Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	K	T	E	L	T	L	N	V	L	Q	T	M	N	A	Q	E	Y	E	D	I	R	A	A	G	S	D	E	R	R	E	L	T	H	A	V	M	R	E	L	D	A	P	D	N	W	T	M	N	G	E	Y	G	S	E	F	G	G	F	F
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?					?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		P	V	Q	V	R	F	T	P	A	H	E	R	F	H	L	A	L	C	S	P	G	D	V	S	Q	V	W	V	L	V	L	V	N	A	G	G	E	P	F	A	V	V	Q	V	Q	R	R	F	A	S	E	A	V	S	H	S	L	A	L	A
Secondary structure
SS confidence
Disorder																										?																					?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.
Sequence		A	S	L	D	T	Q	G	Y	S	V	N	D	I	I	H	I	S	M	A	E	G	G	Q	V
Secondary structure
SS confidence
Disorder				?		?	?														?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 3nct chain C Region: 5 - 143 Aligned: 139 Modelled: 139 Confidence: 100.0% Identity: 96% PDB header:dna binding protein, chaperone Chain: C: PDB Molecule:protein psib; PDBTitle: x-ray crystal structure of the bacterial conjugation factor psib, a2 negative regulator of reca Phyre2 PDB 3d30 chain A Region: 32 - 107 Aligned: 64 Modelled: 64 Confidence: 84.1% Identity: 14% PDB header:peptidoglycan-binding protein Chain: A: PDB Molecule:expansin like protein; PDBTitle: structure of an expansin like protein from bacillus subtilis at 1.9a2 resolution Phyre2 PDB 2w56 chain B Region: 52 - 76 Aligned: 25 Modelled: 25 Confidence: 56.9% Identity: 24% PDB header:unknown function Chain: B: PDB Molecule:vc0508; PDBTitle: structure of the hypothetical protein vc0508 from vibrio cholerae2 vsp-ii pathogenicity island Phyre2 PDB 2v1l chain A Region: 51 - 76 Aligned: 26 Modelled: 26 Confidence: 48.6% Identity: 27% PDB header:unknown function Chain: A: PDB Molecule:hypothetical protein; PDBTitle: structure of the conserved hypothetical protein vc1805 from2 pathogenicity island vpi-2 of vibrio cholerae o1 biovar3 eltor str. n16961 shares structural homology with the4 human p32 protein Phyre2 PDB 2nox chain P Region: 6 - 24 Aligned: 19 Modelled: 19 Confidence: 33.7% Identity: 42% PDB header:oxidoreductase Chain: P: PDB Molecule:tryptophan 2,3-dioxygenase; PDBTitle: crystal structure of tryptophan 2,3-dioxygenase from ralstonia2 metallidurans Phyre2 PDB 2nw8 chain A domain 1 Region: 6 - 24 Aligned: 19 Modelled: 19 Confidence: 19.7% Identity: 32% Fold: Indolic compounds 2,3-dioxygenase-like Superfamily: Indolic compounds 2,3-dioxygenase-like Family: Bacterial tryptophan 2,3-dioxygenase Phyre2 PDB 2nw7 chain C Region: 6 - 24 Aligned: 19 Modelled: 19 Confidence: 17.8% Identity: 32% PDB header:oxidoreductase Chain: C: PDB Molecule:tryptophan 2,3-dioxygenase; PDBTitle: crystal structure of tryptophan 2,3-dioxygenase (tdo) from2 xanthomonas campestris in complex with ferric heme.3 northeast structural genomics target xcr13 Phyre2 PDB 2hcz chain X Region: 58 - 101 Aligned: 44 Modelled: 44 Confidence: 16.4% Identity: 14% PDB header:allergen Chain: X: PDB Molecule:beta-expansin 1a; PDBTitle: crystal structure of expb1 (zea m 1), a beta-expansin and group-12 pollen allergen from maize Phyre2 PDB 1dx5 chain I domain 3 Region: 52 - 80 Aligned: 26 Modelled: 29 Confidence: 13.5% Identity: 27% Fold: Knottins (small inhibitors, toxins, lectins) Superfamily: EGF/Laminin Family: EGF-type module Phyre2 PDB 2i0k chain A domain 1 Region: 60 - 73 Aligned: 14 Modelled: 14 Confidence: 13.3% Identity: 21% Fold: Ferredoxin-like Superfamily: FAD-linked oxidases, C-terminal domain Family: Cholesterol oxidase Phyre2 PDB 2ftx chain A domain 1 Region: 63 - 138 Aligned: 76 Modelled: 76 Confidence: 13.2% Identity: 18% Fold: Kinetochore globular domain-like Superfamily: Kinetochore globular domain Family: Spc25-like Phyre2 PDB 1c3a chain A Region: 39 - 52 Aligned: 14 Modelled: 14 Confidence: 13.0% Identity: 21% Fold: C-type lectin-like Superfamily: C-type lectin-like Family: C-type lectin domain Phyre2 PDB 3le4 chain A Region: 42 - 49 Aligned: 8 Modelled: 8 Confidence: 12.5% Identity: 50% PDB header:nuclear protein Chain: A: PDB Molecule:microprocessor complex subunit dgcr8; PDBTitle: crystal structure of the dgcr8 dimerization domain Phyre2 PDB 3oib chain B Region: 43 - 111 Aligned: 69 Modelled: 69 Confidence: 12.4% Identity: 13% PDB header:oxidoreductase Chain: B: PDB Molecule:acyl-coa dehydrogenase; PDBTitle: crystal structure of a putative acyl-coa dehydrogenase from2 mycobacterium smegmatis, iodide soak Phyre2 PDB 1lsh chain B Region: 39 - 51 Aligned: 13 Modelled: 13 Confidence: 11.8% Identity: 23% PDB header:lipid binding protein Chain: B: PDB Molecule:lipovitellin (lv-2); PDBTitle: lipid-protein interactions in lipovitellin Phyre2 PDB 1lsh chain B Region: 39 - 51 Aligned: 13 Modelled: 13 Confidence: 11.8% Identity: 23% Fold: Lipovitellin-phosvitin complex; beta-sheet shell regions Superfamily: Lipovitellin-phosvitin complex; beta-sheet shell regions Family: Lipovitellin-phosvitin complex; beta-sheet shell regions Phyre2 PDB 3kbh chain E Region: 67 - 79 Aligned: 13 Modelled: 13 Confidence: 11.6% Identity: 31% PDB header:hydrolase Chain: E: PDB Molecule:spike glycoprotein; PDBTitle: crystal structure of nl63 respiratory coronavirus receptor-binding2 domain complexed with its human receptor Phyre2 PDB 1d5v chain A Region: 2 - 56 Aligned: 55 Modelled: 55 Confidence: 11.2% Identity: 15% Fold: DNA/RNA-binding 3-helical bundle Superfamily: "Winged helix" DNA-binding domain Family: Forkhead DNA-binding domain Phyre2 PDB 1x6v chain A domain 1 Region: 90 - 124 Aligned: 35 Modelled: 35 Confidence: 10.6% Identity: 9% Fold: PUA domain-like Superfamily: PUA domain-like Family: ATP sulfurylase N-terminal domain Phyre2 PDB 1who chain A Region: 84 - 105 Aligned: 22 Modelled: 22 Confidence: 10.6% Identity: 27% Fold: C2 domain-like Superfamily: PHL pollen allergen Family: PHL pollen allergen Phyre2 1 c3nctC_ 2 c3d30A_ 3 c2w56B_ 4 c2v1lA_ 5 c2noxP_ 6 d2nw8a1 7 c2nw7C_ 8 c2hczX_ 9 d1dx5i3 10 d2i0ka1 11 d2ftxa1 12 d1c3aa_ 13 c3le4A_ 14 c3oibB_ 15 c1lshB_ 16 d1lshb_ 17 c3kbhE_ 18 d1d5va_ 19 d1x6va1 20 d1whoa_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c3nctC_ 100.0 96 PDB header:dna binding protein, chaperone Chain: C: PDB Molecule:protein psib; PDBTitle: x-ray crystal structure of the bacterial conjugation factor psib, a2 negative regulator of reca 2 c3d30A_ 84.1 14 PDB header:peptidoglycan-binding protein Chain: A: PDB Molecule:expansin like protein; PDBTitle: structure of an expansin like protein from bacillus subtilis at 1.9a2 resolution 3 c2w56B_ 56.9 24 PDB header:unknown function Chain: B: PDB Molecule:vc0508; PDBTitle: structure of the hypothetical protein vc0508 from vibrio cholerae2 vsp-ii pathogenicity island 4 c2v1lA_ 48.6 27 PDB header:unknown function Chain: A: PDB Molecule:hypothetical protein; PDBTitle: structure of the conserved hypothetical protein vc1805 from2 pathogenicity island vpi-2 of vibrio cholerae o1 biovar3 eltor str. n16961 shares structural homology with the4 human p32 protein 5 c2noxP_ 33.7 42 PDB header:oxidoreductase Chain: P: PDB Molecule:tryptophan 2,3-dioxygenase; PDBTitle: crystal structure of tryptophan 2,3-dioxygenase from ralstonia2 metallidurans 6 d2nw8a1 19.7 32 Fold:Indolic compounds 2,3-dioxygenase-like Superfamily:Indolic compounds 2,3-dioxygenase-like Family:Bacterial tryptophan 2,3-dioxygenase 7 c2nw7C_ 17.8 32 PDB header:oxidoreductase Chain: C: PDB Molecule:tryptophan 2,3-dioxygenase; PDBTitle: crystal structure of tryptophan 2,3-dioxygenase (tdo) from2 xanthomonas campestris in complex with ferric heme.3 northeast structural genomics target xcr13 8 c2hczX_ 16.4 14 PDB header:allergen Chain: X: PDB Molecule:beta-expansin 1a; PDBTitle: crystal structure of expb1 (zea m 1), a beta-expansin and group-12 pollen allergen from maize 9 d1dx5i3 13.5 27 Fold:Knottins (small inhibitors, toxins, lectins) Superfamily:EGF/Laminin Family:EGF-type module 10 d2i0ka1 13.3 21 Fold:Ferredoxin-like Superfamily:FAD-linked oxidases, C-terminal domain Family:Cholesterol oxidase 11 d2ftxa1 13.2 18 Fold:Kinetochore globular domain-like Superfamily:Kinetochore globular domain Family:Spc25-like 12 d1c3aa_ 13.0 21 Fold:C-type lectin-like Superfamily:C-type lectin-like Family:C-type lectin domain 13 c3le4A_ 12.5 50 PDB header:nuclear protein Chain: A: PDB Molecule:microprocessor complex subunit dgcr8; PDBTitle: crystal structure of the dgcr8 dimerization domain 14 c3oibB_ 12.4 13 PDB header:oxidoreductase Chain: B: PDB Molecule:acyl-coa dehydrogenase; PDBTitle: crystal structure of a putative acyl-coa dehydrogenase from2 mycobacterium smegmatis, iodide soak 15 c1lshB_ 11.8 23 PDB header:lipid binding protein Chain: B: PDB Molecule:lipovitellin (lv-2); PDBTitle: lipid-protein interactions in lipovitellin 16 d1lshb_ 11.8 23 Fold:Lipovitellin-phosvitin complex; beta-sheet shell regions Superfamily:Lipovitellin-phosvitin complex; beta-sheet shell regions Family:Lipovitellin-phosvitin complex; beta-sheet shell regions 17 c3kbhE_ 11.6 31 PDB header:hydrolase Chain: E: PDB Molecule:spike glycoprotein; PDBTitle: crystal structure of nl63 respiratory coronavirus receptor-binding2 domain complexed with its human receptor 18 d1d5va_ 11.2 15 Fold:DNA/RNA-binding 3-helical bundle Superfamily:"Winged helix" DNA-binding domain Family:Forkhead DNA-binding domain 19 d1x6va1 10.6 9 Fold:PUA domain-like Superfamily:PUA domain-like Family:ATP sulfurylase N-terminal domain 20 d1whoa_ 10.6 27 Fold:C2 domain-like Superfamily:PHL pollen allergen Family:PHL pollen allergen 21 d1v7wa2 not modelled 10.6 19 Fold:Supersandwich Superfamily:Galactose mutarotase-like Family:Glycosyltransferase family 36 N-terminal domain 22 c2w0tA_ not modelled 10.4 25 PDB header:transcription Chain: A: PDB Molecule:lethal(3)malignant brain tumor-like 2 protein; PDBTitle: solution structure of the fcs zinc finger domain of human2 lmbl2 23 d1qo3c_ not modelled 10.3 24 Fold:C-type lectin-like Superfamily:C-type lectin-like Family:C-type lectin domain 24 c2y7eA_ not modelled 10.0 17 PDB header:lyase Chain: A: PDB Molecule:3-keto-5-aminohexanoate cleavage enzyme; PDBTitle: crystal structure of the 3-keto-5-aminohexanoate cleavage enzyme2 (kce) from candidatus cloacamonas acidaminovorans (tetragonal form) 25 c2c5sA_ not modelled 9.9 23 PDB header:rna-binding protein Chain: A: PDB Molecule:probable thiamine biosynthesis protein thii; PDBTitle: crystal structure of bacillus anthracis thii, a trna-2 modifying enzyme containing the predicted rna-binding3 thump domain 26 c1j1eC_ not modelled 9.8 27 PDB header:contractile protein Chain: C: PDB Molecule:troponin i; PDBTitle: crystal structure of the 52kda domain of human cardiac2 troponin in the ca2+ saturated form 27 c2qjfB_ not modelled 9.6 8 PDB header:transferase Chain: B: PDB Molecule:bifunctional 3'-phosphoadenosine 5'- PDBTitle: crystal structure of atp-sulfurylase domain of human paps2 synthetase 1 28 c2wmhA_ not modelled 9.3 15 PDB header:hydrolase Chain: A: PDB Molecule:fucolectin-related protein; PDBTitle: crystal structure of the catalytic module of a family 982 glycoside hydrolase from streptococcus pneumoniae tigr4 in3 complex with the h-disaccharide blood group antigen. 29 c2j83B_ not modelled 9.1 10 PDB header:hydrolase Chain: B: PDB Molecule:ulilysin; PDBTitle: ulilysin metalloprotease in complex with batimastat. 30 d1j6ra_ not modelled 8.7 14 Fold:Methionine synthase activation domain-like Superfamily:Methionine synthase activation domain-like Family:Hypothetical protein TM0269 31 d1s48a_ not modelled 8.5 20 Fold:DNA/RNA polymerases Superfamily:DNA/RNA polymerases Family:RNA-dependent RNA-polymerase 32 c1v47B_ not modelled 8.3 20 PDB header:transferase Chain: B: PDB Molecule:atp sulfurylase; PDBTitle: crystal structure of atp sulfurylase from thermus2 thermophillus hb8 in complex with aps 33 d2a07f1 not modelled 8.1 18 Fold:DNA/RNA-binding 3-helical bundle Superfamily:"Winged helix" DNA-binding domain Family:Forkhead DNA-binding domain 34 c2zibA_ not modelled 7.8 36 PDB header:antifreeze protein Chain: A: PDB Molecule:type ii antifreeze protein; PDBTitle: crystal structure analysis of calcium-independent type ii2 antifreeze protein 35 c3e4wB_ not modelled 7.7 36 PDB header:oxidoreductase Chain: B: PDB Molecule:putative uncharacterized protein; PDBTitle: crystal structure of a 33kda catalase-related protein from2 mycobacterium avium subsp. paratuberculosis. p2(1)2(1)2(1) crystal3 form. 36 c1vq0A_ not modelled 7.7 30 PDB header:chaperone Chain: A: PDB Molecule:33 kda chaperonin; PDBTitle: crystal structure of 33 kda chaperonin (heat shock protein 33 homolog)2 (hsp33) (tm1394) from thermotoga maritima at 2.20 a resolution 37 c2p04B_ not modelled 7.6 50 PDB header:transferase Chain: B: PDB Molecule:signal transduction histidine kinase; PDBTitle: 2.1 ang structure of the dimerized pas domain of signal transduction2 histidine kinase from nostoc punctiforme pcc 73102 with homology to3 the h-noxa/h-noba domain of the soluble guanylyl cyclase 38 c1xwjB_ not modelled 7.5 78 PDB header:cell adhesion/protein binding Chain: B: PDB Molecule:talin; PDBTitle: vinculin head (1-258) in complex with the talin vinculin2 binding site 3 (1945-1969) 39 d3bdwa1 not modelled 7.5 9 Fold:C-type lectin-like Superfamily:C-type lectin-like Family:C-type lectin domain 40 c2dlwA_ not modelled 6.9 37 PDB header:signaling protein Chain: A: PDB Molecule:docking protein 2, isoform a; PDBTitle: solution structure of the irs domain of human docking2 protein 2, isoform a 41 c2r5kE_ not modelled 6.6 31 PDB header:viral protein Chain: E: PDB Molecule:major capsid protein l1; PDBTitle: pentamer structure of major capsid protein l1 of human2 papilloma virus type 11 42 d1deca_ not modelled 6.6 33 Fold:Knottins (small inhibitors, toxins, lectins) Superfamily:Leech antihemostatic proteins Family:Hirudin-like 43 c2yruA_ not modelled 6.6 17 PDB header:apoptosis Chain: A: PDB Molecule:steroid receptor rna activator 1; PDBTitle: solution structure of mouse steroid receptor rna activator2 1 (sra1) protein 44 c1rkcB_ not modelled 6.4 78 PDB header:cell adhesion, structural protein Chain: B: PDB Molecule:talin; PDBTitle: human vinculin head (1-258) in complex with talin's2 vinculin binding site 3 (residues 1944-1969) 45 d1atxa_ not modelled 6.4 25 Fold:Defensin-like Superfamily:Defensin-like Family:Defensin 46 c2lc0A_ not modelled 6.3 15 PDB header:protein binding Chain: A: PDB Molecule:putative uncharacterized protein tb39.8; PDBTitle: rv0020c_nter structure 47 d1gyxa_ not modelled 6.3 15 Fold:Tautomerase/MIF Superfamily:Tautomerase/MIF Family:4-oxalocrotonate tautomerase-like 48 c3tixB_ not modelled 6.3 21 PDB header:gene regulation/protein binding Chain: B: PDB Molecule:chromo domain-containing protein 1; PDBTitle: crystal structure of the chp1-tas3 complex core 49 c1fm5A_ not modelled 6.3 8 PDB header:immune system Chain: A: PDB Molecule:early activation antigen cd69; PDBTitle: crystal structure of human cd69 50 c2ox8A_ not modelled 6.2 17 PDB header:sugar binding protein Chain: A: PDB Molecule:scavenger receptor with c-type lectin type i; PDBTitle: human scavenger receptor c-type lectin carbohydrate-2 recognition domain. 51 c3m9zA_ not modelled 6.2 23 PDB header:signaling protein Chain: A: PDB Molecule:killer cell lectin-like receptor subfamily b member 1a; PDBTitle: crystal structure of extracellular domain of mouse nkr-p1a 52 d1t3ta1 not modelled 6.0 10 Fold:RuvA C-terminal domain-like Superfamily:FGAM synthase PurL, linker domain Family:FGAM synthase PurL, linker domain 53 d1skza1 not modelled 5.9 67 Fold:Knottins (small inhibitors, toxins, lectins) Superfamily:Leech antihemostatic proteins Family:Huristasin-like 54 c3hj7A_ not modelled 5.8 27 PDB header:ligase Chain: A: PDB Molecule:trna(ile)-lysidine synthase; PDBTitle: crystal structure of tils c-terminal domain 55 d1i8gb_ not modelled 5.7 22 Fold:WW domain-like Superfamily:WW domain Family:WW domain 56 d1ib8a2 not modelled 5.6 38 Fold:Alpha-lytic protease prodomain-like Superfamily:YhbC-like, N-terminal domain Family:YhbC-like, N-terminal domain 57 d1umra_ not modelled 5.6 38 Fold:C-type lectin-like Superfamily:C-type lectin-like Family:C-type lectin domain 58 d1gpja3 not modelled 5.6 29 Fold:Ferredoxin-like Superfamily:Glutamyl tRNA-reductase catalytic, N-terminal domain Family:Glutamyl tRNA-reductase catalytic, N-terminal domain 59 c1n10A_ not modelled 5.5 13 PDB header:allergen Chain: A: PDB Molecule:pollen allergen phl p 1; PDBTitle: crystal structure of phl p 1, a major timothy grass pollen allergen 60 c3gprC_ not modelled 5.5 13 PDB header:cell adhesion Chain: C: PDB Molecule:rhodocetin subunit gamma; PDBTitle: crystal structure of rhodocetin 61 d1psea_ not modelled 5.3 71 Fold:SH3-like barrel Superfamily:Electron transport accessory proteins Family:Photosystem I accessory protein E (PsaE) 62 d1jb0e_ not modelled 5.3 71 Fold:SH3-like barrel Superfamily:Electron transport accessory proteins Family:Photosystem I accessory protein E (PsaE) 63 d1dxga_ not modelled 5.2 33 Fold:Rubredoxin-like Superfamily:Rubredoxin-like Family:Desulforedoxin 64 d1qp3a_ not modelled 5.0 71 Fold:SH3-like barrel Superfamily:Electron transport accessory proteins Family:Photosystem I accessory protein E (PsaE)

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0