Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	V	S	E	T	K	T	T	E	A	P	G	L	R	R	E	L	K	A	R	H	L	T	M	I	A	I	G	G	S	I	G	T	G	L	F	V	A	S	G	A	T	I	S	Q	A	G	P	G	G	A	L	L	S	Y	M	L	I	G	L
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		M	V	Y	F	L	M	T	S	L	G	E	L	A	A	Y	M	P	V	S	G	S	F	A	T	Y	G	Q	N	Y	V	E	E	G	F	G	F	A	L	G	W	N	Y	W	Y	N	W	A	V	T	I	A	V	D	L	V	A	A	Q	L	V
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		M	S	W	W	F	P	D	T	P	G	W	I	W	S	A	L	F	L	G	V	I	F	L	L	N	Y	I	S	V	R	G	F	G	E	A	E	Y	W	F	S	L	I	K	V	T	T	V	I	V	F	I	I	V	G	V	L	M	I	I	G
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		I	F	K	G	A	Q	P	A	G	W	S	N	W	T	I	G	E	A	P	F	A	G	G	F	A	A	M	I	G	V	A	M	I	V	G	F	S	F	Q	G	T	E	L	I	G	I	A	A	G	E	S	E	D	P	A	K	N	I	P	R
Secondary structure
SS confidence
Disorder																			?	?																																			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		A	V	R	Q	V	F	W	R	I	L	L	F	Y	V	F	A	I	L	I	I	S	L	I	I	P	Y	T	D	P	S	L	L	R	N	D	V	K	D	I	S	V	S	P	F	T	L	V	F	Q	H	A	G	L	L	S	A	A	A	V	M
Secondary structure
SS confidence
Disorder																														?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		N	A	V	I	L	T	A	V	L	S	A	G	N	S	G	M	Y	A	S	T	R	M	L	Y	T	L	A	C	D	G	K	A	P	R	I	F	A	K	L	S	R	G	G	V	P	R	N	A	L	Y	A	T	T	V	I	A	G	L	C	F
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		L	T	S	M	F	G	N	Q	T	V	Y	L	W	L	L	N	T	S	G	M	T	G	F	I	A	W	L	G	I	A	I	S	H	Y	R	F	R	R	G	Y	V	L	Q	G	H	D	I	N	D	L	P	Y	R	S	G	F	F	P	L	G
Secondary structure
SS confidence
Disorder				?	?	?																																					?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		P	I	F	A	F	I	L	C	L	I	I	T	L	G	Q	N	Y	E	A	F	L	K	D	T	I	D	W	G	G	V	A	A	T	Y	I	G	I	P	L	F	L	I	I	W	F	G	Y	K	L	I	K	G	T	H	F	V	R	Y	S	E
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.
Sequence		M	K	F	P	Q	N	D	K	K
Secondary structure
SS confidence
Disorder				?	?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 3gia chain A Region: 14 - 482 Aligned: 429 Modelled: 454 Confidence: 100.0% Identity: 19% PDB header:transport protein Chain: A: PDB Molecule:uncharacterized protein mj0609; PDBTitle: crystal structure of apct transporter Phyre2 PDB 3lrc chain C Region: 14 - 478 Aligned: 408 Modelled: 408 Confidence: 100.0% Identity: 18% PDB header:transport protein Chain: C: PDB Molecule:arginine/agmatine antiporter; PDBTitle: structure of e. coli adic (p1) Phyre2 PDB 2jln chain A Region: 3 - 487 Aligned: 452 Modelled: 474 Confidence: 100.0% Identity: 11% PDB header:membrane protein Chain: A: PDB Molecule:mhp1; PDBTitle: structure of mhp1, a nucleobase-cation-symport-1 family2 transporter Phyre2 PDB 2xq2 chain A Region: 15 - 489 Aligned: 449 Modelled: 449 Confidence: 99.5% Identity: 10% PDB header:transport protein Chain: A: PDB Molecule:sodium/glucose cotransporter; PDBTitle: structure of the k294a mutant of vsglt Phyre2 PDB 3dh4 chain A Region: 15 - 489 Aligned: 447 Modelled: 456 Confidence: 99.3% Identity: 9% PDB header:transport protein Chain: A: PDB Molecule:sodium/glucose cotransporter; PDBTitle: crystal structure of sodium/sugar symporter with bound galactose from2 vibrio parahaemolyticus Phyre2 PDB 2a65 chain A domain 1 Region: 18 - 474 Aligned: 449 Modelled: 449 Confidence: 98.2% Identity: 14% Fold: SNF-like Superfamily: SNF-like Family: SNF-like Phyre2 PDB 2w8a chain C Region: 10 - 413 Aligned: 390 Modelled: 386 Confidence: 97.3% Identity: 9% PDB header:membrane protein Chain: C: PDB Molecule:glycine betaine transporter betp; PDBTitle: crystal structure of the sodium-coupled glycine betaine2 symporter betp from corynebacterium glutamicum with bound3 substrate Phyre2 PDB 3hfx chain A Region: 52 - 402 Aligned: 343 Modelled: 351 Confidence: 92.4% Identity: 10% PDB header:transport protein Chain: A: PDB Molecule:l-carnitine/gamma-butyrobetaine antiporter; PDBTitle: crystal structure of carnitine transporter Phyre2 PDB 2knc chain A Region: 450 - 488 Aligned: 39 Modelled: 39 Confidence: 55.5% Identity: 15% PDB header:cell adhesion Chain: A: PDB Molecule:integrin alpha-iib; PDBTitle: platelet integrin alfaiib-beta3 transmembrane-cytoplasmic2 heterocomplex Phyre2 PDB 1ujl chain A Region: 7 - 28 Aligned: 22 Modelled: 22 Confidence: 17.7% Identity: 23% PDB header:membrane protein Chain: A: PDB Molecule:potassium voltage-gated channel subfamily h PDBTitle: solution structure of the herg k+ channel s5-p2 extracellular linker Phyre2 PDB 2p8z chain S Region: 471 - 489 Aligned: 19 Modelled: 19 Confidence: 16.5% Identity: 5% PDB header:translation Chain: S: PDB Molecule:elongation factor tu-b; PDBTitle: fitted structure of adpr-eef2 in the 80s:adpr-2 eef2:gdpnp:sordarin cryo-em reconstruction Phyre2 PDB 3qnq chain D Region: 453 - 489 Aligned: 37 Modelled: 37 Confidence: 15.4% Identity: 5% PDB header:membrane protein, transport protein Chain: D: PDB Molecule:pts system, cellobiose-specific iic component; PDBTitle: crystal structure of the transporter chbc, the iic component from the2 n,n'-diacetylchitobiose-specific phosphotransferase system Phyre2 PDB 3b8e chain C Region: 383 - 477 Aligned: 95 Modelled: 95 Confidence: 12.6% Identity: 8% PDB header:hydrolase/transport protein Chain: C: PDB Molecule:sodium/potassium-transporting atpase subunit PDBTitle: crystal structure of the sodium-potassium pump Phyre2 PDB 1fft chain B domain 2 Region: 368 - 443 Aligned: 76 Modelled: 76 Confidence: 7.6% Identity: 9% Fold: Transmembrane helix hairpin Superfamily: Cytochrome c oxidase subunit II-like, transmembrane region Family: Cytochrome c oxidase subunit II-like, transmembrane region Phyre2 PDB 2zxe chain A Region: 371 - 474 Aligned: 104 Modelled: 104 Confidence: 6.8% Identity: 7% PDB header:hydrolase/transport protein Chain: A: PDB Molecule:na, k-atpase alpha subunit; PDBTitle: crystal structure of the sodium - potassium pump in the e2.2k+.pi2 state Phyre2 PDB 2bbj chain B Region: 418 - 474 Aligned: 51 Modelled: 57 Confidence: 5.9% Identity: 12% PDB header:metal transport/membrane protein Chain: B: PDB Molecule:divalent cation transport-related protein; PDBTitle: crystal structure of the cora mg2+ transporter Phyre2 PDB 1m57 chain H Region: 368 - 437 Aligned: 70 Modelled: 70 Confidence: 5.5% Identity: 11% PDB header:oxidoreductase Chain: H: PDB Molecule:cytochrome c oxidase; PDBTitle: structure of cytochrome c oxidase from rhodobacter2 sphaeroides (eq(i-286) mutant)) Phyre2 1 c3giaA_ 2 c3lrcC_ 3 c2jlnA_ 4 c2xq2A_ 5 c3dh4A_ 6 d2a65a1 7 c2w8aC_ 8 c3hfxA_ 9 c2kncA_ 10 c1ujlA_ 11 c2p8zS_ 12 c3qnqD_ 13 c3b8eC_ 14 d1fftb2 15 c2zxeA_ 16 c2bbjB_ 17 c1m57H_

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c3giaA_ 100.0 19 PDB header:transport protein Chain: A: PDB Molecule:uncharacterized protein mj0609; PDBTitle: crystal structure of apct transporter 2 c3lrcC_ 100.0 18 PDB header:transport protein Chain: C: PDB Molecule:arginine/agmatine antiporter; PDBTitle: structure of e. coli adic (p1) 3 c2jlnA_ 100.0 11 PDB header:membrane protein Chain: A: PDB Molecule:mhp1; PDBTitle: structure of mhp1, a nucleobase-cation-symport-1 family2 transporter 4 c2xq2A_ 99.5 10 PDB header:transport protein Chain: A: PDB Molecule:sodium/glucose cotransporter; PDBTitle: structure of the k294a mutant of vsglt 5 c3dh4A_ 99.3 9 PDB header:transport protein Chain: A: PDB Molecule:sodium/glucose cotransporter; PDBTitle: crystal structure of sodium/sugar symporter with bound galactose from2 vibrio parahaemolyticus 6 d2a65a1 98.2 14 Fold:SNF-like Superfamily:SNF-like Family:SNF-like 7 c2w8aC_ 97.3 9 PDB header:membrane protein Chain: C: PDB Molecule:glycine betaine transporter betp; PDBTitle: crystal structure of the sodium-coupled glycine betaine2 symporter betp from corynebacterium glutamicum with bound3 substrate 8 c3hfxA_ 92.4 10 PDB header:transport protein Chain: A: PDB Molecule:l-carnitine/gamma-butyrobetaine antiporter; PDBTitle: crystal structure of carnitine transporter 9 c2kncA_ 55.5 15 PDB header:cell adhesion Chain: A: PDB Molecule:integrin alpha-iib; PDBTitle: platelet integrin alfaiib-beta3 transmembrane-cytoplasmic2 heterocomplex 10 c1ujlA_ 17.7 23 PDB header:membrane protein Chain: A: PDB Molecule:potassium voltage-gated channel subfamily h PDBTitle: solution structure of the herg k+ channel s5-p2 extracellular linker 11 c2p8zS_ 16.5 5 PDB header:translation Chain: S: PDB Molecule:elongation factor tu-b; PDBTitle: fitted structure of adpr-eef2 in the 80s:adpr-2 eef2:gdpnp:sordarin cryo-em reconstruction 12 c3qnqD_ 15.4 5 PDB header:membrane protein, transport protein Chain: D: PDB Molecule:pts system, cellobiose-specific iic component; PDBTitle: crystal structure of the transporter chbc, the iic component from the2 n,n'-diacetylchitobiose-specific phosphotransferase system 13 c3b8eC_ 12.6 8 PDB header:hydrolase/transport protein Chain: C: PDB Molecule:sodium/potassium-transporting atpase subunit PDBTitle: crystal structure of the sodium-potassium pump 14 d1fftb2 7.6 9 Fold:Transmembrane helix hairpin Superfamily:Cytochrome c oxidase subunit II-like, transmembrane region Family:Cytochrome c oxidase subunit II-like, transmembrane region 15 c2zxeA_ 6.8 7 PDB header:hydrolase/transport protein Chain: A: PDB Molecule:na, k-atpase alpha subunit; PDBTitle: crystal structure of the sodium - potassium pump in the e2.2k+.pi2 state 16 c2bbjB_ 5.9 12 PDB header:metal transport/membrane protein Chain: B: PDB Molecule:divalent cation transport-related protein; PDBTitle: crystal structure of the cora mg2+ transporter 17 c1m57H_ 5.5 11 PDB header:oxidoreductase Chain: H: PDB Molecule:cytochrome c oxidase; PDBTitle: structure of cytochrome c oxidase from rhodobacter2 sphaeroides (eq(i-286) mutant))

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0