Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	L	E	Q	L	K	A	D	V	L	A	A	N	L	A	L	P	A	H	H	L	V	T	F	T	W	G	N	V	S	A	V	D	E	T	R	Q	W	M	V	I	K	P	S	G	V	E	Y	D	V	M	T	A	D	D	M	V	V	V	E
Secondary structure
SS confidence
Disorder		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		I	A	S	G	K	V	V	E	G	S	K	K	P	S	S	D	T	P	T	H	L	A	L	Y	R	R	Y	A	E	I	G	G	I	V	H	T	H	S	R	H	A	T	I	W	S	Q	A	G	L	D	L	P	A	W	G	T	T	H	A	D
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		Y	F	Y	G	A	I	P	C	T	R	Q	M	T	A	E	E	I	N	G	E	Y	E	Y	Q	T	G	E	V	I	I	E	T	F	E	E	R	G	R	S	P	A	Q	I	P	A	V	L	V	H	S	H	G	P	F	A	W	G	K	N	A
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.
Sequence		A	D	A	V	H	N	A	V	V	L	E	E	C	A	Y	M	G	L	F	S	R	Q	L	A	P	Q	L	P	A	M	Q	N	E	L	L	D	K	H	Y	L	R	K	H	G	A	N	A	Y	Y	G	Q
Secondary structure
SS confidence
Disorder																									?	?	?	?	?	?	?	?												?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1k0w chain A Region: 1 - 223 Aligned: 223 Modelled: 223 Confidence: 100.0% Identity: 74% Fold: AraD/HMP-PK domain-like Superfamily: AraD/HMP-PK domain-like Family: AraD-like aldolase/epimerase Phyre2 PDB 3ocr chain A Region: 3 - 230 Aligned: 214 Modelled: 216 Confidence: 100.0% Identity: 17% PDB header:lyase Chain: A: PDB Molecule:class ii aldolase/adducin domain protein; PDBTitle: crystal structure of aldolase ii superfamily protein from pseudomonas2 syringae Phyre2 PDB 1e4c chain P Region: 3 - 221 Aligned: 202 Modelled: 206 Confidence: 100.0% Identity: 27% Fold: AraD/HMP-PK domain-like Superfamily: AraD/HMP-PK domain-like Family: AraD-like aldolase/epimerase Phyre2 PDB 1ojr chain A Region: 4 - 225 Aligned: 209 Modelled: 209 Confidence: 100.0% Identity: 15% Fold: AraD/HMP-PK domain-like Superfamily: AraD/HMP-PK domain-like Family: AraD-like aldolase/epimerase Phyre2 PDB 2z7b chain A Region: 3 - 217 Aligned: 207 Modelled: 211 Confidence: 100.0% Identity: 15% PDB header:lyase Chain: A: PDB Molecule:mlr6791 protein; PDBTitle: crystal structure of mesorhizobium loti 3-hydroxy-2-methylpyridine-4,2 5-dicarboxylate decarboxylase Phyre2 PDB 1pvt chain A Region: 3 - 209 Aligned: 194 Modelled: 194 Confidence: 100.0% Identity: 22% Fold: AraD/HMP-PK domain-like Superfamily: AraD/HMP-PK domain-like Family: AraD-like aldolase/epimerase Phyre2 PDB 2opi chain B Region: 3 - 216 Aligned: 196 Modelled: 199 Confidence: 100.0% Identity: 17% PDB header:lyase Chain: B: PDB Molecule:l-fuculose-1-phosphate aldolase; PDBTitle: crystal structure of l-fuculose-1-phosphate aldolase from bacteroides2 thetaiotaomicron Phyre2 PDB 2irp chain A Region: 2 - 203 Aligned: 198 Modelled: 202 Confidence: 100.0% Identity: 22% PDB header:lyase Chain: A: PDB Molecule:putative aldolase class 2 protein aq_1979; PDBTitle: crystal structure of the l-fuculose-1-phosphate aldolase (aq_1979)2 from aquifex aeolicus vf5 Phyre2 PDB 2fk5 chain B Region: 3 - 208 Aligned: 186 Modelled: 190 Confidence: 100.0% Identity: 27% PDB header:lyase Chain: B: PDB Molecule:fuculose-1-phosphate aldolase; PDBTitle: crystal structure of l-fuculose-1-phosphate aldolase from thermus2 thermophilus hb8 Phyre2 PDB 3m4r chain A Region: 5 - 198 Aligned: 170 Modelled: 181 Confidence: 100.0% Identity: 16% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: structure of the n-terminal class ii aldolase domain of a conserved2 protein from thermoplasma acidophilum Phyre2 PDB 2cfu chain A Region: 145 - 231 Aligned: 82 Modelled: 87 Confidence: 34.7% Identity: 11% PDB header:hydrolase Chain: A: PDB Molecule:sdsa1; PDBTitle: crystal structure of sdsa1, an alkylsulfatase from2 pseudomonas aeruginosa, in complex with 1-decane-sulfonic-3 acid. Phyre2 PDB 2yzt chain A Region: 172 - 190 Aligned: 19 Modelled: 19 Confidence: 34.1% Identity: 0% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:putative uncharacterized protein ttha1756; PDBTitle: crystal structure of uncharacterized conserved protein from thermus2 thermophilus hb8 Phyre2 PDB 2cfu chain A domain 2 Region: 145 - 231 Aligned: 82 Modelled: 87 Confidence: 27.0% Identity: 11% Fold: Metallo-hydrolase/oxidoreductase Superfamily: Metallo-hydrolase/oxidoreductase Family: Alkylsulfatase-like Phyre2 PDB 3kva chain A Region: 31 - 85 Aligned: 46 Modelled: 55 Confidence: 19.2% Identity: 20% PDB header:h3k4me3 binding protein, transferase Chain: A: PDB Molecule:jmjc domain-containing histone demethylation protein 1d; PDBTitle: structure of kiaa1718 jumonji domain in complex with alpha-2 ketoglutarate Phyre2 PDB 1j5u chain A Region: 172 - 190 Aligned: 19 Modelled: 19 Confidence: 16.4% Identity: 11% Fold: MTH1598-like Superfamily: MTH1598-like Family: MTH1598-like Phyre2 PDB 2w3p chain B Region: 124 - 182 Aligned: 59 Modelled: 59 Confidence: 15.7% Identity: 14% PDB header:lyase Chain: B: PDB Molecule:benzoyl-coa-dihydrodiol lyase; PDBTitle: boxc crystal structure Phyre2 PDB 1jw3 chain A Region: 172 - 190 Aligned: 19 Modelled: 19 Confidence: 14.2% Identity: 26% Fold: MTH1598-like Superfamily: MTH1598-like Family: MTH1598-like Phyre2 PDB 1gp6 chain A Region: 125 - 173 Aligned: 42 Modelled: 49 Confidence: 12.9% Identity: 12% Fold: Double-stranded beta-helix Superfamily: Clavaminate synthase-like Family: Penicillin synthase-like Phyre2 PDB 1odm chain A Region: 125 - 173 Aligned: 42 Modelled: 49 Confidence: 12.4% Identity: 14% Fold: Double-stranded beta-helix Superfamily: Clavaminate synthase-like Family: Penicillin synthase-like Phyre2 PDB 2btw chain A Region: 2 - 41 Aligned: 40 Modelled: 40 Confidence: 12.3% Identity: 18% PDB header:transferase Chain: A: PDB Molecule:alr0975 protein; PDBTitle: crystal structure of alr0975 Phyre2 1 d1k0wa_ 2 c3ocrA_ 3 d1e4cp_ 4 d1ojra_ 5 c2z7bA_ 6 d1pvta_ 7 c2opiB_ 8 c2irpA_ 9 c2fk5B_ 10 c3m4rA_ 11 c2cfuA_ 12 c2yztA_ 13 d2cfua2 14 c3kvaA_ 15 d1j5ua_ 16 c2w3pB_ 17 d1jw3a_ 18 d1gp6a_ 19 d1odma_ 20 c2btwA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d1k0wa_ 100.0 74 Fold:AraD/HMP-PK domain-like Superfamily:AraD/HMP-PK domain-like Family:AraD-like aldolase/epimerase 2 c3ocrA_ 100.0 17 PDB header:lyase Chain: A: PDB Molecule:class ii aldolase/adducin domain protein; PDBTitle: crystal structure of aldolase ii superfamily protein from pseudomonas2 syringae 3 d1e4cp_ 100.0 27 Fold:AraD/HMP-PK domain-like Superfamily:AraD/HMP-PK domain-like Family:AraD-like aldolase/epimerase 4 d1ojra_ 100.0 15 Fold:AraD/HMP-PK domain-like Superfamily:AraD/HMP-PK domain-like Family:AraD-like aldolase/epimerase 5 c2z7bA_ 100.0 15 PDB header:lyase Chain: A: PDB Molecule:mlr6791 protein; PDBTitle: crystal structure of mesorhizobium loti 3-hydroxy-2-methylpyridine-4,2 5-dicarboxylate decarboxylase 6 d1pvta_ 100.0 22 Fold:AraD/HMP-PK domain-like Superfamily:AraD/HMP-PK domain-like Family:AraD-like aldolase/epimerase 7 c2opiB_ 100.0 17 PDB header:lyase Chain: B: PDB Molecule:l-fuculose-1-phosphate aldolase; PDBTitle: crystal structure of l-fuculose-1-phosphate aldolase from bacteroides2 thetaiotaomicron 8 c2irpA_ 100.0 22 PDB header:lyase Chain: A: PDB Molecule:putative aldolase class 2 protein aq_1979; PDBTitle: crystal structure of the l-fuculose-1-phosphate aldolase (aq_1979)2 from aquifex aeolicus vf5 9 c2fk5B_ 100.0 27 PDB header:lyase Chain: B: PDB Molecule:fuculose-1-phosphate aldolase; PDBTitle: crystal structure of l-fuculose-1-phosphate aldolase from thermus2 thermophilus hb8 10 c3m4rA_ 100.0 16 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: structure of the n-terminal class ii aldolase domain of a conserved2 protein from thermoplasma acidophilum 11 c2cfuA_ 34.7 11 PDB header:hydrolase Chain: A: PDB Molecule:sdsa1; PDBTitle: crystal structure of sdsa1, an alkylsulfatase from2 pseudomonas aeruginosa, in complex with 1-decane-sulfonic-3 acid. 12 c2yztA_ 34.1 0 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:putative uncharacterized protein ttha1756; PDBTitle: crystal structure of uncharacterized conserved protein from thermus2 thermophilus hb8 13 d2cfua2 27.0 11 Fold:Metallo-hydrolase/oxidoreductase Superfamily:Metallo-hydrolase/oxidoreductase Family:Alkylsulfatase-like 14 c3kvaA_ 19.2 20 PDB header:h3k4me3 binding protein, transferase Chain: A: PDB Molecule:jmjc domain-containing histone demethylation protein 1d; PDBTitle: structure of kiaa1718 jumonji domain in complex with alpha-2 ketoglutarate 15 d1j5ua_ 16.4 11 Fold:MTH1598-like Superfamily:MTH1598-like Family:MTH1598-like 16 c2w3pB_ 15.7 14 PDB header:lyase Chain: B: PDB Molecule:benzoyl-coa-dihydrodiol lyase; PDBTitle: boxc crystal structure 17 d1jw3a_ 14.2 26 Fold:MTH1598-like Superfamily:MTH1598-like Family:MTH1598-like 18 d1gp6a_ 12.9 12 Fold:Double-stranded beta-helix Superfamily:Clavaminate synthase-like Family:Penicillin synthase-like 19 d1odma_ 12.4 14 Fold:Double-stranded beta-helix Superfamily:Clavaminate synthase-like Family:Penicillin synthase-like 20 c2btwA_ 12.3 18 PDB header:transferase Chain: A: PDB Molecule:alr0975 protein; PDBTitle: crystal structure of alr0975 21 c2ra9A_ not modelled 9.1 10 PDB header:unknown function Chain: A: PDB Molecule:uncharacterized protein duf1285; PDBTitle: crystal structure of a duf1285 family protein (sbal_2486) from2 shewanella baltica os155 at 1.40 a resolution 22 d2bu3a1 not modelled 8.4 18 Fold:Cysteine proteinases Superfamily:Cysteine proteinases Family:Phytochelatin synthase 23 c2kouA_ not modelled 7.8 26 PDB header:hydrolase Chain: A: PDB Molecule:dicer-like protein 4; PDBTitle: dicer like protein 24 c1gn4B_ not modelled 7.5 10 PDB header:oxidoreductase Chain: B: PDB Molecule:superoxide dismutase; PDBTitle: h145e mutant of mycobacterium tuberculosis iron-superoxide2 dismutase. 25 c1fcuA_ not modelled 7.4 9 PDB header:hydrolase Chain: A: PDB Molecule:hyaluronoglucosaminidase; PDBTitle: crystal structure (trigonal) of bee venom hyaluronidase 26 c3kv4A_ not modelled 7.1 20 PDB header:h3k4me3 binding protein, transferase Chain: A: PDB Molecule:phd finger protein 8; PDBTitle: structure of phf8 in complex with histone h3 27 c2i0tB_ not modelled 7.0 23 PDB header:oxidoreductase Chain: B: PDB Molecule:aromatic amine dehydrogenase; PDBTitle: crystal structure of phenylacetaldehyde derived r-2 carbinolamine adduct of aromatic amine dehydrogenase 28 c2yz3B_ not modelled 7.0 13 PDB header:hydrolase Chain: B: PDB Molecule:metallo-beta-lactamase; PDBTitle: crystallographic investigation of inhibition mode of the2 vim-2 metallo-beta-lactamase from pseudomonas aeruginosa3 with mercaptocarboxylate inhibitor 29 c3euhF_ not modelled 7.0 23 PDB header:cell cycle Chain: F: PDB Molecule:muke; PDBTitle: crystal structure of the muke-mukf complex 30 c2oqkA_ not modelled 6.8 20 PDB header:translation Chain: A: PDB Molecule:putative translation initiation factor eif-1a; PDBTitle: crystal structure of putative cryptosporidium parvum translation2 initiation factor eif-1a 31 d1y67a2 not modelled 6.7 10 Fold:Fe,Mn superoxide dismutase (SOD), C-terminal domain Superfamily:Fe,Mn superoxide dismutase (SOD), C-terminal domain Family:Fe,Mn superoxide dismutase (SOD), C-terminal domain 32 d1fcqa_ not modelled 6.4 9 Fold:TIM beta/alpha-barrel Superfamily:(Trans)glycosidases Family:Bee venom hyaluronidase 33 d1wi9a_ not modelled 6.3 25 Fold:DNA/RNA-binding 3-helical bundle Superfamily:"Winged helix" DNA-binding domain Family:PCI domain (PINT motif) 34 d1f28a_ not modelled 5.9 11 Fold:Thymidylate synthase/dCMP hydroxymethylase Superfamily:Thymidylate synthase/dCMP hydroxymethylase Family:Thymidylate synthase/dCMP hydroxymethylase 35 d1a9xa5 not modelled 5.9 19 Fold:ATP-grasp Superfamily:Glutathione synthetase ATP-binding domain-like Family:BC ATP-binding domain-like 36 c2e1nA_ not modelled 5.6 14 PDB header:circadian clock protein Chain: A: PDB Molecule:pex; PDBTitle: crystal structure of the cyanobacterium circadian clock modifier pex 37 d1kzyc2 not modelled 5.6 14 Fold:BRCT domain Superfamily:BRCT domain Family:53BP1 38 c1ibtC_ not modelled 5.6 50 PDB header:lyase Chain: C: PDB Molecule:histidine decarboxylase beta chain; PDBTitle: structure of the d53,54n mutant of histidine decarboxylase at-170 c 39 d1uerc2 not modelled 5.6 24 Fold:Fe,Mn superoxide dismutase (SOD), C-terminal domain Superfamily:Fe,Mn superoxide dismutase (SOD), C-terminal domain Family:Fe,Mn superoxide dismutase (SOD), C-terminal domain 40 d1b06a2 not modelled 5.5 19 Fold:Fe,Mn superoxide dismutase (SOD), C-terminal domain Superfamily:Fe,Mn superoxide dismutase (SOD), C-terminal domain Family:Fe,Mn superoxide dismutase (SOD), C-terminal domain 41 c1kkcB_ not modelled 5.3 10 PDB header:oxidoreductase Chain: B: PDB Molecule:manganese superoxide dismutase; PDBTitle: crystal structure of aspergillus fumigatus mnsod 42 c3pu3A_ not modelled 5.2 17 PDB header:protein binding Chain: A: PDB Molecule:phd finger protein 2; PDBTitle: phf2 jumonji domain-nog complex 43 c3da4B_ not modelled 5.1 20 PDB header:antibiotic Chain: B: PDB Molecule:colicin-m; PDBTitle: crystal structure of colicin m, a novel phosphatase2 specifically imported by escherichia coli 44 d1gv3a2 not modelled 5.1 19 Fold:Fe,Mn superoxide dismutase (SOD), C-terminal domain Superfamily:Fe,Mn superoxide dismutase (SOD), C-terminal domain Family:Fe,Mn superoxide dismutase (SOD), C-terminal domain

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0