3 45 Fold:Immunoglobulin-like beta-sandwich
Superfamily:Thiol:disulfide interchange protein DsbD, N-terminal domain (DsbD-alpha)
Family:Thiol:disulfide interchange protein DsbD, N-terminal domain (DsbD-alpha)
24d1uzka3
not modelled 16.2 38 Fold:TB module/8-cys domain
Superfamily:TB module/8-cys domain
Family:TB module/8-cys domain
25c2k0rA_
not modelled 16.1 36 PDB header:oxidoreductase
Chain: A: PDB Molecule:thiol:disulfide interchange protein dsbd;
PDBTitle: solution structure of the c103s mutant of the n-terminal2 domain of dsbd from neisseria meningitidis
26d1tdza3
not modelled 15.9 33 Fold:Glucocorticoid receptor-like (DNA-binding domain)
Superfamily:Glucocorticoid receptor-like (DNA-binding domain)
Family:C-terminal, Zn-finger domain of MutM-like DNA repair proteins
27c2a05A_
not modelled 15.4 46 PDB header:signaling protein
Chain: A: PDB Molecule:cysteine-rich secretory protein-2;
PDBTitle: the cysteine-rich secretory protein domain of tpx-1 is2 related to ion channel toxins and regulates ryanodine3 receptor ca2+ signaling
28c2knnA_
not modelled 14.9 35 PDB header:plant protein
Chain: A: PDB Molecule:cycloviolacin-o2;
PDBTitle: solution structure of the cyclotide cycloviolacin o2 with2 glu6 methylated (cyo2me)
29c3rv2B_
not modelled 14.6 11 PDB header:transferase
Chain: B: PDB Molecule:s-adenosylmethionine synthase;
PDBTitle: crystal structure of s-adenosylmethionine synthetase from2 mycobacterium marinum
30d1sg1x1
not modelled 9.8 33 Fold:TNF receptor-like
Superfamily:TNF receptor-like
Family:TNF receptor-like
31c3vgxD_
not modelled 9.3 29 PDB header:membrane protein
Chain: D: PDB Molecule:envelope glycoprotein gp160;
PDBTitle: structure of gp41 t21/cp621-652
32d1vk3a1
not modelled 9.1 21 Fold:Bacillus chorismate mutase-like
Superfamily:PurM N-terminal domain-like
Family:PurM N-terminal domain-like
33c3imlB_
not modelled 8.9 10 PDB header:transferase
Chain: B: PDB Molecule:s-adenosylmethionine synthetase;
PDBTitle: crystal structure of s-adenosylmethionine synthetase from burkholderia2 pseudomallei
34c1jpeA_
not modelled 8.7 45 PDB header:electron transport
Chain: A: PDB Molecule:dsbd-alpha;
PDBTitle: crystal structure of dsbd-alpha; the n-terminal domain of2 dsbd
35c3so4C_
not modelled 8.6 12 PDB header:transferase
Chain: C: PDB Molecule:methionine-adenosyltransferase;
PDBTitle: methionine-adenosyltransferase from entamoeba histolytica
36d1hpia_
not modelled 8.2 22 Fold:HIPIP (high potential iron protein)
Superfamily:HIPIP (high potential iron protein)
Family:HIPIP (high potential iron protein)
37d1l1ta3
not modelled 6.7 38 Fold:Glucocorticoid receptor-like (DNA-binding domain)
Superfamily:Glucocorticoid receptor-like (DNA-binding domain)
Family:C-terminal, Zn-finger domain of MutM-like DNA repair proteins
38c2hs0A_
not modelled 6.2 24 PDB header:ligase
Chain: A: PDB Molecule:phosphoribosylformylglycinamidine synthase ii;
PDBTitle: t. maritima purl complexed with atp
39d1i25a_
not modelled 5.8 28 Fold:Knottins (small inhibitors, toxins, lectins)
Superfamily:omega toxin-like
Family:Spider toxins
40c1i25A_
not modelled 5.8 28 PDB header:toxin
Chain: A: PDB Molecule:huwentoxin-ii;
PDBTitle: three dimensional solution structure of huwentoxin-ii by 2d2 1h-nmr
41c1t3tA_
not modelled 5.5 18 PDB header:ligase
Chain: A: PDB Molecule:phosphoribosylformylglycinamidine synthase;
PDBTitle: structure of formylglycinamide synthetase
42d1sg1x3
not modelled 5.3 33 Fold:TNF receptor-like
Superfamily:TNF receptor-like
Family:TNF receptor-like
43d1k3xa3
not modelled 5.3 29 Fold:Glucocorticoid receptor-like (DNA-binding domain)
Superfamily:Glucocorticoid receptor-like (DNA-binding domain)
Family:C-terminal, Zn-finger domain of MutM-like DNA repair proteins
44d1apja_
not modelled 5.3 27 Fold:TB module/8-cys domain
Superfamily:TB module/8-cys domain
Family:TB module/8-cys domain
45c1iqrA_
not modelled 5.1 11 PDB header:lyase
Chain: A: PDB Molecule:photolyase;
PDBTitle: crystal structure of dna photolyase from thermus2 thermophilus

Binding site prediction 

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