Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	D	T	K	R	N	T	I	G	K	F	G	L	L	S	L	T	F	A	A	V	Y	S	F	N	N	V	I	N	N	N	I	E	L	G	L	A	S	A	P	M	F	F	L	A	T	I	F	Y	F	I	P	F	C	L	I	I	A	E
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?																			?										?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		F	V	S	L	N	K	N	S	E	A	G	V	Y	A	W	V	K	S	S	L	G	G	R	W	A	F	I	T	A	Y	T	Y	W	F	V	N	L	F	F	F	T	S	L	L	P	R	V	I	A	Y	A	S	Y	A	F	L	G	Y	E	Y
Secondary structure
SS confidence
Disorder				?	?	?		?	?																																																				?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		I	M	T	P	V	A	T	T	I	I	S	M	V	L	F	A	F	S	T	W	V	S	T	N	G	A	K	M	L	G	P	I	T	S	V	T	S	T	L	M	L	L	L	T	L	S	Y	I	L	L	A	G	T	A	L	V	G	G	V	Q
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		P	A	D	A	I	T	V	D	A	M	I	P	N	F	N	W	A	F	L	G	V	T	T	W	I	F	M	A	A	G	G	A	E	S	V	A	V	Y	V	N	D	V	K	G	G	S	K	S	F	V	K	V	I	I	L	A	G	I	F	I
Secondary structure
SS confidence
Disorder			?					?	?	?			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		G	V	L	Y	S	V	S	S	V	L	I	N	V	F	V	S	S	K	E	L	K	F	T	G	G	S	V	Q	V	F	H	G	M	A	A	Y	F	G	L	P	E	A	L	M	N	R	F	V	G	L	V	S	F	T	A	M	F	G	S	L
Secondary structure
SS confidence
Disorder																					?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		L	M	W	T	A	T	P	V	K	I	F	F	S	E	I	P	E	G	I	F	G	K	K	T	V	E	L	N	E	N	G	V	P	A	R	A	A	W	I	Q	F	L	I	V	I	P	L	M	I	I	P	M	L	G	S	N	T	V	Q	D
Secondary structure
SS confidence
Disorder																																																					?	?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		L	M	N	T	I	I	N	M	T	A	A	A	S	M	L	P	P	L	F	I	M	L	A	Y	L	N	L	R	A	K	L	D	H	L	P	R	D	F	R	M	G	S	R	R	T	G	I	I	V	V	S	M	L	I	A	I	F	A	V	G
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.
Sequence		F	V	A	S	T	F	P	T	G	A	N	I	L	T	I	I	F	Y	N	V	G	G	I	V	I	F	L	G	F	A	W	W	K	Y	S	K	Y	I	K	G	L	T	A	E	E	R	H	I	E	A	T	P	A	S	N	V	D
Secondary structure
SS confidence
Disorder							?	?	?	?	?																												?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 3gia chain A Region: 5 - 465 Aligned: 429 Modelled: 429 Confidence: 100.0% Identity: 12% PDB header:transport protein Chain: A: PDB Molecule:uncharacterized protein mj0609; PDBTitle: crystal structure of apct transporter Phyre2 PDB 3lrc chain C Region: 5 - 460 Aligned: 407 Modelled: 407 Confidence: 100.0% Identity: 16% PDB header:transport protein Chain: C: PDB Molecule:arginine/agmatine antiporter; PDBTitle: structure of e. coli adic (p1) Phyre2 PDB 2jln chain A Region: 3 - 469 Aligned: 441 Modelled: 454 Confidence: 100.0% Identity: 11% PDB header:membrane protein Chain: A: PDB Molecule:mhp1; PDBTitle: structure of mhp1, a nucleobase-cation-symport-1 family2 transporter Phyre2 PDB 2xq2 chain A Region: 7 - 475 Aligned: 441 Modelled: 441 Confidence: 99.1% Identity: 13% PDB header:transport protein Chain: A: PDB Molecule:sodium/glucose cotransporter; PDBTitle: structure of the k294a mutant of vsglt Phyre2 PDB 3dh4 chain A Region: 7 - 476 Aligned: 442 Modelled: 442 Confidence: 98.6% Identity: 10% PDB header:transport protein Chain: A: PDB Molecule:sodium/glucose cotransporter; PDBTitle: crystal structure of sodium/sugar symporter with bound galactose from2 vibrio parahaemolyticus Phyre2 PDB 2a65 chain A domain 1 Region: 10 - 460 Aligned: 436 Modelled: 447 Confidence: 98.2% Identity: 12% Fold: SNF-like Superfamily: SNF-like Family: SNF-like Phyre2 PDB 2w8a chain C Region: 2 - 392 Aligned: 378 Modelled: 391 Confidence: 97.8% Identity: 11% PDB header:membrane protein Chain: C: PDB Molecule:glycine betaine transporter betp; PDBTitle: crystal structure of the sodium-coupled glycine betaine2 symporter betp from corynebacterium glutamicum with bound3 substrate Phyre2 PDB 3hfx chain A Region: 4 - 393 Aligned: 379 Modelled: 379 Confidence: 93.4% Identity: 10% PDB header:transport protein Chain: A: PDB Molecule:l-carnitine/gamma-butyrobetaine antiporter; PDBTitle: crystal structure of carnitine transporter Phyre2 PDB 3qnq chain D Region: 421 - 472 Aligned: 52 Modelled: 52 Confidence: 81.1% Identity: 12% PDB header:membrane protein, transport protein Chain: D: PDB Molecule:pts system, cellobiose-specific iic component; PDBTitle: crystal structure of the transporter chbc, the iic component from the2 n,n'-diacetylchitobiose-specific phosphotransferase system Phyre2 PDB 1fft chain B domain 2 Region: 357 - 425 Aligned: 69 Modelled: 69 Confidence: 32.1% Identity: 14% Fold: Transmembrane helix hairpin Superfamily: Cytochrome c oxidase subunit II-like, transmembrane region Family: Cytochrome c oxidase subunit II-like, transmembrane region Phyre2 PDB 2jo1 chain A Region: 426 - 475 Aligned: 50 Modelled: 50 Confidence: 31.5% Identity: 18% PDB header:hydrolase regulator Chain: A: PDB Molecule:phospholemman; PDBTitle: structure of the na,k-atpase regulatory protein fxyd1 in2 micelles Phyre2 PDB 2knc chain A Region: 434 - 469 Aligned: 36 Modelled: 36 Confidence: 17.5% Identity: 8% PDB header:cell adhesion Chain: A: PDB Molecule:integrin alpha-iib; PDBTitle: platelet integrin alfaiib-beta3 transmembrane-cytoplasmic2 heterocomplex Phyre2 PDB 3b8e chain C Region: 369 - 465 Aligned: 97 Modelled: 97 Confidence: 8.7% Identity: 11% PDB header:hydrolase/transport protein Chain: C: PDB Molecule:sodium/potassium-transporting atpase subunit PDBTitle: crystal structure of the sodium-potassium pump Phyre2 PDB 2jp3 chain A Region: 426 - 471 Aligned: 46 Modelled: 46 Confidence: 7.9% Identity: 15% PDB header:transcription Chain: A: PDB Molecule:fxyd domain-containing ion transport regulator 4; PDBTitle: solution structure of the human fxyd4 (chif) protein in sds2 micelles Phyre2 PDB 2bbj chain B Region: 413 - 459 Aligned: 47 Modelled: 47 Confidence: 7.9% Identity: 17% PDB header:metal transport/membrane protein Chain: B: PDB Molecule:divalent cation transport-related protein; PDBTitle: crystal structure of the cora mg2+ transporter Phyre2 PDB 1m57 chain H Region: 358 - 424 Aligned: 67 Modelled: 67 Confidence: 6.0% Identity: 19% PDB header:oxidoreductase Chain: H: PDB Molecule:cytochrome c oxidase; PDBTitle: structure of cytochrome c oxidase from rhodobacter2 sphaeroides (eq(i-286) mutant)) Phyre2 1 c3giaA_ 2 c3lrcC_ 3 c2jlnA_ 4 c2xq2A_ 5 c3dh4A_ 6 d2a65a1 7 c2w8aC_ 8 c3hfxA_ 9 c3qnqD_ 10 d1fftb2 11 c2jo1A_ 12 c2kncA_ 13 c3b8eC_ 14 c2jp3A_ 15 c2bbjB_ 16 c1m57H_

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c3giaA_ 100.0 12 PDB header:transport protein Chain: A: PDB Molecule:uncharacterized protein mj0609; PDBTitle: crystal structure of apct transporter 2 c3lrcC_ 100.0 16 PDB header:transport protein Chain: C: PDB Molecule:arginine/agmatine antiporter; PDBTitle: structure of e. coli adic (p1) 3 c2jlnA_ 100.0 11 PDB header:membrane protein Chain: A: PDB Molecule:mhp1; PDBTitle: structure of mhp1, a nucleobase-cation-symport-1 family2 transporter 4 c2xq2A_ 99.1 13 PDB header:transport protein Chain: A: PDB Molecule:sodium/glucose cotransporter; PDBTitle: structure of the k294a mutant of vsglt 5 c3dh4A_ 98.6 10 PDB header:transport protein Chain: A: PDB Molecule:sodium/glucose cotransporter; PDBTitle: crystal structure of sodium/sugar symporter with bound galactose from2 vibrio parahaemolyticus 6 d2a65a1 98.2 12 Fold:SNF-like Superfamily:SNF-like Family:SNF-like 7 c2w8aC_ 97.8 11 PDB header:membrane protein Chain: C: PDB Molecule:glycine betaine transporter betp; PDBTitle: crystal structure of the sodium-coupled glycine betaine2 symporter betp from corynebacterium glutamicum with bound3 substrate 8 c3hfxA_ 93.4 10 PDB header:transport protein Chain: A: PDB Molecule:l-carnitine/gamma-butyrobetaine antiporter; PDBTitle: crystal structure of carnitine transporter 9 c3qnqD_ 81.1 12 PDB header:membrane protein, transport protein Chain: D: PDB Molecule:pts system, cellobiose-specific iic component; PDBTitle: crystal structure of the transporter chbc, the iic component from the2 n,n'-diacetylchitobiose-specific phosphotransferase system 10 d1fftb2 32.1 14 Fold:Transmembrane helix hairpin Superfamily:Cytochrome c oxidase subunit II-like, transmembrane region Family:Cytochrome c oxidase subunit II-like, transmembrane region 11 c2jo1A_ 31.5 18 PDB header:hydrolase regulator Chain: A: PDB Molecule:phospholemman; PDBTitle: structure of the na,k-atpase regulatory protein fxyd1 in2 micelles 12 c2kncA_ 17.5 8 PDB header:cell adhesion Chain: A: PDB Molecule:integrin alpha-iib; PDBTitle: platelet integrin alfaiib-beta3 transmembrane-cytoplasmic2 heterocomplex 13 c3b8eC_ 8.7 11 PDB header:hydrolase/transport protein Chain: C: PDB Molecule:sodium/potassium-transporting atpase subunit PDBTitle: crystal structure of the sodium-potassium pump 14 c2jp3A_ 7.9 15 PDB header:transcription Chain: A: PDB Molecule:fxyd domain-containing ion transport regulator 4; PDBTitle: solution structure of the human fxyd4 (chif) protein in sds2 micelles 15 c2bbjB_ 7.9 17 PDB header:metal transport/membrane protein Chain: B: PDB Molecule:divalent cation transport-related protein; PDBTitle: crystal structure of the cora mg2+ transporter 16 c1m57H_ 6.0 19 PDB header:oxidoreductase Chain: H: PDB Molecule:cytochrome c oxidase; PDBTitle: structure of cytochrome c oxidase from rhodobacter2 sphaeroides (eq(i-286) mutant))

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0