Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	T	R	N	I	H	V	N	T	A	S	Y	T	L	L	V	A	G	K	K	K	N	T	G	E	E	W	D	V	L	E	F	S	S	L	T	E	L	K	K	Y	R	K	S	H	P	E	K	M	A	F	S	Y	S	Y	A	L	S	R
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?												?		?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.
Sequence		G	V	D	T	Q	F	R	H	I	N	I	A	E	A	D	H	F	K	Q	F	L	R	Q	I	K	R	A	G	L	D	I	R	A	I	C
Secondary structure
SS confidence
Disorder																															?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 3mbf chain A Region: 36 - 89 Aligned: 52 Modelled: 54 Confidence: 79.9% Identity: 31% PDB header:lyase Chain: A: PDB Molecule:fructose-bisphosphate aldolase; PDBTitle: crystal structure of fructose bisphosphate aldolase from2 encephalitozoon cuniculi, bound to fructose 1,6-bisphosphate Phyre2 PDB 3kx6 chain C Region: 36 - 89 Aligned: 51 Modelled: 54 Confidence: 58.1% Identity: 27% PDB header:lyase Chain: C: PDB Molecule:fructose-bisphosphate aldolase; PDBTitle: crystal structure of fructose-1,6-bisphosphate aldolase from babesia2 bovis at 2.1a resolution Phyre2 PDB 1zai chain A domain 1 Region: 36 - 75 Aligned: 40 Modelled: 40 Confidence: 47.2% Identity: 25% Fold: TIM beta/alpha-barrel Superfamily: Aldolase Family: Class I aldolase Phyre2 PDB 2itb chain A domain 1 Region: 43 - 94 Aligned: 52 Modelled: 52 Confidence: 43.3% Identity: 21% Fold: Ferritin-like Superfamily: Ferritin-like Family: MiaE-like Phyre2 PDB 1tz9 chain A Region: 15 - 91 Aligned: 69 Modelled: 72 Confidence: 39.6% Identity: 25% Fold: TIM beta/alpha-barrel Superfamily: Xylose isomerase-like Family: UxuA-like Phyre2 PDB 1qo5 chain B Region: 36 - 75 Aligned: 40 Modelled: 40 Confidence: 39.1% Identity: 23% Fold: TIM beta/alpha-barrel Superfamily: Aldolase Family: Class I aldolase Phyre2 PDB 1fdj chain A Region: 36 - 75 Aligned: 40 Modelled: 40 Confidence: 38.6% Identity: 23% Fold: TIM beta/alpha-barrel Superfamily: Aldolase Family: Class I aldolase Phyre2 PDB 1f2j chain A Region: 36 - 75 Aligned: 40 Modelled: 40 Confidence: 31.8% Identity: 20% Fold: TIM beta/alpha-barrel Superfamily: Aldolase Family: Class I aldolase Phyre2 PDB 2qap chain C Region: 36 - 75 Aligned: 40 Modelled: 40 Confidence: 30.5% Identity: 20% PDB header:lyase Chain: C: PDB Molecule:fructose-1,6-bisphosphate aldolase; PDBTitle: fructose-1,6-bisphosphate aldolase from leishmania mexicana Phyre2 PDB 2qap chain A domain 1 Region: 36 - 75 Aligned: 40 Modelled: 40 Confidence: 30.2% Identity: 20% Fold: TIM beta/alpha-barrel Superfamily: Aldolase Family: Class I aldolase Phyre2 PDB 3mmt chain C Region: 46 - 74 Aligned: 29 Modelled: 29 Confidence: 27.3% Identity: 34% PDB header:hydrolase Chain: C: PDB Molecule:fructose-bisphosphate aldolase; PDBTitle: crystal structure of fructose bisphosphate aldolase from bartonella2 henselae, bound to fructose bisphosphate Phyre2 PDB 1xfb chain A domain 1 Region: 36 - 74 Aligned: 39 Modelled: 39 Confidence: 24.2% Identity: 26% Fold: TIM beta/alpha-barrel Superfamily: Aldolase Family: Class I aldolase Phyre2 PDB 2pc4 chain B Region: 46 - 74 Aligned: 29 Modelled: 29 Confidence: 22.8% Identity: 38% PDB header:lyase Chain: B: PDB Molecule:fructose-bisphosphate aldolase; PDBTitle: crystal structure of fructose-bisphosphate aldolase from plasmodium2 falciparum in complex with trap-tail determined at 2.4 angstrom3 resolution Phyre2 PDB 3bdk chain B Region: 15 - 91 Aligned: 69 Modelled: 72 Confidence: 22.2% Identity: 23% PDB header:lyase Chain: B: PDB Molecule:d-mannonate dehydratase; PDBTitle: crystal structure of streptococcus suis mannonate2 dehydratase complexed with substrate analogue Phyre2 PDB 1a5c chain A Region: 46 - 74 Aligned: 29 Modelled: 29 Confidence: 21.8% Identity: 38% Fold: TIM beta/alpha-barrel Superfamily: Aldolase Family: Class I aldolase Phyre2 PDB 1ro5 chain A Region: 11 - 94 Aligned: 77 Modelled: 84 Confidence: 21.3% Identity: 19% Fold: Acyl-CoA N-acyltransferases (Nat) Superfamily: Acyl-CoA N-acyltransferases (Nat) Family: Autoinducer synthetase Phyre2 PDB 2dt7 chain A Region: 33 - 51 Aligned: 19 Modelled: 19 Confidence: 17.7% Identity: 21% PDB header:rna binding protein Chain: A: PDB Molecule:splicing factor 3a subunit 3; PDBTitle: solution structure of the second surp domain of human2 splicing factor sf3a120 in complex with a fragment of3 human splicing factor sf3a60 Phyre2 PDB 1fba chain A Region: 36 - 89 Aligned: 54 Modelled: 54 Confidence: 16.3% Identity: 22% Fold: TIM beta/alpha-barrel Superfamily: Aldolase Family: Class I aldolase Phyre2 PDB 2ekc chain A Region: 34 - 90 Aligned: 45 Modelled: 57 Confidence: 14.7% Identity: 22% PDB header:lyase Chain: A: PDB Molecule:tryptophan synthase alpha chain; PDBTitle: structural study of project id aq_1548 from aquifex aeolicus vf5 Phyre2 PDB 2iqt chain A Region: 49 - 65 Aligned: 17 Modelled: 17 Confidence: 13.8% Identity: 29% PDB header:lyase Chain: A: PDB Molecule:fructose-bisphosphate aldolase class 1; PDBTitle: crystal structure of fructose-bisphosphate aldolase, class i from2 porphyromonas gingivalis Phyre2 1 c3mbfA_ 2 c3kx6C_ 3 d1zaia1 4 d2itba1 5 d1tz9a_ 6 d1qo5b_ 7 d1fdja_ 8 d1f2ja_ 9 c2qapC_ 10 d2qapa1 11 c3mmtC_ 12 d1xfba1 13 c2pc4B_ 14 c3bdkB_ 15 d1a5ca_ 16 d1ro5a_ 17 c2dt7A_ 18 d1fbaa_ 19 c2ekcA_ 20 c2iqtA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c3mbfA_ 79.9 31 PDB header:lyase Chain: A: PDB Molecule:fructose-bisphosphate aldolase; PDBTitle: crystal structure of fructose bisphosphate aldolase from2 encephalitozoon cuniculi, bound to fructose 1,6-bisphosphate 2 c3kx6C_ 58.1 27 PDB header:lyase Chain: C: PDB Molecule:fructose-bisphosphate aldolase; PDBTitle: crystal structure of fructose-1,6-bisphosphate aldolase from babesia2 bovis at 2.1a resolution 3 d1zaia1 47.2 25 Fold:TIM beta/alpha-barrel Superfamily:Aldolase Family:Class I aldolase 4 d2itba1 43.3 21 Fold:Ferritin-like Superfamily:Ferritin-like Family:MiaE-like 5 d1tz9a_ 39.6 25 Fold:TIM beta/alpha-barrel Superfamily:Xylose isomerase-like Family:UxuA-like 6 d1qo5b_ 39.1 23 Fold:TIM beta/alpha-barrel Superfamily:Aldolase Family:Class I aldolase 7 d1fdja_ 38.6 23 Fold:TIM beta/alpha-barrel Superfamily:Aldolase Family:Class I aldolase 8 d1f2ja_ 31.8 20 Fold:TIM beta/alpha-barrel Superfamily:Aldolase Family:Class I aldolase 9 c2qapC_ 30.5 20 PDB header:lyase Chain: C: PDB Molecule:fructose-1,6-bisphosphate aldolase; PDBTitle: fructose-1,6-bisphosphate aldolase from leishmania mexicana 10 d2qapa1 30.2 20 Fold:TIM beta/alpha-barrel Superfamily:Aldolase Family:Class I aldolase 11 c3mmtC_ 27.3 34 PDB header:hydrolase Chain: C: PDB Molecule:fructose-bisphosphate aldolase; PDBTitle: crystal structure of fructose bisphosphate aldolase from bartonella2 henselae, bound to fructose bisphosphate 12 d1xfba1 24.2 26 Fold:TIM beta/alpha-barrel Superfamily:Aldolase Family:Class I aldolase 13 c2pc4B_ 22.8 38 PDB header:lyase Chain: B: PDB Molecule:fructose-bisphosphate aldolase; PDBTitle: crystal structure of fructose-bisphosphate aldolase from plasmodium2 falciparum in complex with trap-tail determined at 2.4 angstrom3 resolution 14 c3bdkB_ 22.2 23 PDB header:lyase Chain: B: PDB Molecule:d-mannonate dehydratase; PDBTitle: crystal structure of streptococcus suis mannonate2 dehydratase complexed with substrate analogue 15 d1a5ca_ 21.8 38 Fold:TIM beta/alpha-barrel Superfamily:Aldolase Family:Class I aldolase 16 d1ro5a_ 21.3 19 Fold:Acyl-CoA N-acyltransferases (Nat) Superfamily:Acyl-CoA N-acyltransferases (Nat) Family:Autoinducer synthetase 17 c2dt7A_ 17.7 21 PDB header:rna binding protein Chain: A: PDB Molecule:splicing factor 3a subunit 3; PDBTitle: solution structure of the second surp domain of human2 splicing factor sf3a120 in complex with a fragment of3 human splicing factor sf3a60 18 d1fbaa_ 16.3 22 Fold:TIM beta/alpha-barrel Superfamily:Aldolase Family:Class I aldolase 19 c2ekcA_ 14.7 22 PDB header:lyase Chain: A: PDB Molecule:tryptophan synthase alpha chain; PDBTitle: structural study of project id aq_1548 from aquifex aeolicus vf5 20 c2iqtA_ 13.8 29 PDB header:lyase Chain: A: PDB Molecule:fructose-bisphosphate aldolase class 1; PDBTitle: crystal structure of fructose-bisphosphate aldolase, class i from2 porphyromonas gingivalis 21 c3q4nA_ not modelled 13.5 16 PDB header:unknown function Chain: A: PDB Molecule:uncharacterized protein mj0754; PDBTitle: crystal structure of hypothetical protein mj0754 from methanococcus2 jannaschii dsm 2661 22 c2kp7A_ not modelled 12.6 28 PDB header:hydrolase Chain: A: PDB Molecule:crossover junction endonuclease mus81; PDBTitle: solution nmr structure of the mus81 n-terminal hhh.2 northeast structural genomics consortium target mmt1a 23 c3p2fA_ not modelled 12.2 17 PDB header:signaling protein Chain: A: PDB Molecule:ahl synthase; PDBTitle: crystal structure of tofi in an apo form 24 d1ofcx1 not modelled 12.1 37 Fold:DNA/RNA-binding 3-helical bundle Superfamily:Homeodomain-like Family:Myb/SANT domain 25 c3lo3E_ not modelled 10.6 25 PDB header:structure genomics, unknown function Chain: E: PDB Molecule:uncharacterized conserved protein; PDBTitle: the crystal structure of a conserved functionally unknown2 protein from colwellia psychrerythraea 34h. 26 d1kzfa_ not modelled 10.4 20 Fold:Acyl-CoA N-acyltransferases (Nat) Superfamily:Acyl-CoA N-acyltransferases (Nat) Family:Autoinducer synthetase 27 c2ktaA_ not modelled 8.6 22 PDB header:hydrolase Chain: A: PDB Molecule:putative helicase; PDBTitle: solution nmr structure of a domain of protein a6ky75 from bacteroides2 vulgatus, northeast structural genomics target bvr106a 28 d1udxa3 not modelled 8.1 13 Fold:Obg GTP-binding protein C-terminal domain Superfamily:Obg GTP-binding protein C-terminal domain Family:Obg GTP-binding protein C-terminal domain 29 d2cpya1 not modelled 8.0 27 Fold:Ferredoxin-like Superfamily:RNA-binding domain, RBD Family:Canonical RBD 30 c3cz8A_ not modelled 7.9 19 PDB header:hydrolase Chain: A: PDB Molecule:putative sporulation-specific glycosylase ydhd; PDBTitle: crystal structure of putative sporulation-specific glycosylase ydhd2 from bacillus subtilis 31 d1wapa_ not modelled 7.7 64 Fold:Double-stranded beta-helix Superfamily:TRAP-like Family:Trp RNA-binding attenuation protein (TRAP) 32 d1gtfa_ not modelled 7.5 64 Fold:Double-stranded beta-helix Superfamily:TRAP-like Family:Trp RNA-binding attenuation protein (TRAP) 33 d1e0ba_ not modelled 7.5 45 Fold:SH3-like barrel Superfamily:Chromo domain-like Family:Chromo domain 34 d1iapa_ not modelled 6.9 21 Fold:Regulator of G-protein signaling, RGS Superfamily:Regulator of G-protein signaling, RGS Family:Regulator of G-protein signaling, RGS 35 c3qpiA_ not modelled 6.7 21 PDB header:oxidoreductase Chain: A: PDB Molecule:chlorite dismutase; PDBTitle: crystal structure of dimeric chlorite dismutases from nitrobacter2 winogradskyi 36 d1q4ra_ not modelled 6.7 26 Fold:Ferredoxin-like Superfamily:Dimeric alpha+beta barrel Family:Plant stress-induced protein 37 c1y7xA_ not modelled 6.5 57 PDB header:structural protein, protein binding Chain: A: PDB Molecule:major vault protein; PDBTitle: solution structure of a two-repeat fragment of major vault2 protein 38 d1usta_ not modelled 6.3 29 Fold:DNA/RNA-binding 3-helical bundle Superfamily:"Winged helix" DNA-binding domain Family:Linker histone H1/H5 39 c2rh0B_ not modelled 6.3 24 PDB header:nuclear protein Chain: B: PDB Molecule:nudc domain-containing protein 2; PDBTitle: crystal structure of nudc domain-containing protein 22 (13542905) from mus musculus at 1.95 a resolution 40 c3cxnB_ not modelled 5.9 21 PDB header:chaperone Chain: B: PDB Molecule:urease accessory protein uref; PDBTitle: structure of the urease accessory protein uref from helicobacter2 pylori 41 d2nt0a2 not modelled 5.9 29 Fold:TIM beta/alpha-barrel Superfamily:(Trans)glycosidases Family:beta-glycanases 42 c2rqpA_ not modelled 5.5 23 PDB header:gene regulation Chain: A: PDB Molecule:heterochromatin protein 1-binding protein 3; PDBTitle: the solution structure of heterochromatin protein 1-binding2 protein 74 histone h1 like domain 43 c1u6tA_ not modelled 5.4 14 PDB header:protein binding, signaling protein Chain: A: PDB Molecule:sh3 domain-binding glutamic acid-rich-like PDBTitle: crystal structure of the human sh3 binding glutamic-rich2 protein like 44 c2qr4B_ not modelled 5.3 14 PDB header:hydrolase Chain: B: PDB Molecule:peptidase m3b, oligoendopeptidase f; PDBTitle: crystal structure of oligoendopeptidase-f from enterococcus faecium

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0