Secondary structure and disorder prediction

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Sequence		M	F	C	V	I	Y	R	S	S	K	R	D	Q	T	Y	L	Y	V	E	K	K	D	D	F	S	R	V	P	E	E	L	M	K	G	F	G	Q	P	Q	L	A	M	I	L	P	L	D	G	R	K	K	L	V	N	A	D	I	E	K	V
Secondary structure
SS confidence
Disorder		?						?																																								?	?	?	?				?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.
Sequence		K	Q	A	L	T	E	Q	G	Y	Y	L	Q	L	P	P	P	P	E	D	L	L	K	Q	H	L	S	V	M	G	Q	K	T	D	D	T	N	K
Secondary structure
SS confidence
Disorder																													?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2h7a chain A domain 1 Region: 1 - 97 Aligned: 97 Modelled: 97 Confidence: 100.0% Identity: 100% Fold: YcgL-like Superfamily: YcgL-like Family: YcgL-like Phyre2 PDB 2qz7 chain B Region: 1 - 36 Aligned: 34 Modelled: 34 Confidence: 22.4% Identity: 15% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:uncharacterized protein sco6318; PDBTitle: the crystal structure of a homologue of telluride resistance protein2 (terd), sco6318 from streptomyces coelicolor a3(2) Phyre2 PDB 3ol0 chain C Region: 68 - 75 Aligned: 8 Modelled: 8 Confidence: 21.1% Identity: 50% PDB header:de novo protein Chain: C: PDB Molecule:de novo designed monomer trefoil-fold sub-domain which PDBTitle: crystal structure of monofoil-4p homo-trimer: de novo designed monomer2 trefoil-fold sub-domain which forms homo-trimer assembly Phyre2 PDB 2jn4 chain A Region: 1 - 22 Aligned: 20 Modelled: 22 Confidence: 20.0% Identity: 35% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical protein fixu, nift; PDBTitle: solution nmr structure of protein rp4601 from2 rhodopseudomonas palustris. northeast structural genomics3 consortium target rpt2; ontario center for structural4 proteomics target rp4601. Phyre2 PDB 2jn4 chain A domain 1 Region: 1 - 22 Aligned: 20 Modelled: 22 Confidence: 20.0% Identity: 35% Fold: NifT/FixU barrel-like Superfamily: NifT/FixU-like Family: NifT/FixU Phyre2 PDB 1q8k chain A domain 2 Region: 36 - 96 Aligned: 61 Modelled: 61 Confidence: 17.8% Identity: 16% Fold: Ferredoxin-like Superfamily: eIF-2-alpha, C-terminal domain Family: eIF-2-alpha, C-terminal domain Phyre2 PDB 1rrq chain A Region: 50 - 70 Aligned: 21 Modelled: 21 Confidence: 17.0% Identity: 38% PDB header:hydrolase/dna Chain: A: PDB Molecule:muty; PDBTitle: muty adenine glycosylase in complex with dna containing an2 a:oxog pair Phyre2 PDB 2hfq chain A Region: 58 - 71 Aligned: 14 Modelled: 14 Confidence: 14.4% Identity: 29% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical protein; PDBTitle: nmr structure of protein ne1680 from nitrosomonas europaea:2 northeast structural genomics consortium target net5 Phyre2 PDB 2hfq chain A domain 1 Region: 58 - 71 Aligned: 14 Modelled: 14 Confidence: 14.4% Identity: 29% Fold: NE1680-like Superfamily: NE1680-like Family: NE1680-like Phyre2 PDB 1bb8 chain A Region: 8 - 52 Aligned: 33 Modelled: 45 Confidence: 13.5% Identity: 30% Fold: DNA-binding domain Superfamily: DNA-binding domain Family: DNA-binding domain from tn916 integrase Phyre2 PDB 2k4b chain A Region: 46 - 69 Aligned: 24 Modelled: 24 Confidence: 12.6% Identity: 8% PDB header:dna binding protein Chain: A: PDB Molecule:transcriptional regulator; PDBTitle: copr repressor structure Phyre2 PDB 2hzq chain A Region: 36 - 69 Aligned: 34 Modelled: 34 Confidence: 11.8% Identity: 15% PDB header:transport protein Chain: A: PDB Molecule:apolipoprotein d; PDBTitle: crystal structure of human apolipoprotein d (apod) in2 complex with progesterone Phyre2 PDB 1ngn chain A Region: 29 - 70 Aligned: 31 Modelled: 42 Confidence: 11.5% Identity: 26% Fold: DNA-glycosylase Superfamily: DNA-glycosylase Family: Mismatch glycosylase Phyre2 PDB 1lrz chain A domain 2 Region: 2 - 69 Aligned: 68 Modelled: 68 Confidence: 9.8% Identity: 12% Fold: Acyl-CoA N-acyltransferases (Nat) Superfamily: Acyl-CoA N-acyltransferases (Nat) Family: FemXAB nonribosomal peptidyltransferases Phyre2 PDB 2g9w chain A domain 1 Region: 46 - 69 Aligned: 24 Modelled: 24 Confidence: 9.7% Identity: 25% Fold: DNA/RNA-binding 3-helical bundle Superfamily: "Winged helix" DNA-binding domain Family: Penicillinase repressor Phyre2 PDB 3a52 chain A Region: 15 - 73 Aligned: 58 Modelled: 59 Confidence: 9.5% Identity: 17% PDB header:hydrolase Chain: A: PDB Molecule:cold-active alkaline phosphatase; PDBTitle: crystal structure of cold-active alkailne phosphatase from2 psychrophile shewanella sp. Phyre2 PDB 1sed chain A Region: 53 - 70 Aligned: 18 Modelled: 18 Confidence: 9.2% Identity: 39% Fold: Hypothetical protein YhaI Superfamily: Hypothetical protein YhaI Family: Hypothetical protein YhaI Phyre2 PDB 1sd4 chain A Region: 46 - 69 Aligned: 24 Modelled: 24 Confidence: 8.8% Identity: 13% Fold: DNA/RNA-binding 3-helical bundle Superfamily: "Winged helix" DNA-binding domain Family: Penicillinase repressor Phyre2 PDB 1g8f chain A domain 3 Region: 57 - 70 Aligned: 14 Modelled: 14 Confidence: 8.4% Identity: 29% Fold: P-loop containing nucleoside triphosphate hydrolases Superfamily: P-loop containing nucleoside triphosphate hydrolases Family: ATP sulfurylase C-terminal domain Phyre2 PDB 1orn chain A Region: 29 - 70 Aligned: 31 Modelled: 42 Confidence: 8.4% Identity: 23% Fold: DNA-glycosylase Superfamily: DNA-glycosylase Family: Endonuclease III Phyre2 1 d2h7aa1 2 c2qz7B_ 3 c3ol0C_ 4 c2jn4A_ 5 d2jn4a1 6 d1q8ka2 7 c1rrqA_ 8 c2hfqA_ 9 d2hfqa1 10 d1bb8a_ 11 c2k4bA_ 12 c2hzqA_ 13 d1ngna_ 14 d1lrza2 15 d2g9wa1 16 c3a52A_ 17 d1seda_ 18 d1sd4a_ 19 d1g8fa3 20 d1orna_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d2h7aa1 100.0 100 Fold:YcgL-like Superfamily:YcgL-like Family:YcgL-like 2 c2qz7B_ 22.4 15 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:uncharacterized protein sco6318; PDBTitle: the crystal structure of a homologue of telluride resistance protein2 (terd), sco6318 from streptomyces coelicolor a3(2) 3 c3ol0C_ 21.1 50 PDB header:de novo protein Chain: C: PDB Molecule:de novo designed monomer trefoil-fold sub-domain which PDBTitle: crystal structure of monofoil-4p homo-trimer: de novo designed monomer2 trefoil-fold sub-domain which forms homo-trimer assembly 4 c2jn4A_ 20.0 35 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical protein fixu, nift; PDBTitle: solution nmr structure of protein rp4601 from2 rhodopseudomonas palustris. northeast structural genomics3 consortium target rpt2; ontario center for structural4 proteomics target rp4601. 5 d2jn4a1 20.0 35 Fold:NifT/FixU barrel-like Superfamily:NifT/FixU-like Family:NifT/FixU 6 d1q8ka2 17.8 16 Fold:Ferredoxin-like Superfamily:eIF-2-alpha, C-terminal domain Family:eIF-2-alpha, C-terminal domain 7 c1rrqA_ 17.0 38 PDB header:hydrolase/dna Chain: A: PDB Molecule:muty; PDBTitle: muty adenine glycosylase in complex with dna containing an2 a:oxog pair 8 c2hfqA_ 14.4 29 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical protein; PDBTitle: nmr structure of protein ne1680 from nitrosomonas europaea:2 northeast structural genomics consortium target net5 9 d2hfqa1 14.4 29 Fold:NE1680-like Superfamily:NE1680-like Family:NE1680-like 10 d1bb8a_ 13.5 30 Fold:DNA-binding domain Superfamily:DNA-binding domain Family:DNA-binding domain from tn916 integrase 11 c2k4bA_ 12.6 8 PDB header:dna binding protein Chain: A: PDB Molecule:transcriptional regulator; PDBTitle: copr repressor structure 12 c2hzqA_ 11.8 15 PDB header:transport protein Chain: A: PDB Molecule:apolipoprotein d; PDBTitle: crystal structure of human apolipoprotein d (apod) in2 complex with progesterone 13 d1ngna_ 11.5 26 Fold:DNA-glycosylase Superfamily:DNA-glycosylase Family:Mismatch glycosylase 14 d1lrza2 9.8 12 Fold:Acyl-CoA N-acyltransferases (Nat) Superfamily:Acyl-CoA N-acyltransferases (Nat) Family:FemXAB nonribosomal peptidyltransferases 15 d2g9wa1 9.7 25 Fold:DNA/RNA-binding 3-helical bundle Superfamily:"Winged helix" DNA-binding domain Family:Penicillinase repressor 16 c3a52A_ 9.5 17 PDB header:hydrolase Chain: A: PDB Molecule:cold-active alkaline phosphatase; PDBTitle: crystal structure of cold-active alkailne phosphatase from2 psychrophile shewanella sp. 17 d1seda_ 9.2 39 Fold:Hypothetical protein YhaI Superfamily:Hypothetical protein YhaI Family:Hypothetical protein YhaI 18 d1sd4a_ 8.8 13 Fold:DNA/RNA-binding 3-helical bundle Superfamily:"Winged helix" DNA-binding domain Family:Penicillinase repressor 19 d1g8fa3 8.4 29 Fold:P-loop containing nucleoside triphosphate hydrolases Superfamily:P-loop containing nucleoside triphosphate hydrolases Family:ATP sulfurylase C-terminal domain 20 d1orna_ 8.4 23 Fold:DNA-glycosylase Superfamily:DNA-glycosylase Family:Endonuclease III 21 c3ogfA_ not modelled 8.3 50 PDB header:de novo protein Chain: A: PDB Molecule:de novo designed dimeric trefoil-fold sub-domain which PDBTitle: crystal structure of difoil-4p homo-trimer: de novo designed dimeric2 trefoil-fold sub-domain which forms homo-trimer assembly 22 c1rrbA_ not modelled 8.1 12 PDB header:transferase Chain: A: PDB Molecule:raf proto-oncogene serine/threonine-protein PDBTitle: the ras-binding domain of raf-1 from rat, nmr, 1 structure 23 d1y6va1 not modelled 8.1 24 Fold:Alkaline phosphatase-like Superfamily:Alkaline phosphatase-like Family:Alkaline phosphatase 24 c3hi2D_ not modelled 7.7 22 PDB header:dna binding protein/toxin Chain: D: PDB Molecule:motility quorum-sensing regulator mqsr; PDBTitle: structure of the n-terminal domain of the e. coli antitoxin mqsa2 (ygit/b3021) in complex with the e. coli toxin mqsr (ygiu/b3022) 25 d1pd0a4 not modelled 7.3 20 Fold:Gelsolin-like Superfamily:C-terminal, gelsolin-like domain of Sec23/24 Family:C-terminal, gelsolin-like domain of Sec23/24 26 d1e7la1 not modelled 7.2 15 Fold:LEM/SAP HeH motif Superfamily:Recombination endonuclease VII, C-terminal and dimerization domains Family:Recombination endonuclease VII, C-terminal and dimerization domains 27 d2abka_ not modelled 6.9 26 Fold:DNA-glycosylase Superfamily:DNA-glycosylase Family:Endonuclease III 28 c3n5nX_ not modelled 6.9 38 PDB header:hydrolase Chain: X: PDB Molecule:a/g-specific adenine dna glycosylase; PDBTitle: crystal structure analysis of the catalytic domain and interdomain2 connector of human muty homologue 29 d1fima_ not modelled 6.8 15 Fold:Tautomerase/MIF Superfamily:Tautomerase/MIF Family:MIF-related 30 d1jaea2 not modelled 6.8 30 Fold:TIM beta/alpha-barrel Superfamily:(Trans)glycosidases Family:Amylase, catalytic domain 31 c2os5C_ not modelled 6.7 10 PDB header:cytokine Chain: C: PDB Molecule:acemif; PDBTitle: macrophage migration inhibitory factor from ancylostoma ceylanicum 32 c1nyqA_ not modelled 6.5 16 PDB header:ligase Chain: A: PDB Molecule:threonyl-trna synthetase 1; PDBTitle: structure of staphylococcus aureus threonyl-trna synthetase2 complexed with an analogue of threonyl adenylate 33 d2bykb1 not modelled 6.5 22 Fold:Histone-fold Superfamily:Histone-fold Family:TBP-associated factors, TAFs 34 c2bykB_ not modelled 6.5 22 PDB header:dna-binding protein Chain: B: PDB Molecule:chrac-14; PDBTitle: histone fold heterodimer of the chromatin accessibility2 complex 35 d1xova1 not modelled 6.2 57 Fold:SH3-like barrel Superfamily:Prokaryotic SH3-related domain Family:Ply C-terminal domain-like 36 d1pu6a_ not modelled 6.2 24 Fold:DNA-glycosylase Superfamily:DNA-glycosylase Family:3-Methyladenine DNA glycosylase III (MagIII) 37 d2gdga1 not modelled 6.0 15 Fold:Tautomerase/MIF Superfamily:Tautomerase/MIF Family:MIF-related 38 d1kg2a_ not modelled 6.0 38 Fold:DNA-glycosylase Superfamily:DNA-glycosylase Family:Mismatch glycosylase 39 d1lcda_ not modelled 5.9 25 Fold:lambda repressor-like DNA-binding domains Superfamily:lambda repressor-like DNA-binding domains Family:GalR/LacI-like bacterial regulator 40 c2kxvA_ not modelled 5.8 12 PDB header:unknown function Chain: A: PDB Molecule:tellurite resistance protein; PDBTitle: nmr structure and calcium-binding properties of the tellurite2 resistance protein terd from klebsiella pneumoniae 41 d1qupa2 not modelled 5.8 13 Fold:Ferredoxin-like Superfamily:HMA, heavy metal-associated domain Family:HMA, heavy metal-associated domain 42 c3m05A_ not modelled 5.7 13 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein pepe_1480; PDBTitle: the crystal structure of a functionally unknown protein2 pepe_1480 from pediococcus pentosaceus atcc 25745 43 d1kyqa2 not modelled 5.7 29 Fold:Siroheme synthase middle domains-like Superfamily:Siroheme synthase middle domains-like Family:Siroheme synthase middle domains-like 44 c3k0tA_ not modelled 5.6 24 PDB header:sugar binding protein Chain: A: PDB Molecule:endoribonuclease l-psp, putative; PDBTitle: crystal structure of pspto -psp protein in complex with d-beta-glucose2 from pseudomonas syringae pv. tomato str. dc3000 45 c1pwaA_ not modelled 5.5 11 PDB header:hormone/growth factor Chain: A: PDB Molecule:fibroblast growth factor-19; PDBTitle: crystal structure of fibroblast growth factor 19 46 d1pwaa_ not modelled 5.5 11 Fold:beta-Trefoil Superfamily:Cytokine Family:Fibroblast growth factors (FGF) 47 c2lcvA_ not modelled 5.5 33 PDB header:transcription regulator Chain: A: PDB Molecule:hth-type transcriptional repressor cytr; PDBTitle: structure of the cytidine repressor dna-binding domain; an alternate2 calculation 48 d1p6ra_ not modelled 5.4 17 Fold:DNA/RNA-binding 3-helical bundle Superfamily:"Winged helix" DNA-binding domain Family:Penicillinase repressor 49 d2isba1 not modelled 5.4 19 Fold:The "swivelling" beta/beta/alpha domain Superfamily:FumA C-terminal domain-like Family:FumA C-terminal domain-like 50 d1n1ja_ not modelled 5.3 16 Fold:Histone-fold Superfamily:Histone-fold Family:TBP-associated factors, TAFs

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0