Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	I	S	L	K	A	P	H	N	N	L	M	P	Y	T	Q	Q	S	I	L	N	T	V	K	N	N	Q	L	P	E	D	I	K	S	S	L	V	S	C	V	D	I	F	K	V	L	I	K	Q	Y	Y	D	Y	P	Y	D	C	R	D	D
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?																		?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		L	V	D	D	D	K	L	I	H	L	M	A	A	V	R	D	C	E	W	S	D	D	N	A	L	T	I	N	V	Q	F	N	D	F	P	G	F	Y	D	W	M	D	Y	P	D	H	P	V	K	F	V	F	H	I	L	E	N	Q	K	G
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		T	V	W	V	Y	D	Q	D	D	A	F	L	D	I	K	A	N	V	Q	A	G	R	F	T	G	L	K	K	L	V	Q	F	I	D	S	V	R	T	D	C	K	C	I	L	L	E	Y	H	M	P	L	L	R	I	F	P	K	G	K	E
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		C	M	H	V	E	K	W	L	R	E	M	S	S	I	P	E	T	D	A	P	I	K	Q	A	L	A	H	G	L	L	L	H	L	K	N	I	Y	P	V	F	P	E	S	L	V	M	L	L	L	S	V	L	D	V	K	T	Y	R	D	D
Secondary structure
SS confidence
Disorder														?	?	?	?	?	?																																				?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.
Sequence		A	R	L	N	E	W	I	S	N	R	V	Q	E	L	G	D	R	Y	Y	P	V	N	K	H	V	K	I	R	Y	T	L
Secondary structure
SS confidence
Disorder																															?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1bco chain A domain 1 Region: 120 - 132 Aligned: 13 Modelled: 13 Confidence: 29.0% Identity: 38% Fold: mu transposase, C-terminal domain Superfamily: mu transposase, C-terminal domain Family: mu transposase, C-terminal domain Phyre2 PDB 1hci chain A domain 1 Region: 241 - 260 Aligned: 20 Modelled: 20 Confidence: 24.9% Identity: 30% Fold: Spectrin repeat-like Superfamily: Spectrin repeat Family: Spectrin repeat Phyre2 PDB 3nb2 chain B Region: 188 - 248 Aligned: 61 Modelled: 61 Confidence: 21.6% Identity: 18% PDB header:ligase Chain: B: PDB Molecule:secreted effector protein; PDBTitle: crystal structure of e. coli o157:h7 effector protein nlel Phyre2 PDB 2qza chain A Region: 188 - 248 Aligned: 56 Modelled: 59 Confidence: 21.2% Identity: 32% PDB header:ligase Chain: A: PDB Molecule:secreted effector protein; PDBTitle: crystal structure of salmonella effector protein sopa Phyre2 PDB 3r7w chain C Region: 87 - 193 Aligned: 98 Modelled: 106 Confidence: 17.3% Identity: 17% PDB header:protein transport Chain: C: PDB Molecule:gtp-binding protein gtr1; PDBTitle: crystal structure of gtr1p-gtr2p complex Phyre2 PDB 3oa7 chain A Region: 180 - 250 Aligned: 69 Modelled: 71 Confidence: 16.8% Identity: 19% PDB header:structural protein Chain: A: PDB Molecule:head morphogenesis protein, chaotic nuclear migration PDBTitle: structure of the c-terminal domain of cnm67, a core component of the2 spindle pole body of saccharomyces cerevisiae Phyre2 PDB 3fd9 chain C Region: 143 - 198 Aligned: 56 Modelled: 56 Confidence: 16.5% Identity: 18% PDB header:unknown function Chain: C: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of the transcriptional anti-activator exsd2 from pseudomonas aeruginosa Phyre2 PDB 1hss chain A Region: 98 - 105 Aligned: 8 Modelled: 8 Confidence: 15.9% Identity: 50% Fold: Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin Superfamily: Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin Family: Proteinase/alpha-amylase inhibitors Phyre2 PDB 1g3j chain B Region: 31 - 37 Aligned: 7 Modelled: 7 Confidence: 13.3% Identity: 86% PDB header:transcription Chain: B: PDB Molecule:tcf3-cbd (catenin binding domain); PDBTitle: crystal structure of the xtcf3-cbd/beta-catenin armadillo2 repeat complex Phyre2 PDB 1ag9 chain A Region: 96 - 146 Aligned: 51 Modelled: 51 Confidence: 12.8% Identity: 24% Fold: Flavodoxin-like Superfamily: Flavoproteins Family: Flavodoxin-related Phyre2 PDB 1hm4 chain A Region: 165 - 241 Aligned: 76 Modelled: 77 Confidence: 9.6% Identity: 21% PDB header:lyase Chain: A: PDB Molecule:pentalenene synthase; PDBTitle: n219l pentalenene synthase Phyre2 PDB 1usm chain A Region: 78 - 102 Aligned: 25 Modelled: 25 Confidence: 9.2% Identity: 20% Fold: DCoH-like Superfamily: PCD-like Family: PCD-like Phyre2 PDB 1jdh chain B Region: 31 - 37 Aligned: 7 Modelled: 7 Confidence: 9.0% Identity: 86% PDB header:transcription Chain: B: PDB Molecule:htcf-4; PDBTitle: crystal structure of beta-catenin and htcf-4 Phyre2 PDB 2qb5 chain B Region: 89 - 121 Aligned: 33 Modelled: 33 Confidence: 8.8% Identity: 18% PDB header:transferase Chain: B: PDB Molecule:inositol-tetrakisphosphate 1-kinase; PDBTitle: crystal structure of human inositol 1,3,4-trisphosphate 5/6-kinase2 (itpk1) in complex with adp and mn2+ Phyre2 PDB 1ufz chain A Region: 21 - 41 Aligned: 21 Modelled: 21 Confidence: 8.8% Identity: 43% Fold: RuvA C-terminal domain-like Superfamily: HBS1-like domain Family: HBS1-like domain Phyre2 PDB 3lr4 chain A Region: 60 - 98 Aligned: 37 Modelled: 37 Confidence: 8.6% Identity: 27% PDB header:transferase Chain: A: PDB Molecule:sensor protein; PDBTitle: periplasmic domain of the riss sensor protein from burkholderia2 pseudomallei, barium phased at low ph Phyre2 PDB 3oux chain B Region: 31 - 37 Aligned: 7 Modelled: 7 Confidence: 8.5% Identity: 100% PDB header:protein binding Chain: B: PDB Molecule:lymphoid enhancer-binding factor 1; PDBTitle: structure of beta-catenin with phosphorylated lef-1 Phyre2 PDB 1pvj chain A Region: 6 - 74 Aligned: 64 Modelled: 69 Confidence: 7.5% Identity: 36% Fold: Cysteine proteinases Superfamily: Cysteine proteinases Family: Papain-like Phyre2 PDB 2gjx chain A domain 2 Region: 132 - 163 Aligned: 32 Modelled: 32 Confidence: 7.4% Identity: 16% Fold: Zincin-like Superfamily: beta-N-acetylhexosaminidase-like domain Family: beta-N-acetylhexosaminidase domain Phyre2 PDB 2cup chain A domain 1 Region: 119 - 126 Aligned: 8 Modelled: 8 Confidence: 7.3% Identity: 75% Fold: Glucocorticoid receptor-like (DNA-binding domain) Superfamily: Glucocorticoid receptor-like (DNA-binding domain) Family: LIM domain Phyre2 1 d1bcoa1 2 d1hcia1 3 c3nb2B_ 4 c2qzaA_ 5 c3r7wC_ 6 c3oa7A_ 7 c3fd9C_ 8 d1hssa_ 9 c1g3jB_ 10 d1ag9a_ 11 c1hm4A_ 12 d1usma_ 13 c1jdhB_ 14 c2qb5B_ 15 d1ufza_ 16 c3lr4A_ 17 c3ouxB_ 18 d1pvja_ 19 d2gjxa2 20 d2cupa1 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d1bcoa1 29.0 38 Fold:mu transposase, C-terminal domain Superfamily:mu transposase, C-terminal domain Family:mu transposase, C-terminal domain 2 d1hcia1 24.9 30 Fold:Spectrin repeat-like Superfamily:Spectrin repeat Family:Spectrin repeat 3 c3nb2B_ 21.6 18 PDB header:ligase Chain: B: PDB Molecule:secreted effector protein; PDBTitle: crystal structure of e. coli o157:h7 effector protein nlel 4 c2qzaA_ 21.2 32 PDB header:ligase Chain: A: PDB Molecule:secreted effector protein; PDBTitle: crystal structure of salmonella effector protein sopa 5 c3r7wC_ 17.3 17 PDB header:protein transport Chain: C: PDB Molecule:gtp-binding protein gtr1; PDBTitle: crystal structure of gtr1p-gtr2p complex 6 c3oa7A_ 16.8 19 PDB header:structural protein Chain: A: PDB Molecule:head morphogenesis protein, chaotic nuclear migration PDBTitle: structure of the c-terminal domain of cnm67, a core component of the2 spindle pole body of saccharomyces cerevisiae 7 c3fd9C_ 16.5 18 PDB header:unknown function Chain: C: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of the transcriptional anti-activator exsd2 from pseudomonas aeruginosa 8 d1hssa_ 15.9 50 Fold:Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin Superfamily:Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin Family:Proteinase/alpha-amylase inhibitors 9 c1g3jB_ 13.3 86 PDB header:transcription Chain: B: PDB Molecule:tcf3-cbd (catenin binding domain); PDBTitle: crystal structure of the xtcf3-cbd/beta-catenin armadillo2 repeat complex 10 d1ag9a_ 12.8 24 Fold:Flavodoxin-like Superfamily:Flavoproteins Family:Flavodoxin-related 11 c1hm4A_ 9.6 21 PDB header:lyase Chain: A: PDB Molecule:pentalenene synthase; PDBTitle: n219l pentalenene synthase 12 d1usma_ 9.2 20 Fold:DCoH-like Superfamily:PCD-like Family:PCD-like 13 c1jdhB_ 9.0 86 PDB header:transcription Chain: B: PDB Molecule:htcf-4; PDBTitle: crystal structure of beta-catenin and htcf-4 14 c2qb5B_ 8.8 18 PDB header:transferase Chain: B: PDB Molecule:inositol-tetrakisphosphate 1-kinase; PDBTitle: crystal structure of human inositol 1,3,4-trisphosphate 5/6-kinase2 (itpk1) in complex with adp and mn2+ 15 d1ufza_ 8.8 43 Fold:RuvA C-terminal domain-like Superfamily:HBS1-like domain Family:HBS1-like domain 16 c3lr4A_ 8.6 27 PDB header:transferase Chain: A: PDB Molecule:sensor protein; PDBTitle: periplasmic domain of the riss sensor protein from burkholderia2 pseudomallei, barium phased at low ph 17 c3ouxB_ 8.5 100 PDB header:protein binding Chain: B: PDB Molecule:lymphoid enhancer-binding factor 1; PDBTitle: structure of beta-catenin with phosphorylated lef-1 18 d1pvja_ 7.5 36 Fold:Cysteine proteinases Superfamily:Cysteine proteinases Family:Papain-like 19 d2gjxa2 7.4 16 Fold:Zincin-like Superfamily:beta-N-acetylhexosaminidase-like domain Family:beta-N-acetylhexosaminidase domain 20 d2cupa1 7.3 75 Fold:Glucocorticoid receptor-like (DNA-binding domain) Superfamily:Glucocorticoid receptor-like (DNA-binding domain) Family:LIM domain 21 d1dkia_ not modelled 7.2 25 Fold:Cysteine proteinases Superfamily:Cysteine proteinases Family:Papain-like 22 d2bv3a5 not modelled 6.5 16 Fold:Ferredoxin-like Superfamily:EF-G C-terminal domain-like Family:EF-G/eEF-2 domains III and V 23 d1x63a1 not modelled 6.3 75 Fold:Glucocorticoid receptor-like (DNA-binding domain) Superfamily:Glucocorticoid receptor-like (DNA-binding domain) Family:LIM domain 24 d1go4a_ not modelled 6.0 24 Fold:The spindle assembly checkpoint protein mad2 Superfamily:The spindle assembly checkpoint protein mad2 Family:The spindle assembly checkpoint protein mad2 25 d2bw3a1 not modelled 5.9 20 Fold:Hermes dimerisation domain Superfamily:Hermes dimerisation domain Family:Hermes dimerisation domain 26 c2eefA_ not modelled 5.7 60 PDB header:sugar binding protein Chain: A: PDB Molecule:protein phosphatase 1, regulatory (inhibitor) PDBTitle: solution structure of the cbm_21 domain from human protein2 phosphatase 1, regulatory (inhibitor) subunit 3b 27 c2z0lA_ not modelled 5.7 31 PDB header:replication Chain: A: PDB Molecule:early antigen protein d; PDBTitle: crystal structure of ebv-dna polymerase accessory protein2 bmrf1 28 c1dipA_ not modelled 5.5 75 PDB header:acetylation Chain: A: PDB Molecule:delta-sleep-inducing peptide immunoreactive PDBTitle: the solution structure of porcine delta-sleep-inducing2 peptide immunoreactive peptide, nmr, 10 structures 29 d1h2vc2 not modelled 5.5 25 Fold:alpha-alpha superhelix Superfamily:ARM repeat Family:MIF4G domain-like 30 c1jpwD_ not modelled 5.3 86 PDB header:cell adhesion Chain: D: PDB Molecule:transcription factor 7-like 2; PDBTitle: crystal structure of a human tcf-4 / beta-catenin complex 31 c3bbaB_ not modelled 5.2 32 PDB header:hydrolase Chain: B: PDB Molecule:interpain a; PDBTitle: structure of active wild-type prevotella intermedia interpain a2 cysteine protease 32 d1ydla1 not modelled 5.2 42 Fold:TFB5-like Superfamily:TFB5-like Family:TFB5-like 33 c2xxsA_ not modelled 5.2 50 PDB header:protein binding Chain: A: PDB Molecule:protein mxig; PDBTitle: solution structure of the n-terminal domain of the shigella2 type iii secretion protein mxig 34 c2gedB_ not modelled 5.1 21 PDB header:protein transport, signaling protein Chain: B: PDB Molecule:signal recognition particle receptor beta PDBTitle: signal recognition particle receptor beta-subunit in2 nucleotide-free dimerized form 35 d1dvka_ not modelled 5.1 28 Fold:Functional domain of the splicing factor Prp18 Superfamily:Functional domain of the splicing factor Prp18 Family:Functional domain of the splicing factor Prp18

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

---

Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0