Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	R	L	S	D	Y	F	P	E	S	S	I	S	V	I	H	S	A	K	D	W	Q	E	A	I	D	F	S	M	V	S	L	L	D	K	N	Y	I	S	E	N	Y	I	Q	A	I	K	D	S	T	I	N	N	G	P	Y	Y	I	L	A
Secondary structure
SS confidence
Disorder		?	?				?																															?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		P	G	V	A	M	P	H	A	R	P	E	C	G	A	L	K	T	G	M	S	L	T	L	L	E	Q	G	V	Y	F	P	G	N	D	E	P	I	K	L	L	I	G	L	S	A	A	D	A	D	S	H	I	G	A	I	Q	A	L	S	E
Secondary structure
SS confidence
Disorder																														?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.
Sequence		L	L	C	E	E	E	I	L	E	Q	L	L	T	A	S	S	E	K	Q	L	A	D	I	I	S	R	G
Secondary structure
SS confidence
Disorder																										?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2oq3 chain A Region: 1 - 147 Aligned: 147 Modelled: 147 Confidence: 100.0% Identity: 100% PDB header:transferase Chain: A: PDB Molecule:mannitol-specific cryptic phosphotransferase PDBTitle: solution structure of the mannitol- specific cryptic2 phosphotransferase enzyme iia cmtb from escherichia coli Phyre2 PDB 3oxp chain B Region: 3 - 146 Aligned: 144 Modelled: 144 Confidence: 100.0% Identity: 38% PDB header:transferase Chain: B: PDB Molecule:phosphotransferase enzyme ii, a component; PDBTitle: structure of phosphotransferase enzyme ii, a component from yersinia2 pestis co92 at 1.2 a resolution Phyre2 PDB 3oxp chain A Region: 3 - 146 Aligned: 144 Modelled: 144 Confidence: 100.0% Identity: 38% PDB header:transferase Chain: A: PDB Molecule:phosphotransferase enzyme ii, a component; PDBTitle: structure of phosphotransferase enzyme ii, a component from yersinia2 pestis co92 at 1.2 a resolution Phyre2 PDB 3bjv chain A Region: 1 - 147 Aligned: 146 Modelled: 147 Confidence: 100.0% Identity: 33% PDB header:transferase Chain: A: PDB Molecule:rmpa; PDBTitle: the crystal structure of a putative pts iia(ptxa) from streptococcus2 mutans Phyre2 PDB 2oqt chain D Region: 3 - 146 Aligned: 143 Modelled: 144 Confidence: 100.0% Identity: 30% PDB header:transferase Chain: D: PDB Molecule:hypothetical protein spy0176; PDBTitle: structural genomics, the crystal structure of a putative2 pts iia domain from streptococcus pyogenes m1 gas Phyre2 PDB 3urr chain B Region: 1 - 146 Aligned: 142 Modelled: 146 Confidence: 100.0% Identity: 20% PDB header:transferase Chain: B: PDB Molecule:pts iia-like nitrogen-regulatory protein ptsn; PDBTitle: structure of pts iia-like nitrogen-regulatory protein ptsn (bth_i0484)2 (ptsn) Phyre2 PDB 1a6j chain A Region: 1 - 146 Aligned: 144 Modelled: 146 Confidence: 100.0% Identity: 19% Fold: Phoshotransferase/anion transport protein Superfamily: Phoshotransferase/anion transport protein Family: IIA domain of mannitol-specific and ntr phosphotransferase EII Phyre2 PDB 1a3a chain A Region: 7 - 146 Aligned: 137 Modelled: 140 Confidence: 100.0% Identity: 28% Fold: Phoshotransferase/anion transport protein Superfamily: Phoshotransferase/anion transport protein Family: IIA domain of mannitol-specific and ntr phosphotransferase EII Phyre2 PDB 2a0j chain A Region: 3 - 145 Aligned: 140 Modelled: 143 Confidence: 100.0% Identity: 20% PDB header:transferase Chain: A: PDB Molecule:pts system, nitrogen regulatory iia protein; PDBTitle: crystal structure of nitrogen regulatory protein iia-ntr from2 neisseria meningitidis Phyre2 PDB 1xiz chain A Region: 3 - 146 Aligned: 143 Modelled: 144 Confidence: 100.0% Identity: 15% Fold: Phoshotransferase/anion transport protein Superfamily: Phoshotransferase/anion transport protein Family: IIA domain of mannitol-specific and ntr phosphotransferase EII Phyre2 PDB 1hyn chain Q Region: 3 - 146 Aligned: 141 Modelled: 144 Confidence: 97.5% Identity: 13% PDB header:membrane protein Chain: Q: PDB Molecule:band 3 anion transport protein; PDBTitle: crystal structure of the cytoplasmic domain of human2 erythrocyte band-3 protein Phyre2 PDB 1hyn chain P Region: 3 - 146 Aligned: 140 Modelled: 144 Confidence: 97.5% Identity: 14% Fold: Phoshotransferase/anion transport protein Superfamily: Phoshotransferase/anion transport protein Family: Anion transport protein, cytoplasmic domain Phyre2 PDB 2wwa chain J Region: 124 - 147 Aligned: 24 Modelled: 24 Confidence: 12.6% Identity: 13% PDB header:ribosome Chain: J: PDB Molecule:60s ribosomal protein l19; PDBTitle: cryo-em structure of idle yeast ssh1 complex bound to the2 yeast 80s ribosome Phyre2 PDB 2hnt chain E Region: 65 - 97 Aligned: 33 Modelled: 33 Confidence: 9.7% Identity: 24% PDB header:serine protease Chain: E: PDB Molecule:gamma-thrombin; PDBTitle: crystallographic structure of human gamma-thrombin Phyre2 PDB 1a3x chain A domain 3 Region: 12 - 41 Aligned: 30 Modelled: 30 Confidence: 9.4% Identity: 10% Fold: Pyruvate kinase C-terminal domain-like Superfamily: PK C-terminal domain-like Family: Pyruvate kinase, C-terminal domain Phyre2 PDB 1ept chain B Region: 65 - 97 Aligned: 33 Modelled: 33 Confidence: 8.8% Identity: 12% PDB header:hydrolase (serine protease) Chain: B: PDB Molecule:porcine e-trypsin; PDBTitle: refined 1.8 angstroms resolution crystal structure of2 porcine epsilon-trypsin Phyre2 PDB 3pvl chain A Region: 3 - 99 Aligned: 94 Modelled: 97 Confidence: 8.4% Identity: 14% PDB header:motor protein/protein transport Chain: A: PDB Molecule:myosin viia isoform 1; PDBTitle: structure of myosin viia myth4-ferm-sh3 in complex with the cen1 of2 sans Phyre2 PDB 1sus chain A domain 1 Region: 10 - 65 Aligned: 56 Modelled: 56 Confidence: 7.8% Identity: 9% Fold: S-adenosyl-L-methionine-dependent methyltransferases Superfamily: S-adenosyl-L-methionine-dependent methyltransferases Family: COMT-like Phyre2 PDB 1gtd chain A Region: 10 - 40 Aligned: 31 Modelled: 31 Confidence: 7.4% Identity: 13% Fold: PurS-like Superfamily: PurS-like Family: PurS subunit of FGAM synthetase Phyre2 PDB 3dfg chain A Region: 22 - 48 Aligned: 27 Modelled: 27 Confidence: 7.3% Identity: 11% PDB header:recombination Chain: A: PDB Molecule:regulatory protein recx; PDBTitle: crystal structure of recx: a potent inhibitor protein of2 reca from xanthomonas campestris Phyre2 1 c2oq3A_ 2 c3oxpB_ 3 c3oxpA_ 4 c3bjvA_ 5 c2oqtD_ 6 c3urrB_ 7 d1a6ja_ 8 d1a3aa_ 9 c2a0jA_ 10 d1xiza_ 11 c1hynQ_ 12 d1hynp_ 13 c2wwaJ_ 14 c2hntE_ 15 d1a3xa3 16 c1eptB_ 17 c3pvlA_ 18 d1susa1 19 d1gtda_ 20 c3dfgA_ 21 22 23 24 25 26

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c2oq3A_ 100.0 100 PDB header:transferase Chain: A: PDB Molecule:mannitol-specific cryptic phosphotransferase PDBTitle: solution structure of the mannitol- specific cryptic2 phosphotransferase enzyme iia cmtb from escherichia coli 2 c3oxpB_ 100.0 38 PDB header:transferase Chain: B: PDB Molecule:phosphotransferase enzyme ii, a component; PDBTitle: structure of phosphotransferase enzyme ii, a component from yersinia2 pestis co92 at 1.2 a resolution 3 c3oxpA_ 100.0 38 PDB header:transferase Chain: A: PDB Molecule:phosphotransferase enzyme ii, a component; PDBTitle: structure of phosphotransferase enzyme ii, a component from yersinia2 pestis co92 at 1.2 a resolution 4 c3bjvA_ 100.0 33 PDB header:transferase Chain: A: PDB Molecule:rmpa; PDBTitle: the crystal structure of a putative pts iia(ptxa) from streptococcus2 mutans 5 c2oqtD_ 100.0 30 PDB header:transferase Chain: D: PDB Molecule:hypothetical protein spy0176; PDBTitle: structural genomics, the crystal structure of a putative2 pts iia domain from streptococcus pyogenes m1 gas 6 c3urrB_ 100.0 20 PDB header:transferase Chain: B: PDB Molecule:pts iia-like nitrogen-regulatory protein ptsn; PDBTitle: structure of pts iia-like nitrogen-regulatory protein ptsn (bth_i0484)2 (ptsn) 7 d1a6ja_ 100.0 19 Fold:Phoshotransferase/anion transport protein Superfamily:Phoshotransferase/anion transport protein Family:IIA domain of mannitol-specific and ntr phosphotransferase EII 8 d1a3aa_ 100.0 28 Fold:Phoshotransferase/anion transport protein Superfamily:Phoshotransferase/anion transport protein Family:IIA domain of mannitol-specific and ntr phosphotransferase EII 9 c2a0jA_ 100.0 20 PDB header:transferase Chain: A: PDB Molecule:pts system, nitrogen regulatory iia protein; PDBTitle: crystal structure of nitrogen regulatory protein iia-ntr from2 neisseria meningitidis 10 d1xiza_ 100.0 15 Fold:Phoshotransferase/anion transport protein Superfamily:Phoshotransferase/anion transport protein Family:IIA domain of mannitol-specific and ntr phosphotransferase EII 11 c1hynQ_ 97.5 13 PDB header:membrane protein Chain: Q: PDB Molecule:band 3 anion transport protein; PDBTitle: crystal structure of the cytoplasmic domain of human2 erythrocyte band-3 protein 12 d1hynp_ 97.5 14 Fold:Phoshotransferase/anion transport protein Superfamily:Phoshotransferase/anion transport protein Family:Anion transport protein, cytoplasmic domain 13 c2wwaJ_ 12.6 13 PDB header:ribosome Chain: J: PDB Molecule:60s ribosomal protein l19; PDBTitle: cryo-em structure of idle yeast ssh1 complex bound to the2 yeast 80s ribosome 14 c2hntE_ 9.7 24 PDB header:serine protease Chain: E: PDB Molecule:gamma-thrombin; PDBTitle: crystallographic structure of human gamma-thrombin 15 d1a3xa3 9.4 10 Fold:Pyruvate kinase C-terminal domain-like Superfamily:PK C-terminal domain-like Family:Pyruvate kinase, C-terminal domain 16 c1eptB_ 8.8 12 PDB header:hydrolase (serine protease) Chain: B: PDB Molecule:porcine e-trypsin; PDBTitle: refined 1.8 angstroms resolution crystal structure of2 porcine epsilon-trypsin 17 c3pvlA_ 8.4 14 PDB header:motor protein/protein transport Chain: A: PDB Molecule:myosin viia isoform 1; PDBTitle: structure of myosin viia myth4-ferm-sh3 in complex with the cen1 of2 sans 18 d1susa1 7.8 9 Fold:S-adenosyl-L-methionine-dependent methyltransferases Superfamily:S-adenosyl-L-methionine-dependent methyltransferases Family:COMT-like 19 d1gtda_ 7.4 13 Fold:PurS-like Superfamily:PurS-like Family:PurS subunit of FGAM synthetase 20 c3dfgA_ 7.3 11 PDB header:recombination Chain: A: PDB Molecule:regulatory protein recx; PDBTitle: crystal structure of recx: a potent inhibitor protein of2 reca from xanthomonas campestris 21 d2i5ua1 not modelled 6.3 29 Fold:DnaD domain-like Superfamily:DnaD domain-like Family:DnaD domain 22 d1vlfm2 not modelled 6.0 27 Fold:Formate dehydrogenase/DMSO reductase, domains 1-3 Superfamily:Formate dehydrogenase/DMSO reductase, domains 1-3 Family:Formate dehydrogenase/DMSO reductase, domains 1-3 23 d2avda1 not modelled 5.9 11 Fold:S-adenosyl-L-methionine-dependent methyltransferases Superfamily:S-adenosyl-L-methionine-dependent methyltransferases Family:COMT-like 24 d1g8ka2 not modelled 5.6 13 Fold:Formate dehydrogenase/DMSO reductase, domains 1-3 Superfamily:Formate dehydrogenase/DMSO reductase, domains 1-3 Family:Formate dehydrogenase/DMSO reductase, domains 1-3 25 c1ojhK_ not modelled 5.3 19 PDB header:protein binding Chain: K: PDB Molecule:nbla; PDBTitle: crystal structure of nbla from pcc 7120 26 c3ntvB_ not modelled 5.3 13 PDB header:transferase Chain: B: PDB Molecule:mw1564 protein; PDBTitle: crystal structure of a putative caffeoyl-coa o-methyltransferase from2 staphylococcus aureus

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0