Email l.a.kelley@imperial.ac.uk Description C6Y4A7 Date Sun Jul 8 11:45:05 BST 2012 Unique Job ID f564deef9d77addc

Summary

Top model

Image coloured by rainbow N → C terminus Close Jmol

Model (left) based on template c2kwvA_ Top template information PDB header:protein binding/signaling protein Chain: A: PDB Molecule:dna polymerase iota; PDBTitle: solution structure of ubm1 of murine polymerase iota in complex with2 ubiquitin Confidence and coverage Confidence: 12.8% Coverage: 10% 11 residues ( 10% of your sequence) have been modelled with 12.8% confidence by the single highest scoring template. You may wish to submit your sequence to Phyrealarm. This will automatically scan your sequence every week for new potential templates as they appear in the Phyre2 library. Please note: You must be registered and logged in to use Phyrealarm. 3D viewing Interactive 3D view in Jmol

Sequence analysis

Secondary structure and disorder prediction

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2kwv chain A Region: 40 - 50 Aligned: 11 Modelled: 11 Confidence: 12.8% Identity: 45% PDB header:protein binding/signaling protein Chain: A: PDB Molecule:dna polymerase iota; PDBTitle: solution structure of ubm1 of murine polymerase iota in complex with2 ubiquitin Phyre2 PDB 2rlw chain A Region: 25 - 54 Aligned: 29 Modelled: 30 Confidence: 11.0% Identity: 21% PDB header:toxin Chain: A: PDB Molecule:plnf; PDBTitle: three-dimensional structure of the two peptides that2 constitute the two-peptide bacteriocin plantaracin ef Phyre2 PDB 2glo chain A Region: 98 - 105 Aligned: 8 Modelled: 8 Confidence: 10.4% Identity: 25% PDB header:transcription/dna Chain: A: PDB Molecule:brinker cg9653-pa; PDBTitle: solution structure of the brinker dna binding domain in2 complex with the omb enhancer Phyre2 PDB 1usd chain A Region: 94 - 106 Aligned: 13 Modelled: 13 Confidence: 8.3% Identity: 38% PDB header:signaling protein Chain: A: PDB Molecule:vasodilator-stimulated phosphoprotein; PDBTitle: human vasp tetramerisation domain l352m Phyre2 PDB 3e9o chain A domain 1 Region: 59 - 105 Aligned: 30 Modelled: 30 Confidence: 7.8% Identity: 30% Fold: Ribonuclease H-like motif Superfamily: Ribonuclease H-like Family: Prp8 beta-finger domain-like Phyre2 PDB 3e66 chain B Region: 59 - 105 Aligned: 30 Modelled: 30 Confidence: 7.6% Identity: 30% PDB header:splicing Chain: B: PDB Molecule:prp8; PDBTitle: crystal structure of the beta-finger domain of yeast prp8 Phyre2 PDB 3o4z chain D Region: 12 - 32 Aligned: 21 Modelled: 21 Confidence: 7.4% Identity: 33% PDB header:protein binding Chain: D: PDB Molecule:telomere length regulation protein tel2; PDBTitle: tel2 structure and function in the hsp90-dependent maturation of mtor2 and atr complexes Phyre2 PDB 3enb chain A domain 1 Region: 59 - 105 Aligned: 30 Modelled: 30 Confidence: 6.3% Identity: 33% Fold: Ribonuclease H-like motif Superfamily: Ribonuclease H-like Family: Prp8 beta-finger domain-like Phyre2 PDB 2w2s chain A Region: 50 - 84 Aligned: 35 Modelled: 35 Confidence: 6.2% Identity: 26% PDB header:viral protein Chain: A: PDB Molecule:matrix protein; PDBTitle: structure of the lagos bat virus matrix protein Phyre2 PDB 3e9l chain A domain 1 Region: 59 - 105 Aligned: 30 Modelled: 30 Confidence: 6.0% Identity: 33% Fold: Ribonuclease H-like motif Superfamily: Ribonuclease H-like Family: Prp8 beta-finger domain-like Phyre2 PDB 1y6u chain A Region: 97 - 106 Aligned: 10 Modelled: 10 Confidence: 5.7% Identity: 20% PDB header:dna binding protein Chain: A: PDB Molecule:excisionase from transposon tn916; PDBTitle: the structure of the excisionase (xis) protein from2 conjugative transposon tn916 provides insights into the3 regulation of heterobivalent tyrosine recombinases Phyre2 PDB 2fly chain A Region: 71 - 79 Aligned: 9 Modelled: 9 Confidence: 5.4% Identity: 44% PDB header:hormone/growth factor Chain: A: PDB Molecule:proadrenomedullin n-20 terminal peptide; PDBTitle: proadrenomedullin n-terminal 20 peptide Phyre2 1 c2kwvA_ 2 c2rlwA_ 3 c2gloA_ 4 c1usdA_ 5 d3e9oa1 6 c3e66B_ 7 c3o4zD_ 8 d3enba1 9 c2w2sA_ 10 d3e9la1 11 c1y6uA_ 12 c2flyA_

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0