Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	N	K	S	M	L	A	G	I	G	I	G	V	A	A	A	L	G	V	A	A	V	A	S	L	N	V	F	E	R	G	P	Q	Y	A	Q	V	V	S	A	T	P	I	K	E	T	V	K	T	P	R	Q	E	C	R	N	V	T	V	T
Secondary structure
SS confidence
Disorder		?	?	?	?																			?		?				?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		H	R	R	P	V	Q	D	E	N	R	I	T	G	S	V	L	G	A	V	A	G	G	V	I	G	H	Q	F	G	G	G	R	G	K	D	V	A	T	V	V	G	A	L	G	G	G	Y	A	G	N	Q	I	Q	G	S	L	Q	E	S	D
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?														?	?	?	?	?	?	?	?	?												?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.
Sequence		T	Y	T	T	T	Q	Q	R	C	K	T	V	Y	D	K	S	E	K	M	L	G	Y	D	V	T	Y	K	I	G	D	Q	Q	G	K	I	R	M	D	R	D	P	G	T	Q	I	P	L	D	S	N	G	Q	L	I	L	N	N	K	V
Secondary structure
SS confidence
Disorder		?	?	?											?	?		?																																						?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1i4m chain A Region: 73 - 90 Aligned: 18 Modelled: 18 Confidence: 39.7% Identity: 28% Fold: Prion-like Superfamily: Prion-like Family: Prion-like Phyre2 PDB 2lbg chain A Region: 71 - 89 Aligned: 19 Modelled: 19 Confidence: 23.2% Identity: 37% PDB header:membrane protein Chain: A: PDB Molecule:major prion protein; PDBTitle: structure of the chr of the prion protein in dpc micelles Phyre2 PDB 1v7w chain A Region: 141 - 174 Aligned: 34 Modelled: 34 Confidence: 22.5% Identity: 21% PDB header:transferase Chain: A: PDB Molecule:chitobiose phosphorylase; PDBTitle: crystal structure of vibrio proteolyticus chitobiose phosphorylase in2 complex with glcnac Phyre2 PDB 2cqt chain A Region: 141 - 179 Aligned: 39 Modelled: 39 Confidence: 22.0% Identity: 23% PDB header:transferase Chain: A: PDB Molecule:cellobiose phosphorylase; PDBTitle: crystal structure of cellvibrio gilvus cellobiose phosphorylase2 crystallized from sodium/potassium phosphate Phyre2 PDB 1u5l chain A Region: 73 - 90 Aligned: 18 Modelled: 18 Confidence: 21.8% Identity: 39% Fold: Prion-like Superfamily: Prion-like Family: Prion-like Phyre2 PDB 3hfw chain A Region: 90 - 109 Aligned: 20 Modelled: 20 Confidence: 21.2% Identity: 30% PDB header:hydrolase Chain: A: PDB Molecule:protein adp-ribosylarginine hydrolase; PDBTitle: crystal structure of human adp-ribosylhydrolase 1 (harh1) Phyre2 PDB 1ktd chain B domain 2 Region: 104 - 173 Aligned: 67 Modelled: 70 Confidence: 20.7% Identity: 18% Fold: MHC antigen-recognition domain Superfamily: MHC antigen-recognition domain Family: MHC antigen-recognition domain Phyre2 PDB 1i3r chain B domain 2 Region: 104 - 173 Aligned: 67 Modelled: 70 Confidence: 17.4% Identity: 18% Fold: MHC antigen-recognition domain Superfamily: MHC antigen-recognition domain Family: MHC antigen-recognition domain Phyre2 PDB 2qty chain B Region: 90 - 111 Aligned: 22 Modelled: 22 Confidence: 16.0% Identity: 41% PDB header:hydrolase Chain: B: PDB Molecule:poly(adp-ribose) glycohydrolase arh3; PDBTitle: crystal structure of mouse adp-ribosylhydrolase 3 (marh3) Phyre2 PDB 1t5j chain A Region: 90 - 111 Aligned: 22 Modelled: 22 Confidence: 16.0% Identity: 36% Fold: ADP-ribosylglycohydrolase Superfamily: ADP-ribosylglycohydrolase Family: ADP-ribosylglycohydrolase Phyre2 PDB 1u3m chain A Region: 73 - 90 Aligned: 18 Modelled: 18 Confidence: 15.9% Identity: 39% Fold: Prion-like Superfamily: Prion-like Family: Prion-like Phyre2 PDB 3g9d chain B Region: 90 - 111 Aligned: 22 Modelled: 22 Confidence: 13.6% Identity: 27% PDB header:hydrolase Chain: B: PDB Molecule:dinitrogenase reductase activacting PDBTitle: crystal structure glycohydrolase Phyre2 PDB 1i7o chain C Region: 160 - 179 Aligned: 20 Modelled: 20 Confidence: 11.5% Identity: 30% PDB header:isomerase, lyase Chain: C: PDB Molecule:4-hydroxyphenylacetate degradation bifunctional PDBTitle: crystal structure of hpce Phyre2 PDB 2woc chain A Region: 90 - 111 Aligned: 22 Modelled: 22 Confidence: 11.5% Identity: 27% PDB header:hydrolase Chain: A: PDB Molecule:adp-ribosyl-[dinitrogen reductase] glycohydrolase; PDBTitle: crystal structure of the dinitrogenase reductase-activating2 glycohydrolase (drag) from rhodospirillum rubrum Phyre2 PDB 1xyk chain A Region: 75 - 90 Aligned: 16 Modelled: 16 Confidence: 10.3% Identity: 25% Fold: Prion-like Superfamily: Prion-like Family: Prion-like Phyre2 PDB 1bx2 chain B domain 2 Region: 117 - 176 Aligned: 57 Modelled: 60 Confidence: 9.8% Identity: 12% Fold: MHC antigen-recognition domain Superfamily: MHC antigen-recognition domain Family: MHC antigen-recognition domain Phyre2 PDB 2vv5 chain A domain 1 Region: 158 - 168 Aligned: 11 Modelled: 11 Confidence: 9.4% Identity: 18% Fold: Sm-like fold Superfamily: Sm-like ribonucleoproteins Family: Mechanosensitive channel protein MscS (YggB), middle domain Phyre2 PDB 1aml chain A Region: 69 - 84 Aligned: 16 Modelled: 16 Confidence: 9.2% Identity: 31% PDB header:serine protease inhibitor Chain: A: PDB Molecule:amyloid a4; PDBTitle: the alzheimer`s disease amyloid a4 peptide (residues 1-40) Phyre2 PDB 2yzw chain A Region: 82 - 111 Aligned: 30 Modelled: 30 Confidence: 8.9% Identity: 33% PDB header:hydrolase Chain: A: PDB Molecule:adp-ribosylglycohydrolase; PDBTitle: adp-ribosylglycohydrolase-related protein complex Phyre2 PDB 1xyx chain A Region: 75 - 90 Aligned: 16 Modelled: 16 Confidence: 8.9% Identity: 25% Fold: Prion-like Superfamily: Prion-like Family: Prion-like Phyre2 1 d1i4ma_ 2 c2lbgA_ 3 c1v7wA_ 4 c2cqtA_ 5 d1u5la_ 6 c3hfwA_ 7 d1ktdb2 8 d1i3rb2 9 c2qtyB_ 10 d1t5ja_ 11 d1u3ma_ 12 c3g9dB_ 13 c1i7oC_ 14 c2wocA_ 15 d1xyka_ 16 d1bx2b2 17 d2vv5a1 18 c1amlA_ 19 c2yzwA_ 20 d1xyxa_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d1i4ma_ 39.7 28 Fold:Prion-like Superfamily:Prion-like Family:Prion-like 2 c2lbgA_ 23.2 37 PDB header:membrane protein Chain: A: PDB Molecule:major prion protein; PDBTitle: structure of the chr of the prion protein in dpc micelles 3 c1v7wA_ 22.5 21 PDB header:transferase Chain: A: PDB Molecule:chitobiose phosphorylase; PDBTitle: crystal structure of vibrio proteolyticus chitobiose phosphorylase in2 complex with glcnac 4 c2cqtA_ 22.0 23 PDB header:transferase Chain: A: PDB Molecule:cellobiose phosphorylase; PDBTitle: crystal structure of cellvibrio gilvus cellobiose phosphorylase2 crystallized from sodium/potassium phosphate 5 d1u5la_ 21.8 39 Fold:Prion-like Superfamily:Prion-like Family:Prion-like 6 c3hfwA_ 21.2 30 PDB header:hydrolase Chain: A: PDB Molecule:protein adp-ribosylarginine hydrolase; PDBTitle: crystal structure of human adp-ribosylhydrolase 1 (harh1) 7 d1ktdb2 20.7 18 Fold:MHC antigen-recognition domain Superfamily:MHC antigen-recognition domain Family:MHC antigen-recognition domain 8 d1i3rb2 17.4 18 Fold:MHC antigen-recognition domain Superfamily:MHC antigen-recognition domain Family:MHC antigen-recognition domain 9 c2qtyB_ 16.0 41 PDB header:hydrolase Chain: B: PDB Molecule:poly(adp-ribose) glycohydrolase arh3; PDBTitle: crystal structure of mouse adp-ribosylhydrolase 3 (marh3) 10 d1t5ja_ 16.0 36 Fold:ADP-ribosylglycohydrolase Superfamily:ADP-ribosylglycohydrolase Family:ADP-ribosylglycohydrolase 11 d1u3ma_ 15.9 39 Fold:Prion-like Superfamily:Prion-like Family:Prion-like 12 c3g9dB_ 13.6 27 PDB header:hydrolase Chain: B: PDB Molecule:dinitrogenase reductase activacting PDBTitle: crystal structure glycohydrolase 13 c1i7oC_ 11.5 30 PDB header:isomerase, lyase Chain: C: PDB Molecule:4-hydroxyphenylacetate degradation bifunctional PDBTitle: crystal structure of hpce 14 c2wocA_ 11.5 27 PDB header:hydrolase Chain: A: PDB Molecule:adp-ribosyl-[dinitrogen reductase] glycohydrolase; PDBTitle: crystal structure of the dinitrogenase reductase-activating2 glycohydrolase (drag) from rhodospirillum rubrum 15 d1xyka_ 10.3 25 Fold:Prion-like Superfamily:Prion-like Family:Prion-like 16 d1bx2b2 9.8 12 Fold:MHC antigen-recognition domain Superfamily:MHC antigen-recognition domain Family:MHC antigen-recognition domain 17 d2vv5a1 9.4 18 Fold:Sm-like fold Superfamily:Sm-like ribonucleoproteins Family:Mechanosensitive channel protein MscS (YggB), middle domain 18 c1amlA_ 9.2 31 PDB header:serine protease inhibitor Chain: A: PDB Molecule:amyloid a4; PDBTitle: the alzheimer`s disease amyloid a4 peptide (residues 1-40) 19 c2yzwA_ 8.9 33 PDB header:hydrolase Chain: A: PDB Molecule:adp-ribosylglycohydrolase; PDBTitle: adp-ribosylglycohydrolase-related protein complex 20 d1xyxa_ 8.9 25 Fold:Prion-like Superfamily:Prion-like Family:Prion-like 21 d1xyqa_ not modelled 8.9 25 Fold:Prion-like Superfamily:Prion-like Family:Prion-like 22 d1nppa2 not modelled 8.8 15 Fold:SH3-like barrel Superfamily:Translation proteins SH3-like domain Family:N-utilization substance G protein NusG, C-terminal domain 23 d1d5mb2 not modelled 7.6 13 Fold:MHC antigen-recognition domain Superfamily:MHC antigen-recognition domain Family:MHC antigen-recognition domain 24 d1xyua_ not modelled 7.5 25 Fold:Prion-like Superfamily:Prion-like Family:Prion-like 25 d2gu3a1 not modelled 7.4 24 Fold:Cystatin-like Superfamily:Cystatin/monellin Family:PepSY-like 26 d1v7wa1 not modelled 6.6 21 Fold:alpha/alpha toroid Superfamily:Six-hairpin glycosidases Family:Glycosyltransferase family 36 C-terminal domain 27 d1q5xa_ not modelled 6.2 15 Fold:The "swivelling" beta/beta/alpha domain Superfamily:RraA-like Family:RraA-like 28 d2ifra1 not modelled 5.8 18 Fold:Concanavalin A-like lectins/glucanases Superfamily:Concanavalin A-like lectins/glucanases Family:Peptidase A4 29 c3ge2A_ not modelled 5.5 27 PDB header:lipoprotein Chain: A: PDB Molecule:lipoprotein, putative; PDBTitle: crystal structure of putative lipoprotein sp_0198 from streptococcus2 pneumoniae 30 d1fngb2 not modelled 5.4 15 Fold:MHC antigen-recognition domain Superfamily:MHC antigen-recognition domain Family:MHC antigen-recognition domain 31 c1iclA_ not modelled 5.4 33 PDB header:de novo protein Chain: A: PDB Molecule:th1ox; PDBTitle: solution structure of designed beta-sheet mini-protein th1ox 32 d1nfia2 not modelled 5.4 13 Fold:Common fold of diphtheria toxin/transcription factors/cytochrome f Superfamily:p53-like transcription factors Family:Rel/Dorsal transcription factors, DNA-binding domain 33 d1mj4a_ not modelled 5.3 42 Fold:Cytochrome b5-like heme/steroid binding domain Superfamily:Cytochrome b5-like heme/steroid binding domain Family:Cytochrome b5 34 c2jcbA_ not modelled 5.2 19 PDB header:ligase Chain: A: PDB Molecule:5-formyltetrahydrofolate cyclo-ligase family protein; PDBTitle: the crystal structure of 5-formyl-tetrahydrofolate2 cycloligase from bacillus anthracis (ba4489) 35 c2rfuA_ not modelled 5.1 19 PDB header:viral protein Chain: A: PDB Molecule:influenza b hemagglutinin (ha); PDBTitle: crystal structure of influenza b virus hemagglutinin in complex with2 lstc receptor analog 36 c3c8oB_ not modelled 5.1 25 PDB header:hydrolase regulator Chain: B: PDB Molecule:regulator of ribonuclease activity a; PDBTitle: the crystal structure of rraa from pao1

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0