Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	A	Q	E	I	E	L	K	F	I	V	N	H	S	A	V	E	A	L	R	D	H	L	N	T	L	G	G	E	H	H	D	P	V	Q	L	L	N	I	Y	Y	E	T	P	D	N	W	L	R	G	H	D	M	G	L	R	I	R	G	E
Secondary structure
SS confidence
Disorder		?	?	?	?																					?	?			?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		N	G	R	Y	E	M	T	M	K	V	A	G	R	V	T	G	G	L	H	Q	R	P	E	Y	N	V	A	L	S	E	P	T	L	D	L	A	Q	L	P	T	E	V	W	P	N	G	E	L	P	A	D	L	A	S	R	V	Q	P	L	F
Secondary structure
SS confidence
Disorder														?	?	?	?	?	?		?																													?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		S	T	D	F	Y	R	E	K	W	L	V	A	V	D	G	S	Q	I	E	I	A	L	D	Q	G	E	V	K	A	G	E	F	A	E	P	I	C	E	L	E	L	E	L	L	S	G	D	T	R	A	V	L	K	L	A	N	Q	L	V	S
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		Q	T	G	L	R	Q	G	S	L	S	K	A	A	R	G	Y	H	L	A	Q	G	N	P	A	R	E	I	K	P	T	T	I	L	H	V	A	A	K	A	D	V	E	Q	G	L	E	A	A	L	E	L	A	L	A	Q	W	Q	Y	H	E
Secondary structure
SS confidence
Disorder																						?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		E	L	W	V	R	G	N	D	A	A	K	E	Q	V	L	A	A	I	S	L	V	R	H	T	L	M	L	F	G	G	I	V	P	R	K	A	S	T	H	L	R	D	L	L	T	Q	C	E	A	T	I	A	S	A	V	S	A	V	T	A
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		V	Y	S	T	E	T	A	M	A	K	L	A	L	T	E	W	L	V	S	K	A	W	Q	P	F	L	D	A	K	A	Q	G	K	I	S	D	S	F	K	R	F	A	D	I	H	L	S	R	H	A	A	E	L	K	S	V	F	C	Q	P
Secondary structure
SS confidence
Disorder														?					?		?	?	?	?	?	?	?	?	?	?	?		?																										?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		L	G	D	R	Y	R	D	Q	L	P	R	L	T	R	D	I	D	S	I	L	L	L	A	G	Y	Y	D	P	V	V	A	Q	A	W	L	E	N	W	Q	G	L	H	H	A	I	A	T	G	Q	R	I	E	I	E	H	F	R	N	E	A
Secondary structure
SS confidence
Disorder		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.
Sequence		N	N	Q	E	P	F	W	L	H	S	G	K	R
Secondary structure
SS confidence
Disorder										?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 3e0s chain A Region: 213 - 429 Aligned: 212 Modelled: 217 Confidence: 100.0% Identity: 12% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of an uncharacterized protein from2 chlorobium tepidum Phyre2 PDB 2gfg chain B Region: 2 - 197 Aligned: 178 Modelled: 196 Confidence: 100.0% Identity: 24% PDB header:unknown function Chain: B: PDB Molecule:bh2851; PDBTitle: crystal structure of a putative adenylate cyclase (bh2851) from2 bacillus halodurans at 2.12 a resolution Phyre2 PDB 2jmu chain A domain 1 Region: 1 - 224 Aligned: 217 Modelled: 222 Confidence: 100.0% Identity: 19% Fold: CYTH-like phosphatases Superfamily: CYTH-like phosphatases Family: CYTH domain Phyre2 PDB 3sy3 chain D Region: 1 - 186 Aligned: 166 Modelled: 186 Confidence: 100.0% Identity: 23% PDB header:lyase Chain: D: PDB Molecule:gbaa_1210 protein; PDBTitle: gbaa_1210 protein, a putative adenylate cyclase, from bacillus2 anthracis Phyre2 PDB 2fjt chain A Region: 4 - 190 Aligned: 157 Modelled: 174 Confidence: 99.8% Identity: 18% PDB header:lyase Chain: A: PDB Molecule:adenylyl cyclase class iv; PDBTitle: adenylyl cyclase class iv from yersinia pestis Phyre2 PDB 2aca chain A domain 1 Region: 2 - 190 Aligned: 160 Modelled: 176 Confidence: 99.8% Identity: 16% Fold: CYTH-like phosphatases Superfamily: CYTH-like phosphatases Family: CYTH domain Phyre2 PDB 2dc4 chain A Region: 3 - 191 Aligned: 156 Modelled: 185 Confidence: 99.8% Identity: 21% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:165aa long hypothetical protein; PDBTitle: structure of ph1012 protein from pyrococcus horikoshii ot3 Phyre2 PDB 1yem chain A Region: 3 - 191 Aligned: 156 Modelled: 176 Confidence: 99.7% Identity: 17% Fold: CYTH-like phosphatases Superfamily: CYTH-like phosphatases Family: CYTH domain Phyre2 PDB 2een chain A Region: 4 - 198 Aligned: 168 Modelled: 183 Confidence: 99.7% Identity: 25% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical protein ph1819; PDBTitle: structure of ph1819 protein from pyrococcus horikoshii ot3 Phyre2 PDB 3g3r chain A Region: 5 - 208 Aligned: 202 Modelled: 204 Confidence: 98.5% Identity: 16% PDB header:biosynthetic protein Chain: A: PDB Molecule:vacuolar transporter chaperone 4; PDBTitle: crystal structure of a eukaryotic polyphosphate polymerase2 in complex with appnhp-mn2+ Phyre2 PDB 3g3o chain A Region: 8 - 198 Aligned: 186 Modelled: 190 Confidence: 98.3% Identity: 17% PDB header:biosynthetic protein Chain: A: PDB Molecule:vacuolar transporter chaperone 2; PDBTitle: crystal structure of the cytoplasmic tunnel domain in yeast2 vtc2p Phyre2 PDB 2fbl chain A domain 1 Region: 3 - 165 Aligned: 110 Modelled: 151 Confidence: 97.2% Identity: 28% Fold: CYTH-like phosphatases Superfamily: CYTH-like phosphatases Family: CYTH domain Phyre2 PDB 3oq0 chain D Region: 39 - 45 Aligned: 7 Modelled: 7 Confidence: 21.0% Identity: 43% PDB header:cell cycle Chain: D: PDB Molecule:dbf4; PDBTitle: crystal structure of motif n of saccharomyces cerevisiae dbf4 Phyre2 PDB 1b77 chain A domain 2 Region: 159 - 178 Aligned: 20 Modelled: 20 Confidence: 9.5% Identity: 20% Fold: DNA clamp Superfamily: DNA clamp Family: DNA polymerase processivity factor Phyre2 PDB 2y3y chain C Region: 159 - 192 Aligned: 34 Modelled: 34 Confidence: 9.4% Identity: 26% PDB header:transcription Chain: C: PDB Molecule:putative nickel-responsive regulator; PDBTitle: holo-ni(ii) hpnikr is a symmetric tetramer containing four2 canonic square-planar ni(ii) ions at physiological ph Phyre2 PDB 2agh chain A Region: 1 - 8 Aligned: 8 Modelled: 8 Confidence: 8.9% Identity: 63% PDB header:transcription Chain: A: PDB Molecule:myb proto-oncogene protein; PDBTitle: structural basis for cooperative transcription factor2 binding to the cbp coactivator Phyre2 PDB 1czd chain A domain 2 Region: 159 - 178 Aligned: 20 Modelled: 20 Confidence: 8.8% Identity: 20% Fold: DNA clamp Superfamily: DNA clamp Family: DNA polymerase processivity factor Phyre2 PDB 1nh1 chain A Region: 168 - 228 Aligned: 61 Modelled: 61 Confidence: 8.4% Identity: 15% Fold: Antivirulence factor Superfamily: Antivirulence factor Family: Antivirulence factor Phyre2 PDB 1nh1 chain A Region: 168 - 228 Aligned: 61 Modelled: 61 Confidence: 8.4% Identity: 15% PDB header:avirulence protein Chain: A: PDB Molecule:avirulence b protein; PDBTitle: crystal structure of the type iii effector avrb from2 pseudomonas syringae. Phyre2 PDB 2y9x chain G Region: 58 - 75 Aligned: 18 Modelled: 18 Confidence: 7.8% Identity: 28% PDB header:oxidoreductase Chain: G: PDB Molecule:lectin-like fold protein; PDBTitle: crystal structure of ppo3, a tyrosinase from agaricus bisporus, in2 deoxy-form that contains additional unknown lectin-like subunit,3 with inhibitor tropolone Phyre2 1 c3e0sA_ 2 c2gfgB_ 3 d2jmua1 4 c3sy3D_ 5 c2fjtA_ 6 d2acaa1 7 c2dc4A_ 8 d1yema_ 9 c2eenA_ 10 c3g3rA_ 11 c3g3oA_ 12 d2fbla1 13 c3oq0D_ 14 d1b77a2 15 c2y3yC_ 16 c2aghA_ 17 d1czda2 18 d1nh1a_ 19 c1nh1A_ 20 c2y9xG_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c3e0sA_ 100.0 12 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of an uncharacterized protein from2 chlorobium tepidum 2 c2gfgB_ 100.0 24 PDB header:unknown function Chain: B: PDB Molecule:bh2851; PDBTitle: crystal structure of a putative adenylate cyclase (bh2851) from2 bacillus halodurans at 2.12 a resolution 3 d2jmua1 100.0 19 Fold:CYTH-like phosphatases Superfamily:CYTH-like phosphatases Family:CYTH domain 4 c3sy3D_ 100.0 23 PDB header:lyase Chain: D: PDB Molecule:gbaa_1210 protein; PDBTitle: gbaa_1210 protein, a putative adenylate cyclase, from bacillus2 anthracis 5 c2fjtA_ 99.8 18 PDB header:lyase Chain: A: PDB Molecule:adenylyl cyclase class iv; PDBTitle: adenylyl cyclase class iv from yersinia pestis 6 d2acaa1 99.8 16 Fold:CYTH-like phosphatases Superfamily:CYTH-like phosphatases Family:CYTH domain 7 c2dc4A_ 99.8 21 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:165aa long hypothetical protein; PDBTitle: structure of ph1012 protein from pyrococcus horikoshii ot3 8 d1yema_ 99.7 17 Fold:CYTH-like phosphatases Superfamily:CYTH-like phosphatases Family:CYTH domain 9 c2eenA_ 99.7 25 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical protein ph1819; PDBTitle: structure of ph1819 protein from pyrococcus horikoshii ot3 10 c3g3rA_ 98.5 16 PDB header:biosynthetic protein Chain: A: PDB Molecule:vacuolar transporter chaperone 4; PDBTitle: crystal structure of a eukaryotic polyphosphate polymerase2 in complex with appnhp-mn2+ 11 c3g3oA_ 98.3 17 PDB header:biosynthetic protein Chain: A: PDB Molecule:vacuolar transporter chaperone 2; PDBTitle: crystal structure of the cytoplasmic tunnel domain in yeast2 vtc2p 12 d2fbla1 97.2 28 Fold:CYTH-like phosphatases Superfamily:CYTH-like phosphatases Family:CYTH domain 13 c3oq0D_ 21.0 43 PDB header:cell cycle Chain: D: PDB Molecule:dbf4; PDBTitle: crystal structure of motif n of saccharomyces cerevisiae dbf4 14 d1b77a2 9.5 20 Fold:DNA clamp Superfamily:DNA clamp Family:DNA polymerase processivity factor 15 c2y3yC_ 9.4 26 PDB header:transcription Chain: C: PDB Molecule:putative nickel-responsive regulator; PDBTitle: holo-ni(ii) hpnikr is a symmetric tetramer containing four2 canonic square-planar ni(ii) ions at physiological ph 16 c2aghA_ 8.9 63 PDB header:transcription Chain: A: PDB Molecule:myb proto-oncogene protein; PDBTitle: structural basis for cooperative transcription factor2 binding to the cbp coactivator 17 d1czda2 8.8 20 Fold:DNA clamp Superfamily:DNA clamp Family:DNA polymerase processivity factor 18 d1nh1a_ 8.4 15 Fold:Antivirulence factor Superfamily:Antivirulence factor Family:Antivirulence factor 19 c1nh1A_ 8.4 15 PDB header:avirulence protein Chain: A: PDB Molecule:avirulence b protein; PDBTitle: crystal structure of the type iii effector avrb from2 pseudomonas syringae. 20 c2y9xG_ 7.8 28 PDB header:oxidoreductase Chain: G: PDB Molecule:lectin-like fold protein; PDBTitle: crystal structure of ppo3, a tyrosinase from agaricus bisporus, in2 deoxy-form that contains additional unknown lectin-like subunit,3 with inhibitor tropolone 21 c1sb0B_ not modelled 7.6 63 PDB header:transcription Chain: B: PDB Molecule:protein c-myb; PDBTitle: solution structure of the kix domain of cbp bound to the2 transactivation domain of c-myb 22 d1n8ia_ not modelled 7.4 22 Fold:TIM beta/alpha-barrel Superfamily:Malate synthase G Family:Malate synthase G 23 c3ectA_ not modelled 7.4 12 PDB header:transferase Chain: A: PDB Molecule:hexapeptide-repeat containing-acetyltransferase; PDBTitle: crystal structure of the hexapeptide-repeat containing-2 acetyltransferase vca0836 from vibrio cholerae 24 c2imuA_ not modelled 7.2 28 PDB header:viral protein Chain: A: PDB Molecule:structural polyprotein (pp) p1; PDBTitle: nmr structure of pep46 from the infectious bursal disease2 virus (ibdv) in dodecylphosphocholin (dpc). 25 d2oyza1 not modelled 7.1 33 Fold:Double-stranded beta-helix Superfamily:RmlC-like cupins Family:VPA0057-like 26 d1qr5a_ not modelled 6.8 31 Fold:HPr-like Superfamily:HPr-like Family:HPr-like 27 d1ka5a_ not modelled 6.8 25 Fold:HPr-like Superfamily:HPr-like Family:HPr-like 28 c2eqeA_ not modelled 6.6 43 PDB header:hydrolase Chain: A: PDB Molecule:tumor necrosis factor, alpha-induced protein 3; PDBTitle: solution structure of the fourth a20-type zinc finger2 domain from human tumor necrosis factor, alpha-induced3 protein3 29 d2ae8a2 not modelled 6.6 16 Fold:Ribosomal protein S5 domain 2-like Superfamily:Ribosomal protein S5 domain 2-like Family:Imidazole glycerol phosphate dehydratase 30 c2bnoA_ not modelled 6.5 20 PDB header:oxidoreductase Chain: A: PDB Molecule:epoxidase; PDBTitle: the structure of hydroxypropylphosphonic acid epoxidase2 from s. wedmorenis. 31 d2ofya1 not modelled 6.3 20 Fold:lambda repressor-like DNA-binding domains Superfamily:lambda repressor-like DNA-binding domains Family:SinR domain-like 32 d1ok7a2 not modelled 6.2 15 Fold:DNA clamp Superfamily:DNA clamp Family:DNA polymerase III, beta subunit 33 d2nzul1 not modelled 6.1 31 Fold:HPr-like Superfamily:HPr-like Family:HPr-like 34 c3eo6B_ not modelled 6.1 17 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:protein of unknown function (duf1255); PDBTitle: crystal structure of protein of unknown function (duf1255)2 (afe_2634) from acidithiobacillus ferrooxidans ncib8455 at3 0.97 a resolution 35 c3pxpA_ not modelled 6.0 20 PDB header:transcription regulator Chain: A: PDB Molecule:helix-turn-helix domain protein; PDBTitle: crystal structure of a pas and dna binding domain containing protein2 (caur_2278) from chloroflexus aurantiacus j-10-fl at 2.30 a3 resolution 36 c3hqxA_ not modelled 5.9 33 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:upf0345 protein aciad0356; PDBTitle: crystal structure of protein of unknown function (duf1255,pf06865)2 from acinetobacter sp. adp1 37 c3fbnC_ not modelled 5.8 17 PDB header:transcription Chain: C: PDB Molecule:mediator of rna polymerase ii transcription subunit 7; PDBTitle: structure of the mediator submodule med7n/31 38 c1y9qA_ not modelled 5.8 25 PDB header:transcription regulator Chain: A: PDB Molecule:transcriptional regulator, hth_3 family; PDBTitle: crystal structure of hth_3 family transcriptional regulator2 from vibrio cholerae 39 c3eusB_ not modelled 5.8 15 PDB header:dna binding protein Chain: B: PDB Molecule:dna-binding protein; PDBTitle: the crystal structure of the dna binding protein from silicibacter2 pomeroyi 40 d1w0ba_ not modelled 5.8 20 Fold:Spectrin repeat-like Superfamily:Alpha-hemoglobin stabilizing protein AHSP Family:Alpha-hemoglobin stabilizing protein AHSP 41 c3f3bA_ not modelled 5.7 67 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:phage-like element pbsx protein xkdh; PDBTitle: structure of the phage-like element pbsx protein xkdh from2 bacillus subtilus. northeast structural genomics3 consortium target sr352. 42 d2j0oa1 not modelled 5.6 9 Fold:IpaD-like Superfamily:IpaD-like Family:IpaD-like 43 c2j0oA_ not modelled 5.6 9 PDB header:cell invasion Chain: A: PDB Molecule:invasin ipad; PDBTitle: shigella flexneri ipad 44 d1d8ca_ not modelled 5.6 19 Fold:TIM beta/alpha-barrel Superfamily:Malate synthase G Family:Malate synthase G 45 c2hw2A_ not modelled 5.5 14 PDB header:transferase Chain: A: PDB Molecule:rifampin adp-ribosyl transferase; PDBTitle: crystal structure of rifampin adp-ribosyl transferase in2 complex with rifampin 46 d1xu2r_ not modelled 5.3 25 Fold:TNF receptor-like Superfamily:TNF receptor-like Family:BAFF receptor-like 47 c1xu2R_ not modelled 5.3 25 PDB header:cytokine, hormone/growth factor receptor Chain: R: PDB Molecule:tumor necrosis factor receptor superfamily member 17; PDBTitle: the crystal structure of april bound to bcma 48 d1d8ia_ not modelled 5.3 23 Fold:CYTH-like phosphatases Superfamily:CYTH-like phosphatases Family:mRNA triphosphatase CET1 49 c1b8hA_ not modelled 5.1 21 PDB header:transferase Chain: A: PDB Molecule:dna polymerase processivity component; PDBTitle: sliding clamp, dna polymerase 50 d1z8ua1 not modelled 5.1 20 Fold:Spectrin repeat-like Superfamily:Alpha-hemoglobin stabilizing protein AHSP Family:Alpha-hemoglobin stabilizing protein AHSP 51 c3sr2A_ not modelled 5.1 3 PDB header:dna binding protein/protein binding Chain: A: PDB Molecule:dna repair protein xrcc4; PDBTitle: crystal structure of human xlf-xrcc4 complex 52 d1v7wa2 not modelled 5.1 5 Fold:Supersandwich Superfamily:Galactose mutarotase-like Family:Glycosyltransferase family 36 N-terminal domain

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0