Phyre 2 Results for A2A5K6

Email	l.a.kelley@imperial.ac.uk
Description	A2A5K6
Date	Tue Jul 30 13:04:49 BST 2013
Unique Job ID	14298b10e4ad365c
Sequence	MEENEVESSS ... Download FASTA

Summary

Top model

Image coloured by rainbow N → C terminus

Model dimensions (Å):

X:47.288 Y:49.375 Z:50.255

Model (left) based on template c4ijdA_

Top template information

PDB header:transferase
Chain: A: PDB Molecule:histone-lysine n-methyltransferase prdm9;
PDBTitle: crystal structure of methyltransferase domain of human pr domain-2 containing protein 9

Confidence and coverage

Confidence:

100.0%

Coverage:

15%

198 residues ( 15% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.

Additional confident templates have been detected (see Domain analysis) which cover other regions of your sequence.

418 residues ( 31%) could be modelled at >90% confidence using multiple-templates.

You may wish to try resubmitting your sequence in "intensive" mode to model more of your sequence.

3D viewing

Interactive 3D view in Jmol

For other options to view your downloaded structure offline see the FAQ

Sequence analysis

Secondary structure and disorder prediction

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60

Sequence M E E N E V E S S S D A A P R P G Q P E E P S E S G L G V C T S E A V S A D S S D A A T V P G L T E A D D S G V G Q S S

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 70 . . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120

Sequence D G G N H S V E E V S E S I S T D P L P H G C L P D S S S V S R G P V A E M P G G P P A L V H S S V L P D P S M L V S D

Secondary structure

SS confidence

Disorder ?
? ? ? ? ? ? ? ? ? ? ? ? ?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
? ? ? ? ? ? ?
?

Disorder confidence

. . . . . . . . . 130 . . . . . . . . . 140 . . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180

Sequence C T A S S S D L G S A I D K I I E S T I G P D L I Q S C I T V T S G E E G G A E T T Q Y L I L Q G P D D G A P M A S S M

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ?
?
?
? ? ? ? ?
? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210 . . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240

Sequence S T S T L A N S L A A I E A L A D G P T S T S A C L E P P E E P Q G D P S S V A Q Q P P A P V T E E L D L Q S L E A M M

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ?
? ? ? ? ? ? ? ?
? ?
? ? ? ? ? ? ? ? ? ?
? ? ?
? ? ? ? ? ? ? ?
?

Disorder confidence

. . . . . . . . . 250 . . . . . . . . . 260 . . . . . . . . . 270 . . . . . . . . . 280 . . . . . . . . . 290 . . . . . . . . . 300

Sequence E V V V V Q Q F K C K M C Q Y R S S T K A T L L R H M R E R H F R P A L A A A A A A T G K R G R V R K W G T S T K T T E

Secondary structure

SS confidence

Disorder
?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 310 . . . . . . . . . 320 . . . . . . . . . 330 . . . . . . . . . 340 . . . . . . . . . 350 . . . . . . . . . 360

Sequence E D R P E E E E E D D D I V D A G A I D D L E E D S D Y N P A E D E P R G R Q L R L Q R P T P S T P R P R R R P G R P R

Secondary structure

SS confidence

Disorder
? ?
?
?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
?
? ?
?

Disorder confidence

. . . . . . . . . 370 . . . . . . . . . 380 . . . . . . . . . 390 . . . . . . . . . 400 . . . . . . . . . 410 . . . . . . . . . 420

Sequence K L P R L E T S D L H D G V G Q P L V S S Q S T Q S P P E L Q D L E A P S S S G L R A L G K V G R G L V E S G V S Q S D

Secondary structure

SS confidence

Disorder
? ? ? ? ?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
? ? ? ? ? ? ? ? ? ? ? ?
? ?
?
?

Disorder confidence

. . . . . . . . . 430 . . . . . . . . . 440 . . . . . . . . . 450 . . . . . . . . . 460 . . . . . . . . . 470 . . . . . . . . . 480

Sequence A E N A A P S C Q D E A D A P P R R R G R P S R R F L G K K Y R K Y Y Y K S P K P L L R P Y L C R I C G S R F L S H E D

Secondary structure

SS confidence

Disorder ? ? ? ? ?
? ? ? ? ? ?
? ? ? ? ? ?
?
? ? ?

Disorder confidence

. . . . . . . . . 490 . . . . . . . . . 500 . . . . . . . . . 510 . . . . . . . . . 520 . . . . . . . . . 530 . . . . . . . . . 540

Sequence L R F H V N S H E A G D P Q L F R C L Q C S Y R S R R W S S L K E H M F N H V G S K P Y K C D E C S Y T S V Y R K D V I

Secondary structure

SS confidence

Disorder
?
?

Disorder confidence

. . . . . . . . . 550 . . . . . . . . . 560 . . . . . . . . . 570 . . . . . . . . . 580 . . . . . . . . . 590 . . . . . . . . . 600

Sequence R H A A V H S Q D R K K R P D P T P K L S S F P C P V C G R V Y P M Q K R L T Q H M K T H S T E K P H M C D K C G K S F

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 610 . . . . . . . . . 620 . . . . . . . . . 630 . . . . . . . . . 640 . . . . . . . . . 650 . . . . . . . . . 660

Sequence K K R Y T F K M H L L T H I Q A V A N R R F K C E F C E F V C E D K K A L L N H Q L S H V S D K P F K C S F C P Y R T F

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 670 . . . . . . . . . 680 . . . . . . . . . 690 . . . . . . . . . 700 . . . . . . . . . 710 . . . . . . . . . 720

Sequence R E D F L L S H V A V K H T G A K P F A C E Y C H F S T R H K K N L R L H V R C R H A N S F E E W G R R H P E E P P S R

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 730 . . . . . . . . . 740 . . . . . . . . . 750 . . . . . . . . . 760 . . . . . . . . . 770 . . . . . . . . . 780

Sequence R R P F F S L Q Q I E E L K Q Q H S T A P G P P L S S P G P E A P Q E P A P F Q S P E T P P L L C P D A L G G T T I I Y

Secondary structure

SS confidence

Disorder
? ? ? ?
? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 790 . . . . . . . . . 800 . . . . . . . . . 810 . . . . . . . . . 820 . . . . . . . . . 830 . . . . . . . . . 840

Sequence Q Q G A E E S T A V A T Q T A L D L L L N M S A Q R E L G A T A L Q V A V V K S E G I E A E L T S T G G Q P S P E D T T

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ?
? ?
?
? ?

Disorder confidence

. . . . . . . . . 850 . . . . . . . . . 860 . . . . . . . . . 870 . . . . . . . . . 880 . . . . . . . . . 890 . . . . . . . . . 900

Sequence P R V V T L H M A E S G S S V A A E S Q L G P S D L Q Q I A L P S G P F G G A S Y S V I T A P P V E G R T S A S G P P Y

Secondary structure

SS confidence

Disorder
? ? ? ? ?
? ? ? ? ? ? ?
? ? ? ?
? ?
?
? ? ? ? ?

Disorder confidence

. . . . . . . . . 910 . . . . . . . . . 920 . . . . . . . . . 930 . . . . . . . . . 940 . . . . . . . . . 950 . . . . . . . . . 960

Sequence R E E P P G E A A Q A V V V S D T L K E A G T H Y I M A A D G T Q L H H I E L T A D G S I S F P S P D T L A P G T K W P

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ? ?
?
? ? ? ?
?
?
? ? ? ? ? ? ?
? ? ?

Disorder confidence

. . . . . . . . . 970 . . . . . . . . . 980 . . . . . . . . . 990 . . . . . . . . . 1000 . . . . . . . . . 1010 . . . . . . . . . 1020

Sequence L L Q C G G P P R D G S E V L S P T K T H H M G G S Q G S S T P P P A A S H T L G L V V P Q S P P S A A A S S T K K F S

Secondary structure

SS confidence

Disorder
?
? ? ? ? ?
? ? ? ?

Disorder confidence

. . . . . . . . . 1030 . . . . . . . . . 1040 . . . . . . . . . 1050 . . . . . . . . . 1060 . . . . . . . . . 1070 . . . . . . . . . 1080

Sequence C K V C S E A F P S R A E M E S H K R A H A G P A A F K C P D C P F S A R Q W P E V R A H M A Q H S S L R P H Q C N Q C

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 1090 . . . . . . . . . 1100 . . . . . . . . . 1110 . . . . . . . . . 1120 . . . . . . . . . 1130 . . . . . . . . . 1140

Sequence S F A S K N K K D L R R H M L T H T N E K P F S C H V C G Q R F N R N G H L K F H I Q R L H S I D G R K T G T S T A R A

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 1150 . . . . . . . . . 1160 . . . . . . . . . 1170 . . . . . . . . . 1180 . . . . . . . . . 1190 . . . . . . . . . 1200

Sequence P A Q T I I L N S E E E T L A T L H T A F Q S S H G V L G T E R L Q Q A L S Q E H I I V A Q E Q T V T N Q E E A T Y I Q

Secondary structure

SS confidence

Disorder
? ?
?
?
? ? ?

Disorder confidence

. . . . . . . . . 1210 . . . . . . . . . 1220 . . . . . . . . . 1230 . . . . . . . . . 1240 . . . . . . . . . 1250 . . . . . . . . . 1260

Sequence E I T A D G Q T V Q H L V T S D N Q V Q Y I I S Q D G V Q H L L P Q E Y V V V P D G H H I Q V Q E G Q I T H I Q Y E Q G

Secondary structure

SS confidence

Disorder
? ? ? ? ?

Disorder confidence

. . . . . . . . . 1270 . . . . . . . . . 1280 . . . . . . . . . 1290 . . . . . . . . . 1300 . . . . . . . . . 1310 . . . . . . . . . 1320

Sequence T P F L Q E S Q I Q Y V P V S P S Q Q L V T Q A Q L E A A A H S A V T A V A D A A M A Q A Q G L F G T E E A V P E Q I H

Secondary structure

SS confidence

Disorder
?

Disorder confidence

. . . . . . . . . 1330 . . . . . . .

Sequence Q L Q H Q G I E Y D V I T L S D D

Secondary structure

SS confidence

Disorder
?
? ? ? ? ?

Disorder confidence

Confidence Key
High(9) Low (0)

? Disordered ( 28%)

Alpha helix ( 16%)

Beta strand ( 20%)

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank	Aligned region

PDB 4ijd chain A

Region: 926 - 1127
Aligned: 198
Modelled: 202
Confidence: 100.0%
Identity: 10%
PDB header:transferase
Chain: A: PDB Molecule:histone-lysine n-methyltransferase prdm9;
PDBTitle: crystal structure of methyltransferase domain of human pr domain-2 containing protein 9

Phyre2

PDB 1tf6 chain D

Region: 1016 - 1126
Aligned: 111
Modelled: 111
Confidence: 99.9%
Identity: 17%
PDB header:transcription/dna
Chain: D: PDB Molecule:protein (transcription factor iiia);
PDBTitle: co-crystal structure of xenopus tfiiia zinc finger domain2 bound to the 5s ribosomal rna gene internal control region

Phyre2

PDB 2csh chain A

Region: 1009 - 1118
Aligned: 107
Modelled: 110
Confidence: 99.9%
Identity: 21%
PDB header:transcription
Chain: A: PDB Molecule:zinc finger protein 297b;
PDBTitle: solution structure of tandem repeat of the zf-c2h2 domains2 of human zinc finger protein 297b

Phyre2

PDB 2wbt chain A

Region: 1012 - 1128
Aligned: 115
Modelled: 117
Confidence: 99.9%
Identity: 14%
PDB header:dna-binding protein
Chain: A: PDB Molecule:b-129;
PDBTitle: the structure of a double c2h2 zinc finger protein from a2 hyperthermophilic archaeal virus in the absence of dna

Phyre2

PDB 2dmd chain A

Region: 1011 - 1105
Aligned: 95
Modelled: 95
Confidence: 99.9%
Identity: 29%
PDB header:transcription
Chain: A: PDB Molecule:zinc finger protein 64, isoforms 1 and 2;
PDBTitle: solution structure of the n-terminal c2h2 type zinc-binding2 domain of the zinc finger protein 64, isoforms 1 and 2

Phyre2

PDB 1x6h chain A

Region: 1033 - 1112
Aligned: 80
Modelled: 80
Confidence: 99.9%
Identity: 19%
PDB header:dna binding protein
Chain: A: PDB Molecule:transcriptional repressor ctcf;
PDBTitle: solution structures of the c2h2 type zinc finger domain of2 human transcriptional repressor ctcf

Phyre2

PDB 2dmi chain A

Region: 1029 - 1137
Aligned: 109
Modelled: 109
Confidence: 99.9%
Identity: 19%
PDB header:transcription
Chain: A: PDB Molecule:teashirt homolog 3;
PDBTitle: solution structure of the first and the second zf-c2h2 like2 domains of human teashirt homolog 3

Phyre2

PDB 2rsi chain A

Region: 1039 - 1130
Aligned: 91
Modelled: 92
Confidence: 99.9%
Identity: 21%
PDB header:metal binding protein
Chain: A: PDB Molecule:zinc finger protein zfat;
PDBTitle: solution structures of the dna-binding domains of immune-related zinc-2 finger protein zfat

Phyre2

PDB 1g2d chain C

Region: 1044 - 1130
Aligned: 86
Modelled: 87
Confidence: 99.9%
Identity: 29%
PDB header:transcription/dna
Chain: C: PDB Molecule:tata box zinc finger protein;
PDBTitle: structure of a cys2his2 zinc finger/tata box complex (clone2 #2)

Phyre2

PDB 1wjp chain A

Region: 1043 - 1132
Aligned: 87
Modelled: 90
Confidence: 99.9%
Identity: 16%
PDB header:metal binding protein
Chain: A: PDB Molecule:zinc finger protein 295;
PDBTitle: solution structure of zf-c2h2 domains from human zinc2 finger protein 295

Phyre2

PDB 2ee8 chain A

Region: 1030 - 1136
Aligned: 106
Modelled: 107
Confidence: 99.9%
Identity: 26%
PDB header:gene regulation
Chain: A: PDB Molecule:protein odd-skipped-related 2;
PDBTitle: solution structure of three zf-c2h2 domains from mouse2 protein odd-skipped-related 2 splicing isoform 2

Phyre2

PDB 2rsj chain A

Region: 1040 - 1130
Aligned: 90
Modelled: 91
Confidence: 99.9%
Identity: 30%
PDB header:metal binding protein
Chain: A: PDB Molecule:zinc finger protein zfat;
PDBTitle: solution structures of the dna-binding domains of immune-related zinc-2 finger protein zfat

Phyre2

PDB 1llm chain C

Region: 1045 - 1129
Aligned: 84
Modelled: 85
Confidence: 99.9%
Identity: 18%
PDB header:transcription/dna
Chain: C: PDB Molecule:chimera of zif23-gcn4;
PDBTitle: crystal structure of a zif23-gcn4 chimera bound to dna

Phyre2

PDB 2yt9 chain A

Region: 1041 - 1130
Aligned: 90
Modelled: 90
Confidence: 99.9%
Identity: 30%
PDB header:transcription
Chain: A: PDB Molecule:zinc finger-containing protein 1;
PDBTitle: solution structure of c2h2 type zinc finger domain 345 in2 zinc finger protein 278

Phyre2

PDB 2kmk chain A

Region: 1046 - 1128
Aligned: 82
Modelled: 82
Confidence: 99.9%
Identity: 34%
PDB header:dna binding protein/dna
Chain: A: PDB Molecule:zinc finger protein gfi-1;
PDBTitle: gfi-1 zinc fingers 3-5 complexed with dna

Phyre2

PDB 4f6n chain A

Region: 1010 - 1112
Aligned: 103
Modelled: 103
Confidence: 99.9%
Identity: 16%
PDB header:dna binding protein/dna
Chain: A: PDB Molecule:transcriptional regulator kaiso;
PDBTitle: crystal structure of kaiso zinc finger dna binding protein in complex2 with methylated cpg site dna

Phyre2

PDB 2cot chain A

Region: 1030 - 1103
Aligned: 74
Modelled: 74
Confidence: 99.9%
Identity: 22%
PDB header:transcription
Chain: A: PDB Molecule:zinc finger protein 435;
PDBTitle: solution structure of the first and second zf-c2h2 domain2 of zinc finger protein 435

Phyre2

PDB 2lce chain A

Region: 1040 - 1103
Aligned: 64
Modelled: 64
Confidence: 99.8%
Identity: 27%
PDB header:transcription regulator
Chain: A: PDB Molecule:b-cell lymphoma 6 protein;
PDBTitle: chemical shift assignment of hr4436b from homo sapiens, northeast2 structural genomics consortium

Phyre2

PDB 2rpc chain A

Region: 459 - 594
Aligned: 127
Modelled: 136
Confidence: 99.8%
Identity: 19%
PDB header:transcription
Chain: A: PDB Molecule:zinc finger protein zic 3;
PDBTitle: solution structure of the tandem zf-c2h2 domains from the2 human zinc finger protein zic 3

Phyre2

PDB 2dlq chain A

Region: 1012 - 1132
Aligned: 121
Modelled: 121
Confidence: 99.8%
Identity: 29%
PDB header:transcription
Chain: A: PDB Molecule:gli-kruppel family member hkr3;
PDBTitle: solution structure of the tandem four zf-c2h2 domain2 repeats of murine gli-kruppel family member hkr3

Phyre2

PDB 1b8t chain A

Region: 496 - 699
Aligned: 177
Modelled: 177
Confidence: 99.2%
Identity: 11%
PDB header:contractile
Chain: A: PDB Molecule:protein (crp1);
PDBTitle: solution structure of the chicken crp1

Phyre2

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	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence	M	E	E	N	E	V	E	S	S	S	D	A	A	P	R	P	G	Q	P	E	E	P	S	E	S	G	L	G	V	C	T	S	E	A	V	S	A	D	S	S	D	A	A	T	V	P	G	L	T	E	A	D	D	S	G	V	G	Q	S	S
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence	D	G	G	N	H	S	V	E	E	V	S	E	S	I	S	T	D	P	L	P	H	G	C	L	P	D	S	S	S	V	S	R	G	P	V	A	E	M	P	G	G	P	P	A	L	V	H	S	S	V	L	P	D	P	S	M	L	V	S	D
Secondary structure
SS confidence
Disorder	?								?	?	?	?	?	?	?	?	?	?	?	?	?				?	?	?	?	?	?	?	?	?	?	?	?	?	?	?										?	?	?	?	?	?	?				?
Disorder confidence

	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence	C	T	A	S	S	S	D	L	G	S	A	I	D	K	I	I	E	S	T	I	G	P	D	L	I	Q	S	C	I	T	V	T	S	G	E	E	G	G	A	E	T	T	Q	Y	L	I	L	Q	G	P	D	D	G	A	P	M	A	S	S	M
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?	?																								?		?		?	?	?	?	?															?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence	S	T	S	T	L	A	N	S	L	A	A	I	E	A	L	A	D	G	P	T	S	T	S	A	C	L	E	P	P	E	E	P	Q	G	D	P	S	S	V	A	Q	Q	P	P	A	P	V	T	E	E	L	D	L	Q	S	L	E	A	M	M
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?	?	?							?	?	?	?	?	?	?	?				?	?		?	?	?	?	?	?	?	?	?	?			?	?	?		?	?	?	?	?	?	?	?							?
Disorder confidence

	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence	E	V	V	V	V	Q	Q	F	K	C	K	M	C	Q	Y	R	S	S	T	K	A	T	L	L	R	H	M	R	E	R	H	F	R	P	A	L	A	A	A	A	A	A	T	G	K	R	G	R	V	R	K	W	G	T	S	T	K	T	T	E
Secondary structure
SS confidence
Disorder																																									?		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence	E	D	R	P	E	E	E	E	E	D	D	D	I	V	D	A	G	A	I	D	D	L	E	E	D	S	D	Y	N	P	A	E	D	E	P	R	G	R	Q	L	R	L	Q	R	P	T	P	S	T	P	R	P	R	R	R	P	G	R	P	R
Secondary structure
SS confidence
Disorder																		?	?			?			?										?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?				?		?	?		?
Disorder confidence

	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence	K	L	P	R	L	E	T	S	D	L	H	D	G	V	G	Q	P	L	V	S	S	Q	S	T	Q	S	P	P	E	L	Q	D	L	E	A	P	S	S	S	G	L	R	A	L	G	K	V	G	R	G	L	V	E	S	G	V	S	Q	S	D
Secondary structure
SS confidence
Disorder					?	?	?	?	?		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?		?	?	?	?	?	?	?	?	?	?	?	?		?	?		?															?
Disorder confidence

	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence	A	E	N	A	A	P	S	C	Q	D	E	A	D	A	P	P	R	R	R	G	R	P	S	R	R	F	L	G	K	K	Y	R	K	Y	Y	Y	K	S	P	K	P	L	L	R	P	Y	L	C	R	I	C	G	S	R	F	L	S	H	E	D
Secondary structure
SS confidence
Disorder	?	?	?	?	?			?	?	?	?	?	?																?	?	?	?	?	?		?		?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence	L	R	F	H	V	N	S	H	E	A	G	D	P	Q	L	F	R	C	L	Q	C	S	Y	R	S	R	R	W	S	S	L	K	E	H	M	F	N	H	V	G	S	K	P	Y	K	C	D	E	C	S	Y	T	S	V	Y	R	K	D	V	I
Secondary structure
SS confidence
Disorder					?		?
Disorder confidence

	.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600
Sequence	R	H	A	A	V	H	S	Q	D	R	K	K	R	P	D	P	T	P	K	L	S	S	F	P	C	P	V	C	G	R	V	Y	P	M	Q	K	R	L	T	Q	H	M	K	T	H	S	T	E	K	P	H	M	C	D	K	C	G	K	S	F
Secondary structure
SS confidence
Disorder														?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630	.	.	.	.	.	.	.	.	.	640	.	.	.	.	.	.	.	.	.	650	.	.	.	.	.	.	.	.	.	660
Sequence	K	K	R	Y	T	F	K	M	H	L	L	T	H	I	Q	A	V	A	N	R	R	F	K	C	E	F	C	E	F	V	C	E	D	K	K	A	L	L	N	H	Q	L	S	H	V	S	D	K	P	F	K	C	S	F	C	P	Y	R	T	F
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	670	.	.	.	.	.	.	.	.	.	680	.	.	.	.	.	.	.	.	.	690	.	.	.	.	.	.	.	.	.	700	.	.	.	.	.	.	.	.	.	710	.	.	.	.	.	.	.	.	.	720
Sequence	R	E	D	F	L	L	S	H	V	A	V	K	H	T	G	A	K	P	F	A	C	E	Y	C	H	F	S	T	R	H	K	K	N	L	R	L	H	V	R	C	R	H	A	N	S	F	E	E	W	G	R	R	H	P	E	E	P	P	S	R
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	730	.	.	.	.	.	.	.	.	.	740	.	.	.	.	.	.	.	.	.	750	.	.	.	.	.	.	.	.	.	760	.	.	.	.	.	.	.	.	.	770	.	.	.	.	.	.	.	.	.	780
Sequence	R	R	P	F	F	S	L	Q	Q	I	E	E	L	K	Q	Q	H	S	T	A	P	G	P	P	L	S	S	P	G	P	E	A	P	Q	E	P	A	P	F	Q	S	P	E	T	P	P	L	L	C	P	D	A	L	G	G	T	T	I	I	Y
Secondary structure
SS confidence
Disorder																?	?	?	?													?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	790	.	.	.	.	.	.	.	.	.	800	.	.	.	.	.	.	.	.	.	810	.	.	.	.	.	.	.	.	.	820	.	.	.	.	.	.	.	.	.	830	.	.	.	.	.	.	.	.	.	840
Sequence	Q	Q	G	A	E	E	S	T	A	V	A	T	Q	T	A	L	D	L	L	L	N	M	S	A	Q	R	E	L	G	A	T	A	L	Q	V	A	V	V	K	S	E	G	I	E	A	E	L	T	S	T	G	G	Q	P	S	P	E	D	T	T
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?	?	?	?	?	?	?																											?	?						?					?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	850	.	.	.	.	.	.	.	.	.	860	.	.	.	.	.	.	.	.	.	870	.	.	.	.	.	.	.	.	.	880	.	.	.	.	.	.	.	.	.	890	.	.	.	.	.	.	.	.	.	900
Sequence	P	R	V	V	T	L	H	M	A	E	S	G	S	S	V	A	A	E	S	Q	L	G	P	S	D	L	Q	Q	I	A	L	P	S	G	P	F	G	G	A	S	Y	S	V	I	T	A	P	P	V	E	G	R	T	S	A	S	G	P	P	Y
Secondary structure
SS confidence
Disorder									?	?	?	?	?				?	?	?	?	?	?	?		?	?	?	?		?	?														?								?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	910	.	.	.	.	.	.	.	.	.	920	.	.	.	.	.	.	.	.	.	930	.	.	.	.	.	.	.	.	.	940	.	.	.	.	.	.	.	.	.	950	.	.	.	.	.	.	.	.	.	960
Sequence	R	E	E	P	P	G	E	A	A	Q	A	V	V	V	S	D	T	L	K	E	A	G	T	H	Y	I	M	A	A	D	G	T	Q	L	H	H	I	E	L	T	A	D	G	S	I	S	F	P	S	P	D	T	L	A	P	G	T	K	W	P
Secondary structure
SS confidence
Disorder													?	?	?	?	?	?	?	?	?	?		?		?	?	?	?											?			?		?	?	?	?	?	?	?		?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	970	.	.	.	.	.	.	.	.	.	980	.	.	.	.	.	.	.	.	.	990	.	.	.	.	.	.	.	.	.	1000	.	.	.	.	.	.	.	.	.	1010	.	.	.	.	.	.	.	.	.	1020
Sequence	L	L	Q	C	G	G	P	P	R	D	G	S	E	V	L	S	P	T	K	T	H	H	M	G	G	S	Q	G	S	S	T	P	P	P	A	A	S	H	T	L	G	L	V	V	P	Q	S	P	P	S	A	A	A	S	S	T	K	K	F	S
Secondary structure
SS confidence
Disorder																		?																											?	?	?	?	?		?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1030	.	.	.	.	.	.	.	.	.	1040	.	.	.	.	.	.	.	.	.	1050	.	.	.	.	.	.	.	.	.	1060	.	.	.	.	.	.	.	.	.	1070	.	.	.	.	.	.	.	.	.	1080
Sequence	C	K	V	C	S	E	A	F	P	S	R	A	E	M	E	S	H	K	R	A	H	A	G	P	A	A	F	K	C	P	D	C	P	F	S	A	R	Q	W	P	E	V	R	A	H	M	A	Q	H	S	S	L	R	P	H	Q	C	N	Q	C
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	1090	.	.	.	.	.	.	.	.	.	1100	.	.	.	.	.	.	.	.	.	1110	.	.	.	.	.	.	.	.	.	1120	.	.	.	.	.	.	.	.	.	1130	.	.	.	.	.	.	.	.	.	1140
Sequence	S	F	A	S	K	N	K	K	D	L	R	R	H	M	L	T	H	T	N	E	K	P	F	S	C	H	V	C	G	Q	R	F	N	R	N	G	H	L	K	F	H	I	Q	R	L	H	S	I	D	G	R	K	T	G	T	S	T	A	R	A
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	1150	.	.	.	.	.	.	.	.	.	1160	.	.	.	.	.	.	.	.	.	1170	.	.	.	.	.	.	.	.	.	1180	.	.	.	.	.	.	.	.	.	1190	.	.	.	.	.	.	.	.	.	1200
Sequence	P	A	Q	T	I	I	L	N	S	E	E	E	T	L	A	T	L	H	T	A	F	Q	S	S	H	G	V	L	G	T	E	R	L	Q	Q	A	L	S	Q	E	H	I	I	V	A	Q	E	Q	T	V	T	N	Q	E	E	A	T	Y	I	Q
Secondary structure
SS confidence
Disorder																	?	?																		?			?		?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1210	.	.	.	.	.	.	.	.	.	1220	.	.	.	.	.	.	.	.	.	1230	.	.	.	.	.	.	.	.	.	1240	.	.	.	.	.	.	.	.	.	1250	.	.	.	.	.	.	.	.	.	1260
Sequence	E	I	T	A	D	G	Q	T	V	Q	H	L	V	T	S	D	N	Q	V	Q	Y	I	I	S	Q	D	G	V	Q	H	L	L	P	Q	E	Y	V	V	V	P	D	G	H	H	I	Q	V	Q	E	G	Q	I	T	H	I	Q	Y	E	Q	G
Secondary structure
SS confidence
Disorder																																						?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1270	.	.	.	.	.	.	.	.	.	1280	.	.	.	.	.	.	.	.	.	1290	.	.	.	.	.	.	.	.	.	1300	.	.	.	.	.	.	.	.	.	1310	.	.	.	.	.	.	.	.	.	1320
Sequence	T	P	F	L	Q	E	S	Q	I	Q	Y	V	P	V	S	P	S	Q	Q	L	V	T	Q	A	Q	L	E	A	A	A	H	S	A	V	T	A	V	A	D	A	A	M	A	Q	A	Q	G	L	F	G	T	E	E	A	V	P	E	Q	I	H
Secondary structure
SS confidence
Disorder													?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1330	.	.	.	.	.	.	.
Sequence	Q	L	Q	H	Q	G	I	E	Y	D	V	I	T	L	S	D	D
Secondary structure
SS confidence
Disorder					?								?	?	?	?	?
Disorder confidence